The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL)
Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dehghani, Mehdi [verfasserIn] Shokrgozar, Negin [verfasserIn] Ramzi, Mani [verfasserIn] Kalani, Mehdi [verfasserIn] Golmoghaddam, Hossein [verfasserIn] Arandi, Nargess [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Cancer immunology immunotherapy - Berlin : Springer, 1976, 70(2021), 10 vom: 15. März, Seite 2961-2969 |
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| Übergeordnetes Werk: |
volume:70 ; year:2021 ; number:10 ; day:15 ; month:03 ; pages:2961-2969 |
| Links: |
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| DOI / URN: |
10.1007/s00262-021-02889-5 |
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| Katalog-ID: |
SPR045014027 |
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| 245 | 1 | 4 | |a The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) |
| 264 | 1 | |c 2021 | |
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| 500 | |a © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 | ||
| 520 | |a Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. | ||
| 650 | 4 | |a Selenium (Se) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Diffuse large B-cell lymphoma (DLBCL) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Regulatory T cells (Tregs) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immune checkpoint receptors |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Shokrgozar, Negin |e verfasserin |4 aut | |
| 700 | 1 | |a Ramzi, Mani |e verfasserin |4 aut | |
| 700 | 1 | |a Kalani, Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Golmoghaddam, Hossein |e verfasserin |4 aut | |
| 700 | 1 | |a Arandi, Nargess |e verfasserin |4 aut | |
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10.1007/s00262-021-02889-5 doi (DE-627)SPR045014027 (SPR)s00262-021-02889-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl 44.45 bkl Dehghani, Mehdi verfasserin aut The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. Selenium (Se) (dpeaa)DE-He213 Diffuse large B-cell lymphoma (DLBCL) (dpeaa)DE-He213 Regulatory T cells (Tregs) (dpeaa)DE-He213 Immune checkpoint receptors (dpeaa)DE-He213 Shokrgozar, Negin verfasserin aut Ramzi, Mani verfasserin aut Kalani, Mehdi verfasserin aut Golmoghaddam, Hossein verfasserin aut Arandi, Nargess verfasserin aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 70(2021), 10 vom: 15. März, Seite 2961-2969 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:70 year:2021 number:10 day:15 month:03 pages:2961-2969 https://dx.doi.org/10.1007/s00262-021-02889-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.45 ASE AR 70 2021 10 15 03 2961-2969 |
| spelling |
10.1007/s00262-021-02889-5 doi (DE-627)SPR045014027 (SPR)s00262-021-02889-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl 44.45 bkl Dehghani, Mehdi verfasserin aut The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. Selenium (Se) (dpeaa)DE-He213 Diffuse large B-cell lymphoma (DLBCL) (dpeaa)DE-He213 Regulatory T cells (Tregs) (dpeaa)DE-He213 Immune checkpoint receptors (dpeaa)DE-He213 Shokrgozar, Negin verfasserin aut Ramzi, Mani verfasserin aut Kalani, Mehdi verfasserin aut Golmoghaddam, Hossein verfasserin aut Arandi, Nargess verfasserin aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 70(2021), 10 vom: 15. März, Seite 2961-2969 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:70 year:2021 number:10 day:15 month:03 pages:2961-2969 https://dx.doi.org/10.1007/s00262-021-02889-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.45 ASE AR 70 2021 10 15 03 2961-2969 |
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10.1007/s00262-021-02889-5 doi (DE-627)SPR045014027 (SPR)s00262-021-02889-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl 44.45 bkl Dehghani, Mehdi verfasserin aut The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. Selenium (Se) (dpeaa)DE-He213 Diffuse large B-cell lymphoma (DLBCL) (dpeaa)DE-He213 Regulatory T cells (Tregs) (dpeaa)DE-He213 Immune checkpoint receptors (dpeaa)DE-He213 Shokrgozar, Negin verfasserin aut Ramzi, Mani verfasserin aut Kalani, Mehdi verfasserin aut Golmoghaddam, Hossein verfasserin aut Arandi, Nargess verfasserin aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 70(2021), 10 vom: 15. März, Seite 2961-2969 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:70 year:2021 number:10 day:15 month:03 pages:2961-2969 https://dx.doi.org/10.1007/s00262-021-02889-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.45 ASE AR 70 2021 10 15 03 2961-2969 |
| allfieldsGer |
10.1007/s00262-021-02889-5 doi (DE-627)SPR045014027 (SPR)s00262-021-02889-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl 44.45 bkl Dehghani, Mehdi verfasserin aut The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. Selenium (Se) (dpeaa)DE-He213 Diffuse large B-cell lymphoma (DLBCL) (dpeaa)DE-He213 Regulatory T cells (Tregs) (dpeaa)DE-He213 Immune checkpoint receptors (dpeaa)DE-He213 Shokrgozar, Negin verfasserin aut Ramzi, Mani verfasserin aut Kalani, Mehdi verfasserin aut Golmoghaddam, Hossein verfasserin aut Arandi, Nargess verfasserin aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 70(2021), 10 vom: 15. März, Seite 2961-2969 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:70 year:2021 number:10 day:15 month:03 pages:2961-2969 https://dx.doi.org/10.1007/s00262-021-02889-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.45 ASE AR 70 2021 10 15 03 2961-2969 |
