Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer
Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important elem...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Beilner, Daniel [verfasserIn] Kuhn, Christina [verfasserIn] Kost, Bernd P. [verfasserIn] Vilsmaier, Theresa [verfasserIn] Vattai, Aurelia [verfasserIn] Kaltofen, Till [verfasserIn] Mahner, Sven [verfasserIn] Schmoeckel, Elisa [verfasserIn] Dannecker, Christian [verfasserIn] Jückstock, Julia [verfasserIn] Mayr, Doris [verfasserIn] Jeschke, Udo [verfasserIn] Heidegger, Helene Hildegard [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Archives of gynecology and obstetrics - Berlin : Springer, 1870, 304(2021), 5 vom: 16. Apr., Seite 1307-1314 |
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| Übergeordnetes Werk: |
volume:304 ; year:2021 ; number:5 ; day:16 ; month:04 ; pages:1307-1314 |
| Links: |
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| DOI / URN: |
10.1007/s00404-021-06053-3 |
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| Katalog-ID: |
SPR045212260 |
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| 245 | 1 | 0 | |a Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer |
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| 520 | |a Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. | ||
| 650 | 4 | |a NCoR |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Epigenetic |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cervical cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunohistochemistry |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kuhn, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Kost, Bernd P. |e verfasserin |4 aut | |
| 700 | 1 | |a Vilsmaier, Theresa |e verfasserin |4 aut | |
| 700 | 1 | |a Vattai, Aurelia |e verfasserin |4 aut | |
| 700 | 1 | |a Kaltofen, Till |e verfasserin |4 aut | |
| 700 | 1 | |a Mahner, Sven |e verfasserin |4 aut | |
| 700 | 1 | |a Schmoeckel, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Dannecker, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Jückstock, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Mayr, Doris |e verfasserin |4 aut | |
| 700 | 1 | |a Jeschke, Udo |e verfasserin |4 aut | |
| 700 | 1 | |a Heidegger, Helene Hildegard |e verfasserin |4 aut | |
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10.1007/s00404-021-06053-3 doi (DE-627)SPR045212260 (SPR)s00404-021-06053-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Beilner, Daniel verfasserin aut Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. NCoR (dpeaa)DE-He213 Epigenetic (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Kuhn, Christina verfasserin aut Kost, Bernd P. verfasserin aut Vilsmaier, Theresa verfasserin aut Vattai, Aurelia verfasserin aut Kaltofen, Till verfasserin aut Mahner, Sven verfasserin aut Schmoeckel, Elisa verfasserin aut Dannecker, Christian verfasserin aut Jückstock, Julia verfasserin aut Mayr, Doris verfasserin aut Jeschke, Udo verfasserin aut Heidegger, Helene Hildegard verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 304(2021), 5 vom: 16. Apr., Seite 1307-1314 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:304 year:2021 number:5 day:16 month:04 pages:1307-1314 https://dx.doi.org/10.1007/s00404-021-06053-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 304 2021 5 16 04 1307-1314 |
| spelling |
10.1007/s00404-021-06053-3 doi (DE-627)SPR045212260 (SPR)s00404-021-06053-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Beilner, Daniel verfasserin aut Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. NCoR (dpeaa)DE-He213 Epigenetic (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Kuhn, Christina verfasserin aut Kost, Bernd P. verfasserin aut Vilsmaier, Theresa verfasserin aut Vattai, Aurelia verfasserin aut Kaltofen, Till verfasserin aut Mahner, Sven verfasserin aut Schmoeckel, Elisa verfasserin aut Dannecker, Christian verfasserin aut Jückstock, Julia verfasserin aut Mayr, Doris verfasserin aut Jeschke, Udo verfasserin aut Heidegger, Helene Hildegard verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 304(2021), 5 vom: 16. Apr., Seite 1307-1314 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:304 year:2021 number:5 day:16 month:04 pages:1307-1314 https://dx.doi.org/10.1007/s00404-021-06053-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 304 2021 5 16 04 1307-1314 |
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10.1007/s00404-021-06053-3 doi (DE-627)SPR045212260 (SPR)s00404-021-06053-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Beilner, Daniel verfasserin aut Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. NCoR (dpeaa)DE-He213 Epigenetic (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Kuhn, Christina verfasserin aut Kost, Bernd P. verfasserin aut Vilsmaier, Theresa verfasserin aut Vattai, Aurelia verfasserin aut Kaltofen, Till verfasserin aut Mahner, Sven verfasserin aut Schmoeckel, Elisa verfasserin aut Dannecker, Christian verfasserin aut Jückstock, Julia verfasserin aut Mayr, Doris verfasserin aut Jeschke, Udo verfasserin aut Heidegger, Helene Hildegard verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 304(2021), 5 vom: 16. Apr., Seite 1307-1314 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:304 year:2021 number:5 day:16 month:04 pages:1307-1314 https://dx.doi.org/10.1007/s00404-021-06053-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 304 2021 5 16 04 1307-1314 |
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10.1007/s00404-021-06053-3 doi (DE-627)SPR045212260 (SPR)s00404-021-06053-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Beilner, Daniel verfasserin aut Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. NCoR (dpeaa)DE-He213 Epigenetic (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Kuhn, Christina verfasserin aut Kost, Bernd P. verfasserin aut Vilsmaier, Theresa verfasserin aut Vattai, Aurelia verfasserin aut Kaltofen, Till verfasserin aut Mahner, Sven verfasserin aut Schmoeckel, Elisa verfasserin aut Dannecker, Christian verfasserin aut Jückstock, Julia verfasserin aut Mayr, Doris verfasserin aut Jeschke, Udo verfasserin aut Heidegger, Helene Hildegard verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 304(2021), 5 vom: 16. Apr., Seite 1307-1314 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:304 year:2021 number:5 day:16 month:04 pages:1307-1314 https://dx.doi.org/10.1007/s00404-021-06053-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 304 2021 5 16 04 1307-1314 |
