Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy

Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of pa...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Watanabe, Alexandra Sayuri [verfasserIn] Ferreira, Marcelo Alves Ventura, Anne Karoline Rocha Medrado Galvao, Clóvis Eduardo Santo Kalil, Jorge Santos, Keity Souza Castro, Fabio Fernandes Morato

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Fire ant allergy Hymenoptera allergy Hymenoptera immunotherapy Allergen immunotherapy

Anmerkung:	© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022

Übergeordnetes Werk:	Enthalten in: SN comprehensive clinical medicine - [Cham] : Springer International Publishing, 2019, 4(2022), 1 vom: 05. März
Übergeordnetes Werk:	volume:4 ; year:2022 ; number:1 ; day:05 ; month:03

Links:	Volltext

DOI / URN:	10.1007/s42399-022-01150-z

Katalog-ID:	SPR046408258

Internformat


LEADER	01000caa a22002652 4500
001	SPR046408258
003	DE-627
005	20230519143201.0
007	cr uuu---uuuuu
008	220306s2022 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1007/s42399-022-01150-z \|2 doi
035			\|a (DE-627)SPR046408258
035			\|a (SPR)s42399-022-01150-z-e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	1		\|a Watanabe, Alexandra Sayuri \|e verfasserin \|0 (orcid)0000-0002-3443-0362 \|4 aut
245	1	0	\|a Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy
264		1	\|c 2022
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022
520			\|a Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe.
650		4	\|a Fire ant allergy \|7 (dpeaa)DE-He213
650		4	\|a Hymenoptera allergy \|7 (dpeaa)DE-He213
650		4	\|a Hymenoptera immunotherapy \|7 (dpeaa)DE-He213
650		4	\|a Allergen immunotherapy \|7 (dpeaa)DE-He213
700	1		\|a Ferreira, Marcelo Alves \|4 aut
700	1		\|a Ventura, Anne Karoline Rocha Medrado \|4 aut
700	1		\|a Galvao, Clóvis Eduardo Santo \|4 aut
700	1		\|a Kalil, Jorge \|4 aut
700	1		\|a Santos, Keity Souza \|4 aut
700	1		\|a Castro, Fabio Fernandes Morato \|4 aut
773	0	8	\|i Enthalten in \|t SN comprehensive clinical medicine \|d [Cham] : Springer International Publishing, 2019 \|g 4(2022), 1 vom: 05. März \|w (DE-627)1037103696 \|w (DE-600)2947252-0 \|x 2523-8973 \|7 nnns
773	1	8	\|g volume:4 \|g year:2022 \|g number:1 \|g day:05 \|g month:03
856	4	0	\|u https://dx.doi.org/10.1007/s42399-022-01150-z \|z lizenzpflichtig \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_SPRINGER
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 4 \|j 2022 \|e 1 \|b 05 \|c 03

