Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile
Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Merz, J. [verfasserIn] Nettesheim, A. [verfasserIn] von Garlen, S. [verfasserIn] Albrecht, P. [verfasserIn] Saller, B. S. [verfasserIn] Engelmann, J. [verfasserIn] Hertle, L. [verfasserIn] Schäfer, I. [verfasserIn] Dimanski, D. [verfasserIn] König, S. [verfasserIn] Karnbrock, L. [verfasserIn] Bulatova, K. [verfasserIn] Peikert, A. [verfasserIn] Hoppe, N. [verfasserIn] Hilgendorf, I. [verfasserIn] von zur Mühlen, C. [verfasserIn] Wolf, D. [verfasserIn] Groß, O. [verfasserIn] Bode, C. [verfasserIn] Zirlik, A. [verfasserIn] Stachon, P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Purinergic signalling - Dordrecht : Springer Science + Business Media B.V., 2004, 17(2021), 3 vom: 20. Juli, Seite 481-492 |
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| Übergeordnetes Werk: |
volume:17 ; year:2021 ; number:3 ; day:20 ; month:07 ; pages:481-492 |
| Links: |
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| DOI / URN: |
10.1007/s11302-021-09798-3 |
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| Katalog-ID: |
SPR044968337 |
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| 245 | 1 | 0 | |a Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
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| 500 | |a © The Author(s) 2021 | ||
| 520 | |a Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. | ||
| 650 | 4 | |a Macrophages |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Polarization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Purinergic receptor: Inflammation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Nettesheim, A. |e verfasserin |4 aut | |
| 700 | 1 | |a von Garlen, S. |e verfasserin |4 aut | |
| 700 | 1 | |a Albrecht, P. |e verfasserin |4 aut | |
| 700 | 1 | |a Saller, B. S. |e verfasserin |4 aut | |
| 700 | 1 | |a Engelmann, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Hertle, L. |e verfasserin |4 aut | |
| 700 | 1 | |a Schäfer, I. |e verfasserin |4 aut | |
| 700 | 1 | |a Dimanski, D. |e verfasserin |4 aut | |
| 700 | 1 | |a König, S. |e verfasserin |4 aut | |
| 700 | 1 | |a Karnbrock, L. |e verfasserin |4 aut | |
| 700 | 1 | |a Bulatova, K. |e verfasserin |4 aut | |
| 700 | 1 | |a Peikert, A. |e verfasserin |4 aut | |
| 700 | 1 | |a Hoppe, N. |e verfasserin |4 aut | |
| 700 | 1 | |a Hilgendorf, I. |e verfasserin |4 aut | |
| 700 | 1 | |a von zur Mühlen, C. |e verfasserin |4 aut | |
| 700 | 1 | |a Wolf, D. |e verfasserin |4 aut | |
| 700 | 1 | |a Groß, O. |e verfasserin |4 aut | |
| 700 | 1 | |a Bode, C. |e verfasserin |4 aut | |
| 700 | 1 | |a Zirlik, A. |e verfasserin |4 aut | |
| 700 | 1 | |a Stachon, P. |e verfasserin |4 aut | |
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10.1007/s11302-021-09798-3 doi (DE-627)SPR044968337 (SPR)s11302-021-09798-3-e DE-627 ger DE-627 rakwb eng 610 540 ASE 44.33 bkl Merz, J. verfasserin aut Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. Macrophages (dpeaa)DE-He213 Polarization (dpeaa)DE-He213 Purinergic receptor: Inflammation (dpeaa)DE-He213 Nettesheim, A. verfasserin aut von Garlen, S. verfasserin aut Albrecht, P. verfasserin aut Saller, B. S. verfasserin aut Engelmann, J. verfasserin aut Hertle, L. verfasserin aut Schäfer, I. verfasserin aut Dimanski, D. verfasserin aut König, S. verfasserin aut Karnbrock, L. verfasserin aut Bulatova, K. verfasserin aut Peikert, A. verfasserin aut Hoppe, N. verfasserin aut Hilgendorf, I. verfasserin aut von zur Mühlen, C. verfasserin aut Wolf, D. verfasserin aut Groß, O. verfasserin aut Bode, C. verfasserin aut Zirlik, A. verfasserin aut Stachon, P. verfasserin aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 17(2021), 3 vom: 20. Juli, Seite 481-492 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:17 year:2021 number:3 day:20 month:07 pages:481-492 https://dx.doi.org/10.1007/s11302-021-09798-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.33 ASE AR 17 2021 3 20 07 481-492 |
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10.1007/s11302-021-09798-3 doi (DE-627)SPR044968337 (SPR)s11302-021-09798-3-e DE-627 ger DE-627 rakwb eng 610 540 ASE 44.33 bkl Merz, J. verfasserin aut Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. Macrophages (dpeaa)DE-He213 Polarization (dpeaa)DE-He213 Purinergic receptor: Inflammation (dpeaa)DE-He213 Nettesheim, A. verfasserin aut von Garlen, S. verfasserin aut Albrecht, P. verfasserin aut Saller, B. S. verfasserin aut Engelmann, J. verfasserin aut Hertle, L. verfasserin aut Schäfer, I. verfasserin aut Dimanski, D. verfasserin aut König, S. verfasserin aut Karnbrock, L. verfasserin aut Bulatova, K. verfasserin aut Peikert, A. verfasserin aut Hoppe, N. verfasserin aut Hilgendorf, I. verfasserin aut von zur Mühlen, C. verfasserin aut Wolf, D. verfasserin aut Groß, O. verfasserin aut Bode, C. verfasserin aut Zirlik, A. verfasserin aut Stachon, P. verfasserin aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 17(2021), 3 vom: 20. Juli, Seite 481-492 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:17 year:2021 number:3 day:20 month:07 pages:481-492 https://dx.doi.org/10.1007/s11302-021-09798-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.33 ASE AR 17 2021 3 20 07 481-492 |
