Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis
Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on G...
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| Autor*in: |
Dutra, Tamires Pereira [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Clinical Oral Investigations - Springer-Verlag, 2001, 26(2021), 2 vom: 23. Nov., Seite 1183-1197 |
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| Übergeordnetes Werk: |
volume:26 ; year:2021 ; number:2 ; day:23 ; month:11 ; pages:1183-1197 |
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| DOI / URN: |
10.1007/s00784-021-04267-y |
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| Katalog-ID: |
SPR046153543 |
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| 245 | 1 | 0 | |a Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis |
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| 520 | |a Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. | ||
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| 650 | 4 | |a Smokers |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Sallum, Enílson Antonio |4 aut | |
| 700 | 1 | |a Ruiz, Karina Gonzales Silverio |4 aut | |
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10.1007/s00784-021-04267-y doi (DE-627)SPR046153543 (SPR)s00784-021-04267-y-e DE-627 ger DE-627 rakwb eng Dutra, Tamires Pereira verfasserin (orcid)0000-0003-0325-4439 aut Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. Periodontium (dpeaa)DE-He213 Smokers (dpeaa)DE-He213 Gingival crevicular fluid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Sacramento, Catharina Marques aut Nagay, Bruna Egumi aut Magno, Marcela Baraúna aut Marañón-Vásquez, Guido Artemio aut Maia, Lucianne Cople aut Sallum, Enílson Antonio aut Ruiz, Karina Gonzales Silverio aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 26(2021), 2 vom: 23. Nov., Seite 1183-1197 (DE-627)SPR007794231 nnns volume:26 year:2021 number:2 day:23 month:11 pages:1183-1197 https://dx.doi.org/10.1007/s00784-021-04267-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 26 2021 2 23 11 1183-1197 |
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10.1007/s00784-021-04267-y doi (DE-627)SPR046153543 (SPR)s00784-021-04267-y-e DE-627 ger DE-627 rakwb eng Dutra, Tamires Pereira verfasserin (orcid)0000-0003-0325-4439 aut Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. Periodontium (dpeaa)DE-He213 Smokers (dpeaa)DE-He213 Gingival crevicular fluid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Sacramento, Catharina Marques aut Nagay, Bruna Egumi aut Magno, Marcela Baraúna aut Marañón-Vásquez, Guido Artemio aut Maia, Lucianne Cople aut Sallum, Enílson Antonio aut Ruiz, Karina Gonzales Silverio aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 26(2021), 2 vom: 23. Nov., Seite 1183-1197 (DE-627)SPR007794231 nnns volume:26 year:2021 number:2 day:23 month:11 pages:1183-1197 https://dx.doi.org/10.1007/s00784-021-04267-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 26 2021 2 23 11 1183-1197 |
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10.1007/s00784-021-04267-y doi (DE-627)SPR046153543 (SPR)s00784-021-04267-y-e DE-627 ger DE-627 rakwb eng Dutra, Tamires Pereira verfasserin (orcid)0000-0003-0325-4439 aut Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. Periodontium (dpeaa)DE-He213 Smokers (dpeaa)DE-He213 Gingival crevicular fluid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Sacramento, Catharina Marques aut Nagay, Bruna Egumi aut Magno, Marcela Baraúna aut Marañón-Vásquez, Guido Artemio aut Maia, Lucianne Cople aut Sallum, Enílson Antonio aut Ruiz, Karina Gonzales Silverio aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 26(2021), 2 vom: 23. Nov., Seite 1183-1197 (DE-627)SPR007794231 nnns volume:26 year:2021 number:2 day:23 month:11 pages:1183-1197 https://dx.doi.org/10.1007/s00784-021-04267-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 26 2021 2 23 11 1183-1197 |
| allfieldsGer |
10.1007/s00784-021-04267-y doi (DE-627)SPR046153543 (SPR)s00784-021-04267-y-e DE-627 ger DE-627 rakwb eng Dutra, Tamires Pereira verfasserin (orcid)0000-0003-0325-4439 aut Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. Periodontium (dpeaa)DE-He213 Smokers (dpeaa)DE-He213 Gingival crevicular fluid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Sacramento, Catharina Marques aut Nagay, Bruna Egumi aut Magno, Marcela Baraúna aut Marañón-Vásquez, Guido Artemio aut Maia, Lucianne Cople aut Sallum, Enílson Antonio aut Ruiz, Karina Gonzales Silverio aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 26(2021), 2 vom: 23. Nov., Seite 1183-1197 (DE-627)SPR007794231 nnns volume:26 year:2021 number:2 day:23 month:11 pages:1183-1197 https://dx.doi.org/10.1007/s00784-021-04267-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 26 2021 2 23 11 1183-1197 |
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10.1007/s00784-021-04267-y doi (DE-627)SPR046153543 (SPR)s00784-021-04267-y-e DE-627 ger DE-627 rakwb eng Dutra, Tamires Pereira verfasserin (orcid)0000-0003-0325-4439 aut Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. Periodontium (dpeaa)DE-He213 Smokers (dpeaa)DE-He213 Gingival crevicular fluid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Sacramento, Catharina Marques aut Nagay, Bruna Egumi aut Magno, Marcela Baraúna aut Marañón-Vásquez, Guido Artemio aut Maia, Lucianne Cople aut Sallum, Enílson Antonio aut Ruiz, Karina Gonzales Silverio aut Enthalten in Clinical Oral Investigations Springer-Verlag, 2001 26(2021), 2 vom: 23. Nov., Seite 1183-1197 (DE-627)SPR007794231 nnns volume:26 year:2021 number:2 day:23 month:11 pages:1183-1197 https://dx.doi.org/10.1007/s00784-021-04267-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 26 2021 2 23 11 1183-1197 |
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Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. 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Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis Periodontium (dpeaa)DE-He213 Smokers (dpeaa)DE-He213 Gingival crevicular fluid (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 |
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Dutra, Tamires Pereira Sacramento, Catharina Marques Nagay, Bruna Egumi Magno, Marcela Baraúna Marañón-Vásquez, Guido Artemio Maia, Lucianne Cople Sallum, Enílson Antonio Ruiz, Karina Gonzales Silverio |
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do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? a systematic review and meta-analysis |
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Do smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysis |
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Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
| abstractGer |
Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
| abstract_unstemmed |
Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD − 30.06 [− 40.17, − 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD − 15.22 [− 16.05, − 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. Clinical relevance. Indicating a distinct GCF profile of cytokines in periodontal healthy smokers may help to understand the mechanism whereby smoking may affect the host response. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
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