Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA)
Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enroll...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sardanelli, Francesco [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021. corrected publication 2022 |
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| Übergeordnetes Werk: |
Enthalten in: European radiology - Berlin : Springer, 1991, 32(2021), 3 vom: 13. Okt., Seite 1611-1623 |
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| Übergeordnetes Werk: |
volume:32 ; year:2021 ; number:3 ; day:13 ; month:10 ; pages:1611-1623 |
| Links: |
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| DOI / URN: |
10.1007/s00330-021-08240-x |
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| Katalog-ID: |
SPR046198598 |
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| 100 | 1 | |a Sardanelli, Francesco |e verfasserin |0 (orcid)0000-0001-6545-9427 |4 aut | |
| 245 | 1 | 0 | |a Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) |
| 264 | 1 | |c 2021 | |
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| 520 | |a Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. | ||
| 650 | 4 | |a Breast cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Magnetic resonance imaging |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mastectomy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Breast-conserving surgery |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Reoperation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Trimboli, Rubina M. |4 aut | |
| 700 | 1 | |a Houssami, Nehmat |4 aut | |
| 700 | 1 | |a Gilbert, Fiona J. |4 aut | |
| 700 | 1 | |a Helbich, Thomas H. |4 aut | |
| 700 | 1 | |a Álvarez Benito, Marina |4 aut | |
| 700 | 1 | |a Balleyguier, Corinne |4 aut | |
| 700 | 1 | |a Bazzocchi, Massimo |4 aut | |
| 700 | 1 | |a Bult, Peter |4 aut | |
| 700 | 1 | |a Calabrese, Massimo |4 aut | |
| 700 | 1 | |a Camps Herrero, Julia |4 aut | |
| 700 | 1 | |a Cartia, Francesco |4 aut | |
| 700 | 1 | |a Cassano, Enrico |4 aut | |
| 700 | 1 | |a Clauser, Paola |4 aut | |
| 700 | 1 | |a Cozzi, Andrea |4 aut | |
| 700 | 1 | |a de Andrade, Danúbia A. |4 aut | |
| 700 | 1 | |a de Lima Docema, Marcos F. |4 aut | |
| 700 | 1 | |a Depretto, Catherine |4 aut | |
| 700 | 1 | |a Dominelli, Valeria |4 aut | |
| 700 | 1 | |a Forrai, Gábor |4 aut | |
| 700 | 1 | |a Girometti, Rossano |4 aut | |
| 700 | 1 | |a Harms, Steven E. |4 aut | |
| 700 | 1 | |a Hilborne, Sarah |4 aut | |
| 700 | 1 | |a Ienzi, Raffaele |4 aut | |
| 700 | 1 | |a Lobbes, Marc B. I. |4 aut | |
| 700 | 1 | |a Losio, Claudio |4 aut | |
| 700 | 1 | |a Mann, Ritse M. |4 aut | |
| 700 | 1 | |a Montemezzi, Stefania |4 aut | |
| 700 | 1 | |a Obdeijn, Inge-Marie |4 aut | |
| 700 | 1 | |a Ozcan, Umit A. |4 aut | |
| 700 | 1 | |a Pediconi, Federica |4 aut | |
| 700 | 1 | |a Pinker, Katja |4 aut | |
| 700 | 1 | |a Preibsch, Heike |4 aut | |
| 700 | 1 | |a Raya Povedano, José L. |4 aut | |
| 700 | 1 | |a Sacchetto, Daniela |4 aut | |
| 700 | 1 | |a Scaperrotta, Gianfranco P. |4 aut | |
| 700 | 1 | |a Schiaffino, Simone |4 aut | |
| 700 | 1 | |a Schlooz, Margrethe |4 aut | |
| 700 | 1 | |a Szabó, Botond K. |4 aut | |
| 700 | 1 | |a Taylor, Donna B. |4 aut | |
| 700 | 1 | |a Ulus, Özden S. |4 aut | |
| 700 | 1 | |a Van Goethem, Mireille |4 aut | |
| 700 | 1 | |a Veltman, Jeroen |4 aut | |
| 700 | 1 | |a Weigel, Stefanie |4 aut | |
| 700 | 1 | |a Wenkel, Evelyn |4 aut | |
| 700 | 1 | |a Zuiani, Chiara |4 aut | |
| 700 | 1 | |a Di Leo, Giovanni |4 aut | |
