Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study

Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Terui, Sakiko [verfasserIn] Akamatsu, Ryoichi [verfasserIn] Arai, Masanori [verfasserIn] Inoue, Ryota [verfasserIn] Okuyama, Tomoko [verfasserIn] Kyohara, Mayu [verfasserIn] Li, Jinghe [verfasserIn] Tsuno, Takahiro [verfasserIn] Miyashita, Daisuke [verfasserIn] Togashi, Yu [verfasserIn] Terauchi, Yasuo [verfasserIn] Shirakawa, Jun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Dulaglutide Glucagon-like peptide 1 receptor agonist Type 2 diabetes

Anmerkung:	© The Author(s) 2021

Übergeordnetes Werk:	Enthalten in: Diabetes therapy - New York, NY [u.a.] : Springer Healthcare Communications, 2010, 12(2021), 11 vom: 17. Sept., Seite 2873-2889
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:11 ; day:17 ; month:09 ; pages:2873-2889

Links:	Volltext

DOI / URN:	10.1007/s13300-021-01147-2

Katalog-ID:	SPR045308551

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245	1	0	\|a Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
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520			\|a Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting.
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allfields	10.1007/s13300-021-01147-2 doi (DE-627)SPR045308551 (SPR)s13300-021-01147-2-e DE-627 ger DE-627 rakwb eng 610 ASE Terui, Sakiko verfasserin aut Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. Dulaglutide (dpeaa)DE-He213 Glucagon-like peptide 1 receptor agonist (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Akamatsu, Ryoichi verfasserin aut Arai, Masanori verfasserin aut Inoue, Ryota verfasserin aut Okuyama, Tomoko verfasserin aut Kyohara, Mayu verfasserin aut Li, Jinghe verfasserin aut Tsuno, Takahiro verfasserin aut Miyashita, Daisuke verfasserin aut Togashi, Yu verfasserin aut Terauchi, Yasuo verfasserin aut Shirakawa, Jun verfasserin aut Enthalten in Diabetes therapy New York, NY [u.a.] : Springer Healthcare Communications, 2010 12(2021), 11 vom: 17. Sept., Seite 2873-2889 (DE-627)632439165 (DE-600)2566702-6 1869-6961 nnns volume:12 year:2021 number:11 day:17 month:09 pages:2873-2889 https://dx.doi.org/10.1007/s13300-021-01147-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 11 17 09 2873-2889
spelling	10.1007/s13300-021-01147-2 doi (DE-627)SPR045308551 (SPR)s13300-021-01147-2-e DE-627 ger DE-627 rakwb eng 610 ASE Terui, Sakiko verfasserin aut Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. Dulaglutide (dpeaa)DE-He213 Glucagon-like peptide 1 receptor agonist (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Akamatsu, Ryoichi verfasserin aut Arai, Masanori verfasserin aut Inoue, Ryota verfasserin aut Okuyama, Tomoko verfasserin aut Kyohara, Mayu verfasserin aut Li, Jinghe verfasserin aut Tsuno, Takahiro verfasserin aut Miyashita, Daisuke verfasserin aut Togashi, Yu verfasserin aut Terauchi, Yasuo verfasserin aut Shirakawa, Jun verfasserin aut Enthalten in Diabetes therapy New York, NY [u.a.] : Springer Healthcare Communications, 2010 12(2021), 11 vom: 17. Sept., Seite 2873-2889 (DE-627)632439165 (DE-600)2566702-6 1869-6961 nnns volume:12 year:2021 number:11 day:17 month:09 pages:2873-2889 https://dx.doi.org/10.1007/s13300-021-01147-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 11 17 09 2873-2889
allfields_unstemmed	10.1007/s13300-021-01147-2 doi (DE-627)SPR045308551 (SPR)s13300-021-01147-2-e DE-627 ger DE-627 rakwb eng 610 ASE Terui, Sakiko verfasserin aut Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. Dulaglutide (dpeaa)DE-He213 Glucagon-like peptide 1 receptor agonist (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Akamatsu, Ryoichi verfasserin aut Arai, Masanori verfasserin aut Inoue, Ryota verfasserin aut Okuyama, Tomoko verfasserin aut Kyohara, Mayu verfasserin aut Li, Jinghe verfasserin aut Tsuno, Takahiro verfasserin aut Miyashita, Daisuke verfasserin aut Togashi, Yu verfasserin aut Terauchi, Yasuo verfasserin aut Shirakawa, Jun verfasserin aut Enthalten in Diabetes therapy New York, NY [u.a.] : Springer Healthcare Communications, 2010 12(2021), 11 vom: 17. Sept., Seite 2873-2889 (DE-627)632439165 (DE-600)2566702-6 1869-6961 nnns volume:12 year:2021 number:11 day:17 month:09 pages:2873-2889 https://dx.doi.org/10.1007/s13300-021-01147-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 11 17 09 2873-2889
allfieldsGer	10.1007/s13300-021-01147-2 doi (DE-627)SPR045308551 (SPR)s13300-021-01147-2-e DE-627 ger DE-627 rakwb eng 610 ASE Terui, Sakiko verfasserin aut Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. Dulaglutide (dpeaa)DE-He213 Glucagon-like peptide 1 receptor agonist (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Akamatsu, Ryoichi verfasserin aut Arai, Masanori verfasserin aut Inoue, Ryota verfasserin aut Okuyama, Tomoko verfasserin aut Kyohara, Mayu verfasserin aut Li, Jinghe verfasserin aut Tsuno, Takahiro verfasserin aut Miyashita, Daisuke verfasserin aut Togashi, Yu verfasserin aut Terauchi, Yasuo verfasserin aut Shirakawa, Jun verfasserin aut Enthalten in Diabetes therapy New York, NY [u.a.] : Springer Healthcare Communications, 2010 12(2021), 11 vom: 17. Sept., Seite 2873-2889 (DE-627)632439165 (DE-600)2566702-6 1869-6961 nnns volume:12 year:2021 number:11 day:17 month:09 pages:2873-2889 https://dx.doi.org/10.1007/s13300-021-01147-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 11 17 09 2873-2889