Indexfelder

author_variant	a s w as asw m a f ma maf a k r m v akrm akrmv c e s g ces cesg j k jk k s s ks kss f f m c ffm ffmc
matchkey_str	article:25238973:2022----::lnclnlbrtrpoiefainsihnpyaitfrateoslnpisu
hierarchy_sort_str	2022
publishDate	2022
allfields	10.1007/s42399-022-01150-z doi (DE-627)SPR046408258 (SPR)s42399-022-01150-z-e DE-627 ger DE-627 rakwb eng Watanabe, Alexandra Sayuri verfasserin (orcid)0000-0002-3443-0362 aut Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. Fire ant allergy (dpeaa)DE-He213 Hymenoptera allergy (dpeaa)DE-He213 Hymenoptera immunotherapy (dpeaa)DE-He213 Allergen immunotherapy (dpeaa)DE-He213 Ferreira, Marcelo Alves aut Ventura, Anne Karoline Rocha Medrado aut Galvao, Clóvis Eduardo Santo aut Kalil, Jorge aut Santos, Keity Souza aut Castro, Fabio Fernandes Morato aut Enthalten in SN comprehensive clinical medicine [Cham] : Springer International Publishing, 2019 4(2022), 1 vom: 05. März (DE-627)1037103696 (DE-600)2947252-0 2523-8973 nnns volume:4 year:2022 number:1 day:05 month:03 https://dx.doi.org/10.1007/s42399-022-01150-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2022 1 05 03
spelling	10.1007/s42399-022-01150-z doi (DE-627)SPR046408258 (SPR)s42399-022-01150-z-e DE-627 ger DE-627 rakwb eng Watanabe, Alexandra Sayuri verfasserin (orcid)0000-0002-3443-0362 aut Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. Fire ant allergy (dpeaa)DE-He213 Hymenoptera allergy (dpeaa)DE-He213 Hymenoptera immunotherapy (dpeaa)DE-He213 Allergen immunotherapy (dpeaa)DE-He213 Ferreira, Marcelo Alves aut Ventura, Anne Karoline Rocha Medrado aut Galvao, Clóvis Eduardo Santo aut Kalil, Jorge aut Santos, Keity Souza aut Castro, Fabio Fernandes Morato aut Enthalten in SN comprehensive clinical medicine [Cham] : Springer International Publishing, 2019 4(2022), 1 vom: 05. März (DE-627)1037103696 (DE-600)2947252-0 2523-8973 nnns volume:4 year:2022 number:1 day:05 month:03 https://dx.doi.org/10.1007/s42399-022-01150-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2022 1 05 03
allfields_unstemmed	10.1007/s42399-022-01150-z doi (DE-627)SPR046408258 (SPR)s42399-022-01150-z-e DE-627 ger DE-627 rakwb eng Watanabe, Alexandra Sayuri verfasserin (orcid)0000-0002-3443-0362 aut Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. Fire ant allergy (dpeaa)DE-He213 Hymenoptera allergy (dpeaa)DE-He213 Hymenoptera immunotherapy (dpeaa)DE-He213 Allergen immunotherapy (dpeaa)DE-He213 Ferreira, Marcelo Alves aut Ventura, Anne Karoline Rocha Medrado aut Galvao, Clóvis Eduardo Santo aut Kalil, Jorge aut Santos, Keity Souza aut Castro, Fabio Fernandes Morato aut Enthalten in SN comprehensive clinical medicine [Cham] : Springer International Publishing, 2019 4(2022), 1 vom: 05. März (DE-627)1037103696 (DE-600)2947252-0 2523-8973 nnns volume:4 year:2022 number:1 day:05 month:03 https://dx.doi.org/10.1007/s42399-022-01150-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2022 1 05 03
allfieldsGer	10.1007/s42399-022-01150-z doi (DE-627)SPR046408258 (SPR)s42399-022-01150-z-e DE-627 ger DE-627 rakwb eng Watanabe, Alexandra Sayuri verfasserin (orcid)0000-0002-3443-0362 aut Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. Fire ant allergy (dpeaa)DE-He213 Hymenoptera allergy (dpeaa)DE-He213 Hymenoptera immunotherapy (dpeaa)DE-He213 Allergen immunotherapy (dpeaa)DE-He213 Ferreira, Marcelo Alves aut Ventura, Anne Karoline Rocha Medrado aut Galvao, Clóvis Eduardo Santo aut Kalil, Jorge aut Santos, Keity Souza aut Castro, Fabio Fernandes Morato aut Enthalten in SN comprehensive clinical medicine [Cham] : Springer International Publishing, 2019 4(2022), 1 vom: 05. März (DE-627)1037103696 (DE-600)2947252-0 2523-8973 nnns volume:4 year:2022 number:1 day:05 month:03 https://dx.doi.org/10.1007/s42399-022-01150-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2022 1 05 03
allfieldsSound	10.1007/s42399-022-01150-z doi (DE-627)SPR046408258 (SPR)s42399-022-01150-z-e DE-627 ger DE-627 rakwb eng Watanabe, Alexandra Sayuri verfasserin (orcid)0000-0002-3443-0362 aut Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. Fire ant allergy (dpeaa)DE-He213 Hymenoptera allergy (dpeaa)DE-He213 Hymenoptera immunotherapy (dpeaa)DE-He213 Allergen immunotherapy (dpeaa)DE-He213 Ferreira, Marcelo Alves aut Ventura, Anne Karoline Rocha Medrado aut Galvao, Clóvis Eduardo Santo aut Kalil, Jorge aut Santos, Keity Souza aut Castro, Fabio Fernandes Morato aut Enthalten in SN comprehensive clinical medicine [Cham] : Springer International Publishing, 2019 4(2022), 1 vom: 05. März (DE-627)1037103696 (DE-600)2947252-0 2523-8973 nnns volume:4 year:2022 number:1 day:05 month:03 https://dx.doi.org/10.1007/s42399-022-01150-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2022 1 05 03
language	English
source	Enthalten in SN comprehensive clinical medicine 4(2022), 1 vom: 05. März volume:4 year:2022 number:1 day:05 month:03
sourceStr	Enthalten in SN comprehensive clinical medicine 4(2022), 1 vom: 05. März volume:4 year:2022 number:1 day:05 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Fire ant allergy Hymenoptera allergy Hymenoptera immunotherapy Allergen immunotherapy
isfreeaccess_bool	false
container_title	SN comprehensive clinical medicine
authorswithroles_txt_mv	Watanabe, Alexandra Sayuri @@aut@@ Ferreira, Marcelo Alves @@aut@@ Ventura, Anne Karoline Rocha Medrado @@aut@@ Galvao, Clóvis Eduardo Santo @@aut@@ Kalil, Jorge @@aut@@ Santos, Keity Souza @@aut@@ Castro, Fabio Fernandes Morato @@aut@@
