Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial
Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL s...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
González, Alma Patricia [verfasserIn] Flores-Ramírez, Anaisa [verfasserIn] Gutiérrez-Castro, Karla Paola [verfasserIn] Luévano-Contreras, Claudia [verfasserIn] Gómez-Ojeda, Armando [verfasserIn] Sosa-Bustamante, Gloria Patricia [verfasserIn] Caccavello, Russell [verfasserIn] Barrera-de León, Juan Carlos [verfasserIn] Garay-Sevilla, Ma Eugenia [verfasserIn] Gugliucci, Alejandro [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
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| Übergeordnetes Werk: |
Enthalten in: European journal of pediatrics - Berlin : Springer Science & Business Media B.V., 1975, 180(2021), 8 vom: 16. Apr., Seite 2493-2503 |
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| Übergeordnetes Werk: |
volume:180 ; year:2021 ; number:8 ; day:16 ; month:04 ; pages:2493-2503 |
| Links: |
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| DOI / URN: |
10.1007/s00431-021-04064-5 |
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| Katalog-ID: |
SPR04457004X |
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| 100 | 1 | |a González, Alma Patricia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial |
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| 500 | |a © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 | ||
| 520 | |a Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. | ||
| 650 | 4 | |a Obesity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adolescents |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a sdLDL |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a IL-6 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cardiovascular risk |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a MetS |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Flores-Ramírez, Anaisa |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez-Castro, Karla Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Luévano-Contreras, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez-Ojeda, Armando |e verfasserin |4 aut | |
| 700 | 1 | |a Sosa-Bustamante, Gloria Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Caccavello, Russell |e verfasserin |4 aut | |
| 700 | 1 | |a Barrera-de León, Juan Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Garay-Sevilla, Ma Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Gugliucci, Alejandro |e verfasserin |4 aut | |
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10.1007/s00431-021-04064-5 doi (DE-627)SPR04457004X (SPR)s00431-021-04064-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl González, Alma Patricia verfasserin aut Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. Obesity (dpeaa)DE-He213 Adolescents (dpeaa)DE-He213 sdLDL (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Cardiovascular risk (dpeaa)DE-He213 MetS (dpeaa)DE-He213 Flores-Ramírez, Anaisa verfasserin aut Gutiérrez-Castro, Karla Paola verfasserin aut Luévano-Contreras, Claudia verfasserin aut Gómez-Ojeda, Armando verfasserin aut Sosa-Bustamante, Gloria Patricia verfasserin aut Caccavello, Russell verfasserin aut Barrera-de León, Juan Carlos verfasserin aut Garay-Sevilla, Ma Eugenia verfasserin aut Gugliucci, Alejandro verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 180(2021), 8 vom: 16. Apr., Seite 2493-2503 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:180 year:2021 number:8 day:16 month:04 pages:2493-2503 https://dx.doi.org/10.1007/s00431-021-04064-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 180 2021 8 16 04 2493-2503 |
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10.1007/s00431-021-04064-5 doi (DE-627)SPR04457004X (SPR)s00431-021-04064-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl González, Alma Patricia verfasserin aut Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. Obesity (dpeaa)DE-He213 Adolescents (dpeaa)DE-He213 sdLDL (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Cardiovascular risk (dpeaa)DE-He213 MetS (dpeaa)DE-He213 Flores-Ramírez, Anaisa verfasserin aut Gutiérrez-Castro, Karla Paola verfasserin aut Luévano-Contreras, Claudia verfasserin aut Gómez-Ojeda, Armando verfasserin aut Sosa-Bustamante, Gloria Patricia verfasserin aut Caccavello, Russell verfasserin aut Barrera-de León, Juan Carlos verfasserin aut Garay-Sevilla, Ma Eugenia verfasserin aut Gugliucci, Alejandro verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 180(2021), 8 vom: 16. Apr., Seite 2493-2503 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:180 year:2021 number:8 day:16 month:04 pages:2493-2503 https://dx.doi.org/10.1007/s00431-021-04064-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 180 2021 8 16 04 2493-2503 |
| allfields_unstemmed |
