Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma
Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently,...
Ausführliche Beschreibung
Autor*in: |
Yoshimatsu, Yuki [verfasserIn] Noguchi, Rei [verfasserIn] Sin, Yooksil [verfasserIn] Tsuchiya, Ryuto [verfasserIn] Ono, Takuya [verfasserIn] Sei, Akane [verfasserIn] Sugaya, Jun [verfasserIn] Iwata, Shintaro [verfasserIn] Yoshida, Akihiko [verfasserIn] Kawai, Akira [verfasserIn] Kondo, Tadashi [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Anmerkung: |
© Japan Human Cell Society 2021 |
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Übergeordnetes Werk: |
Enthalten in: Human cell - Heidelberg [u.a.] : Springer, 2002, 34(2021), 6 vom: 17. Sept., Seite 1919-1928 |
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Übergeordnetes Werk: |
volume:34 ; year:2021 ; number:6 ; day:17 ; month:09 ; pages:1919-1928 |
Links: |
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DOI / URN: |
10.1007/s13577-021-00612-1 |
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Katalog-ID: |
SPR04521798X |
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245 | 1 | 0 | |a Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma |
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520 | |a Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. | ||
650 | 4 | |a Low-grade fibromyxoid sarcoma |7 (dpeaa)DE-He213 | |
650 | 4 | |a Sarcoma |7 (dpeaa)DE-He213 | |
650 | 4 | |a Patient-derived cancer model |7 (dpeaa)DE-He213 | |
650 | 4 | |a Patient-derived cell line |7 (dpeaa)DE-He213 | |
650 | 4 | |a Fusion gene |7 (dpeaa)DE-He213 | |
700 | 1 | |a Noguchi, Rei |e verfasserin |4 aut | |
700 | 1 | |a Sin, Yooksil |e verfasserin |4 aut | |
700 | 1 | |a Tsuchiya, Ryuto |e verfasserin |4 aut | |
700 | 1 | |a Ono, Takuya |e verfasserin |4 aut | |
700 | 1 | |a Sei, Akane |e verfasserin |4 aut | |
700 | 1 | |a Sugaya, Jun |e verfasserin |4 aut | |
700 | 1 | |a Iwata, Shintaro |e verfasserin |4 aut | |
700 | 1 | |a Yoshida, Akihiko |e verfasserin |4 aut | |
700 | 1 | |a Kawai, Akira |e verfasserin |4 aut | |
700 | 1 | |a Kondo, Tadashi |e verfasserin |4 aut | |
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10.1007/s13577-021-00612-1 doi (DE-627)SPR04521798X (SPR)s13577-021-00612-1-e DE-627 ger DE-627 rakwb eng 610 ASE Yoshimatsu, Yuki verfasserin aut Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Human Cell Society 2021 Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. Low-grade fibromyxoid sarcoma (dpeaa)DE-He213 Sarcoma (dpeaa)DE-He213 Patient-derived cancer model (dpeaa)DE-He213 Patient-derived cell line (dpeaa)DE-He213 Fusion gene (dpeaa)DE-He213 Noguchi, Rei verfasserin aut Sin, Yooksil verfasserin aut Tsuchiya, Ryuto verfasserin aut Ono, Takuya verfasserin aut Sei, Akane verfasserin aut Sugaya, Jun verfasserin aut Iwata, Shintaro verfasserin aut Yoshida, Akihiko verfasserin aut Kawai, Akira verfasserin aut Kondo, Tadashi verfasserin aut Enthalten in Human cell Heidelberg [u.a.] : Springer, 2002 34(2021), 6 vom: 17. Sept., Seite 1919-1928 (DE-627)512663122 (DE-600)2236773-1 1749-0774 nnns volume:34 year:2021 number:6 day:17 month:09 pages:1919-1928 https://dx.doi.org/10.1007/s13577-021-00612-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2021 6 17 09 1919-1928 |
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10.1007/s13577-021-00612-1 doi (DE-627)SPR04521798X (SPR)s13577-021-00612-1-e DE-627 ger DE-627 rakwb eng 610 ASE Yoshimatsu, Yuki verfasserin aut Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Human Cell Society 2021 Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. Low-grade fibromyxoid sarcoma (dpeaa)DE-He213 Sarcoma (dpeaa)DE-He213 Patient-derived cancer model (dpeaa)DE-He213 Patient-derived cell line (dpeaa)DE-He213 Fusion gene (dpeaa)DE-He213 Noguchi, Rei verfasserin aut Sin, Yooksil verfasserin aut Tsuchiya, Ryuto verfasserin aut Ono, Takuya verfasserin aut Sei, Akane verfasserin aut Sugaya, Jun verfasserin aut Iwata, Shintaro verfasserin aut Yoshida, Akihiko verfasserin aut Kawai, Akira verfasserin aut Kondo, Tadashi verfasserin aut Enthalten in Human cell Heidelberg [u.a.] : Springer, 2002 34(2021), 6 vom: 17. Sept., Seite 1919-1928 (DE-627)512663122 (DE-600)2236773-1 1749-0774 nnns volume:34 year:2021 number:6 day:17 month:09 pages:1919-1928 https://dx.doi.org/10.1007/s13577-021-00612-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2021 6 17 09 1919-1928 |
