Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial

Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (I...
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Autor*in:	Dietzsch, Stefan [verfasserIn] Braesigk, Annett Seidel, Clemens Remmele, Julia Kitzing, Ralf Schlender, Tina Mynarek, Martin Geismar, Dirk Jablonska, Karolina Schwarz, Rudolf Pazos, Montserrat Weber, Damien C. Frick, Silke Gurtner, Kristin Matuschek, Christiane Harrabi, Semi Ben Glück, Albrecht Lewitzki, Victor Dieckmann, Karin Benesch, Martin Gerber, Nicolas U. Obrecht, Denise Rutkowski, Stefan Timmermann, Beate Kortmann, Rolf-Dieter

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Brain tumor Pediatric Focal radiotherapy Quality assurance Individual case review

Anmerkung:	© The Author(s) 2021

Übergeordnetes Werk:	Enthalten in: Strahlentherapie und Onkologie - Berlin : Springer Medizin, 1997, 198(2021), 3 vom: 05. Aug., Seite 282-290
Übergeordnetes Werk:	volume:198 ; year:2021 ; number:3 ; day:05 ; month:08 ; pages:282-290

Links:	Volltext

DOI / URN:	10.1007/s00066-021-01822-0

Katalog-ID:	SPR046303723

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100	1		\|a Dietzsch, Stefan \|e verfasserin \|0 (orcid)0000-0001-6141-2170 \|4 aut
245	1	0	\|a Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
264		1	\|c 2021
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520			\|a Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed.
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650		4	\|a Pediatric \|7 (dpeaa)DE-He213
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650		4	\|a Quality assurance \|7 (dpeaa)DE-He213
650		4	\|a Individual case review \|7 (dpeaa)DE-He213
700	1		\|a Braesigk, Annett \|4 aut
700	1		\|a Seidel, Clemens \|4 aut
700	1		\|a Remmele, Julia \|4 aut
700	1		\|a Kitzing, Ralf \|4 aut
700	1		\|a Schlender, Tina \|4 aut
700	1		\|a Mynarek, Martin \|4 aut
700	1		\|a Geismar, Dirk \|4 aut
700	1		\|a Jablonska, Karolina \|4 aut
700	1		\|a Schwarz, Rudolf \|4 aut
700	1		\|a Pazos, Montserrat \|4 aut
700	1		\|a Weber, Damien C. \|4 aut
700	1		\|a Frick, Silke \|4 aut
700	1		\|a Gurtner, Kristin \|4 aut
700	1		\|a Matuschek, Christiane \|4 aut
700	1		\|a Harrabi, Semi Ben \|4 aut
700	1		\|a Glück, Albrecht \|4 aut
700	1		\|a Lewitzki, Victor \|4 aut
700	1		\|a Dieckmann, Karin \|4 aut
700	1		\|a Benesch, Martin \|4 aut
700	1		\|a Gerber, Nicolas U. \|4 aut
700	1		\|a Obrecht, Denise \|4 aut
700	1		\|a Rutkowski, Stefan \|4 aut
700	1		\|a Timmermann, Beate \|4 aut
700	1		\|a Kortmann, Rolf-Dieter \|4 aut
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allfields	10.1007/s00066-021-01822-0 doi (DE-627)SPR046303723 (SPR)s00066-021-01822-0-e DE-627 ger DE-627 rakwb eng Dietzsch, Stefan verfasserin (orcid)0000-0001-6141-2170 aut Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. Brain tumor (dpeaa)DE-He213 Pediatric (dpeaa)DE-He213 Focal radiotherapy (dpeaa)DE-He213 Quality assurance (dpeaa)DE-He213 Individual case review (dpeaa)DE-He213 Braesigk, Annett aut Seidel, Clemens aut Remmele, Julia aut Kitzing, Ralf aut Schlender, Tina aut Mynarek, Martin aut Geismar, Dirk aut Jablonska, Karolina aut Schwarz, Rudolf aut Pazos, Montserrat aut Weber, Damien C. aut Frick, Silke aut Gurtner, Kristin aut Matuschek, Christiane aut Harrabi, Semi Ben aut Glück, Albrecht aut Lewitzki, Victor aut Dieckmann, Karin aut Benesch, Martin aut Gerber, Nicolas U. aut Obrecht, Denise aut Rutkowski, Stefan aut Timmermann, Beate aut Kortmann, Rolf-Dieter aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 198(2021), 3 vom: 05. Aug., Seite 282-290 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:198 year:2021 number:3 day:05 month:08 pages:282-290 https://dx.doi.org/10.1007/s00066-021-01822-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 198 2021 3 05 08 282-290