publishDateDaySort_date	2022-03-05T00:00:00Z
hierarchy_top_id	1037103696
id	SPR046408258
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR046408258</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519143201.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220306s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s42399-022-01150-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR046408258</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s42399-022-01150-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Watanabe, Alexandra Sayuri</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-3443-0362</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fire ant allergy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hymenoptera allergy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hymenoptera immunotherapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Allergen immunotherapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferreira, Marcelo Alves</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ventura, Anne Karoline Rocha Medrado</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Galvao, Clóvis Eduardo Santo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kalil, Jorge</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santos, Keity Souza</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Castro, Fabio Fernandes Morato</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">SN comprehensive clinical medicine</subfield><subfield code="d">[Cham] : Springer International Publishing, 2019</subfield><subfield code="g">4(2022), 1 vom: 05. März</subfield><subfield code="w">(DE-627)1037103696</subfield><subfield code="w">(DE-600)2947252-0</subfield><subfield code="x">2523-8973</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:4</subfield><subfield code="g">year:2022</subfield><subfield code="g">number:1</subfield><subfield code="g">day:05</subfield><subfield code="g">month:03</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s42399-022-01150-z</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_101</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_138</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_150</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_636</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2065</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2093</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2107</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2446</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2472</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2522</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4046</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4246</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4328</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">4</subfield><subfield code="j">2022</subfield><subfield code="e">1</subfield><subfield code="b">05</subfield><subfield code="c">03</subfield></datafield></record></collection>
author	Watanabe, Alexandra Sayuri
spellingShingle	Watanabe, Alexandra Sayuri misc Fire ant allergy misc Hymenoptera allergy misc Hymenoptera immunotherapy misc Allergen immunotherapy Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy
authorStr	Watanabe, Alexandra Sayuri
ppnlink_with_tag_str_mv	@@773@@(DE-627)1037103696
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut
collection	springer
remote_str	true
illustrated	Not Illustrated
issn	2523-8973
topic_title	Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy Fire ant allergy (dpeaa)DE-He213 Hymenoptera allergy (dpeaa)DE-He213 Hymenoptera immunotherapy (dpeaa)DE-He213 Allergen immunotherapy (dpeaa)DE-He213
topic	misc Fire ant allergy misc Hymenoptera allergy misc Hymenoptera immunotherapy misc Allergen immunotherapy
topic_unstemmed	misc Fire ant allergy misc Hymenoptera allergy misc Hymenoptera immunotherapy misc Allergen immunotherapy
topic_browse	misc Fire ant allergy misc Hymenoptera allergy misc Hymenoptera immunotherapy misc Allergen immunotherapy
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	SN comprehensive clinical medicine
hierarchy_parent_id	1037103696
hierarchy_top_title	SN comprehensive clinical medicine
isfreeaccess_txt	false
familylinks_str_mv	(DE-627)1037103696 (DE-600)2947252-0
title	Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy
ctrlnum	(DE-627)SPR046408258 (SPR)s42399-022-01150-z-e
title_full	Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy
author_sort	Watanabe, Alexandra Sayuri
journal	SN comprehensive clinical medicine
journalStr	SN comprehensive clinical medicine
lang_code	eng
isOA_bool	false
recordtype	marc
publishDateSort	2022
contenttype_str_mv	txt
author_browse	Watanabe, Alexandra Sayuri Ferreira, Marcelo Alves Ventura, Anne Karoline Rocha Medrado Galvao, Clóvis Eduardo Santo Kalil, Jorge Santos, Keity Souza Castro, Fabio Fernandes Morato
container_volume	4
format_se	Elektronische Aufsätze
author-letter	Watanabe, Alexandra Sayuri
doi_str_mv	10.1007/s42399-022-01150-z
normlink	(ORCID)0000-0002-3443-0362
normlink_prefix_str_mv	(orcid)0000-0002-3443-0362
title_sort	clinical and laboratory profile of patients with anaphylaxis to fire ant venom (solenopsis sp.) under subcutaneous immunotherapy
title_auth	Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy
abstract	Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022
abstractGer	Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022
abstract_unstemmed	Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700
