Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension

Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean...
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Autor*in:	Razek, Ahmed Abdel Khalek Abdel [verfasserIn] Hafez, Mona Mohamed [verfasserIn] Mahmoud, Walaa [verfasserIn] Ismail, Ahmed Ramadan [verfasserIn] Ali, Khadiga M. [verfasserIn] Barakat, Tarek Elsayed [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Esophageal varices Cirrhosis Child Spleen Diffusion tensor imaging

Anmerkung:	© Japan Radiological Society 2021

Übergeordnetes Werk:	Enthalten in: Radiation medicine - Tokyo : Springer, 1999, 39(2021), 9 vom: 29. Apr., Seite 907-913
Übergeordnetes Werk:	volume:39 ; year:2021 ; number:9 ; day:29 ; month:04 ; pages:907-913

Links:	Volltext

DOI / URN:	10.1007/s11604-021-01123-7

Katalog-ID:	SPR044977247

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245	1	0	\|a Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension
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520			\|a Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension.
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allfields	10.1007/s11604-021-01123-7 doi (DE-627)SPR044977247 (SPR)s11604-021-01123-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. Esophageal varices (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Child (dpeaa)DE-He213 Spleen (dpeaa)DE-He213 Diffusion tensor imaging (dpeaa)DE-He213 Hafez, Mona Mohamed verfasserin aut Mahmoud, Walaa verfasserin aut Ismail, Ahmed Ramadan verfasserin aut Ali, Khadiga M. verfasserin aut Barakat, Tarek Elsayed verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 9 vom: 29. Apr., Seite 907-913 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:9 day:29 month:04 pages:907-913 https://dx.doi.org/10.1007/s11604-021-01123-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 9 29 04 907-913
spelling	10.1007/s11604-021-01123-7 doi (DE-627)SPR044977247 (SPR)s11604-021-01123-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. Esophageal varices (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Child (dpeaa)DE-He213 Spleen (dpeaa)DE-He213 Diffusion tensor imaging (dpeaa)DE-He213 Hafez, Mona Mohamed verfasserin aut Mahmoud, Walaa verfasserin aut Ismail, Ahmed Ramadan verfasserin aut Ali, Khadiga M. verfasserin aut Barakat, Tarek Elsayed verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 9 vom: 29. Apr., Seite 907-913 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:9 day:29 month:04 pages:907-913 https://dx.doi.org/10.1007/s11604-021-01123-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 9 29 04 907-913
allfields_unstemmed	10.1007/s11604-021-01123-7 doi (DE-627)SPR044977247 (SPR)s11604-021-01123-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. Esophageal varices (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Child (dpeaa)DE-He213 Spleen (dpeaa)DE-He213 Diffusion tensor imaging (dpeaa)DE-He213 Hafez, Mona Mohamed verfasserin aut Mahmoud, Walaa verfasserin aut Ismail, Ahmed Ramadan verfasserin aut Ali, Khadiga M. verfasserin aut Barakat, Tarek Elsayed verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 9 vom: 29. Apr., Seite 907-913 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:9 day:29 month:04 pages:907-913 https://dx.doi.org/10.1007/s11604-021-01123-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 9 29 04 907-913
allfieldsGer	10.1007/s11604-021-01123-7 doi (DE-627)SPR044977247 (SPR)s11604-021-01123-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. Esophageal varices (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Child (dpeaa)DE-He213 Spleen (dpeaa)DE-He213 Diffusion tensor imaging (dpeaa)DE-He213 Hafez, Mona Mohamed verfasserin aut Mahmoud, Walaa verfasserin aut Ismail, Ahmed Ramadan verfasserin aut Ali, Khadiga M. verfasserin aut Barakat, Tarek Elsayed verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 9 vom: 29. Apr., Seite 907-913 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:9 day:29 month:04 pages:907-913 https://dx.doi.org/10.1007/s11604-021-01123-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 9 29 04 907-913
allfieldsSound	10.1007/s11604-021-01123-7 doi (DE-627)SPR044977247 (SPR)s11604-021-01123-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. Esophageal varices (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Child (dpeaa)DE-He213 Spleen (dpeaa)DE-He213 Diffusion tensor imaging (dpeaa)DE-He213 Hafez, Mona Mohamed verfasserin aut Mahmoud, Walaa verfasserin aut Ismail, Ahmed Ramadan verfasserin aut Ali, Khadiga M. verfasserin aut Barakat, Tarek Elsayed verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 9 vom: 29. Apr., Seite 907-913 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:9 day:29 month:04 pages:907-913 https://dx.doi.org/10.1007/s11604-021-01123-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 9 29 04 907-913
language	English
source	Enthalten in Radiation medicine 39(2021), 9 vom: 29. Apr., Seite 907-913 volume:39 year:2021 number:9 day:29 month:04 pages:907-913
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institution	findex.gbv.de
topic_facet	Esophageal varices Cirrhosis Child Spleen Diffusion tensor imaging
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authorswithroles_txt_mv	Razek, Ahmed Abdel Khalek Abdel @@aut@@ Hafez, Mona Mohamed @@aut@@ Mahmoud, Walaa @@aut@@ Ismail, Ahmed Ramadan @@aut@@ Ali, Khadiga M. @@aut@@ Barakat, Tarek Elsayed @@aut@@
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Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). 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author	Razek, Ahmed Abdel Khalek Abdel
spellingShingle	Razek, Ahmed Abdel Khalek Abdel ddc 610 bkl 44.64 misc Esophageal varices misc Cirrhosis misc Child misc Spleen misc Diffusion tensor imaging Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension
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topic_title	610 ASE 44.64 bkl Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension Esophageal varices (dpeaa)DE-He213 Cirrhosis (dpeaa)DE-He213 Child (dpeaa)DE-He213 Spleen (dpeaa)DE-He213 Diffusion tensor imaging (dpeaa)DE-He213
topic	ddc 610 bkl 44.64 misc Esophageal varices misc Cirrhosis misc Child misc Spleen misc Diffusion tensor imaging
topic_unstemmed	ddc 610 bkl 44.64 misc Esophageal varices misc Cirrhosis misc Child misc Spleen misc Diffusion tensor imaging
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title	Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension
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title_full	Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension
author_sort	Razek, Ahmed Abdel Khalek Abdel
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author_browse	Razek, Ahmed Abdel Khalek Abdel Hafez, Mona Mohamed Mahmoud, Walaa Ismail, Ahmed Ramadan Ali, Khadiga M. Barakat, Tarek Elsayed
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author-letter	Razek, Ahmed Abdel Khalek Abdel
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title_sort	diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension
title_auth	Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension
abstract	Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. © Japan Radiological Society 2021
abstractGer	Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. © Japan Radiological Society 2021
abstract_unstemmed	Purpose To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). Conclusion DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension. © Japan Radiological Society 2021
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title_short	Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension
url	https://dx.doi.org/10.1007/s11604-021-01123-7
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author2	Hafez, Mona Mohamed Mahmoud, Walaa Ismail, Ahmed Ramadan Ali, Khadiga M. Barakat, Tarek Elsayed
author2Str	Hafez, Mona Mohamed Mahmoud, Walaa Ismail, Ahmed Ramadan Ali, Khadiga M. Barakat, Tarek Elsayed
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doi_str	10.1007/s11604-021-01123-7
up_date	2024-07-04T03:01:01.418Z
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Methods This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. Results Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × $ 10^{−3} %$ mm^{2} $/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = − 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, − 0.380; p = 0.001, 0.016). 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Diffusion tensor imaging of the spleen in prediction and grading of esophageal varices in cirrhotic children with portal hypertension

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