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10.1007/s00404-021-06053-3 doi (DE-627)SPR045212260 (SPR)s00404-021-06053-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Beilner, Daniel verfasserin aut Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. NCoR (dpeaa)DE-He213 Epigenetic (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Kuhn, Christina verfasserin aut Kost, Bernd P. verfasserin aut Vilsmaier, Theresa verfasserin aut Vattai, Aurelia verfasserin aut Kaltofen, Till verfasserin aut Mahner, Sven verfasserin aut Schmoeckel, Elisa verfasserin aut Dannecker, Christian verfasserin aut Jückstock, Julia verfasserin aut Mayr, Doris verfasserin aut Jeschke, Udo verfasserin aut Heidegger, Helene Hildegard verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 304(2021), 5 vom: 16. Apr., Seite 1307-1314 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:304 year:2021 number:5 day:16 month:04 pages:1307-1314 https://dx.doi.org/10.1007/s00404-021-06053-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 304 2021 5 16 04 1307-1314 |
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Enthalten in Archives of gynecology and obstetrics 304(2021), 5 vom: 16. Apr., Seite 1307-1314 volume:304 year:2021 number:5 day:16 month:04 pages:1307-1314 |
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Enthalten in Archives of gynecology and obstetrics 304(2021), 5 vom: 16. Apr., Seite 1307-1314 volume:304 year:2021 number:5 day:16 month:04 pages:1307-1314 |
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NCoR Epigenetic Cervical cancer Prognosis Immunohistochemistry |
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Beilner, Daniel @@aut@@ Kuhn, Christina @@aut@@ Kost, Bernd P. @@aut@@ Vilsmaier, Theresa @@aut@@ Vattai, Aurelia @@aut@@ Kaltofen, Till @@aut@@ Mahner, Sven @@aut@@ Schmoeckel, Elisa @@aut@@ Dannecker, Christian @@aut@@ Jückstock, Julia @@aut@@ Mayr, Doris @@aut@@ Jeschke, Udo @@aut@@ Heidegger, Helene Hildegard @@aut@@ |
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2021-04-16T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR045212260</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519182144.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">211005s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00404-021-06053-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR045212260</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00404-021-06053-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.92</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Beilner, Daniel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. 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Beilner, Daniel |
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Beilner, Daniel ddc 610 bkl 44.92 misc NCoR misc Epigenetic misc Cervical cancer misc Prognosis misc Immunohistochemistry Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer |
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610 ASE 44.92 bkl Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer NCoR (dpeaa)DE-He213 Epigenetic (dpeaa)DE-He213 Cervical cancer (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 |
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ddc 610 bkl 44.92 misc NCoR misc Epigenetic misc Cervical cancer misc Prognosis misc Immunohistochemistry |
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Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer |
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Beilner, Daniel |
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Archives of gynecology and obstetrics |
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Beilner, Daniel Kuhn, Christina Kost, Bernd P. Vilsmaier, Theresa Vattai, Aurelia Kaltofen, Till Mahner, Sven Schmoeckel, Elisa Dannecker, Christian Jückstock, Julia Mayr, Doris Jeschke, Udo Heidegger, Helene Hildegard |
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Beilner, Daniel |
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nuclear receptor corepressor (ncor) is a positive prognosticator for cervical cancer |
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Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer |
| abstract |
Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. © The Author(s) 2021 |
| abstractGer |
Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. © The Author(s) 2021 |
| abstract_unstemmed |
Purpose Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect in cervical cancer. Methods By immunohistochemical staining of 250 tumor samples, the expression strength of NCoR was measured and evaluated by immunoreactive score (IRS) in the nucleus and cytoplasm. Results A low expression of NCoR in our patients was a disadvantage in overall survival. Expression of NCoR was negatively correlated with viral oncoprotein E6, acetylated histone H3 acetyl K9 and FIGO status, and positively correlated to p53. Conclusions Our study has identified epigenetic modification of tumor cells thus seems to be of relevance in cervical cancer as well for diagnosis, as a marker or as a potential therapeutic target in patients with advanced cervical carcinoma. © The Author(s) 2021 |
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Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer |
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https://dx.doi.org/10.1007/s00404-021-06053-3 |
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Kuhn, Christina Kost, Bernd P. Vilsmaier, Theresa Vattai, Aurelia Kaltofen, Till Mahner, Sven Schmoeckel, Elisa Dannecker, Christian Jückstock, Julia Mayr, Doris Jeschke, Udo Heidegger, Helene Hildegard |
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| score |
7.4011374 |