Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction
Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia...
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| Autor*in: |
Arafat, Amr A. [verfasserIn] Hassan, Essam [verfasserIn] Alfonso, Juan J. [verfasserIn] Alanazi, Ebtesam [verfasserIn] Alshammari, Ahmad S. [verfasserIn] Mahmood, Asif [verfasserIn] Al-Otaibi, Khaled [verfasserIn] Adam, Adam I. [verfasserIn] Algarni, Khaled D. [verfasserIn] Pragliola, Claudio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021 |
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| Übergeordnetes Werk: |
Enthalten in: The cardiothoracic surgeon - [Berlin, Heidelberg] : Springer, 2019, 29(2021), 1 vom: 07. Dez. |
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| Übergeordnetes Werk: |
volume:29 ; year:2021 ; number:1 ; day:07 ; month:12 |
| Links: |
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| DOI / URN: |
10.1186/s43057-021-00061-4 |
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| Katalog-ID: |
SPR045759758 |
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| 245 | 1 | 0 | |a Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction |
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| 520 | |a Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. | ||
| 650 | 4 | |a Del Nido cardioplegia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Low ejection fraction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Troponin level |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Warm blood cardioplegia |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hassan, Essam |e verfasserin |4 aut | |
| 700 | 1 | |a Alfonso, Juan J. |e verfasserin |4 aut | |
| 700 | 1 | |a Alanazi, Ebtesam |e verfasserin |4 aut | |
| 700 | 1 | |a Alshammari, Ahmad S. |e verfasserin |4 aut | |
| 700 | 1 | |a Mahmood, Asif |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Otaibi, Khaled |e verfasserin |4 aut | |
| 700 | 1 | |a Adam, Adam I. |e verfasserin |4 aut | |
| 700 | 1 | |a Algarni, Khaled D. |e verfasserin |4 aut | |
| 700 | 1 | |a Pragliola, Claudio |e verfasserin |4 aut | |
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10.1186/s43057-021-00061-4 doi (DE-627)SPR045759758 (SPR)s43057-021-00061-4-e DE-627 ger DE-627 rakwb eng Arafat, Amr A. verfasserin aut Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. Del Nido cardioplegia (dpeaa)DE-He213 Low ejection fraction (dpeaa)DE-He213 Troponin level (dpeaa)DE-He213 Warm blood cardioplegia (dpeaa)DE-He213 Hassan, Essam verfasserin aut Alfonso, Juan J. verfasserin aut Alanazi, Ebtesam verfasserin aut Alshammari, Ahmad S. verfasserin aut Mahmood, Asif verfasserin aut Al-Otaibi, Khaled verfasserin aut Adam, Adam I. verfasserin aut Algarni, Khaled D. verfasserin aut Pragliola, Claudio verfasserin aut Enthalten in The cardiothoracic surgeon [Berlin, Heidelberg] : Springer, 2019 29(2021), 1 vom: 07. Dez. (DE-627)1688112510 (DE-600)3006146-5 2662-2203 nnns volume:29 year:2021 number:1 day:07 month:12 https://dx.doi.org/10.1186/s43057-021-00061-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 29 2021 1 07 12 |
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10.1186/s43057-021-00061-4 doi (DE-627)SPR045759758 (SPR)s43057-021-00061-4-e DE-627 ger DE-627 rakwb eng Arafat, Amr A. verfasserin aut Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. Del Nido cardioplegia (dpeaa)DE-He213 Low ejection fraction (dpeaa)DE-He213 Troponin level (dpeaa)DE-He213 Warm blood cardioplegia (dpeaa)DE-He213 Hassan, Essam verfasserin aut Alfonso, Juan J. verfasserin aut Alanazi, Ebtesam verfasserin aut Alshammari, Ahmad S. verfasserin aut Mahmood, Asif verfasserin aut Al-Otaibi, Khaled verfasserin aut Adam, Adam I. verfasserin aut Algarni, Khaled D. verfasserin aut Pragliola, Claudio verfasserin aut Enthalten in The cardiothoracic surgeon [Berlin, Heidelberg] : Springer, 2019 29(2021), 1 vom: 07. Dez. (DE-627)1688112510 (DE-600)3006146-5 2662-2203 nnns volume:29 year:2021 number:1 day:07 month:12 https://dx.doi.org/10.1186/s43057-021-00061-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 29 2021 1 07 12 |
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10.1186/s43057-021-00061-4 doi (DE-627)SPR045759758 (SPR)s43057-021-00061-4-e DE-627 ger DE-627 rakwb eng Arafat, Amr A. verfasserin aut Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. Del Nido cardioplegia (dpeaa)DE-He213 Low ejection fraction (dpeaa)DE-He213 Troponin level (dpeaa)DE-He213 Warm blood cardioplegia (dpeaa)DE-He213 Hassan, Essam verfasserin aut Alfonso, Juan J. verfasserin aut Alanazi, Ebtesam verfasserin aut Alshammari, Ahmad S. verfasserin aut Mahmood, Asif verfasserin aut Al-Otaibi, Khaled verfasserin aut Adam, Adam I. verfasserin aut Algarni, Khaled D. verfasserin aut Pragliola, Claudio verfasserin aut Enthalten in The cardiothoracic surgeon [Berlin, Heidelberg] : Springer, 2019 29(2021), 1 vom: 07. Dez. (DE-627)1688112510 (DE-600)3006146-5 2662-2203 nnns volume:29 year:2021 number:1 day:07 month:12 https://dx.doi.org/10.1186/s43057-021-00061-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 29 2021 1 07 12 |