10.1007/s00431-021-04064-5 doi (DE-627)SPR04457004X (SPR)s00431-021-04064-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl González, Alma Patricia verfasserin aut Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. Obesity (dpeaa)DE-He213 Adolescents (dpeaa)DE-He213 sdLDL (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Cardiovascular risk (dpeaa)DE-He213 MetS (dpeaa)DE-He213 Flores-Ramírez, Anaisa verfasserin aut Gutiérrez-Castro, Karla Paola verfasserin aut Luévano-Contreras, Claudia verfasserin aut Gómez-Ojeda, Armando verfasserin aut Sosa-Bustamante, Gloria Patricia verfasserin aut Caccavello, Russell verfasserin aut Barrera-de León, Juan Carlos verfasserin aut Garay-Sevilla, Ma Eugenia verfasserin aut Gugliucci, Alejandro verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 180(2021), 8 vom: 16. Apr., Seite 2493-2503 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:180 year:2021 number:8 day:16 month:04 pages:2493-2503 https://dx.doi.org/10.1007/s00431-021-04064-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 180 2021 8 16 04 2493-2503 |
| allfieldsGer |
10.1007/s00431-021-04064-5 doi (DE-627)SPR04457004X (SPR)s00431-021-04064-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl González, Alma Patricia verfasserin aut Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. Obesity (dpeaa)DE-He213 Adolescents (dpeaa)DE-He213 sdLDL (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Cardiovascular risk (dpeaa)DE-He213 MetS (dpeaa)DE-He213 Flores-Ramírez, Anaisa verfasserin aut Gutiérrez-Castro, Karla Paola verfasserin aut Luévano-Contreras, Claudia verfasserin aut Gómez-Ojeda, Armando verfasserin aut Sosa-Bustamante, Gloria Patricia verfasserin aut Caccavello, Russell verfasserin aut Barrera-de León, Juan Carlos verfasserin aut Garay-Sevilla, Ma Eugenia verfasserin aut Gugliucci, Alejandro verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 180(2021), 8 vom: 16. Apr., Seite 2493-2503 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:180 year:2021 number:8 day:16 month:04 pages:2493-2503 https://dx.doi.org/10.1007/s00431-021-04064-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 180 2021 8 16 04 2493-2503 |
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10.1007/s00431-021-04064-5 doi (DE-627)SPR04457004X (SPR)s00431-021-04064-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl González, Alma Patricia verfasserin aut Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. Obesity (dpeaa)DE-He213 Adolescents (dpeaa)DE-He213 sdLDL (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Cardiovascular risk (dpeaa)DE-He213 MetS (dpeaa)DE-He213 Flores-Ramírez, Anaisa verfasserin aut Gutiérrez-Castro, Karla Paola verfasserin aut Luévano-Contreras, Claudia verfasserin aut Gómez-Ojeda, Armando verfasserin aut Sosa-Bustamante, Gloria Patricia verfasserin aut Caccavello, Russell verfasserin aut Barrera-de León, Juan Carlos verfasserin aut Garay-Sevilla, Ma Eugenia verfasserin aut Gugliucci, Alejandro verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 180(2021), 8 vom: 16. Apr., Seite 2493-2503 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:180 year:2021 number:8 day:16 month:04 pages:2493-2503 https://dx.doi.org/10.1007/s00431-021-04064-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 180 2021 8 16 04 2493-2503 |
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Enthalten in European journal of pediatrics 180(2021), 8 vom: 16. Apr., Seite 2493-2503 volume:180 year:2021 number:8 day:16 month:04 pages:2493-2503 |
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González, Alma Patricia @@aut@@ Flores-Ramírez, Anaisa @@aut@@ Gutiérrez-Castro, Karla Paola @@aut@@ Luévano-Contreras, Claudia @@aut@@ Gómez-Ojeda, Armando @@aut@@ Sosa-Bustamante, Gloria Patricia @@aut@@ Caccavello, Russell @@aut@@ Barrera-de León, Juan Carlos @@aut@@ Garay-Sevilla, Ma Eugenia @@aut@@ Gugliucci, Alejandro @@aut@@ |
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González, Alma Patricia |
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González, Alma Patricia ddc 610 bkl 44.67 misc Obesity misc Adolescents misc sdLDL misc IL-6 misc Cardiovascular risk misc MetS Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial |
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610 ASE 44.67 bkl Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial Obesity (dpeaa)DE-He213 Adolescents (dpeaa)DE-He213 sdLDL (dpeaa)DE-He213 IL-6 (dpeaa)DE-He213 Cardiovascular risk (dpeaa)DE-He213 MetS (dpeaa)DE-He213 |
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ddc 610 bkl 44.67 misc Obesity misc Adolescents misc sdLDL misc IL-6 misc Cardiovascular risk misc MetS |
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Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial |
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Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial |
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González, Alma Patricia |
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European journal of pediatrics |