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10.1007/s13577-021-00612-1 doi (DE-627)SPR04521798X (SPR)s13577-021-00612-1-e DE-627 ger DE-627 rakwb eng 610 ASE Yoshimatsu, Yuki verfasserin aut Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Human Cell Society 2021 Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. Low-grade fibromyxoid sarcoma (dpeaa)DE-He213 Sarcoma (dpeaa)DE-He213 Patient-derived cancer model (dpeaa)DE-He213 Patient-derived cell line (dpeaa)DE-He213 Fusion gene (dpeaa)DE-He213 Noguchi, Rei verfasserin aut Sin, Yooksil verfasserin aut Tsuchiya, Ryuto verfasserin aut Ono, Takuya verfasserin aut Sei, Akane verfasserin aut Sugaya, Jun verfasserin aut Iwata, Shintaro verfasserin aut Yoshida, Akihiko verfasserin aut Kawai, Akira verfasserin aut Kondo, Tadashi verfasserin aut Enthalten in Human cell Heidelberg [u.a.] : Springer, 2002 34(2021), 6 vom: 17. Sept., Seite 1919-1928 (DE-627)512663122 (DE-600)2236773-1 1749-0774 nnns volume:34 year:2021 number:6 day:17 month:09 pages:1919-1928 https://dx.doi.org/10.1007/s13577-021-00612-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2021 6 17 09 1919-1928 |
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10.1007/s13577-021-00612-1 doi (DE-627)SPR04521798X (SPR)s13577-021-00612-1-e DE-627 ger DE-627 rakwb eng 610 ASE Yoshimatsu, Yuki verfasserin aut Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Human Cell Society 2021 Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. Low-grade fibromyxoid sarcoma (dpeaa)DE-He213 Sarcoma (dpeaa)DE-He213 Patient-derived cancer model (dpeaa)DE-He213 Patient-derived cell line (dpeaa)DE-He213 Fusion gene (dpeaa)DE-He213 Noguchi, Rei verfasserin aut Sin, Yooksil verfasserin aut Tsuchiya, Ryuto verfasserin aut Ono, Takuya verfasserin aut Sei, Akane verfasserin aut Sugaya, Jun verfasserin aut Iwata, Shintaro verfasserin aut Yoshida, Akihiko verfasserin aut Kawai, Akira verfasserin aut Kondo, Tadashi verfasserin aut Enthalten in Human cell Heidelberg [u.a.] : Springer, 2002 34(2021), 6 vom: 17. Sept., Seite 1919-1928 (DE-627)512663122 (DE-600)2236773-1 1749-0774 nnns volume:34 year:2021 number:6 day:17 month:09 pages:1919-1928 https://dx.doi.org/10.1007/s13577-021-00612-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2021 6 17 09 1919-1928 |
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10.1007/s13577-021-00612-1 doi (DE-627)SPR04521798X (SPR)s13577-021-00612-1-e DE-627 ger DE-627 rakwb eng 610 ASE Yoshimatsu, Yuki verfasserin aut Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Human Cell Society 2021 Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. Low-grade fibromyxoid sarcoma (dpeaa)DE-He213 Sarcoma (dpeaa)DE-He213 Patient-derived cancer model (dpeaa)DE-He213 Patient-derived cell line (dpeaa)DE-He213 Fusion gene (dpeaa)DE-He213 Noguchi, Rei verfasserin aut Sin, Yooksil verfasserin aut Tsuchiya, Ryuto verfasserin aut Ono, Takuya verfasserin aut Sei, Akane verfasserin aut Sugaya, Jun verfasserin aut Iwata, Shintaro verfasserin aut Yoshida, Akihiko verfasserin aut Kawai, Akira verfasserin aut Kondo, Tadashi verfasserin aut Enthalten in Human cell Heidelberg [u.a.] : Springer, 2002 34(2021), 6 vom: 17. Sept., Seite 1919-1928 (DE-627)512663122 (DE-600)2236773-1 1749-0774 nnns volume:34 year:2021 number:6 day:17 month:09 pages:1919-1928 https://dx.doi.org/10.1007/s13577-021-00612-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 34 2021 6 17 09 1919-1928 |
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English |
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Enthalten in Human cell 34(2021), 6 vom: 17. Sept., Seite 1919-1928 volume:34 year:2021 number:6 day:17 month:09 pages:1919-1928 |
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Enthalten in Human cell 34(2021), 6 vom: 17. Sept., Seite 1919-1928 volume:34 year:2021 number:6 day:17 month:09 pages:1919-1928 |
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Low-grade fibromyxoid sarcoma Sarcoma Patient-derived cancer model Patient-derived cell line Fusion gene |
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Yoshimatsu, Yuki @@aut@@ Noguchi, Rei @@aut@@ Sin, Yooksil @@aut@@ Tsuchiya, Ryuto @@aut@@ Ono, Takuya @@aut@@ Sei, Akane @@aut@@ Sugaya, Jun @@aut@@ Iwata, Shintaro @@aut@@ Yoshida, Akihiko @@aut@@ Kawai, Akira @@aut@@ Kondo, Tadashi @@aut@@ |
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2021-09-17T00:00:00Z |
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While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. 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|
author |
Yoshimatsu, Yuki |
spellingShingle |
Yoshimatsu, Yuki ddc 610 misc Low-grade fibromyxoid sarcoma misc Sarcoma misc Patient-derived cancer model misc Patient-derived cell line misc Fusion gene Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma |
