Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting
Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In ce...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Iantsen, Andrei [verfasserIn] Ferreira, Marta [verfasserIn] Lucia, Francois [verfasserIn] Jaouen, Vincent [verfasserIn] Reinhold, Caroline [verfasserIn] Bonaffini, Pietro [verfasserIn] Alfieri, Joanne [verfasserIn] Rovira, Ramon [verfasserIn] Masson, Ingrid [verfasserIn] Robin, Philippe [verfasserIn] Mervoyer, Augustin [verfasserIn] Rousseau, Caroline [verfasserIn] Kridelka, Frédéric [verfasserIn] Decuypere, Marjolein [verfasserIn] Lovinfosse, Pierre [verfasserIn] Pradier, Olivier [verfasserIn] Hustinx, Roland [verfasserIn] Schick, Ulrike [verfasserIn] Visvikis, Dimitris [verfasserIn] Hatt, Mathieu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021 |
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| Übergeordnetes Werk: |
Enthalten in: European journal of nuclear medicine and molecular imaging - Heidelberg [u.a.] : Springer-Verl., 2002, 48(2021), 11 vom: 27. März, Seite 3444-3456 |
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| Übergeordnetes Werk: |
volume:48 ; year:2021 ; number:11 ; day:27 ; month:03 ; pages:3444-3456 |
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| DOI / URN: |
10.1007/s00259-021-05244-z |
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| Katalog-ID: |
SPR045071209 |
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| 100 | 1 | |a Iantsen, Andrei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting |
| 264 | 1 | |c 2021 | |
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| 520 | |a Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. | ||
| 650 | 4 | |a Convolutional neural network |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PET |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Segmentation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cervical cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a U-Net |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ferreira, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Lucia, Francois |e verfasserin |4 aut | |
| 700 | 1 | |a Jaouen, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Reinhold, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Bonaffini, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Alfieri, Joanne |e verfasserin |4 aut | |
| 700 | 1 | |a Rovira, Ramon |e verfasserin |4 aut | |
| 700 | 1 | |a Masson, Ingrid |e verfasserin |4 aut | |
| 700 | 1 | |a Robin, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Mervoyer, Augustin |e verfasserin |4 aut | |
| 700 | 1 | |a Rousseau, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Kridelka, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Decuypere, Marjolein |e verfasserin |4 aut | |
| 700 | 1 | |a Lovinfosse, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Pradier, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Hustinx, Roland |e verfasserin |4 aut | |
| 700 | 1 | |a Schick, Ulrike |e verfasserin |4 aut | |
| 700 | 1 | |a Visvikis, Dimitris |e verfasserin |4 aut | |
| 700 | 1 | |a Hatt, Mathieu |e verfasserin |4 aut | |
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10.1007/s00259-021-05244-z doi (DE-627)SPR045071209 (SPR)s00259-021-05244-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Iantsen, Andrei verfasserin aut Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. Convolutional neural network (dpeaa)DE-He213 PET (dpeaa)DE-He213 Segmentation (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 U-Net (dpeaa)DE-He213 Ferreira, Marta verfasserin aut Lucia, Francois verfasserin aut Jaouen, Vincent verfasserin aut Reinhold, Caroline verfasserin aut Bonaffini, Pietro verfasserin aut Alfieri, Joanne verfasserin aut Rovira, Ramon verfasserin aut Masson, Ingrid verfasserin aut Robin, Philippe verfasserin aut Mervoyer, Augustin verfasserin aut Rousseau, Caroline verfasserin aut Kridelka, Frédéric verfasserin aut Decuypere, Marjolein verfasserin aut Lovinfosse, Pierre verfasserin aut Pradier, Olivier verfasserin aut Hustinx, Roland verfasserin aut Schick, Ulrike verfasserin aut Visvikis, Dimitris verfasserin aut Hatt, Mathieu verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2021), 11 vom: 27. März, Seite 3444-3456 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2021 number:11 day:27 month:03 pages:3444-3456 https://dx.doi.org/10.1007/s00259-021-05244-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2021 11 27 03 3444-3456 |