allfieldsSound	10.1007/s13300-021-01147-2 doi (DE-627)SPR045308551 (SPR)s13300-021-01147-2-e DE-627 ger DE-627 rakwb eng 610 ASE Terui, Sakiko verfasserin aut Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. Dulaglutide (dpeaa)DE-He213 Glucagon-like peptide 1 receptor agonist (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213 Akamatsu, Ryoichi verfasserin aut Arai, Masanori verfasserin aut Inoue, Ryota verfasserin aut Okuyama, Tomoko verfasserin aut Kyohara, Mayu verfasserin aut Li, Jinghe verfasserin aut Tsuno, Takahiro verfasserin aut Miyashita, Daisuke verfasserin aut Togashi, Yu verfasserin aut Terauchi, Yasuo verfasserin aut Shirakawa, Jun verfasserin aut Enthalten in Diabetes therapy New York, NY [u.a.] : Springer Healthcare Communications, 2010 12(2021), 11 vom: 17. Sept., Seite 2873-2889 (DE-627)632439165 (DE-600)2566702-6 1869-6961 nnns volume:12 year:2021 number:11 day:17 month:09 pages:2873-2889 https://dx.doi.org/10.1007/s13300-021-01147-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 11 17 09 2873-2889
language	English
source	Enthalten in Diabetes therapy 12(2021), 11 vom: 17. Sept., Seite 2873-2889 volume:12 year:2021 number:11 day:17 month:09 pages:2873-2889
sourceStr	Enthalten in Diabetes therapy 12(2021), 11 vom: 17. Sept., Seite 2873-2889 volume:12 year:2021 number:11 day:17 month:09 pages:2873-2889
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Dulaglutide Glucagon-like peptide 1 receptor agonist Type 2 diabetes
dewey-raw	610
isfreeaccess_bool	true
container_title	Diabetes therapy
authorswithroles_txt_mv	Terui, Sakiko @@aut@@ Akamatsu, Ryoichi @@aut@@ Arai, Masanori @@aut@@ Inoue, Ryota @@aut@@ Okuyama, Tomoko @@aut@@ Kyohara, Mayu @@aut@@ Li, Jinghe @@aut@@ Tsuno, Takahiro @@aut@@ Miyashita, Daisuke @@aut@@ Togashi, Yu @@aut@@ Terauchi, Yasuo @@aut@@ Shirakawa, Jun @@aut@@
publishDateDaySort_date	2021-09-17T00:00:00Z
hierarchy_top_id	632439165
dewey-sort	3610
id	SPR045308551
language_de	englisch
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However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. 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author	Terui, Sakiko
spellingShingle	Terui, Sakiko ddc 610 misc Dulaglutide misc Glucagon-like peptide 1 receptor agonist misc Type 2 diabetes Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
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topic_title	610 ASE Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study Dulaglutide (dpeaa)DE-He213 Glucagon-like peptide 1 receptor agonist (dpeaa)DE-He213 Type 2 diabetes (dpeaa)DE-He213
topic	ddc 610 misc Dulaglutide misc Glucagon-like peptide 1 receptor agonist misc Type 2 diabetes
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title	Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
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title_full	Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
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author_browse	Terui, Sakiko Akamatsu, Ryoichi Arai, Masanori Inoue, Ryota Okuyama, Tomoko Kyohara, Mayu Li, Jinghe Tsuno, Takahiro Miyashita, Daisuke Togashi, Yu Terauchi, Yasuo Shirakawa, Jun
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title_sort	immediate glucose-lowering effect after the first administration of dulaglutide: a retrospective, single-center, observational study
title_auth	Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
abstract	Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. © The Author(s) 2021
abstractGer	Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. © The Author(s) 2021
abstract_unstemmed	Introduction Dulaglutide is a long-acting glucagon-like peptide 1 receptor agonist that is administered once weekly for the treatment of type 2 diabetes. However, the immediate glucose-lowering effect of dulaglutide after the first administration and the factors affecting the efficacy of the drug remain unclear. Methods This study was a retrospective and observational study of 80 subjects with type 2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed. Results Significant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-point BG levels was observed on day 1 as compared to day − 1 (P < 0.0001) and the reduced BG levels were maintained throughout the remaining observation period of 5 days. The baseline serum hemoglobin A1c and glycoalbumin levels were positively correlated with the reduction of the fasting BG. The Δ BG levels were not related to the parameters of insulin-secreting capacity. Insulin treatment was positively associated with the reduction of the 6-point BG levels. Patients without cerebrovascular disease and patients without diabetic retinopathy showed greater improvements of the fasting BG and SD of the 6-point BG levels, respectively. Urinary microalbumin level was positively correlated with improvements of the 6-point BG levels. Dulaglutide reduced the BG levels, irrespective of the previously used class of antidiabetic medication(s). Conclusion Dulaglutide achieved reduction in glucose level within 24 h of the first injection. The improvement in the BG levels remained stable for a week in the hospitalized clinical setting. © The Author(s) 2021
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title_short	Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
url	https://dx.doi.org/10.1007/s13300-021-01147-2
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author2	Akamatsu, Ryoichi Arai, Masanori Inoue, Ryota Okuyama, Tomoko Kyohara, Mayu Li, Jinghe Tsuno, Takahiro Miyashita, Daisuke Togashi, Yu Terauchi, Yasuo Shirakawa, Jun
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Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study

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