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10.1186/s43057-021-00061-4 doi (DE-627)SPR045759758 (SPR)s43057-021-00061-4-e DE-627 ger DE-627 rakwb eng Arafat, Amr A. verfasserin aut Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. Del Nido cardioplegia (dpeaa)DE-He213 Low ejection fraction (dpeaa)DE-He213 Troponin level (dpeaa)DE-He213 Warm blood cardioplegia (dpeaa)DE-He213 Hassan, Essam verfasserin aut Alfonso, Juan J. verfasserin aut Alanazi, Ebtesam verfasserin aut Alshammari, Ahmad S. verfasserin aut Mahmood, Asif verfasserin aut Al-Otaibi, Khaled verfasserin aut Adam, Adam I. verfasserin aut Algarni, Khaled D. verfasserin aut Pragliola, Claudio verfasserin aut Enthalten in The cardiothoracic surgeon [Berlin, Heidelberg] : Springer, 2019 29(2021), 1 vom: 07. Dez. (DE-627)1688112510 (DE-600)3006146-5 2662-2203 nnns volume:29 year:2021 number:1 day:07 month:12 https://dx.doi.org/10.1186/s43057-021-00061-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 29 2021 1 07 12 |
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10.1186/s43057-021-00061-4 doi (DE-627)SPR045759758 (SPR)s43057-021-00061-4-e DE-627 ger DE-627 rakwb eng Arafat, Amr A. verfasserin aut Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. Del Nido cardioplegia (dpeaa)DE-He213 Low ejection fraction (dpeaa)DE-He213 Troponin level (dpeaa)DE-He213 Warm blood cardioplegia (dpeaa)DE-He213 Hassan, Essam verfasserin aut Alfonso, Juan J. verfasserin aut Alanazi, Ebtesam verfasserin aut Alshammari, Ahmad S. verfasserin aut Mahmood, Asif verfasserin aut Al-Otaibi, Khaled verfasserin aut Adam, Adam I. verfasserin aut Algarni, Khaled D. verfasserin aut Pragliola, Claudio verfasserin aut Enthalten in The cardiothoracic surgeon [Berlin, Heidelberg] : Springer, 2019 29(2021), 1 vom: 07. Dez. (DE-627)1688112510 (DE-600)3006146-5 2662-2203 nnns volume:29 year:2021 number:1 day:07 month:12 https://dx.doi.org/10.1186/s43057-021-00061-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 29 2021 1 07 12 |
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The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. 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Arafat, Amr A. Hassan, Essam Alfonso, Juan J. Alanazi, Ebtesam Alshammari, Ahmad S. Mahmood, Asif Al-Otaibi, Khaled Adam, Adam I. Algarni, Khaled D. Pragliola, Claudio |
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del nido versus warm blood cardioplegia in adult patients with a low ejection fraction |
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Del Nido versus warm blood cardioplegia in adult patients with a low ejection fraction |
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Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. © The Author(s) 2021 |
| abstractGer |
Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. © The Author(s) 2021 |
| abstract_unstemmed |
Background Del Nido cardioplegia was recently introduced to adult cardiac surgery with encouraging results. The effect of Del Nido cardioplegia in patients with low ejection fraction (EF) has not been thoroughly evaluated. The objective of this study was to assess the safety of Del Nido cardioplegia in adult patients with low EF compared to intermittent warm blood cardioplegia. Results During 2018 and 2019, 73 adult patients with an EF of ≤ 40% underwent cardiac surgery using Del Nido cardioplegia. The patients were compared to a historical cohort of consecutive patients with low EF who had intermitted warm blood cardioplegia (n = 81). Patients who had Del Nido cardioplegia had significantly lower EuroSCORE II (2.73 (1.7–4.1) vs. 4.5 (2.4–7.4), P = 0.004). There were no differences in creatinine clearance and preoperative echocardiographic data between the groups. Cardiopulmonary bypass and cross-clamp times were non-significantly lower with Del Nido cardioplegia. There were no differences in stroke and postoperative echocardiographic data between the groups. No hospital mortality was reported in both groups. Peak troponin levels were significantly higher in patients who had Del Nido cardioplegia (0.88 (0.58–1.47) vs. 0.7 (0.44–1.01) ng/dL; P = 0.01); however, after multivariable regression analysis, cardiopulmonary bypass time was the only predictor of postoperative troponin level (coefficient 0.005 (95% CI: 0.003–0.008); P < 0.001). ICU stay was significantly longer in patients who had Del Nido cardioplegia (4 (3–6) vs. 2(1–4) days, P < 0.001), while postoperative hospital stay did not differ between the groups. After multivariable regression, the use of intermittent warm blood cardioplegia was significantly associated with shorter ICU stay (coefficient − 1.80 (95% CI − 3.06 – -0.55); P = 0.01). Conclusions Prolonged ICU was reported with Del Nido cardioplegia; however, there were no differences in the duration of hospital stay and the clinical outcomes between the groups. Despite the proven efficacy of intermittent warm blood cardioplegia, the use of Del Nido cardioplegia might be safe in patients with low EF. © The Author(s) 2021 |
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Hassan, Essam Alfonso, Juan J. Alanazi, Ebtesam Alshammari, Ahmad S. Mahmood, Asif Al-Otaibi, Khaled Adam, Adam I. Algarni, Khaled D. Pragliola, Claudio |
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