Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains
Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Minnullina, Leyla [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
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| Übergeordnetes Werk: |
Enthalten in: International Microbiology - Springer-Verlag, 2001, 25(2021), 1 vom: 07. Aug., Seite 111-122 |
|---|---|
| Übergeordnetes Werk: |
volume:25 ; year:2021 ; number:1 ; day:07 ; month:08 ; pages:111-122 |
| Links: |
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| DOI / URN: |
10.1007/s10123-021-00197-7 |
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| 520 | |a Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. | ||
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10.1007/s10123-021-00197-7 doi (DE-627)SPR045968950 (SPR)s10123-021-00197-7-e DE-627 ger DE-627 rakwb eng Minnullina, Leyla verfasserin (orcid)0000-0002-8818-2114 aut Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. Uropathogens (dpeaa)DE-He213 Motility (dpeaa)DE-He213 Flagella (dpeaa)DE-He213 Virulence-related genes (dpeaa)DE-He213 Flagellar regulon (dpeaa)DE-He213 Pathogenicity islands (dpeaa)DE-He213 Kostennikova, Zarina aut Evtugin, Vladimir aut Akosah, Yaw aut Sharipova, Margarita aut Mardanova, Ayslu aut Enthalten in International Microbiology Springer-Verlag, 2001 25(2021), 1 vom: 07. Aug., Seite 111-122 (DE-627)SPR009351248 nnns volume:25 year:2021 number:1 day:07 month:08 pages:111-122 https://dx.doi.org/10.1007/s10123-021-00197-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2021 1 07 08 111-122 |
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10.1007/s10123-021-00197-7 doi (DE-627)SPR045968950 (SPR)s10123-021-00197-7-e DE-627 ger DE-627 rakwb eng Minnullina, Leyla verfasserin (orcid)0000-0002-8818-2114 aut Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. Uropathogens (dpeaa)DE-He213 Motility (dpeaa)DE-He213 Flagella (dpeaa)DE-He213 Virulence-related genes (dpeaa)DE-He213 Flagellar regulon (dpeaa)DE-He213 Pathogenicity islands (dpeaa)DE-He213 Kostennikova, Zarina aut Evtugin, Vladimir aut Akosah, Yaw aut Sharipova, Margarita aut Mardanova, Ayslu aut Enthalten in International Microbiology Springer-Verlag, 2001 25(2021), 1 vom: 07. Aug., Seite 111-122 (DE-627)SPR009351248 nnns volume:25 year:2021 number:1 day:07 month:08 pages:111-122 https://dx.doi.org/10.1007/s10123-021-00197-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2021 1 07 08 111-122 |
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10.1007/s10123-021-00197-7 doi (DE-627)SPR045968950 (SPR)s10123-021-00197-7-e DE-627 ger DE-627 rakwb eng Minnullina, Leyla verfasserin (orcid)0000-0002-8818-2114 aut Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. Uropathogens (dpeaa)DE-He213 Motility (dpeaa)DE-He213 Flagella (dpeaa)DE-He213 Virulence-related genes (dpeaa)DE-He213 Flagellar regulon (dpeaa)DE-He213 Pathogenicity islands (dpeaa)DE-He213 Kostennikova, Zarina aut Evtugin, Vladimir aut Akosah, Yaw aut Sharipova, Margarita aut Mardanova, Ayslu aut Enthalten in International Microbiology Springer-Verlag, 2001 25(2021), 1 vom: 07. Aug., Seite 111-122 (DE-627)SPR009351248 nnns volume:25 year:2021 number:1 day:07 month:08 pages:111-122 https://dx.doi.org/10.1007/s10123-021-00197-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2021 1 07 08 111-122 |
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10.1007/s10123-021-00197-7 doi (DE-627)SPR045968950 (SPR)s10123-021-00197-7-e DE-627 ger DE-627 rakwb eng Minnullina, Leyla verfasserin (orcid)0000-0002-8818-2114 aut Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. Uropathogens (dpeaa)DE-He213 Motility (dpeaa)DE-He213 Flagella (dpeaa)DE-He213 Virulence-related genes (dpeaa)DE-He213 Flagellar regulon (dpeaa)DE-He213 Pathogenicity islands (dpeaa)DE-He213 Kostennikova, Zarina aut Evtugin, Vladimir aut Akosah, Yaw aut Sharipova, Margarita aut Mardanova, Ayslu aut Enthalten in International Microbiology Springer-Verlag, 2001 25(2021), 1 vom: 07. Aug., Seite 111-122 (DE-627)SPR009351248 nnns volume:25 year:2021 number:1 day:07 month:08 pages:111-122 https://dx.doi.org/10.1007/s10123-021-00197-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2021 1 07 08 111-122 |