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10.1007/s00330-021-08240-x doi (DE-627)SPR046198598 (SPR)s00330-021-08240-x-e DE-627 ger DE-627 rakwb eng Sardanelli, Francesco verfasserin (orcid)0000-0001-6545-9427 aut Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. Breast cancer (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Reoperation (dpeaa)DE-He213 Trimboli, Rubina M. aut Houssami, Nehmat aut Gilbert, Fiona J. aut Helbich, Thomas H. aut Álvarez Benito, Marina aut Balleyguier, Corinne aut Bazzocchi, Massimo aut Bult, Peter aut Calabrese, Massimo aut Camps Herrero, Julia aut Cartia, Francesco aut Cassano, Enrico aut Clauser, Paola aut Cozzi, Andrea aut de Andrade, Danúbia A. aut de Lima Docema, Marcos F. aut Depretto, Catherine aut Dominelli, Valeria aut Forrai, Gábor aut Girometti, Rossano aut Harms, Steven E. aut Hilborne, Sarah aut Ienzi, Raffaele aut Lobbes, Marc B. I. aut Losio, Claudio aut Mann, Ritse M. aut Montemezzi, Stefania aut Obdeijn, Inge-Marie aut Ozcan, Umit A. aut Pediconi, Federica aut Pinker, Katja aut Preibsch, Heike aut Raya Povedano, José L. aut Sacchetto, Daniela aut Scaperrotta, Gianfranco P. aut Schiaffino, Simone aut Schlooz, Margrethe aut Szabó, Botond K. aut Taylor, Donna B. aut Ulus, Özden S. aut Van Goethem, Mireille aut Veltman, Jeroen aut Weigel, Stefanie aut Wenkel, Evelyn aut Zuiani, Chiara aut Di Leo, Giovanni aut Enthalten in European radiology Berlin : Springer, 1991 32(2021), 3 vom: 13. Okt., Seite 1611-1623 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:32 year:2021 number:3 day:13 month:10 pages:1611-1623 https://dx.doi.org/10.1007/s00330-021-08240-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2021 3 13 10 1611-1623 |
| spelling |
10.1007/s00330-021-08240-x doi (DE-627)SPR046198598 (SPR)s00330-021-08240-x-e DE-627 ger DE-627 rakwb eng Sardanelli, Francesco verfasserin (orcid)0000-0001-6545-9427 aut Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. Breast cancer (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Reoperation (dpeaa)DE-He213 Trimboli, Rubina M. aut Houssami, Nehmat aut Gilbert, Fiona J. aut Helbich, Thomas H. aut Álvarez Benito, Marina aut Balleyguier, Corinne aut Bazzocchi, Massimo aut Bult, Peter aut Calabrese, Massimo aut Camps Herrero, Julia aut Cartia, Francesco aut Cassano, Enrico aut Clauser, Paola aut Cozzi, Andrea aut de Andrade, Danúbia A. aut de Lima Docema, Marcos F. aut Depretto, Catherine aut Dominelli, Valeria aut Forrai, Gábor aut Girometti, Rossano aut Harms, Steven E. aut Hilborne, Sarah aut Ienzi, Raffaele aut Lobbes, Marc B. I. aut Losio, Claudio aut Mann, Ritse M. aut Montemezzi, Stefania aut Obdeijn, Inge-Marie aut Ozcan, Umit A. aut Pediconi, Federica aut Pinker, Katja aut Preibsch, Heike aut Raya Povedano, José L. aut Sacchetto, Daniela aut Scaperrotta, Gianfranco P. aut Schiaffino, Simone aut Schlooz, Margrethe aut Szabó, Botond K. aut Taylor, Donna B. aut Ulus, Özden S. aut Van Goethem, Mireille aut Veltman, Jeroen aut Weigel, Stefanie aut Wenkel, Evelyn aut Zuiani, Chiara aut Di Leo, Giovanni aut Enthalten in European radiology Berlin : Springer, 1991 32(2021), 3 vom: 13. Okt., Seite 1611-1623 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:32 year:2021 number:3 day:13 month:10 pages:1611-1623 https://dx.doi.org/10.1007/s00330-021-08240-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2021 3 13 10 1611-1623 |
| allfields_unstemmed |