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10.1007/s00259-021-05244-z doi (DE-627)SPR045071209 (SPR)s00259-021-05244-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Iantsen, Andrei verfasserin aut Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. Convolutional neural network (dpeaa)DE-He213 PET (dpeaa)DE-He213 Segmentation (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 U-Net (dpeaa)DE-He213 Ferreira, Marta verfasserin aut Lucia, Francois verfasserin aut Jaouen, Vincent verfasserin aut Reinhold, Caroline verfasserin aut Bonaffini, Pietro verfasserin aut Alfieri, Joanne verfasserin aut Rovira, Ramon verfasserin aut Masson, Ingrid verfasserin aut Robin, Philippe verfasserin aut Mervoyer, Augustin verfasserin aut Rousseau, Caroline verfasserin aut Kridelka, Frédéric verfasserin aut Decuypere, Marjolein verfasserin aut Lovinfosse, Pierre verfasserin aut Pradier, Olivier verfasserin aut Hustinx, Roland verfasserin aut Schick, Ulrike verfasserin aut Visvikis, Dimitris verfasserin aut Hatt, Mathieu verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2021), 11 vom: 27. März, Seite 3444-3456 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2021 number:11 day:27 month:03 pages:3444-3456 https://dx.doi.org/10.1007/s00259-021-05244-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2021 11 27 03 3444-3456 |
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10.1007/s00259-021-05244-z doi (DE-627)SPR045071209 (SPR)s00259-021-05244-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Iantsen, Andrei verfasserin aut Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. Convolutional neural network (dpeaa)DE-He213 PET (dpeaa)DE-He213 Segmentation (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 U-Net (dpeaa)DE-He213 Ferreira, Marta verfasserin aut Lucia, Francois verfasserin aut Jaouen, Vincent verfasserin aut Reinhold, Caroline verfasserin aut Bonaffini, Pietro verfasserin aut Alfieri, Joanne verfasserin aut Rovira, Ramon verfasserin aut Masson, Ingrid verfasserin aut Robin, Philippe verfasserin aut Mervoyer, Augustin verfasserin aut Rousseau, Caroline verfasserin aut Kridelka, Frédéric verfasserin aut Decuypere, Marjolein verfasserin aut Lovinfosse, Pierre verfasserin aut Pradier, Olivier verfasserin aut Hustinx, Roland verfasserin aut Schick, Ulrike verfasserin aut Visvikis, Dimitris verfasserin aut Hatt, Mathieu verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2021), 11 vom: 27. März, Seite 3444-3456 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2021 number:11 day:27 month:03 pages:3444-3456 https://dx.doi.org/10.1007/s00259-021-05244-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2021 11 27 03 3444-3456 |
| allfieldsGer |
10.1007/s00259-021-05244-z doi (DE-627)SPR045071209 (SPR)s00259-021-05244-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Iantsen, Andrei verfasserin aut Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. Convolutional neural network (dpeaa)DE-He213 PET (dpeaa)DE-He213 Segmentation (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 U-Net (dpeaa)DE-He213 Ferreira, Marta verfasserin aut Lucia, Francois verfasserin aut Jaouen, Vincent verfasserin aut Reinhold, Caroline verfasserin aut Bonaffini, Pietro verfasserin aut Alfieri, Joanne verfasserin aut Rovira, Ramon verfasserin aut Masson, Ingrid verfasserin aut Robin, Philippe verfasserin aut Mervoyer, Augustin verfasserin aut Rousseau, Caroline verfasserin aut Kridelka, Frédéric verfasserin aut Decuypere, Marjolein verfasserin aut Lovinfosse, Pierre verfasserin aut Pradier, Olivier verfasserin aut Hustinx, Roland verfasserin aut Schick, Ulrike verfasserin aut Visvikis, Dimitris verfasserin aut Hatt, Mathieu verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2021), 11 vom: 27. März, Seite 3444-3456 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2021 number:11 day:27 month:03 pages:3444-3456 https://dx.doi.org/10.1007/s00259-021-05244-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2021 11 27 03 3444-3456 |
| allfieldsSound |
10.1007/s00259-021-05244-z doi (DE-627)SPR045071209 (SPR)s00259-021-05244-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Iantsen, Andrei verfasserin aut Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. Convolutional neural network (dpeaa)DE-He213 PET (dpeaa)DE-He213 Segmentation (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 U-Net (dpeaa)DE-He213 Ferreira, Marta verfasserin aut Lucia, Francois verfasserin aut Jaouen, Vincent verfasserin aut Reinhold, Caroline verfasserin aut Bonaffini, Pietro verfasserin aut Alfieri, Joanne verfasserin aut Rovira, Ramon verfasserin aut Masson, Ingrid verfasserin aut Robin, Philippe verfasserin aut Mervoyer, Augustin verfasserin aut Rousseau, Caroline verfasserin aut Kridelka, Frédéric verfasserin aut Decuypere, Marjolein verfasserin aut Lovinfosse, Pierre verfasserin aut Pradier, Olivier verfasserin aut Hustinx, Roland verfasserin aut Schick, Ulrike verfasserin aut Visvikis, Dimitris verfasserin aut Hatt, Mathieu verfasserin aut Enthalten in European journal of nuclear medicine and molecular imaging Heidelberg [u.a.] : Springer-Verl., 2002 48(2021), 11 vom: 27. März, Seite 3444-3456 (DE-627)359787258 (DE-600)2098375-X 1619-7089 nnns volume:48 year:2021 number:11 day:27 month:03 pages:3444-3456 https://dx.doi.org/10.1007/s00259-021-05244-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.64 ASE AR 48 2021 11 27 03 3444-3456 |
