Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics)
We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. admin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mekhtiev, A. A. [verfasserIn] Ismailova, U. S. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media, LLC, part of Springer Nature 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Neurophysiology - New York, NY [u.a.] : Consultants Bureau, 1969, 53(2021), 1 vom: Jan., Seite 41-47 |
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| Übergeordnetes Werk: |
volume:53 ; year:2021 ; number:1 ; month:01 ; pages:41-47 |
| Links: |
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| DOI / URN: |
10.1007/s11062-021-09911-7 |
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SPR045720258 |
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| 520 | |a We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. | ||
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10.1007/s11062-021-09911-7 doi (DE-627)SPR045720258 (SPR)s11062-021-09911-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Mekhtiev, A. A. verfasserin aut Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2021 We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. retina (dpeaa)DE-He213 serotonin-modulating anticonsolidation protein (SMAP) (dpeaa)DE-He213 rhodopsin (dpeaa)DE-He213 heat-shock protein (dpeaa)DE-He213 natural anti-SMAP autoantibodies (dpeaa)DE-He213 Ismailova, U. S. verfasserin aut Enthalten in Neurophysiology New York, NY [u.a.] : Consultants Bureau, 1969 53(2021), 1 vom: Jan., Seite 41-47 (DE-627)325573433 (DE-600)2037679-0 1573-9007 nnns volume:53 year:2021 number:1 month:01 pages:41-47 https://dx.doi.org/10.1007/s11062-021-09911-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 53 2021 1 01 41-47 |
| spelling |
10.1007/s11062-021-09911-7 doi (DE-627)SPR045720258 (SPR)s11062-021-09911-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Mekhtiev, A. A. verfasserin aut Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2021 We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. retina (dpeaa)DE-He213 serotonin-modulating anticonsolidation protein (SMAP) (dpeaa)DE-He213 rhodopsin (dpeaa)DE-He213 heat-shock protein (dpeaa)DE-He213 natural anti-SMAP autoantibodies (dpeaa)DE-He213 Ismailova, U. S. verfasserin aut Enthalten in Neurophysiology New York, NY [u.a.] : Consultants Bureau, 1969 53(2021), 1 vom: Jan., Seite 41-47 (DE-627)325573433 (DE-600)2037679-0 1573-9007 nnns volume:53 year:2021 number:1 month:01 pages:41-47 https://dx.doi.org/10.1007/s11062-021-09911-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 53 2021 1 01 41-47 |
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10.1007/s11062-021-09911-7 doi (DE-627)SPR045720258 (SPR)s11062-021-09911-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Mekhtiev, A. A. verfasserin aut Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2021 We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. retina (dpeaa)DE-He213 serotonin-modulating anticonsolidation protein (SMAP) (dpeaa)DE-He213 rhodopsin (dpeaa)DE-He213 heat-shock protein (dpeaa)DE-He213 natural anti-SMAP autoantibodies (dpeaa)DE-He213 Ismailova, U. S. verfasserin aut Enthalten in Neurophysiology New York, NY [u.a.] : Consultants Bureau, 1969 53(2021), 1 vom: Jan., Seite 41-47 (DE-627)325573433 (DE-600)2037679-0 1573-9007 nnns volume:53 year:2021 number:1 month:01 pages:41-47 https://dx.doi.org/10.1007/s11062-021-09911-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 53 2021 1 01 41-47 |
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10.1007/s11062-021-09911-7 doi (DE-627)SPR045720258 (SPR)s11062-021-09911-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Mekhtiev, A. A. verfasserin aut Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2021 We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. retina (dpeaa)DE-He213 serotonin-modulating anticonsolidation protein (SMAP) (dpeaa)DE-He213 rhodopsin (dpeaa)DE-He213 heat-shock protein (dpeaa)DE-He213 natural anti-SMAP autoantibodies (dpeaa)DE-He213 Ismailova, U. S. verfasserin aut Enthalten in Neurophysiology New York, NY [u.a.] : Consultants Bureau, 1969 53(2021), 1 vom: Jan., Seite 41-47 (DE-627)325573433 (DE-600)2037679-0 1573-9007 nnns volume:53 year:2021 number:1 month:01 pages:41-47 https://dx.doi.org/10.1007/s11062-021-09911-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 53 2021 1 01 41-47 |