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10.1007/s00262-021-02889-5 doi (DE-627)SPR045014027 (SPR)s00262-021-02889-5-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.81 bkl 44.45 bkl Dehghani, Mehdi verfasserin aut The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. Selenium (Se) (dpeaa)DE-He213 Diffuse large B-cell lymphoma (DLBCL) (dpeaa)DE-He213 Regulatory T cells (Tregs) (dpeaa)DE-He213 Immune checkpoint receptors (dpeaa)DE-He213 Shokrgozar, Negin verfasserin aut Ramzi, Mani verfasserin aut Kalani, Mehdi verfasserin aut Golmoghaddam, Hossein verfasserin aut Arandi, Nargess verfasserin aut Enthalten in Cancer immunology immunotherapy Berlin : Springer, 1976 70(2021), 10 vom: 15. März, Seite 2961-2969 (DE-627)253390443 (DE-600)1458489-X 1432-0851 nnns volume:70 year:2021 number:10 day:15 month:03 pages:2961-2969 https://dx.doi.org/10.1007/s00262-021-02889-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE 44.45 ASE AR 70 2021 10 15 03 2961-2969 |
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Enthalten in Cancer immunology immunotherapy 70(2021), 10 vom: 15. März, Seite 2961-2969 volume:70 year:2021 number:10 day:15 month:03 pages:2961-2969 |
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Enthalten in Cancer immunology immunotherapy 70(2021), 10 vom: 15. März, Seite 2961-2969 volume:70 year:2021 number:10 day:15 month:03 pages:2961-2969 |
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Selenium (Se) Diffuse large B-cell lymphoma (DLBCL) Regulatory T cells (Tregs) Immune checkpoint receptors |
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Cancer immunology immunotherapy |
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Dehghani, Mehdi @@aut@@ Shokrgozar, Negin @@aut@@ Ramzi, Mani @@aut@@ Kalani, Mehdi @@aut@@ Golmoghaddam, Hossein @@aut@@ Arandi, Nargess @@aut@@ |
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2021-03-15T00:00:00Z |
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Dehghani, Mehdi |
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Dehghani, Mehdi ddc 610 bkl 44.81 bkl 44.45 misc Selenium (Se) misc Diffuse large B-cell lymphoma (DLBCL) misc Regulatory T cells (Tregs) misc Immune checkpoint receptors The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) |
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610 ASE 44.81 bkl 44.45 bkl The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) Selenium (Se) (dpeaa)DE-He213 Diffuse large B-cell lymphoma (DLBCL) (dpeaa)DE-He213 Regulatory T cells (Tregs) (dpeaa)DE-He213 Immune checkpoint receptors (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 bkl 44.45 misc Selenium (Se) misc Diffuse large B-cell lymphoma (DLBCL) misc Regulatory T cells (Tregs) misc Immune checkpoint receptors |
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The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) |
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The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) |
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Dehghani, Mehdi Shokrgozar, Negin Ramzi, Mani Kalani, Mehdi Golmoghaddam, Hossein Arandi, Nargess |
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impact of selenium on regulatory t cell frequency and immune checkpoint receptor expression in patients with diffuse large b cell lymphoma (dlbcl) |
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The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) |
| abstract |
Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 |
| abstractGer |
Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 |
| abstract_unstemmed |
Abstract For many decades, selenium (Se) has been known as a potential anti-cancer agent that can also improve the function of immune cells in a variety of solid tumors. However, there is no report on the role of Se on $ CD4^{+} $ T cell subsets like $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ regulatory T cells (Tregs) in lymphoma patients. In this randomized clinical trial, we investigated the effect of 3-month Se consumption on the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and the expression of immune checkpoint receptors in thirty-two non-Hodgkin lymphoma (NHL) patients (16 patients with Se (Se+) and 16 without Se (Se−) consumption) with diffuse large B-cell lymphoma (DLBCL) subtype at stable remission. The change in the frequency of Tregs and expression of immune checkpoint receptors including CTLA-4, LAG-3, TIM-3, and PD-L1 genes were evaluated after 3 months in both groups using flow cytometry and SYBR Green Real-time PCR method, respectively. The results showed that the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs and expression of immune checkpoint receptors did not significantly change after 3-month Se consumption in DLBCL patients. However, alteration in the frequency of $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Treg subsets was positively correlated with change in CTLA-4, LAG-3, and TIM-3 expression in the Se+ group. Three-month Se supplementation did not prevent relapse in Se+ group. Taken together, Se supplementation alone did not affect the frequency of $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Tregs, expression of checkpoint receptors, and prevention of relapse in DLBCL patients at stable remission phase but might influence the functional properties of other Treg subsets like $ CD4^{+} %$ CD25^{−} %$ FOXP3^{+} $ Tregs. © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 |
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| title_short |
The impact of selenium on regulatory T cell frequency and immune checkpoint receptor expression in patients with diffuse large B cell lymphoma (DLBCL) |
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