Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment

Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal...
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Autor*in:	Ahmad, Maimuna [verfasserIn] Chari, Divya A. McKenna, Michael J. Quesnel, Alicia M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Otosclerosis Mixed hearing loss Sensorineural hearing loss Bisphosphonates Otopathology

Anmerkung:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022

Übergeordnetes Werk:	Enthalten in: Current otorhinolaryngology reports - New York, NY : Springer, 2013, 10(2022), 1 vom: 12. Feb., Seite 8-15
Übergeordnetes Werk:	volume:10 ; year:2022 ; number:1 ; day:12 ; month:02 ; pages:8-15

Links:	Volltext

DOI / URN:	10.1007/s40136-021-00390-2

Katalog-ID:	SPR046324062

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520			\|a Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation.
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allfields	10.1007/s40136-021-00390-2 doi (DE-627)SPR046324062 (SPR)s40136-021-00390-2-e DE-627 ger DE-627 rakwb eng Ahmad, Maimuna verfasserin aut Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. Otosclerosis (dpeaa)DE-He213 Mixed hearing loss (dpeaa)DE-He213 Sensorineural hearing loss (dpeaa)DE-He213 Bisphosphonates (dpeaa)DE-He213 Otopathology (dpeaa)DE-He213 Chari, Divya A. aut McKenna, Michael J. aut Quesnel, Alicia M. (orcid)0000-0002-4075-0960 aut Enthalten in Current otorhinolaryngology reports New York, NY : Springer, 2013 10(2022), 1 vom: 12. Feb., Seite 8-15 (DE-627)769568580 (DE-600)2735509-3 2167-583X nnns volume:10 year:2022 number:1 day:12 month:02 pages:8-15 https://dx.doi.org/10.1007/s40136-021-00390-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2022 1 12 02 8-15
spelling	10.1007/s40136-021-00390-2 doi (DE-627)SPR046324062 (SPR)s40136-021-00390-2-e DE-627 ger DE-627 rakwb eng Ahmad, Maimuna verfasserin aut Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. Otosclerosis (dpeaa)DE-He213 Mixed hearing loss (dpeaa)DE-He213 Sensorineural hearing loss (dpeaa)DE-He213 Bisphosphonates (dpeaa)DE-He213 Otopathology (dpeaa)DE-He213 Chari, Divya A. aut McKenna, Michael J. aut Quesnel, Alicia M. (orcid)0000-0002-4075-0960 aut Enthalten in Current otorhinolaryngology reports New York, NY : Springer, 2013 10(2022), 1 vom: 12. Feb., Seite 8-15 (DE-627)769568580 (DE-600)2735509-3 2167-583X nnns volume:10 year:2022 number:1 day:12 month:02 pages:8-15 https://dx.doi.org/10.1007/s40136-021-00390-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2022 1 12 02 8-15
allfields_unstemmed	10.1007/s40136-021-00390-2 doi (DE-627)SPR046324062 (SPR)s40136-021-00390-2-e DE-627 ger DE-627 rakwb eng Ahmad, Maimuna verfasserin aut Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. Otosclerosis (dpeaa)DE-He213 Mixed hearing loss (dpeaa)DE-He213 Sensorineural hearing loss (dpeaa)DE-He213 Bisphosphonates (dpeaa)DE-He213 Otopathology (dpeaa)DE-He213 Chari, Divya A. aut McKenna, Michael J. aut Quesnel, Alicia M. (orcid)0000-0002-4075-0960 aut Enthalten in Current otorhinolaryngology reports New York, NY : Springer, 2013 10(2022), 1 vom: 12. Feb., Seite 8-15 (DE-627)769568580 (DE-600)2735509-3 2167-583X nnns volume:10 year:2022 number:1 day:12 month:02 pages:8-15 https://dx.doi.org/10.1007/s40136-021-00390-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2022 1 12 02 8-15
allfieldsGer	10.1007/s40136-021-00390-2 doi (DE-627)SPR046324062 (SPR)s40136-021-00390-2-e DE-627 ger DE-627 rakwb eng Ahmad, Maimuna verfasserin aut Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. Otosclerosis (dpeaa)DE-He213 Mixed hearing loss (dpeaa)DE-He213 Sensorineural hearing loss (dpeaa)DE-He213 Bisphosphonates (dpeaa)DE-He213 Otopathology (dpeaa)DE-He213 Chari, Divya A. aut McKenna, Michael J. aut Quesnel, Alicia M. (orcid)0000-0002-4075-0960 aut Enthalten in Current otorhinolaryngology reports New York, NY : Springer, 2013 10(2022), 1 vom: 12. Feb., Seite 8-15 (DE-627)769568580 (DE-600)2735509-3 2167-583X nnns volume:10 year:2022 number:1 day:12 month:02 pages:8-15 https://dx.doi.org/10.1007/s40136-021-00390-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2022 1 12 02 8-15
allfieldsSound	10.1007/s40136-021-00390-2 doi (DE-627)SPR046324062 (SPR)s40136-021-00390-2-e DE-627 ger DE-627 rakwb eng Ahmad, Maimuna verfasserin aut Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. Otosclerosis (dpeaa)DE-He213 Mixed hearing loss (dpeaa)DE-He213 Sensorineural hearing loss (dpeaa)DE-He213 Bisphosphonates (dpeaa)DE-He213 Otopathology (dpeaa)DE-He213 Chari, Divya A. aut McKenna, Michael J. aut Quesnel, Alicia M. (orcid)0000-0002-4075-0960 aut Enthalten in Current otorhinolaryngology reports New York, NY : Springer, 2013 10(2022), 1 vom: 12. Feb., Seite 8-15 (DE-627)769568580 (DE-600)2735509-3 2167-583X nnns volume:10 year:2022 number:1 day:12 month:02 pages:8-15 https://dx.doi.org/10.1007/s40136-021-00390-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2022 1 12 02 8-15