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10.1007/s11302-021-09798-3 doi (DE-627)SPR044968337 (SPR)s11302-021-09798-3-e DE-627 ger DE-627 rakwb eng 610 540 ASE 44.33 bkl Merz, J. verfasserin aut Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. Macrophages (dpeaa)DE-He213 Polarization (dpeaa)DE-He213 Purinergic receptor: Inflammation (dpeaa)DE-He213 Nettesheim, A. verfasserin aut von Garlen, S. verfasserin aut Albrecht, P. verfasserin aut Saller, B. S. verfasserin aut Engelmann, J. verfasserin aut Hertle, L. verfasserin aut Schäfer, I. verfasserin aut Dimanski, D. verfasserin aut König, S. verfasserin aut Karnbrock, L. verfasserin aut Bulatova, K. verfasserin aut Peikert, A. verfasserin aut Hoppe, N. verfasserin aut Hilgendorf, I. verfasserin aut von zur Mühlen, C. verfasserin aut Wolf, D. verfasserin aut Groß, O. verfasserin aut Bode, C. verfasserin aut Zirlik, A. verfasserin aut Stachon, P. verfasserin aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 17(2021), 3 vom: 20. Juli, Seite 481-492 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:17 year:2021 number:3 day:20 month:07 pages:481-492 https://dx.doi.org/10.1007/s11302-021-09798-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.33 ASE AR 17 2021 3 20 07 481-492 |
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10.1007/s11302-021-09798-3 doi (DE-627)SPR044968337 (SPR)s11302-021-09798-3-e DE-627 ger DE-627 rakwb eng 610 540 ASE 44.33 bkl Merz, J. verfasserin aut Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. Macrophages (dpeaa)DE-He213 Polarization (dpeaa)DE-He213 Purinergic receptor: Inflammation (dpeaa)DE-He213 Nettesheim, A. verfasserin aut von Garlen, S. verfasserin aut Albrecht, P. verfasserin aut Saller, B. S. verfasserin aut Engelmann, J. verfasserin aut Hertle, L. verfasserin aut Schäfer, I. verfasserin aut Dimanski, D. verfasserin aut König, S. verfasserin aut Karnbrock, L. verfasserin aut Bulatova, K. verfasserin aut Peikert, A. verfasserin aut Hoppe, N. verfasserin aut Hilgendorf, I. verfasserin aut von zur Mühlen, C. verfasserin aut Wolf, D. verfasserin aut Groß, O. verfasserin aut Bode, C. verfasserin aut Zirlik, A. verfasserin aut Stachon, P. verfasserin aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 17(2021), 3 vom: 20. Juli, Seite 481-492 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:17 year:2021 number:3 day:20 month:07 pages:481-492 https://dx.doi.org/10.1007/s11302-021-09798-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.33 ASE AR 17 2021 3 20 07 481-492 |
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10.1007/s11302-021-09798-3 doi (DE-627)SPR044968337 (SPR)s11302-021-09798-3-e DE-627 ger DE-627 rakwb eng 610 540 ASE 44.33 bkl Merz, J. verfasserin aut Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. Macrophages (dpeaa)DE-He213 Polarization (dpeaa)DE-He213 Purinergic receptor: Inflammation (dpeaa)DE-He213 Nettesheim, A. verfasserin aut von Garlen, S. verfasserin aut Albrecht, P. verfasserin aut Saller, B. S. verfasserin aut Engelmann, J. verfasserin aut Hertle, L. verfasserin aut Schäfer, I. verfasserin aut Dimanski, D. verfasserin aut König, S. verfasserin aut Karnbrock, L. verfasserin aut Bulatova, K. verfasserin aut Peikert, A. verfasserin aut Hoppe, N. verfasserin aut Hilgendorf, I. verfasserin aut von zur Mühlen, C. verfasserin aut Wolf, D. verfasserin aut Groß, O. verfasserin aut Bode, C. verfasserin aut Zirlik, A. verfasserin aut Stachon, P. verfasserin aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 17(2021), 3 vom: 20. Juli, Seite 481-492 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:17 year:2021 number:3 day:20 month:07 pages:481-492 https://dx.doi.org/10.1007/s11302-021-09798-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.33 ASE AR 17 2021 3 20 07 481-492 |
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Enthalten in Purinergic signalling 17(2021), 3 vom: 20. Juli, Seite 481-492 volume:17 year:2021 number:3 day:20 month:07 pages:481-492 |
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Enthalten in Purinergic signalling 17(2021), 3 vom: 20. Juli, Seite 481-492 volume:17 year:2021 number:3 day:20 month:07 pages:481-492 |