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González, Alma Patricia Flores-Ramírez, Anaisa Gutiérrez-Castro, Karla Paola Luévano-Contreras, Claudia Gómez-Ojeda, Armando Sosa-Bustamante, Gloria Patricia Caccavello, Russell Barrera-de León, Juan Carlos Garay-Sevilla, Ma Eugenia Gugliucci, Alejandro |
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González, Alma Patricia |
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verfasserin |
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reduction of small dense ldl and il-6 after intervention with plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial |
| title_auth |
Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial |
| abstract |
Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
| abstractGer |
Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
| abstract_unstemmed |
Abstract Obesity can lead children and adolescents to an increased cardiovascular disease (CVD) risk. A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
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Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial |
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https://dx.doi.org/10.1007/s00431-021-04064-5 |
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Flores-Ramírez, Anaisa Gutiérrez-Castro, Karla Paola Luévano-Contreras, Claudia Gómez-Ojeda, Armando Sosa-Bustamante, Gloria Patricia Caccavello, Russell Barrera-de León, Juan Carlos Garay-Sevilla, Ma Eugenia Gugliucci, Alejandro |
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Flores-Ramírez, Anaisa Gutiérrez-Castro, Karla Paola Luévano-Contreras, Claudia Gómez-Ojeda, Armando Sosa-Bustamante, Gloria Patricia Caccavello, Russell Barrera-de León, Juan Carlos Garay-Sevilla, Ma Eugenia Gugliucci, Alejandro |
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10.1007/s00431-021-04064-5 |
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2024-07-04T01:20:31.829Z |
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A diet supplemented with Plantago psyllium has been shown to be effective in reducing LDL-C and IL-6 in adolescents. However, there are no studies that have explored small-dense LDL (sdLDL) or HDL subclasses. The aim of this study was to evaluate the impact of a fiber dietary intervention on LDL and HDL subclasses in adolescents with obesity. In this parallel, double blind, randomized clinical trial, the participants were assigned to Plantago psyllium or placebo (10g/day for 7 weeks). We randomized 113 participants, and evaluated and analyzed 100 adolescents (50 in each group), 15 to 19 years with a body mass index of 29–34. We measured biochemical markers LDL and HDL subclasses using the Lipoprint system (Quantimetrix) and IL-6 by ELISA. Post-treatment there was a decrease in sdLDL between the groups 2.0 (0–5.0) vs 1 (0–3.0) mg/dl (p = 0.004), IL-6 median 3.32 (1.24–5.96) vs 1.76 (0.54–3.28) pg/ml, p <0.0001. There were no differences in HDL subclasses and no adverse effects were reported in either group. Conclusions: Small dense LDL and IL-6 reduced in adolescents with obesity when consuming Plantago psyllium. This may be an early good strategy for the reduction of cardiovascular disease risk in this vulnerable population. Trial registration: ISRCTN # 14180431. Date assigned 24/08/2020What is Known:• Supplementing the diet with Plantago psyllium lowers LDL-C levels.What is New:• First evidence that soluble fiber supplementation like Plantago psyllium decreases small dense LDL particles in association with lowered IL-6, reducing the risk of cardiovascular disease in obese adolescents.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obesity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Adolescents</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sdLDL</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IL-6</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cardiovascular risk</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MetS</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Flores-Ramírez, Anaisa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gutiérrez-Castro, Karla Paola</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Luévano-Contreras, Claudia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gómez-Ojeda, Armando</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sosa-Bustamante, Gloria Patricia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Caccavello, Russell</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barrera-de León, Juan Carlos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Garay-Sevilla, Ma Eugenia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gugliucci, Alejandro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">European journal of pediatrics</subfield><subfield code="d">Berlin : Springer Science & Business Media B.V., 1975</subfield><subfield code="g">180(2021), 8 vom: 16. 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