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Enthalten in European journal of nuclear medicine and molecular imaging 48(2021), 11 vom: 27. März, Seite 3444-3456 volume:48 year:2021 number:11 day:27 month:03 pages:3444-3456 |
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Enthalten in European journal of nuclear medicine and molecular imaging 48(2021), 11 vom: 27. März, Seite 3444-3456 volume:48 year:2021 number:11 day:27 month:03 pages:3444-3456 |
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Convolutional neural network PET Segmentation Cervical cancer U-Net |
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Iantsen, Andrei @@aut@@ Ferreira, Marta @@aut@@ Lucia, Francois @@aut@@ Jaouen, Vincent @@aut@@ Reinhold, Caroline @@aut@@ Bonaffini, Pietro @@aut@@ Alfieri, Joanne @@aut@@ Rovira, Ramon @@aut@@ Masson, Ingrid @@aut@@ Robin, Philippe @@aut@@ Mervoyer, Augustin @@aut@@ Rousseau, Caroline @@aut@@ Kridelka, Frédéric @@aut@@ Decuypere, Marjolein @@aut@@ Lovinfosse, Pierre @@aut@@ Pradier, Olivier @@aut@@ Hustinx, Roland @@aut@@ Schick, Ulrike @@aut@@ Visvikis, Dimitris @@aut@@ Hatt, Mathieu @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR045071209</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520000600.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210915s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00259-021-05244-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR045071209</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00259-021-05244-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.64</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Iantsen, Andrei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. 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|
| author |
Iantsen, Andrei |
| spellingShingle |
Iantsen, Andrei ddc 610 bkl 44.64 misc Convolutional neural network misc PET misc Segmentation misc Cervical cancer misc U-Net Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting |
| authorStr |
Iantsen, Andrei |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)359787258 |
| format |
electronic Article |
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Iantsen, Andrei Ferreira, Marta Lucia, Francois Jaouen, Vincent Reinhold, Caroline Bonaffini, Pietro Alfieri, Joanne Rovira, Ramon Masson, Ingrid Robin, Philippe Mervoyer, Augustin Rousseau, Caroline Kridelka, Frédéric Decuypere, Marjolein Lovinfosse, Pierre Pradier, Olivier Hustinx, Roland Schick, Ulrike Visvikis, Dimitris Hatt, Mathieu |
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convolutional neural networks for pet functional volume fully automatic segmentation: development and validation in a multi-center setting |
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Convolutional neural networks for PET functional volume fully automatic segmentation: development and validation in a multi-center setting |
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Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. © The Author(s) 2021 |
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Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. © The Author(s) 2021 |
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Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context of multicenter images with heterogeneous characteristics. Methods In cervical cancer, an additional challenge is the location of the tumor uptake near or even stuck to the bladder. PET datasets of 232 patients from five institutions were exploited. To avoid unreliable manual delineations, the ground truth was generated with a semi-automated approach: a volume containing the tumor and excluding the bladder was first manually determined, then a well-validated, semi-automated approach relying on the Fuzzy locally Adaptive Bayesian (FLAB) algorithm was applied to generate the ground truth. Our model built on the U-Net architecture incorporates residual blocks with concurrent spatial squeeze and excitation modules, as well as learnable non-linear downsampling and upsampling blocks. Experiments relied on cross-validation (four institutions for training and validation, and the fifth for testing). Results The model achieved good Dice similarity coefficient (DSC) with little variability across institutions (0.80 ± 0.03), with higher recall (0.90 ± 0.05) than precision (0.75 ± 0.05) and improved results over the standard U-Net (DSC 0.77 ± 0.05, recall 0.87 ± 0.02, precision 0.74 ± 0.08). Both vastly outperformed a fixed threshold at 40% of SUVmax (DSC 0.33 ± 0.15, recall 0.52 ± 0.17, precision 0.30 ± 0.16). In all cases, the model could determine the tumor uptake without including the bladder. Neither shape priors nor anatomical information was required to achieve efficient training. Conclusion The proposed method could facilitate the deployment of a fully automated radiomics pipeline in such a challenging multicenter context. © The Author(s) 2021 |
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| score |
7.401613 |