MicroRNA clustering on the biogenesis of suboptimal microRNAs
Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Dr...
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| Autor*in: |
Park, Sehee [verfasserIn] Kang, Igojo [verfasserIn] Shin, Chanseok [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of the Korean Society for Applied Biological Chemistry - [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009, 64(2021), 1 vom: 15. Juli |
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| Übergeordnetes Werk: |
volume:64 ; year:2021 ; number:1 ; day:15 ; month:07 |
| Links: |
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| DOI / URN: |
10.1186/s13765-021-00624-3 |
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SPR044567855 |
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| 520 | |a Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. | ||
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10.1186/s13765-021-00624-3 doi (DE-627)SPR044567855 (SPR)s13765-021-00624-3-e DE-627 ger DE-627 rakwb eng 630 640 540 ASE Park, Sehee verfasserin aut MicroRNA clustering on the biogenesis of suboptimal microRNAs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. miRNA cluster (dpeaa)DE-He213 Pri-miR-144~451 (dpeaa)DE-He213 Suboptimal structure (dpeaa)DE-He213 Non-canonical biogenesis (dpeaa)DE-He213 Microprocessor (dpeaa)DE-He213 Kang, Igojo verfasserin aut Shin, Chanseok verfasserin aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 64(2021), 1 vom: 15. Juli (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:64 year:2021 number:1 day:15 month:07 https://dx.doi.org/10.1186/s13765-021-00624-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 64 2021 1 15 07 |
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10.1186/s13765-021-00624-3 doi (DE-627)SPR044567855 (SPR)s13765-021-00624-3-e DE-627 ger DE-627 rakwb eng 630 640 540 ASE Park, Sehee verfasserin aut MicroRNA clustering on the biogenesis of suboptimal microRNAs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. miRNA cluster (dpeaa)DE-He213 Pri-miR-144~451 (dpeaa)DE-He213 Suboptimal structure (dpeaa)DE-He213 Non-canonical biogenesis (dpeaa)DE-He213 Microprocessor (dpeaa)DE-He213 Kang, Igojo verfasserin aut Shin, Chanseok verfasserin aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 64(2021), 1 vom: 15. Juli (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:64 year:2021 number:1 day:15 month:07 https://dx.doi.org/10.1186/s13765-021-00624-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 64 2021 1 15 07 |
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10.1186/s13765-021-00624-3 doi (DE-627)SPR044567855 (SPR)s13765-021-00624-3-e DE-627 ger DE-627 rakwb eng 630 640 540 ASE Park, Sehee verfasserin aut MicroRNA clustering on the biogenesis of suboptimal microRNAs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. miRNA cluster (dpeaa)DE-He213 Pri-miR-144~451 (dpeaa)DE-He213 Suboptimal structure (dpeaa)DE-He213 Non-canonical biogenesis (dpeaa)DE-He213 Microprocessor (dpeaa)DE-He213 Kang, Igojo verfasserin aut Shin, Chanseok verfasserin aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 64(2021), 1 vom: 15. Juli (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:64 year:2021 number:1 day:15 month:07 https://dx.doi.org/10.1186/s13765-021-00624-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 64 2021 1 15 07 |
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10.1186/s13765-021-00624-3 doi (DE-627)SPR044567855 (SPR)s13765-021-00624-3-e DE-627 ger DE-627 rakwb eng 630 640 540 ASE Park, Sehee verfasserin aut MicroRNA clustering on the biogenesis of suboptimal microRNAs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. miRNA cluster (dpeaa)DE-He213 Pri-miR-144~451 (dpeaa)DE-He213 Suboptimal structure (dpeaa)DE-He213 Non-canonical biogenesis (dpeaa)DE-He213 Microprocessor (dpeaa)DE-He213 Kang, Igojo verfasserin aut Shin, Chanseok verfasserin aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 64(2021), 1 vom: 15. Juli (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:64 year:2021 number:1 day:15 month:07 https://dx.doi.org/10.1186/s13765-021-00624-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 64 2021 1 15 07 |
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10.1186/s13765-021-00624-3 doi (DE-627)SPR044567855 (SPR)s13765-021-00624-3-e DE-627 ger DE-627 rakwb eng 630 640 540 ASE Park, Sehee verfasserin aut MicroRNA clustering on the biogenesis of suboptimal microRNAs 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. miRNA cluster (dpeaa)DE-He213 Pri-miR-144~451 (dpeaa)DE-He213 Suboptimal structure (dpeaa)DE-He213 Non-canonical biogenesis (dpeaa)DE-He213 Microprocessor (dpeaa)DE-He213 Kang, Igojo verfasserin aut Shin, Chanseok verfasserin aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 64(2021), 1 vom: 15. Juli (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:64 year:2021 number:1 day:15 month:07 https://dx.doi.org/10.1186/s13765-021-00624-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 64 2021 1 15 07 |
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microrna clustering on the biogenesis of suboptimal micrornas |
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MicroRNA clustering on the biogenesis of suboptimal microRNAs |
| abstract |
Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. © The Author(s) 2021 |
| abstractGer |
Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. © The Author(s) 2021 |
| abstract_unstemmed |
Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons. © The Author(s) 2021 |
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MicroRNA clustering on the biogenesis of suboptimal microRNAs |
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| score |
7.4011183 |