Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis
Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ruan, Dan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© Italian Association of Nuclear Medicine and Molecular Imaging 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Clinical and translational imaging - Berlin : Springer Milan, 2013, 10(2021), 1 vom: 12. Nov., Seite 85-98 |
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| Übergeordnetes Werk: |
volume:10 ; year:2021 ; number:1 ; day:12 ; month:11 ; pages:85-98 |
| Links: |
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| DOI / URN: |
10.1007/s40336-021-00471-8 |
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| Katalog-ID: |
SPR046126171 |
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| 245 | 1 | 0 | |a Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis |
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| 520 | |a Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. | ||
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10.1007/s40336-021-00471-8 doi (DE-627)SPR046126171 (SPR)s40336-021-00471-8-e DE-627 ger DE-627 rakwb eng Ruan, Dan verfasserin aut Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Association of Nuclear Medicine and Molecular Imaging 2021 Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. ATTR-CA (dpeaa)DE-He213 Cardiac amyloidosis (dpeaa)DE-He213 Tc-DPD (dpeaa)DE-He213 Tc-PYP (dpeaa)DE-He213 Tc-HMDP (dpeaa)DE-He213 Sun, Long (orcid)0000-0002-0318-2925 aut Enthalten in Clinical and translational imaging Berlin : Springer Milan, 2013 10(2021), 1 vom: 12. Nov., Seite 85-98 (DE-627)742738752 (DE-600)2712000-4 2281-7565 nnns volume:10 year:2021 number:1 day:12 month:11 pages:85-98 https://dx.doi.org/10.1007/s40336-021-00471-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2021 1 12 11 85-98 |
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10.1007/s40336-021-00471-8 doi (DE-627)SPR046126171 (SPR)s40336-021-00471-8-e DE-627 ger DE-627 rakwb eng Ruan, Dan verfasserin aut Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Association of Nuclear Medicine and Molecular Imaging 2021 Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. ATTR-CA (dpeaa)DE-He213 Cardiac amyloidosis (dpeaa)DE-He213 Tc-DPD (dpeaa)DE-He213 Tc-PYP (dpeaa)DE-He213 Tc-HMDP (dpeaa)DE-He213 Sun, Long (orcid)0000-0002-0318-2925 aut Enthalten in Clinical and translational imaging Berlin : Springer Milan, 2013 10(2021), 1 vom: 12. Nov., Seite 85-98 (DE-627)742738752 (DE-600)2712000-4 2281-7565 nnns volume:10 year:2021 number:1 day:12 month:11 pages:85-98 https://dx.doi.org/10.1007/s40336-021-00471-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2021 1 12 11 85-98 |
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10.1007/s40336-021-00471-8 doi (DE-627)SPR046126171 (SPR)s40336-021-00471-8-e DE-627 ger DE-627 rakwb eng Ruan, Dan verfasserin aut Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Association of Nuclear Medicine and Molecular Imaging 2021 Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. ATTR-CA (dpeaa)DE-He213 Cardiac amyloidosis (dpeaa)DE-He213 Tc-DPD (dpeaa)DE-He213 Tc-PYP (dpeaa)DE-He213 Tc-HMDP (dpeaa)DE-He213 Sun, Long (orcid)0000-0002-0318-2925 aut Enthalten in Clinical and translational imaging Berlin : Springer Milan, 2013 10(2021), 1 vom: 12. Nov., Seite 85-98 (DE-627)742738752 (DE-600)2712000-4 2281-7565 nnns volume:10 year:2021 number:1 day:12 month:11 pages:85-98 https://dx.doi.org/10.1007/s40336-021-00471-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2021 1 12 11 85-98 |
| allfieldsGer |
10.1007/s40336-021-00471-8 doi (DE-627)SPR046126171 (SPR)s40336-021-00471-8-e DE-627 ger DE-627 rakwb eng Ruan, Dan verfasserin aut Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Association of Nuclear Medicine and Molecular Imaging 2021 Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. ATTR-CA (dpeaa)DE-He213 Cardiac amyloidosis (dpeaa)DE-He213 Tc-DPD (dpeaa)DE-He213 Tc-PYP (dpeaa)DE-He213 Tc-HMDP (dpeaa)DE-He213 Sun, Long (orcid)0000-0002-0318-2925 aut Enthalten in Clinical and translational imaging Berlin : Springer Milan, 2013 10(2021), 1 vom: 12. Nov., Seite 85-98 (DE-627)742738752 (DE-600)2712000-4 2281-7565 nnns volume:10 year:2021 number:1 day:12 month:11 pages:85-98 https://dx.doi.org/10.1007/s40336-021-00471-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2021 1 12 11 85-98 |
| allfieldsSound |
10.1007/s40336-021-00471-8 doi (DE-627)SPR046126171 (SPR)s40336-021-00471-8-e DE-627 ger DE-627 rakwb eng Ruan, Dan verfasserin aut Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Italian Association of Nuclear Medicine and Molecular Imaging 2021 Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. ATTR-CA (dpeaa)DE-He213 Cardiac amyloidosis (dpeaa)DE-He213 Tc-DPD (dpeaa)DE-He213 Tc-PYP (dpeaa)DE-He213 Tc-HMDP (dpeaa)DE-He213 Sun, Long (orcid)0000-0002-0318-2925 aut Enthalten in Clinical and translational imaging Berlin : Springer Milan, 2013 10(2021), 1 vom: 12. Nov., Seite 85-98 (DE-627)742738752 (DE-600)2712000-4 2281-7565 nnns volume:10 year:2021 number:1 day:12 month:11 pages:85-98 https://dx.doi.org/10.1007/s40336-021-00471-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2021 1 12 11 85-98 |