spelling	10.1007/s00066-021-01822-0 doi (DE-627)SPR046303723 (SPR)s00066-021-01822-0-e DE-627 ger DE-627 rakwb eng Dietzsch, Stefan verfasserin (orcid)0000-0001-6141-2170 aut Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. Brain tumor (dpeaa)DE-He213 Pediatric (dpeaa)DE-He213 Focal radiotherapy (dpeaa)DE-He213 Quality assurance (dpeaa)DE-He213 Individual case review (dpeaa)DE-He213 Braesigk, Annett aut Seidel, Clemens aut Remmele, Julia aut Kitzing, Ralf aut Schlender, Tina aut Mynarek, Martin aut Geismar, Dirk aut Jablonska, Karolina aut Schwarz, Rudolf aut Pazos, Montserrat aut Weber, Damien C. aut Frick, Silke aut Gurtner, Kristin aut Matuschek, Christiane aut Harrabi, Semi Ben aut Glück, Albrecht aut Lewitzki, Victor aut Dieckmann, Karin aut Benesch, Martin aut Gerber, Nicolas U. aut Obrecht, Denise aut Rutkowski, Stefan aut Timmermann, Beate aut Kortmann, Rolf-Dieter aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 198(2021), 3 vom: 05. Aug., Seite 282-290 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:198 year:2021 number:3 day:05 month:08 pages:282-290 https://dx.doi.org/10.1007/s00066-021-01822-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 198 2021 3 05 08 282-290
allfields_unstemmed	10.1007/s00066-021-01822-0 doi (DE-627)SPR046303723 (SPR)s00066-021-01822-0-e DE-627 ger DE-627 rakwb eng Dietzsch, Stefan verfasserin (orcid)0000-0001-6141-2170 aut Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. Brain tumor (dpeaa)DE-He213 Pediatric (dpeaa)DE-He213 Focal radiotherapy (dpeaa)DE-He213 Quality assurance (dpeaa)DE-He213 Individual case review (dpeaa)DE-He213 Braesigk, Annett aut Seidel, Clemens aut Remmele, Julia aut Kitzing, Ralf aut Schlender, Tina aut Mynarek, Martin aut Geismar, Dirk aut Jablonska, Karolina aut Schwarz, Rudolf aut Pazos, Montserrat aut Weber, Damien C. aut Frick, Silke aut Gurtner, Kristin aut Matuschek, Christiane aut Harrabi, Semi Ben aut Glück, Albrecht aut Lewitzki, Victor aut Dieckmann, Karin aut Benesch, Martin aut Gerber, Nicolas U. aut Obrecht, Denise aut Rutkowski, Stefan aut Timmermann, Beate aut Kortmann, Rolf-Dieter aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 198(2021), 3 vom: 05. Aug., Seite 282-290 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:198 year:2021 number:3 day:05 month:08 pages:282-290 https://dx.doi.org/10.1007/s00066-021-01822-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 198 2021 3 05 08 282-290
allfieldsGer	10.1007/s00066-021-01822-0 doi (DE-627)SPR046303723 (SPR)s00066-021-01822-0-e DE-627 ger DE-627 rakwb eng Dietzsch, Stefan verfasserin (orcid)0000-0001-6141-2170 aut Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. Brain tumor (dpeaa)DE-He213 Pediatric (dpeaa)DE-He213 Focal radiotherapy (dpeaa)DE-He213 Quality assurance (dpeaa)DE-He213 Individual case review (dpeaa)DE-He213 Braesigk, Annett aut Seidel, Clemens aut Remmele, Julia aut Kitzing, Ralf aut Schlender, Tina aut Mynarek, Martin aut Geismar, Dirk aut Jablonska, Karolina aut Schwarz, Rudolf aut Pazos, Montserrat aut Weber, Damien C. aut Frick, Silke aut Gurtner, Kristin aut Matuschek, Christiane aut Harrabi, Semi Ben aut Glück, Albrecht aut Lewitzki, Victor aut Dieckmann, Karin aut Benesch, Martin aut Gerber, Nicolas U. aut Obrecht, Denise aut Rutkowski, Stefan aut Timmermann, Beate aut Kortmann, Rolf-Dieter aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 198(2021), 3 vom: 05. Aug., Seite 282-290 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:198 year:2021 number:3 day:05 month:08 pages:282-290 https://dx.doi.org/10.1007/s00066-021-01822-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 198 2021 3 05 08 282-290