10.1007/s00330-021-08240-x doi (DE-627)SPR046198598 (SPR)s00330-021-08240-x-e DE-627 ger DE-627 rakwb eng Sardanelli, Francesco verfasserin (orcid)0000-0001-6545-9427 aut Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. Breast cancer (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Reoperation (dpeaa)DE-He213 Trimboli, Rubina M. aut Houssami, Nehmat aut Gilbert, Fiona J. aut Helbich, Thomas H. aut Álvarez Benito, Marina aut Balleyguier, Corinne aut Bazzocchi, Massimo aut Bult, Peter aut Calabrese, Massimo aut Camps Herrero, Julia aut Cartia, Francesco aut Cassano, Enrico aut Clauser, Paola aut Cozzi, Andrea aut de Andrade, Danúbia A. aut de Lima Docema, Marcos F. aut Depretto, Catherine aut Dominelli, Valeria aut Forrai, Gábor aut Girometti, Rossano aut Harms, Steven E. aut Hilborne, Sarah aut Ienzi, Raffaele aut Lobbes, Marc B. I. aut Losio, Claudio aut Mann, Ritse M. aut Montemezzi, Stefania aut Obdeijn, Inge-Marie aut Ozcan, Umit A. aut Pediconi, Federica aut Pinker, Katja aut Preibsch, Heike aut Raya Povedano, José L. aut Sacchetto, Daniela aut Scaperrotta, Gianfranco P. aut Schiaffino, Simone aut Schlooz, Margrethe aut Szabó, Botond K. aut Taylor, Donna B. aut Ulus, Özden S. aut Van Goethem, Mireille aut Veltman, Jeroen aut Weigel, Stefanie aut Wenkel, Evelyn aut Zuiani, Chiara aut Di Leo, Giovanni aut Enthalten in European radiology Berlin : Springer, 1991 32(2021), 3 vom: 13. Okt., Seite 1611-1623 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:32 year:2021 number:3 day:13 month:10 pages:1611-1623 https://dx.doi.org/10.1007/s00330-021-08240-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2021 3 13 10 1611-1623 |
| allfieldsGer |
10.1007/s00330-021-08240-x doi (DE-627)SPR046198598 (SPR)s00330-021-08240-x-e DE-627 ger DE-627 rakwb eng Sardanelli, Francesco verfasserin (orcid)0000-0001-6545-9427 aut Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. Breast cancer (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Reoperation (dpeaa)DE-He213 Trimboli, Rubina M. aut Houssami, Nehmat aut Gilbert, Fiona J. aut Helbich, Thomas H. aut Álvarez Benito, Marina aut Balleyguier, Corinne aut Bazzocchi, Massimo aut Bult, Peter aut Calabrese, Massimo aut Camps Herrero, Julia aut Cartia, Francesco aut Cassano, Enrico aut Clauser, Paola aut Cozzi, Andrea aut de Andrade, Danúbia A. aut de Lima Docema, Marcos F. aut Depretto, Catherine aut Dominelli, Valeria aut Forrai, Gábor aut Girometti, Rossano aut Harms, Steven E. aut Hilborne, Sarah aut Ienzi, Raffaele aut Lobbes, Marc B. I. aut Losio, Claudio aut Mann, Ritse M. aut Montemezzi, Stefania aut Obdeijn, Inge-Marie aut Ozcan, Umit A. aut Pediconi, Federica aut Pinker, Katja aut Preibsch, Heike aut Raya Povedano, José L. aut Sacchetto, Daniela aut Scaperrotta, Gianfranco P. aut Schiaffino, Simone aut Schlooz, Margrethe aut Szabó, Botond K. aut Taylor, Donna B. aut Ulus, Özden S. aut Van Goethem, Mireille aut Veltman, Jeroen aut Weigel, Stefanie aut Wenkel, Evelyn aut Zuiani, Chiara aut Di Leo, Giovanni aut Enthalten in European radiology Berlin : Springer, 1991 32(2021), 3 vom: 13. Okt., Seite 1611-1623 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:32 year:2021 number:3 day:13 month:10 pages:1611-1623 https://dx.doi.org/10.1007/s00330-021-08240-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 32 2021 3 13 10 1611-1623 |
| allfieldsSound |
10.1007/s00330-021-08240-x doi (DE-627)SPR046198598 (SPR)s00330-021-08240-x-e DE-627 ger DE-627 rakwb eng Sardanelli, Francesco verfasserin (orcid)0000-0001-6545-9427 aut Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021. corrected publication 2022 Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. Breast cancer (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Reoperation (dpeaa)DE-He213 Trimboli, Rubina M. aut Houssami, Nehmat aut Gilbert, Fiona J. aut Helbich, Thomas H. aut Álvarez Benito, Marina aut Balleyguier, Corinne aut Bazzocchi, Massimo aut Bult, Peter aut Calabrese, Massimo aut Camps Herrero, Julia aut Cartia, Francesco aut Cassano, Enrico aut Clauser, Paola aut Cozzi, Andrea aut de Andrade, Danúbia A. aut