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10.1007/s10123-021-00197-7 doi (DE-627)SPR045968950 (SPR)s10123-021-00197-7-e DE-627 ger DE-627 rakwb eng Minnullina, Leyla verfasserin (orcid)0000-0002-8818-2114 aut Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. Uropathogens (dpeaa)DE-He213 Motility (dpeaa)DE-He213 Flagella (dpeaa)DE-He213 Virulence-related genes (dpeaa)DE-He213 Flagellar regulon (dpeaa)DE-He213 Pathogenicity islands (dpeaa)DE-He213 Kostennikova, Zarina aut Evtugin, Vladimir aut Akosah, Yaw aut Sharipova, Margarita aut Mardanova, Ayslu aut Enthalten in International Microbiology Springer-Verlag, 2001 25(2021), 1 vom: 07. Aug., Seite 111-122 (DE-627)SPR009351248 nnns volume:25 year:2021 number:1 day:07 month:08 pages:111-122 https://dx.doi.org/10.1007/s10123-021-00197-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 25 2021 1 07 08 111-122 |
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Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains Uropathogens (dpeaa)DE-He213 Motility (dpeaa)DE-He213 Flagella (dpeaa)DE-He213 Virulence-related genes (dpeaa)DE-He213 Flagellar regulon (dpeaa)DE-He213 Pathogenicity islands (dpeaa)DE-He213 |
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Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains |
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Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains |
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Minnullina, Leyla |
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International Microbiology |
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Minnullina, Leyla Kostennikova, Zarina Evtugin, Vladimir Akosah, Yaw Sharipova, Margarita Mardanova, Ayslu |
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diversity in the swimming motility and flagellar regulon structure of uropathogenic morganella morganii strains |
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Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains |
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Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
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Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
| abstract_unstemmed |
Abstract In current times, the opportunistic pathogen Morganella morganii is increasingly becoming a cause of urinary tract infections. The condition has been further complicated by the multiple drug resistance of most isolates. Swimming motility plays an important role in the development of urinary tract infections, allowing bacteria to colonize the upper urinary tract. We determined the differences between the growth, swimming motility, and biofilm formation of two M. morganii strains MM 1 and MM 190 isolated from the urine of patients who had community-acquired urinary tract infections. MM 190 showed a lower growth rate but better-formed biofilms in comparison to MM 1. In addition, MM 190 possessed autoaggregation abilities. It was found that a high temperature (37 °C) inhibits the flagellation of strains and makes MM 190 less motile. At the same time, the MM 1 strain maintained its rate of motility at this temperature. We demonstrated that urea at a concentration of 1.5% suppresses the growth and swimming motility of both strains. Genome analysis showed that MM 1 has a 17.7-kb-long insertion in flagellar regulon between fliE and glycosyltransferase genes, which was not identified in corresponding loci of MM 190 and 9 other M. morganii strains with whole genomes. Both strains carry two genes encoding flagellin, which may indicate flagellar antigen phase variation. However, the fliC2 genes have only 91% identity to each other and exhibit some variability in the regulatory region. We assume that all these differences influence the swimming motility of the strains. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
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Diversity in the swimming motility and flagellar regulon structure of uropathogenic Morganella morganii strains |
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Kostennikova, Zarina Evtugin, Vladimir Akosah, Yaw Sharipova, Margarita Mardanova, Ayslu |
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