allfieldsSound	10.1007/s00066-021-01822-0 doi (DE-627)SPR046303723 (SPR)s00066-021-01822-0-e DE-627 ger DE-627 rakwb eng Dietzsch, Stefan verfasserin (orcid)0000-0001-6141-2170 aut Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. Brain tumor (dpeaa)DE-He213 Pediatric (dpeaa)DE-He213 Focal radiotherapy (dpeaa)DE-He213 Quality assurance (dpeaa)DE-He213 Individual case review (dpeaa)DE-He213 Braesigk, Annett aut Seidel, Clemens aut Remmele, Julia aut Kitzing, Ralf aut Schlender, Tina aut Mynarek, Martin aut Geismar, Dirk aut Jablonska, Karolina aut Schwarz, Rudolf aut Pazos, Montserrat aut Weber, Damien C. aut Frick, Silke aut Gurtner, Kristin aut Matuschek, Christiane aut Harrabi, Semi Ben aut Glück, Albrecht aut Lewitzki, Victor aut Dieckmann, Karin aut Benesch, Martin aut Gerber, Nicolas U. aut Obrecht, Denise aut Rutkowski, Stefan aut Timmermann, Beate aut Kortmann, Rolf-Dieter aut Enthalten in Strahlentherapie und Onkologie Berlin : Springer Medizin, 1997 198(2021), 3 vom: 05. Aug., Seite 282-290 (DE-627)312407866 (DE-600)2003907-4 1439-099X nnns volume:198 year:2021 number:3 day:05 month:08 pages:282-290 https://dx.doi.org/10.1007/s00066-021-01822-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 198 2021 3 05 08 282-290
language	English
source	Enthalten in Strahlentherapie und Onkologie 198(2021), 3 vom: 05. Aug., Seite 282-290 volume:198 year:2021 number:3 day:05 month:08 pages:282-290
sourceStr	Enthalten in Strahlentherapie und Onkologie 198(2021), 3 vom: 05. Aug., Seite 282-290 volume:198 year:2021 number:3 day:05 month:08 pages:282-290
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Brain tumor Pediatric Focal radiotherapy Quality assurance Individual case review
isfreeaccess_bool	true
container_title	Strahlentherapie und Onkologie
authorswithroles_txt_mv	Dietzsch, Stefan @@aut@@ Braesigk, Annett @@aut@@ Seidel, Clemens @@aut@@ Remmele, Julia @@aut@@ Kitzing, Ralf @@aut@@ Schlender, Tina @@aut@@ Mynarek, Martin @@aut@@ Geismar, Dirk @@aut@@ Jablonska, Karolina @@aut@@ Schwarz, Rudolf @@aut@@ Pazos, Montserrat @@aut@@ Weber, Damien C. @@aut@@ Frick, Silke @@aut@@ Gurtner, Kristin @@aut@@ Matuschek, Christiane @@aut@@ Harrabi, Semi Ben @@aut@@ Glück, Albrecht @@aut@@ Lewitzki, Victor @@aut@@ Dieckmann, Karin @@aut@@ Benesch, Martin @@aut@@ Gerber, Nicolas U. @@aut@@ Obrecht, Denise @@aut@@ Rutkowski, Stefan @@aut@@ Timmermann, Beate @@aut@@ Kortmann, Rolf-Dieter @@aut@@
publishDateDaySort_date	2021-08-05T00:00:00Z
hierarchy_top_id	312407866
id	SPR046303723
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR046303723</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230507113848.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220223s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00066-021-01822-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR046303723</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00066-021-01822-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Dietzsch, Stefan</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-6141-2170</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. 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author	Dietzsch, Stefan
