Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up
Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fionda, Laura [verfasserIn] Di Pasquale, Antonella [verfasserIn] Morino, Stefania [verfasserIn] Leonardi, Luca [verfasserIn] Vanoli, Fiammetta [verfasserIn] Loreti, Simona [verfasserIn] Garibaldi, Matteo [verfasserIn] Lauletta, Antonio [verfasserIn] Alfieri, Girolamo [verfasserIn] Bucci, Elisabetta [verfasserIn] Salvetti, Marco [verfasserIn] Antonini, Giovanni [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) High-resolution ultrasonography (HRUS) |
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| Anmerkung: |
© Springer-Verlag GmbH, DE part of Springer Nature 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neurology - [Darmstadt] : Steinkopff, 1891, 268(2021), 8 vom: 27. Feb., Seite 3011-3019 |
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| Übergeordnetes Werk: |
volume:268 ; year:2021 ; number:8 ; day:27 ; month:02 ; pages:3011-3019 |
| Links: |
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| DOI / URN: |
10.1007/s00415-021-10485-x |
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| Katalog-ID: |
SPR044590962 |
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| 245 | 1 | 0 | |a Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up |
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| 520 | |a Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. | ||
| 650 | 4 | |a Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a High-resolution ultrasonography (HRUS) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nerve cross-sectional area (NCSA) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nerve conduction study (NCS) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Follow-up study |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Di Pasquale, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Morino, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Leonardi, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Vanoli, Fiammetta |e verfasserin |4 aut | |
| 700 | 1 | |a Loreti, Simona |e verfasserin |4 aut | |
| 700 | 1 | |a Garibaldi, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Lauletta, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Alfieri, Girolamo |e verfasserin |4 aut | |
| 700 | 1 | |a Bucci, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Salvetti, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Antonini, Giovanni |e verfasserin |4 aut | |
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10.1007/s00415-021-10485-x doi (DE-627)SPR044590962 (SPR)s00415-021-10485-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Fionda, Laura verfasserin aut Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH, DE part of Springer Nature 2021 Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (dpeaa)DE-He213 High-resolution ultrasonography (HRUS) (dpeaa)DE-He213 Nerve cross-sectional area (NCSA) (dpeaa)DE-He213 Nerve conduction study (NCS) (dpeaa)DE-He213 Follow-up study (dpeaa)DE-He213 Di Pasquale, Antonella verfasserin aut Morino, Stefania verfasserin aut Leonardi, Luca verfasserin aut Vanoli, Fiammetta verfasserin aut Loreti, Simona verfasserin aut Garibaldi, Matteo verfasserin aut Lauletta, Antonio verfasserin aut Alfieri, Girolamo verfasserin aut Bucci, Elisabetta verfasserin aut Salvetti, Marco verfasserin aut Antonini, Giovanni verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 268(2021), 8 vom: 27. Feb., Seite 3011-3019 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:268 year:2021 number:8 day:27 month:02 pages:3011-3019 https://dx.doi.org/10.1007/s00415-021-10485-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 268 2021 8 27 02 3011-3019 |
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10.1007/s00415-021-10485-x doi (DE-627)SPR044590962 (SPR)s00415-021-10485-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Fionda, Laura verfasserin aut Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH, DE part of Springer Nature 2021 Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (dpeaa)DE-He213 High-resolution ultrasonography (HRUS) (dpeaa)DE-He213 Nerve cross-sectional area (NCSA) (dpeaa)DE-He213 Nerve conduction study (NCS) (dpeaa)DE-He213 Follow-up study (dpeaa)DE-He213 Di Pasquale, Antonella verfasserin aut Morino, Stefania verfasserin aut Leonardi, Luca verfasserin aut Vanoli, Fiammetta verfasserin aut Loreti, Simona verfasserin aut Garibaldi, Matteo verfasserin aut Lauletta, Antonio verfasserin aut Alfieri, Girolamo verfasserin aut Bucci, Elisabetta verfasserin aut Salvetti, Marco verfasserin aut Antonini, Giovanni verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 268(2021), 8 vom: 27. Feb., Seite 3011-3019 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:268 year:2021 number:8 day:27 month:02 pages:3011-3019 https://dx.doi.org/10.1007/s00415-021-10485-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 268 2021 8 27 02 3011-3019 |