language	English
source	Enthalten in Current otorhinolaryngology reports 10(2022), 1 vom: 12. Feb., Seite 8-15 volume:10 year:2022 number:1 day:12 month:02 pages:8-15
sourceStr	Enthalten in Current otorhinolaryngology reports 10(2022), 1 vom: 12. Feb., Seite 8-15 volume:10 year:2022 number:1 day:12 month:02 pages:8-15
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Otosclerosis Mixed hearing loss Sensorineural hearing loss Bisphosphonates Otopathology
isfreeaccess_bool	false
container_title	Current otorhinolaryngology reports
authorswithroles_txt_mv	Ahmad, Maimuna @@aut@@ Chari, Divya A. @@aut@@ McKenna, Michael J. @@aut@@ Quesnel, Alicia M. @@aut@@
publishDateDaySort_date	2022-02-12T00:00:00Z
hierarchy_top_id	769568580
id	SPR046324062
language_de	englisch
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author	Ahmad, Maimuna
spellingShingle	Ahmad, Maimuna misc Otosclerosis misc Mixed hearing loss misc Sensorineural hearing loss misc Bisphosphonates misc Otopathology Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment
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topic_title	Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment Otosclerosis (dpeaa)DE-He213 Mixed hearing loss (dpeaa)DE-He213 Sensorineural hearing loss (dpeaa)DE-He213 Bisphosphonates (dpeaa)DE-He213 Otopathology (dpeaa)DE-He213
topic	misc Otosclerosis misc Mixed hearing loss misc Sensorineural hearing loss misc Bisphosphonates misc Otopathology
topic_unstemmed	misc Otosclerosis misc Mixed hearing loss misc Sensorineural hearing loss misc Bisphosphonates misc Otopathology
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title	Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment
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title_full	Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment
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author_browse	Ahmad, Maimuna Chari, Divya A. McKenna, Michael J. Quesnel, Alicia M.
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title_sort	mixed and sensorineural hearing loss in otosclerosis: incidence, pathophysiology, and treatment
title_auth	Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment
abstract	Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022
abstractGer	Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022
abstract_unstemmed	Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. Current management includes stapedectomy, amplification, consideration of bisphosphonate treatment (off-label), and cochlear implantation. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022
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title_short	Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment
url	https://dx.doi.org/10.1007/s40136-021-00390-2
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author2	Chari, Divya A. McKenna, Michael J. Quesnel, Alicia M.
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up_date	2024-07-03T21:49:57.628Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR046324062</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230507114422.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220224s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40136-021-00390-2</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR046324062</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40136-021-00390-2-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ahmad, Maimuna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose of Review Otosclerosis can lead to mixed or rarely pure sensorineural hearing loss (SNHL). Herein, we review the incidence, pathophysiology, and management of mixed hearing loss in otosclerosis, often termed “cochlear otosclerosis.” Recent Findings Histopathological studies of human temporal bones demonstrate that extension of otosclerotic foci to the cochlear endosteum, which leads to hyalinization of the spiral ligament and upregulation of TGFß-1, is associated with mixed hearing loss. Peri-cochlear extension of otosclerosis can be assessed in life via computed tomography imaging. In small retrospective series, bisphosphonate treatment stabilized hearing in patients with cochlear otosclerosis. Stapedectomy and/or amplification and cochlear implantation remain the main treatment modalities for patients with mixed hearing loss due to cochlear otosclerosis. Summary Approximately one-third of patients diagnosed with otosclerosis will develop a sensorineural hearing loss component, resulting in mixed hearing loss. Further work is needed to characterize the molecular/cellular mechanisms of sensorineural hearing loss in otosclerosis. 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