Epigenetic reorganization during early embryonic lineage specification
Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fang, Haitong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) under exclusive licence to The Genetics Society of Korea 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Genes & Genomics - The Genetics Society of Korea, 2010, 44(2022), 3 vom: 08. Feb., Seite 379-387 |
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| Übergeordnetes Werk: |
volume:44 ; year:2022 ; number:3 ; day:08 ; month:02 ; pages:379-387 |
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| DOI / URN: |
10.1007/s13258-021-01213-w |
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SPR046395601 |
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| 520 | |a Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. | ||
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10.1007/s13258-021-01213-w doi (DE-627)SPR046395601 (SPR)s13258-021-01213-w-e DE-627 ger DE-627 rakwb eng Fang, Haitong verfasserin (orcid)0000-0003-1174-9191 aut Epigenetic reorganization during early embryonic lineage specification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. Early embryo development (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Histone modification (dpeaa)DE-He213 Epigenetic reprogramming (dpeaa)DE-He213 Luo, Zhuojuan aut Lin, Chengqi (orcid)0000-0002-2121-584X aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 44(2022), 3 vom: 08. Feb., Seite 379-387 (DE-627)SPR031096425 nnns volume:44 year:2022 number:3 day:08 month:02 pages:379-387 https://dx.doi.org/10.1007/s13258-021-01213-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2022 3 08 02 379-387 |
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10.1007/s13258-021-01213-w doi (DE-627)SPR046395601 (SPR)s13258-021-01213-w-e DE-627 ger DE-627 rakwb eng Fang, Haitong verfasserin (orcid)0000-0003-1174-9191 aut Epigenetic reorganization during early embryonic lineage specification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. Early embryo development (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Histone modification (dpeaa)DE-He213 Epigenetic reprogramming (dpeaa)DE-He213 Luo, Zhuojuan aut Lin, Chengqi (orcid)0000-0002-2121-584X aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 44(2022), 3 vom: 08. Feb., Seite 379-387 (DE-627)SPR031096425 nnns volume:44 year:2022 number:3 day:08 month:02 pages:379-387 https://dx.doi.org/10.1007/s13258-021-01213-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2022 3 08 02 379-387 |
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10.1007/s13258-021-01213-w doi (DE-627)SPR046395601 (SPR)s13258-021-01213-w-e DE-627 ger DE-627 rakwb eng Fang, Haitong verfasserin (orcid)0000-0003-1174-9191 aut Epigenetic reorganization during early embryonic lineage specification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. Early embryo development (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Histone modification (dpeaa)DE-He213 Epigenetic reprogramming (dpeaa)DE-He213 Luo, Zhuojuan aut Lin, Chengqi (orcid)0000-0002-2121-584X aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 44(2022), 3 vom: 08. Feb., Seite 379-387 (DE-627)SPR031096425 nnns volume:44 year:2022 number:3 day:08 month:02 pages:379-387 https://dx.doi.org/10.1007/s13258-021-01213-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2022 3 08 02 379-387 |
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10.1007/s13258-021-01213-w doi (DE-627)SPR046395601 (SPR)s13258-021-01213-w-e DE-627 ger DE-627 rakwb eng Fang, Haitong verfasserin (orcid)0000-0003-1174-9191 aut Epigenetic reorganization during early embryonic lineage specification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. Early embryo development (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Histone modification (dpeaa)DE-He213 Epigenetic reprogramming (dpeaa)DE-He213 Luo, Zhuojuan aut Lin, Chengqi (orcid)0000-0002-2121-584X aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 44(2022), 3 vom: 08. Feb., Seite 379-387 (DE-627)SPR031096425 nnns volume:44 year:2022 number:3 day:08 month:02 pages:379-387 https://dx.doi.org/10.1007/s13258-021-01213-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2022 3 08 02 379-387 |
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10.1007/s13258-021-01213-w doi (DE-627)SPR046395601 (SPR)s13258-021-01213-w-e DE-627 ger DE-627 rakwb eng Fang, Haitong verfasserin (orcid)0000-0003-1174-9191 aut Epigenetic reorganization during early embryonic lineage specification 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. Early embryo development (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Histone modification (dpeaa)DE-He213 Epigenetic reprogramming (dpeaa)DE-He213 Luo, Zhuojuan aut Lin, Chengqi (orcid)0000-0002-2121-584X aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 44(2022), 3 vom: 08. Feb., Seite 379-387 (DE-627)SPR031096425 nnns volume:44 year:2022 number:3 day:08 month:02 pages:379-387 https://dx.doi.org/10.1007/s13258-021-01213-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 44 2022 3 08 02 379-387 |
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Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. 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Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 |
| abstractGer |
Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 |
| abstract_unstemmed |
Background Dynamic chromatin reorganization occurs during two waves of cell lineage specification process, blastocyst formation and gastrulation, to generate distinct cell types. Epigenetic defects have been associated with severe developmental defects and diseases. How epigenetic remodeling coordinates the two lineage specification waves is becoming uncovered, benefiting from the development and application of new technologies including low-input or single-cell epigenome analysis approached in the past few years. Objective In this review, we aim to highlight the most recent findings on epigenetic remodeling in cell lineage specification during blastocyst formation and gastrulation. Methods First, we introduce how DNA methylation dynamically changes in blastocyst formation and gastrulation and its function in transcriptional regulation lineage-specific genes. Then, we discuss widespread remodeling of histone modification at promoters and enhancers in orchestrating the trajectory of cell lineage specification. Finally, we review dynamics of chromatin accessibility and 3D structure regulating developmental gene expression and associating with specific transcription factor binding events at stage specific manner. We also highlight the key questions that remain to be answered to fully understand chromatin regulation and reorganization in lineage specification. Conclusion Here, we summarize the recent advances and discoveries on epigenetic reorganization and its roles in blastocyst formation and gastrulation, and how it cooperates with the lineage specification, painting from global sequencing data from mouse in vivo tissues. © The Author(s) under exclusive licence to The Genetics Society of Korea 2022 |
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Epigenetic reorganization during early embryonic lineage specification |
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Luo, Zhuojuan Lin, Chengqi |
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10.1007/s13258-021-01213-w |
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2024-07-03T22:17:00.946Z |
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