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Macrophages Polarization Purinergic receptor: Inflammation |
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Merz, J. @@aut@@ Nettesheim, A. @@aut@@ von Garlen, S. @@aut@@ Albrecht, P. @@aut@@ Saller, B. S. @@aut@@ Engelmann, J. @@aut@@ Hertle, L. @@aut@@ Schäfer, I. @@aut@@ Dimanski, D. @@aut@@ König, S. @@aut@@ Karnbrock, L. @@aut@@ Bulatova, K. @@aut@@ Peikert, A. @@aut@@ Hoppe, N. @@aut@@ Hilgendorf, I. @@aut@@ von zur Mühlen, C. @@aut@@ Wolf, D. @@aut@@ Groß, O. @@aut@@ Bode, C. @@aut@@ Zirlik, A. @@aut@@ Stachon, P. @@aut@@ |
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Merz, J. |
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Merz, J. ddc 610 bkl 44.33 misc Macrophages misc Polarization misc Purinergic receptor: Inflammation Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
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610 540 ASE 44.33 bkl Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile Macrophages (dpeaa)DE-He213 Polarization (dpeaa)DE-He213 Purinergic receptor: Inflammation (dpeaa)DE-He213 |
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ddc 610 bkl 44.33 misc Macrophages misc Polarization misc Purinergic receptor: Inflammation |
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Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
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Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
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Merz, J. |
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Purinergic signalling |
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Merz, J. Nettesheim, A. von Garlen, S. Albrecht, P. Saller, B. S. Engelmann, J. Hertle, L. Schäfer, I. Dimanski, D. König, S. Karnbrock, L. Bulatova, K. Peikert, A. Hoppe, N. Hilgendorf, I. von zur Mühlen, C. Wolf, D. Groß, O. Bode, C. Zirlik, A. Stachon, P. |
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Elektronische Aufsätze |
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Merz, J. |
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10.1007/s11302-021-09798-3 |
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610 540 |
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pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
| title_auth |
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
| abstract |
Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. © The Author(s) 2021 |
| abstractGer |
Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. © The Author(s) 2021 |
| abstract_unstemmed |
Abstract Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor $ P2X_{5} $ is selectively upregulated in M1- and M2-polarized macrophages. $ P2X_{7} $ is temporarily expressed in M1 macrophages. Metabotropic P2Y receptors showed a distinct expression profile in M1 and M2-polarized macrophages: Gαq coupled $ P2Y_{1} $ and $ P2Y_{6} $ are exclusively upregulated in M2, whereas Gαi $ P2Y_{13} $ and $ P2Y_{14} $ are overexpressed in M1. This consequently leads to functional differences between M1 and M2 in response to adenosine di-phosphate stimulation (ADP): In contrast to M1, M2 showed increased cytoplasmatic calcium after ADP stimulation. In the present study we show that bone marrow-derived macrophages express a unique repertoire of purinergic receptors. We show for the first time that the repertoire of purinergic receptors is highly flexible and quickly adapts upon pro- and anti-inflammatory macrophage differentiation with functional consequences to nucleotide stimulation. © The Author(s) 2021 |
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Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
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https://dx.doi.org/10.1007/s11302-021-09798-3 |
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Nettesheim, A. von Garlen, S. Albrecht, P. Saller, B. S. Engelmann, J. Hertle, L. Schäfer, I. Dimanski, D. König, S. Karnbrock, L. Bulatova, K. Peikert, A. Hoppe, N. Hilgendorf, I. von zur Mühlen, C. Wolf, D. Groß, O. Bode, C. Zirlik, A. Stachon, P. |
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Nettesheim, A. von Garlen, S. Albrecht, P. Saller, B. S. Engelmann, J. Hertle, L. Schäfer, I. Dimanski, D. König, S. Karnbrock, L. Bulatova, K. Peikert, A. Hoppe, N. Hilgendorf, I. von zur Mühlen, C. Wolf, D. Groß, O. Bode, C. Zirlik, A. Stachon, P. |
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10.1007/s11302-021-09798-3 |
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2024-07-04T02:59:06.620Z |
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| score |
7.399864 |