container_issue	1
title_short	Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy
url	https://dx.doi.org/10.1007/s42399-022-01150-z
remote_bool	true
author2	Ferreira, Marcelo Alves Ventura, Anne Karoline Rocha Medrado Galvao, Clóvis Eduardo Santo Kalil, Jorge Santos, Keity Souza Castro, Fabio Fernandes Morato
author2Str	Ferreira, Marcelo Alves Ventura, Anne Karoline Rocha Medrado Galvao, Clóvis Eduardo Santo Kalil, Jorge Santos, Keity Souza Castro, Fabio Fernandes Morato
ppnlink	1037103696
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s42399-022-01150-z
up_date	2024-07-03T22:20:44.171Z
_version_	1803598161954996224
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR046408258</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519143201.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220306s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s42399-022-01150-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR046408258</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s42399-022-01150-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Watanabe, Alexandra Sayuri</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-3443-0362</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Anaphylaxis to fire ant venom (Solenopsis sp.) is a significant cause of systemic allergic reactions caused by Hymenoptera stings in children. There are only a few reports regarding the safety and efficacy of specific immunotherapy. We evaluated clinical characteristics (IgE and IgG4) of patients undergoing immunotherapy with a whole-body extract of Solenopsis sp. after 1 year of the maintenance phase. Thirty-three patients with severe anaphylaxis from fire ant stings (Solenopsis sp.) were recruited and underwent venom immunotherapy. They were assessed at baseline and 1 year after beginning the maintenance phase with a skin test determining specific IgE and IgG4 antibodies to fire ant venom and tryptase. Although two patients (6.25%) presented a tryptase level higher than 11.4 µg/mL, systemic mastocytosis was ruled out. There was no relationship between reaction severity and gender, tryptase level, atopy, previous reactions, concentration of the allergen in the skin test, or specific IgE level. There was an increase in the specific IgG4/IgE ratio between the baseline and the end of the maintenance period. Reactions were local during the build-up phase, with only two mild systemic reactions. Twenty patients suffered accidental stings during immunotherapy, with 3 presenting only urticaria. Our clinical and laboratory data show that after 1 year of the maintenance phase, patients presented significant specific IgG4 production. Furthermore, reactions to accidental fire ant stings were only mild with none being severe.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fire ant allergy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hymenoptera allergy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hymenoptera immunotherapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Allergen immunotherapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferreira, Marcelo Alves</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ventura, Anne Karoline Rocha Medrado</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Galvao, Clóvis Eduardo Santo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kalil, Jorge</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santos, Keity Souza</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Castro, Fabio Fernandes Morato</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">SN comprehensive clinical medicine</subfield><subfield code="d">[Cham] : Springer International Publishing, 2019</subfield><subfield code="g">4(2022), 1 vom: 05. März</subfield><subfield code="w">(DE-627)1037103696</subfield><subfield code="w">(DE-600)2947252-0</subfield><subfield code="x">2523-8973</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:4</subfield><subfield code="g">year:2022</subfield><subfield code="g">number:1</subfield><subfield code="g">day:05</subfield><subfield code="g">month:03</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s42399-022-01150-z</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_101</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_138</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_150</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_636</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2056</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2065</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2093</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2107</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2446</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2472</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2522</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4046</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4246</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4328</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">4</subfield><subfield code="j">2022</subfield><subfield code="e">1</subfield><subfield code="b">05</subfield><subfield code="c">03</subfield></datafield></record></collection>
score	7.397217

Nicht das Richtige dabei?

Schreiben Sie uns!

Clinical and Laboratory Profile of Patients with Anaphylaxis To Fire Ant Venom (Solenopsis sp.) Under Subcutaneous Immunotherapy

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?