Diffusion tensor imaging of renal cortex in lupus nephritis

Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched heal...
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Autor*in:	Razek, Ahmed Abdel Khalek Abdel [verfasserIn] khalek, Ahmed Mohamed Abdel [verfasserIn] Tharwat, Samar [verfasserIn] Nassar, Mohammed Kamal [verfasserIn] Tharwat, Nihal [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Diffusion Tensor MR imaging Lupus nephritis Kidney

Anmerkung:	© Japan Radiological Society 2021

Übergeordnetes Werk:	Enthalten in: Radiation medicine - Tokyo : Springer, 1999, 39(2021), 11 vom: 14. Juni, Seite 1069-1076
Übergeordnetes Werk:	volume:39 ; year:2021 ; number:11 ; day:14 ; month:06 ; pages:1069-1076

Links:	Volltext

DOI / URN:	10.1007/s11604-021-01154-0

Katalog-ID:	SPR045486344

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245	1	0	\|a Diffusion tensor imaging of renal cortex in lupus nephritis
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520			\|a Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes.
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allfields	10.1007/s11604-021-01154-0 doi (DE-627)SPR045486344 (SPR)s11604-021-01154-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of renal cortex in lupus nephritis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. Diffusion (dpeaa)DE-He213 Tensor (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Lupus nephritis (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 khalek, Ahmed Mohamed Abdel verfasserin aut Tharwat, Samar verfasserin aut Nassar, Mohammed Kamal verfasserin aut Tharwat, Nihal verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 11 vom: 14. Juni, Seite 1069-1076 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:11 day:14 month:06 pages:1069-1076 https://dx.doi.org/10.1007/s11604-021-01154-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 11 14 06 1069-1076
spelling	10.1007/s11604-021-01154-0 doi (DE-627)SPR045486344 (SPR)s11604-021-01154-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of renal cortex in lupus nephritis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. Diffusion (dpeaa)DE-He213 Tensor (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Lupus nephritis (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 khalek, Ahmed Mohamed Abdel verfasserin aut Tharwat, Samar verfasserin aut Nassar, Mohammed Kamal verfasserin aut Tharwat, Nihal verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 11 vom: 14. Juni, Seite 1069-1076 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:11 day:14 month:06 pages:1069-1076 https://dx.doi.org/10.1007/s11604-021-01154-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 11 14 06 1069-1076
allfields_unstemmed	10.1007/s11604-021-01154-0 doi (DE-627)SPR045486344 (SPR)s11604-021-01154-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of renal cortex in lupus nephritis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. Diffusion (dpeaa)DE-He213 Tensor (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Lupus nephritis (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 khalek, Ahmed Mohamed Abdel verfasserin aut Tharwat, Samar verfasserin aut Nassar, Mohammed Kamal verfasserin aut Tharwat, Nihal verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 11 vom: 14. Juni, Seite 1069-1076 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:11 day:14 month:06 pages:1069-1076 https://dx.doi.org/10.1007/s11604-021-01154-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 11 14 06 1069-1076
allfieldsGer	10.1007/s11604-021-01154-0 doi (DE-627)SPR045486344 (SPR)s11604-021-01154-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of renal cortex in lupus nephritis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. Diffusion (dpeaa)DE-He213 Tensor (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Lupus nephritis (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 khalek, Ahmed Mohamed Abdel verfasserin aut Tharwat, Samar verfasserin aut Nassar, Mohammed Kamal verfasserin aut Tharwat, Nihal verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 11 vom: 14. Juni, Seite 1069-1076 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:11 day:14 month:06 pages:1069-1076 https://dx.doi.org/10.1007/s11604-021-01154-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 11 14 06 1069-1076