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Enthalten in Clinical and translational imaging 10(2021), 1 vom: 12. Nov., Seite 85-98 volume:10 year:2021 number:1 day:12 month:11 pages:85-98 |
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Enthalten in Clinical and translational imaging 10(2021), 1 vom: 12. Nov., Seite 85-98 volume:10 year:2021 number:1 day:12 month:11 pages:85-98 |
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We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. 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|
| author |
Ruan, Dan |
| spellingShingle |
Ruan, Dan misc ATTR-CA misc Cardiac amyloidosis misc Tc-DPD misc Tc-PYP misc Tc-HMDP Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis |
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Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis ATTR-CA (dpeaa)DE-He213 Cardiac amyloidosis (dpeaa)DE-He213 Tc-DPD (dpeaa)DE-He213 Tc-PYP (dpeaa)DE-He213 Tc-HMDP (dpeaa)DE-He213 |
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misc ATTR-CA misc Cardiac amyloidosis misc Tc-DPD misc Tc-PYP misc Tc-HMDP |
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misc ATTR-CA misc Cardiac amyloidosis misc Tc-DPD misc Tc-PYP misc Tc-HMDP |
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Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis |
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Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis |
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Ruan, Dan |
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Clinical and translational imaging |
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Ruan, Dan |
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diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and bayesian bivariate meta-analysis |
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Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis |
| abstract |
Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. © Italian Association of Nuclear Medicine and Molecular Imaging 2021 |
| abstractGer |
Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. © Italian Association of Nuclear Medicine and Molecular Imaging 2021 |
| abstract_unstemmed |
Purpose Radionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin (ATTR) cardiac amyloidosis. We aimed to describe the diagnostic value of bone scintigraphy in ATTR amyloid cardiomyopathy (ATTR-CA) by performing a meta-analysis of multiple studies. Methods We searched all literature included in PubMed and EMBASE until August 10, 2021. A Bayesian bivariate meta-analysis was used for all included studies. Diagnostic performance of bone scan for the diagnosis of ATTR-CA was assessed by calculating pooled sensitivity, specificity, LLR + (Log positive likelihood ratio), LLR − (Log negative likelihood ratio), LDOR (Log diagnostic odds ratio), and plotting forest maps. Summary receiver operating characteristic curves (SROC) were fitted based on a Bayesian bivariate hierarchical model to assess the overall diagnostic efficacy of bone scan for the diagnosis of ATTR-CA. A meta-analysis with subgroups based on imaging time, diagnostic criteria, and different radiotracers was performed to compare the differences in diagnostic efficacy. Results We included a total of 39 publications with a total of 3636 patients. The pooled sensitivity, specificity, LLR +, LLR −, and LDOR of bone scan for diagnosing ATTR-CA were 0.97, 0.96, 3.22, − 3.59, and 6.81, respectively; the SROC curve showed excellent diagnostic performance with an area under the curve of 0.99. The semi-quantitative visual score method, quantitative ratio (i.e., H/CL, H/WB, H/M) analysis, and quantitative cardiac SUVmax/peak analysis all had higher pooled sensitivity (0.97 vs. 0.98 vs. 1.00); the pooled specificity of cardiac SUVmax analysis was lower than that of visual scoring and quantitative ratio analysis (0.87 vs. 0.96 vs. 0.96). Regarding imaging time, the pooled sensitivity, specificity, LLR +, LLR − and LDOR were better for 3-h imaging than 1-h (0.98 vs. 0.97; 0.97 vs. 0.95; 3.49 vs. 3.03; − 3.91 vs. − 3.72; 7.40 vs. 6.75). Among the different bone-seeking tracers, the pooled sensitivities of 99mTc-DPD, 99mTc-PYP, and 99mTc-HMDP were 0.98, 0.95, and 1.00, respectively, and the pooled specificities were 0.94, 0.95, and 0.98, respectively. Conclusions Bone scintigraphy has an excellent diagnostic performance in ATTR-CA. An accurate diagnosis of ATTR-CA can be made based on the semi-quantitative visual score, quantitative ratios of planar imaging, and cardiac bone-tracer uptake values of SPECT images. © Italian Association of Nuclear Medicine and Molecular Imaging 2021 |
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Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis |
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| score |
7.400729 |