| allfields_unstemmed |
10.1007/s00415-021-10485-x doi (DE-627)SPR044590962 (SPR)s00415-021-10485-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Fionda, Laura verfasserin aut Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH, DE part of Springer Nature 2021 Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (dpeaa)DE-He213 High-resolution ultrasonography (HRUS) (dpeaa)DE-He213 Nerve cross-sectional area (NCSA) (dpeaa)DE-He213 Nerve conduction study (NCS) (dpeaa)DE-He213 Follow-up study (dpeaa)DE-He213 Di Pasquale, Antonella verfasserin aut Morino, Stefania verfasserin aut Leonardi, Luca verfasserin aut Vanoli, Fiammetta verfasserin aut Loreti, Simona verfasserin aut Garibaldi, Matteo verfasserin aut Lauletta, Antonio verfasserin aut Alfieri, Girolamo verfasserin aut Bucci, Elisabetta verfasserin aut Salvetti, Marco verfasserin aut Antonini, Giovanni verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 268(2021), 8 vom: 27. Feb., Seite 3011-3019 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:268 year:2021 number:8 day:27 month:02 pages:3011-3019 https://dx.doi.org/10.1007/s00415-021-10485-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 268 2021 8 27 02 3011-3019 |
| allfieldsGer |
10.1007/s00415-021-10485-x doi (DE-627)SPR044590962 (SPR)s00415-021-10485-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Fionda, Laura verfasserin aut Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH, DE part of Springer Nature 2021 Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (dpeaa)DE-He213 High-resolution ultrasonography (HRUS) (dpeaa)DE-He213 Nerve cross-sectional area (NCSA) (dpeaa)DE-He213 Nerve conduction study (NCS) (dpeaa)DE-He213 Follow-up study (dpeaa)DE-He213 Di Pasquale, Antonella verfasserin aut Morino, Stefania verfasserin aut Leonardi, Luca verfasserin aut Vanoli, Fiammetta verfasserin aut Loreti, Simona verfasserin aut Garibaldi, Matteo verfasserin aut Lauletta, Antonio verfasserin aut Alfieri, Girolamo verfasserin aut Bucci, Elisabetta verfasserin aut Salvetti, Marco verfasserin aut Antonini, Giovanni verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 268(2021), 8 vom: 27. Feb., Seite 3011-3019 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:268 year:2021 number:8 day:27 month:02 pages:3011-3019 https://dx.doi.org/10.1007/s00415-021-10485-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 268 2021 8 27 02 3011-3019 |
| allfieldsSound |
10.1007/s00415-021-10485-x doi (DE-627)SPR044590962 (SPR)s00415-021-10485-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Fionda, Laura verfasserin aut Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH, DE part of Springer Nature 2021 Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (dpeaa)DE-He213 High-resolution ultrasonography (HRUS) (dpeaa)DE-He213 Nerve cross-sectional area (NCSA) (dpeaa)DE-He213 Nerve conduction study (NCS) (dpeaa)DE-He213 Follow-up study (dpeaa)DE-He213 Di Pasquale, Antonella verfasserin aut Morino, Stefania verfasserin aut Leonardi, Luca verfasserin aut Vanoli, Fiammetta verfasserin aut Loreti, Simona verfasserin aut Garibaldi, Matteo verfasserin aut Lauletta, Antonio verfasserin aut Alfieri, Girolamo verfasserin aut Bucci, Elisabetta verfasserin aut Salvetti, Marco verfasserin aut Antonini, Giovanni verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 268(2021), 8 vom: 27. Feb., Seite 3011-3019 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:268 year:2021 number:8 day:27 month:02 pages:3011-3019 https://dx.doi.org/10.1007/s00415-021-10485-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 268 2021 8 27 02 3011-3019 |
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Enthalten in Journal of neurology 268(2021), 8 vom: 27. Feb., Seite 3011-3019 volume:268 year:2021 number:8 day:27 month:02 pages:3011-3019 |
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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) High-resolution ultrasonography (HRUS) Nerve cross-sectional area (NCSA) Nerve conduction study (NCS) Follow-up study |
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Fionda, Laura @@aut@@ Di Pasquale, Antonella @@aut@@ Morino, Stefania @@aut@@ Leonardi, Luca @@aut@@ Vanoli, Fiammetta @@aut@@ Loreti, Simona @@aut@@ Garibaldi, Matteo @@aut@@ Lauletta, Antonio @@aut@@ Alfieri, Girolamo @@aut@@ Bucci, Elisabetta @@aut@@ Salvetti, Marco @@aut@@ Antonini, Giovanni @@aut@@ |
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2021-02-27T00:00:00Z |
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Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. 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Fionda, Laura |
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Fionda, Laura ddc 610 bkl 44.90 misc Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) misc High-resolution ultrasonography (HRUS) misc Nerve cross-sectional area (NCSA) misc Nerve conduction study (NCS) misc Follow-up study Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up |