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10.1007/s11062-021-09911-7 doi (DE-627)SPR045720258 (SPR)s11062-021-09911-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Mekhtiev, A. A. verfasserin aut Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media, LLC, part of Springer Nature 2021 We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. retina (dpeaa)DE-He213 serotonin-modulating anticonsolidation protein (SMAP) (dpeaa)DE-He213 rhodopsin (dpeaa)DE-He213 heat-shock protein (dpeaa)DE-He213 natural anti-SMAP autoantibodies (dpeaa)DE-He213 Ismailova, U. S. verfasserin aut Enthalten in Neurophysiology New York, NY [u.a.] : Consultants Bureau, 1969 53(2021), 1 vom: Jan., Seite 41-47 (DE-627)325573433 (DE-600)2037679-0 1573-9007 nnns volume:53 year:2021 number:1 month:01 pages:41-47 https://dx.doi.org/10.1007/s11062-021-09911-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 53 2021 1 01 41-47 |
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Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. 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Mekhtiev, A. A. |
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Mekhtiev, A. A. ddc 610 bkl 44.90 misc retina misc serotonin-modulating anticonsolidation protein (SMAP) misc rhodopsin misc heat-shock protein misc natural anti-SMAP autoantibodies Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) |
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610 ASE 44.90 bkl Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) retina (dpeaa)DE-He213 serotonin-modulating anticonsolidation protein (SMAP) (dpeaa)DE-He213 rhodopsin (dpeaa)DE-He213 heat-shock protein (dpeaa)DE-He213 natural anti-SMAP autoantibodies (dpeaa)DE-He213 |
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Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) |
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central serotonergic trophic support of the retina: its impairment in retinitis pigmentosa (in an animal model and in clinics) |
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Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) |
| abstract |
We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. © Springer Science+Business Media, LLC, part of Springer Nature 2021 |
| abstractGer |
We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. © Springer Science+Business Media, LLC, part of Springer Nature 2021 |
| abstract_unstemmed |
We analyzed possible molecular mechanisms of central serotonergic trophic support of the retina and pathogenesis of retinitis pigmentosa (RP) in an experimental model on rabbits and in patients diagnosed with this pathology. Grave-degree experimental RP was induced in male rabbits through i.v. administration of monoiodoacetic acid (MIAA, 26 mg/kg body mass). With application of an indirect ELISA test, the levels of heat shock protein 70 kDa (HSP70) and rhodopsin in the retina and those of natural anti-SMAP autoantibodies in blood serum of the patients were measured. Serotoninmodulating anticonsolidation protein (SMAP, [5]) and anti-SMAP antibodies were administered to the animals with RP. Significant downregulation of the ERG amplitude elicited by light flashes of different intensities (P < 0.001), downregulation of the rhodopsin content (P < 0.001), and upregulation of HSP70 content (P < 0.001) in the retina of MIAA-administered rabbits were observed. Intravitreal injections of SMAP and anti-SMAP antibodies to MIAA-administered rabbits resulted in significant upregulation of the rhodopsin (P < 0.001) and HSP70 (P < 0.001) contents in the retina. Downregulation of titers of natural autoimmune anti-SMAP antibodies in blood serum of the RP-diagnosed patients relative to those in healthy persons of the same age (P < 0.01) was seen. Molecular mechanisms underlying the hypothalamic serotonergic trophic regulatory effects on retinal receptor cells through retrograde and anterograde axonal transports are discussed. © Springer Science+Business Media, LLC, part of Springer Nature 2021 |
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| title_short |
Central Serotonergic Trophic Support of the Retina: Its Impairment in Retinitis Pigmentosa (in an Animal Model and in Clinics) |
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https://dx.doi.org/10.1007/s11062-021-09911-7 |
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| score |
7.4018774 |