spellingShingle	Dietzsch, Stefan misc Brain tumor misc Pediatric misc Focal radiotherapy misc Quality assurance misc Individual case review Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
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topic_title	Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial Brain tumor (dpeaa)DE-He213 Pediatric (dpeaa)DE-He213 Focal radiotherapy (dpeaa)DE-He213 Quality assurance (dpeaa)DE-He213 Individual case review (dpeaa)DE-He213
topic	misc Brain tumor misc Pediatric misc Focal radiotherapy misc Quality assurance misc Individual case review
topic_unstemmed	misc Brain tumor misc Pediatric misc Focal radiotherapy misc Quality assurance misc Individual case review
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title	Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
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title_full	Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
author_sort	Dietzsch, Stefan
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author_browse	Dietzsch, Stefan Braesigk, Annett Seidel, Clemens Remmele, Julia Kitzing, Ralf Schlender, Tina Mynarek, Martin Geismar, Dirk Jablonska, Karolina Schwarz, Rudolf Pazos, Montserrat Weber, Damien C. Frick, Silke Gurtner, Kristin Matuschek, Christiane Harrabi, Semi Ben Glück, Albrecht Lewitzki, Victor Dieckmann, Karin Benesch, Martin Gerber, Nicolas U. Obrecht, Denise Rutkowski, Stefan Timmermann, Beate Kortmann, Rolf-Dieter
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title_sort	types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the german radiotherapy quality control panel in the siop pnet5 mb trial
title_auth	Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
abstract	Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. © The Author(s) 2021
abstractGer	Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. © The Author(s) 2021
abstract_unstemmed	Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. © The Author(s) 2021
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title_short	Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
url	https://dx.doi.org/10.1007/s00066-021-01822-0
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author2	Braesigk, Annett Seidel, Clemens Remmele, Julia Kitzing, Ralf Schlender, Tina Mynarek, Martin Geismar, Dirk Jablonska, Karolina Schwarz, Rudolf Pazos, Montserrat Weber, Damien C. Frick, Silke Gurtner, Kristin Matuschek, Christiane Harrabi, Semi Ben Glück, Albrecht Lewitzki, Victor Dieckmann, Karin Benesch, Martin Gerber, Nicolas U. Obrecht, Denise Rutkowski, Stefan Timmermann, Beate Kortmann, Rolf-Dieter
author2Str	Braesigk, Annett Seidel, Clemens Remmele, Julia Kitzing, Ralf Schlender, Tina Mynarek, Martin Geismar, Dirk Jablonska, Karolina Schwarz, Rudolf Pazos, Montserrat Weber, Damien C. Frick, Silke Gurtner, Kristin Matuschek, Christiane Harrabi, Semi Ben Glück, Albrecht Lewitzki, Victor Dieckmann, Karin Benesch, Martin Gerber, Nicolas U. Obrecht, Denise Rutkowski, Stefan Timmermann, Beate Kortmann, Rolf-Dieter
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doi_str	10.1007/s00066-021-01822-0
up_date	2024-07-03T21:41:44.511Z
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Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial

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