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610 ASE 44.90 bkl Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (dpeaa)DE-He213 High-resolution ultrasonography (HRUS) (dpeaa)DE-He213 Nerve cross-sectional area (NCSA) (dpeaa)DE-He213 Nerve conduction study (NCS) (dpeaa)DE-He213 Follow-up study (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) misc High-resolution ultrasonography (HRUS) misc Nerve cross-sectional area (NCSA) misc Nerve conduction study (NCS) misc Follow-up study |
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ddc 610 bkl 44.90 misc Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) misc High-resolution ultrasonography (HRUS) misc Nerve cross-sectional area (NCSA) misc Nerve conduction study (NCS) misc Follow-up study |
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ddc 610 bkl 44.90 misc Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) misc High-resolution ultrasonography (HRUS) misc Nerve cross-sectional area (NCSA) misc Nerve conduction study (NCS) misc Follow-up study |
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Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up |
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Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up |
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Fionda, Laura |
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Journal of neurology |
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Fionda, Laura Di Pasquale, Antonella Morino, Stefania Leonardi, Luca Vanoli, Fiammetta Loreti, Simona Garibaldi, Matteo Lauletta, Antonio Alfieri, Girolamo Bucci, Elisabetta Salvetti, Marco Antonini, Giovanni |
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changes of clinical, neurophysiological and nerve ultrasound characteristics in cidp over time: a 3-year follow-up |
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Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up |
| abstract |
Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. © Springer-Verlag GmbH, DE part of Springer Nature 2021 |
| abstractGer |
Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. © Springer-Verlag GmbH, DE part of Springer Nature 2021 |
| abstract_unstemmed |
Objectives To evaluate, in a prospective study, high-resolution ultrasound (HRUS) changes of nerve segments in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and their relationships with clinical and electrodiagnostic (EDX) characteristics. Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. During FU, NCSA increased in 51% of nerve segments (p = 0.006), in correlation with INCAT increase and with NCV and cMAP reduction. Considering EDX changes in subgroups that reflect the different types of nerve damage, NCSA significantly increased in those nerve segments that from normal EDX switched to prevalent myelinopathic EDX characteristics. Conclusions Peripheral nerve size tends to increase over time in patients with CIDP, in correlation with clinical and EDX changes, in particular in those nerve segments that undergo a predominantly demyelinating damage. © Springer-Verlag GmbH, DE part of Springer Nature 2021 |
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Changes of clinical, neurophysiological and nerve ultrasound characteristics in CIDP over time: a 3-year follow-up |
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Di Pasquale, Antonella Morino, Stefania Leonardi, Luca Vanoli, Fiammetta Loreti, Simona Garibaldi, Matteo Lauletta, Antonio Alfieri, Girolamo Bucci, Elisabetta Salvetti, Marco Antonini, Giovanni |
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Di Pasquale, Antonella Morino, Stefania Leonardi, Luca Vanoli, Fiammetta Loreti, Simona Garibaldi, Matteo Lauletta, Antonio Alfieri, Girolamo Bucci, Elisabetta Salvetti, Marco Antonini, Giovanni |
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10.1007/s00415-021-10485-x |
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Methods Twenty-three consecutive patients with CIDP were included in a 3-year follow-up (FU) study. Each patient underwent neurologic examination, EDX and HRUS study. HRUS was performed on median, ulnar and peroneal nerves, yielding a total of 319 scanned nerve segments. INCAT and MRC-sum scores, motor nerve conduction velocity (NCV), compound muscle action potential (cMAP) amplitude, and nerve cross-sectional area (NCSA) were collected at baseline and at FU end, and were used for statistical analysis. Twenty-two healthy individuals, matched to patients for age and BMI, served as controls. Results NCSA was higher in patients than in controls (p < 0.0001) and showed significant direct correlation with disease severity, and inverse correlation with NCV and cMAP amplitude, both at baseline and at FU end. Disease duration, clinical scores and EDX were predictors of NCSA enlargement at both time points. 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