de Lima Docema, Marcos F. aut Depretto, Catherine aut Dominelli, Valeria aut Forrai, Gábor aut Girometti, Rossano aut Harms, Steven E. aut Hilborne, Sarah aut Ienzi, Raffaele aut Lobbes, Marc B. I. aut Losio, Claudio aut Mann, Ritse M. aut Montemezzi, Stefania aut Obdeijn, Inge-Marie aut Ozcan, Umit A. aut Pediconi, Federica aut Pinker, Katja aut Preibsch, Heike aut Raya Povedano, José L. aut Sacchetto, Daniela aut Scaperrotta, Gianfranco P. aut Schiaffino, Simone aut Schlooz, Margrethe aut Szabó, Botond K. aut Taylor, Donna B. aut Ulus, Özden S. aut Van Goethem, Mireille aut Veltman, Jeroen aut Weigel, Stefanie aut Wenkel, Evelyn aut Zuiani, Chiara aut Di Leo, Giovanni aut Enthalten in European radiology Berlin : Springer, 1991 32(2021), 3 vom: 13. 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Enthalten in European radiology 32(2021), 3 vom: 13. Okt., Seite 1611-1623 volume:32 year:2021 number:3 day:13 month:10 pages:1611-1623 |
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Enthalten in European radiology 32(2021), 3 vom: 13. Okt., Seite 1611-1623 volume:32 year:2021 number:3 day:13 month:10 pages:1611-1623 |
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Breast cancer Magnetic resonance imaging Mastectomy Breast-conserving surgery Reoperation |
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Sardanelli, Francesco @@aut@@ Trimboli, Rubina M. @@aut@@ Houssami, Nehmat @@aut@@ Gilbert, Fiona J. @@aut@@ Helbich, Thomas H. @@aut@@ Álvarez Benito, Marina @@aut@@ Balleyguier, Corinne @@aut@@ Bazzocchi, Massimo @@aut@@ Bult, Peter @@aut@@ Calabrese, Massimo @@aut@@ Camps Herrero, Julia @@aut@@ Cartia, Francesco @@aut@@ Cassano, Enrico @@aut@@ Clauser, Paola @@aut@@ Cozzi, Andrea @@aut@@ de Andrade, Danúbia A. @@aut@@ de Lima Docema, Marcos F. @@aut@@ Depretto, Catherine @@aut@@ Dominelli, Valeria @@aut@@ Forrai, Gábor @@aut@@ Girometti, Rossano @@aut@@ Harms, Steven E. @@aut@@ Hilborne, Sarah @@aut@@ Ienzi, Raffaele @@aut@@ Lobbes, Marc B. I. @@aut@@ Losio, Claudio @@aut@@ Mann, Ritse M. @@aut@@ Montemezzi, Stefania @@aut@@ Obdeijn, Inge-Marie @@aut@@ Ozcan, Umit A. @@aut@@ Pediconi, Federica @@aut@@ Pinker, Katja @@aut@@ Preibsch, Heike @@aut@@ Raya Povedano, José L. @@aut@@ Sacchetto, Daniela @@aut@@ Scaperrotta, Gianfranco P. @@aut@@ Schiaffino, Simone @@aut@@ Schlooz, Margrethe @@aut@@ Szabó, Botond K. @@aut@@ Taylor, Donna B. @@aut@@ Ulus, Özden S. @@aut@@ Van Goethem, Mireille @@aut@@ Veltman, Jeroen @@aut@@ Weigel, Stefanie @@aut@@ Wenkel, Evelyn @@aut@@ Zuiani, Chiara @@aut@@ Di Leo, Giovanni @@aut@@ |
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2021-10-13T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR046198598</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230507113850.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220211s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00330-021-08240-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR046198598</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00330-021-08240-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sardanelli, Francesco</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-6545-9427</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2021. corrected publication 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Breast cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Magnetic resonance imaging</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mastectomy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Breast-conserving surgery</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Reoperation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Trimboli, Rubina M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Houssami, Nehmat</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gilbert, Fiona J.