allfieldsSound	10.1007/s11604-021-01154-0 doi (DE-627)SPR045486344 (SPR)s11604-021-01154-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.64 bkl Razek, Ahmed Abdel Khalek Abdel verfasserin aut Diffusion tensor imaging of renal cortex in lupus nephritis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Japan Radiological Society 2021 Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. Diffusion (dpeaa)DE-He213 Tensor (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Lupus nephritis (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 khalek, Ahmed Mohamed Abdel verfasserin aut Tharwat, Samar verfasserin aut Nassar, Mohammed Kamal verfasserin aut Tharwat, Nihal verfasserin aut Enthalten in Radiation medicine Tokyo : Springer, 1999 39(2021), 11 vom: 14. Juni, Seite 1069-1076 (DE-627)368312305 (DE-600)2117284-5 1862-5274 nnns volume:39 year:2021 number:11 day:14 month:06 pages:1069-1076 https://dx.doi.org/10.1007/s11604-021-01154-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.64 ASE AR 39 2021 11 14 06 1069-1076
language	English
source	Enthalten in Radiation medicine 39(2021), 11 vom: 14. Juni, Seite 1069-1076 volume:39 year:2021 number:11 day:14 month:06 pages:1069-1076
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topic_facet	Diffusion Tensor MR imaging Lupus nephritis Kidney
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authorswithroles_txt_mv	Razek, Ahmed Abdel Khalek Abdel @@aut@@ khalek, Ahmed Mohamed Abdel @@aut@@ Tharwat, Samar @@aut@@ Nassar, Mohammed Kamal @@aut@@ Tharwat, Nihal @@aut@@
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Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). 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author	Razek, Ahmed Abdel Khalek Abdel
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topic_title	610 ASE 44.64 bkl Diffusion tensor imaging of renal cortex in lupus nephritis Diffusion (dpeaa)DE-He213 Tensor (dpeaa)DE-He213 MR imaging (dpeaa)DE-He213 Lupus nephritis (dpeaa)DE-He213 Kidney (dpeaa)DE-He213
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title	Diffusion tensor imaging of renal cortex in lupus nephritis
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title_full	Diffusion tensor imaging of renal cortex in lupus nephritis
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title_sort	diffusion tensor imaging of renal cortex in lupus nephritis
title_auth	Diffusion tensor imaging of renal cortex in lupus nephritis
abstract	Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. © Japan Radiological Society 2021
abstractGer	Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. © Japan Radiological Society 2021
abstract_unstemmed	Purpose To evaluate the diagnostic value of diffusion tensor imaging (DTI) of renal cortex in assessment of lupus nephritis (LN) and prediction of its pathological subtypes. Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). Conclusion MD and FA of renal cortex may help to assess renal affection in LN patients and predict its pathological subtypes. © Japan Radiological Society 2021
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title_short	Diffusion tensor imaging of renal cortex in lupus nephritis
url	https://dx.doi.org/10.1007/s11604-021-01154-0
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author2	khalek, Ahmed Mohamed Abdel Tharwat, Samar Nassar, Mohammed Kamal Tharwat, Nihal
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Methods Prospective study was performed upon 39 female patients with pathologically proven LN and 16 sex- and age-matched healthy controls. Patients and controls underwent DTI of kidney. Mean diffusivity (MD) and fractional anisotropy (FA) of renal cortex were calculated by two radiologists. LN patients were pathologically classified into either non-proliferative (n = 15) or proliferative (n = 24). Results Mean MD of renal cortex in LN was significantly lower (p = 0.001) than that of controls with cut-off (2.16 and 2.2 $ X10^{−3} %$ mm^{2} $/s), area under curve (AUC) of (0.92, 0.94) and accuracy of (91%, 89%) for both observers. Mean FA of renal cortex in LN was significantly higher (p = 0.001) than that of controls with cut-off (0.20, 0.21), AUC of (0.86, 0.82) and accuracy of (86%, 84%) for both observers. Renal cortex MD and FA in non-proliferative LN were significantly different (p = 0.001) from that of proliferative LN for both observers. There was excellent inter-observer agreement of MD and FA (ICC = 0.96 and 0.81). 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