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Yoshimatsu, Yuki |
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1749-0774 |
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610 ASE Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma Low-grade fibromyxoid sarcoma (dpeaa)DE-He213 Sarcoma (dpeaa)DE-He213 Patient-derived cancer model (dpeaa)DE-He213 Patient-derived cell line (dpeaa)DE-He213 Fusion gene (dpeaa)DE-He213 |
topic |
ddc 610 misc Low-grade fibromyxoid sarcoma misc Sarcoma misc Patient-derived cancer model misc Patient-derived cell line misc Fusion gene |
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ddc 610 misc Low-grade fibromyxoid sarcoma misc Sarcoma misc Patient-derived cancer model misc Patient-derived cell line misc Fusion gene |
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ddc 610 misc Low-grade fibromyxoid sarcoma misc Sarcoma misc Patient-derived cancer model misc Patient-derived cell line misc Fusion gene |
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610 - Medicine & health |
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(DE-627)512663122 (DE-600)2236773-1 |
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Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma |
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(DE-627)SPR04521798X (SPR)s13577-021-00612-1-e |
title_full |
Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma |
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Yoshimatsu, Yuki |
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Human cell |
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Yoshimatsu, Yuki Noguchi, Rei Sin, Yooksil Tsuchiya, Ryuto Ono, Takuya Sei, Akane Sugaya, Jun Iwata, Shintaro Yoshida, Akihiko Kawai, Akira Kondo, Tadashi |
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Elektronische Aufsätze |
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Yoshimatsu, Yuki |
doi_str_mv |
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title_sort |
establishment and characterization of ncc-lgfms1-c1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma |
title_auth |
Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma |
abstract |
Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. © Japan Human Cell Society 2021 |
abstractGer |
Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. © Japan Human Cell Society 2021 |
abstract_unstemmed |
Abstract Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue sarcoma genetically characterized by the presence of the FUS-CREB3L2 gene fusion. While LGFMS exhibits indolent features during its early stages, the rates of recurrence, metastasis, and death from the disease are high. Presently, the role of FUS-CREB3L2 gene fusions in the unique features of LGFMS is not clear, and there is no modality to improve the clinical outcomes of patients with LGFMS; thus, extensive studies on LGFMS are required. Patient-derived cancer cell lines are critical tools for cancer research. However, no cell line has been established for LGFMS. Here, we aimed to develop a novel cell line for LGFMS and successfully established it using surgically resected tumor tissues. The cells, named NCC-LGFMS1-C1, possessed the same fusion genes as their original tumor and visible copy number variations. The cells had a fibroblastic appearance, formed spheroids when they were seeded in a low-attachment dish, and exhibited constant growth and invasion. Additionally, we demonstrated the feasibility of high-throughput drug screening using these cells. In conclusion, the NCC-LGFMS1-C1 cell line is a useful tool for studying LGFMS. © Japan Human Cell Society 2021 |
collection_details |
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container_issue |
6 |
title_short |
Establishment and characterization of NCC-LGFMS1-C1: a novel patient-derived cell line of low-grade fibromyxoid sarcoma |
url |
https://dx.doi.org/10.1007/s13577-021-00612-1 |
remote_bool |
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author2 |
Noguchi, Rei Sin, Yooksil Tsuchiya, Ryuto Ono, Takuya Sei, Akane Sugaya, Jun Iwata, Shintaro Yoshida, Akihiko Kawai, Akira Kondo, Tadashi |
author2Str |
Noguchi, Rei Sin, Yooksil Tsuchiya, Ryuto Ono, Takuya Sei, Akane Sugaya, Jun Iwata, Shintaro Yoshida, Akihiko Kawai, Akira Kondo, Tadashi |
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doi_str |
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up_date |
2024-07-03T14:32:46.758Z |
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|
score |
7.4003267 |