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Helbich, Thomas H.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Álvarez Benito, Marina</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Balleyguier, Corinne</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bazzocchi, Massimo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bult, Peter</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Calabrese, Massimo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Camps Herrero, Julia</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cartia, Francesco</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cassano, Enrico</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Clauser, Paola</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cozzi, Andrea</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Andrade, Danúbia A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Lima Docema, Marcos F.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Depretto, Catherine</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dominelli, Valeria</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Forrai, Gábor</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Girometti, Rossano</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Harms, Steven E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hilborne, Sarah</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ienzi, Raffaele</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lobbes, Marc B. 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Sardanelli, Francesco |
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Sardanelli, Francesco misc Breast cancer misc Magnetic resonance imaging misc Mastectomy misc Breast-conserving surgery misc Reoperation Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) |
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Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) Breast cancer (dpeaa)DE-He213 Magnetic resonance imaging (dpeaa)DE-He213 Mastectomy (dpeaa)DE-He213 Breast-conserving surgery (dpeaa)DE-He213 Reoperation (dpeaa)DE-He213 |
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Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) |
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Sardanelli, Francesco Trimboli, Rubina M. Houssami, Nehmat Gilbert, Fiona J. Helbich, Thomas H. Álvarez Benito, Marina Balleyguier, Corinne Bazzocchi, Massimo Bult, Peter Calabrese, Massimo Camps Herrero, Julia Cartia, Francesco Cassano, Enrico Clauser, Paola Cozzi, Andrea de Andrade, Danúbia A. de Lima Docema, Marcos F. Depretto, Catherine Dominelli, Valeria Forrai, Gábor Girometti, Rossano Harms, Steven E. Hilborne, Sarah Ienzi, Raffaele Lobbes, Marc B. I. Losio, Claudio Mann, Ritse M. Montemezzi, Stefania Obdeijn, Inge-Marie Ozcan, Umit A. Pediconi, Federica Pinker, Katja Preibsch, Heike Raya Povedano, José L. Sacchetto, Daniela Scaperrotta, Gianfranco P. Schiaffino, Simone Schlooz, Margrethe Szabó, Botond K. Taylor, Donna B. Ulus, Özden S. Van Goethem, Mireille Veltman, Jeroen Weigel, Stefanie Wenkel, Evelyn Zuiani, Chiara Di Leo, Giovanni |
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Sardanelli, Francesco |
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magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (mipa) |
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Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) |
| abstract |
Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. © The Author(s) 2021. corrected publication 2022 |
| abstractGer |
Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. © The Author(s) 2021. corrected publication 2022 |
| abstract_unstemmed |
Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. Key Points • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making. © The Author(s) 2021. corrected publication 2022 |
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Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA) |
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Trimboli, Rubina M. Houssami, Nehmat Gilbert, Fiona J. Helbich, Thomas H. Álvarez Benito, Marina Balleyguier, Corinne Bazzocchi, Massimo Bult, Peter Calabrese, Massimo Camps Herrero, Julia Cartia, Francesco Cassano, Enrico Clauser, Paola Cozzi, Andrea de Andrade, Danúbia A. de Lima Docema, Marcos F. Depretto, Catherine Dominelli, Valeria Forrai, Gábor Girometti, Rossano Harms, Steven E. Hilborne, Sarah Ienzi, Raffaele Lobbes, Marc B. I. Losio, Claudio Mann, Ritse M. Montemezzi, Stefania Obdeijn, Inge-Marie Ozcan, Umit A. Pediconi, Federica Pinker, Katja Preibsch, Heike Raya Povedano, José L. Sacchetto, Daniela Scaperrotta, Gianfranco P. Schiaffino, Simone Schlooz, Margrethe Szabó, Botond K. Taylor, Donna B. Ulus, Özden S. Van Goethem, Mireille Veltman, Jeroen Weigel, Stefanie Wenkel, Evelyn Zuiani, Chiara Di Leo, Giovanni |
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Trimboli, Rubina M. Houssami, Nehmat Gilbert, Fiona J. Helbich, Thomas H. Álvarez Benito, Marina Balleyguier, Corinne Bazzocchi, Massimo Bult, Peter Calabrese, Massimo Camps Herrero, Julia Cartia, Francesco Cassano, Enrico Clauser, Paola Cozzi, Andrea de Andrade, Danúbia A. de Lima Docema, Marcos F. Depretto, Catherine Dominelli, Valeria Forrai, Gábor Girometti, Rossano Harms, Steven E. Hilborne, Sarah Ienzi, Raffaele Lobbes, Marc B. I. Losio, Claudio Mann, Ritse M. Montemezzi, Stefania Obdeijn, Inge-Marie Ozcan, Umit A. Pediconi, Federica Pinker, Katja Preibsch, Heike Raya Povedano, José L. Sacchetto, Daniela Scaperrotta, Gianfranco P. Schiaffino, Simone Schlooz, Margrethe Szabó, Botond K. Taylor, Donna B. Ulus, Özden S. Van Goethem, Mireille Veltman, Jeroen Weigel, Stefanie Wenkel, Evelyn Zuiani, Chiara Di Leo, Giovanni |
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10.1007/s00330-021-08240-x |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR046198598</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230507113850.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220211s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00330-021-08240-x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR046198598</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00330-021-08240-x-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Sardanelli, Francesco</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-6545-9427</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2021. corrected publication 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. Methods This observational study enrolled women aged 18–80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Results Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p < 0.001 for all comparisons). Mastectomy was planned based on conventional imaging in 22.4% (MRI group) versus 14.4% (noMRI group) (p < 0.001). The additional planned mastectomy rate in the MRI group was 11.3%. The overall performed first- plus second-line mastectomy rate was 36.3% (MRI group) versus 18.0% (noMRI group) (p < 0.001). In women receiving conserving surgery, MRI group had a significantly lower reoperation rate (8.5% versus 11.7%, p < 0.001). Conclusions Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. 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| score |
7.4001884 |