Heart Transplant Donor Selection: Recent Insights
Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Baran, David A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Current transplantation reports - Cham : Springer Internat. Publ., 2014, 9(2022), 1 vom: 19. Jan., Seite 12-18 |
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| Übergeordnetes Werk: |
volume:9 ; year:2022 ; number:1 ; day:19 ; month:01 ; pages:12-18 |
| Links: |
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| DOI / URN: |
10.1007/s40472-022-00355-4 |
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| Katalog-ID: |
SPR046447032 |
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| 520 | |a Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. | ||
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10.1007/s40472-022-00355-4 doi (DE-627)SPR046447032 (SPR)s40472-022-00355-4-e DE-627 ger DE-627 rakwb eng Baran, David A. verfasserin (orcid)0000-0002-7754-9953 aut Heart Transplant Donor Selection: Recent Insights 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. Mohammed, Asim aut Macdonald, Peter aut Copeland, Hannah (orcid)0000-0002-3753-5194 aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 9(2022), 1 vom: 19. Jan., Seite 12-18 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:9 year:2022 number:1 day:19 month:01 pages:12-18 https://dx.doi.org/10.1007/s40472-022-00355-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 1 19 01 12-18 |
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10.1007/s40472-022-00355-4 doi (DE-627)SPR046447032 (SPR)s40472-022-00355-4-e DE-627 ger DE-627 rakwb eng Baran, David A. verfasserin (orcid)0000-0002-7754-9953 aut Heart Transplant Donor Selection: Recent Insights 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. Mohammed, Asim aut Macdonald, Peter aut Copeland, Hannah (orcid)0000-0002-3753-5194 aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 9(2022), 1 vom: 19. Jan., Seite 12-18 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:9 year:2022 number:1 day:19 month:01 pages:12-18 https://dx.doi.org/10.1007/s40472-022-00355-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 1 19 01 12-18 |
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10.1007/s40472-022-00355-4 doi (DE-627)SPR046447032 (SPR)s40472-022-00355-4-e DE-627 ger DE-627 rakwb eng Baran, David A. verfasserin (orcid)0000-0002-7754-9953 aut Heart Transplant Donor Selection: Recent Insights 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. Mohammed, Asim aut Macdonald, Peter aut Copeland, Hannah (orcid)0000-0002-3753-5194 aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 9(2022), 1 vom: 19. Jan., Seite 12-18 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:9 year:2022 number:1 day:19 month:01 pages:12-18 https://dx.doi.org/10.1007/s40472-022-00355-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 1 19 01 12-18 |
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10.1007/s40472-022-00355-4 doi (DE-627)SPR046447032 (SPR)s40472-022-00355-4-e DE-627 ger DE-627 rakwb eng Baran, David A. verfasserin (orcid)0000-0002-7754-9953 aut Heart Transplant Donor Selection: Recent Insights 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. Mohammed, Asim aut Macdonald, Peter aut Copeland, Hannah (orcid)0000-0002-3753-5194 aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 9(2022), 1 vom: 19. Jan., Seite 12-18 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:9 year:2022 number:1 day:19 month:01 pages:12-18 https://dx.doi.org/10.1007/s40472-022-00355-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 1 19 01 12-18 |
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10.1007/s40472-022-00355-4 doi (DE-627)SPR046447032 (SPR)s40472-022-00355-4-e DE-627 ger DE-627 rakwb eng Baran, David A. verfasserin (orcid)0000-0002-7754-9953 aut Heart Transplant Donor Selection: Recent Insights 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. Mohammed, Asim aut Macdonald, Peter aut Copeland, Hannah (orcid)0000-0002-3753-5194 aut Enthalten in Current transplantation reports Cham : Springer Internat. Publ., 2014 9(2022), 1 vom: 19. Jan., Seite 12-18 (DE-627)78037844X (DE-600)2760306-4 2196-3029 nnns volume:9 year:2022 number:1 day:19 month:01 pages:12-18 https://dx.doi.org/10.1007/s40472-022-00355-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 1 19 01 12-18 |
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Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. 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Baran, David A. Heart Transplant Donor Selection: Recent Insights |
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Heart Transplant Donor Selection: Recent Insights |
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heart transplant donor selection: recent insights |
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Heart Transplant Donor Selection: Recent Insights |
| abstract |
Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 |
| abstractGer |
Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 |
| abstract_unstemmed |
Purpose of Review There are several aspects of donor selection for heart transplantation that are particularly challenging. Information about the donor is often limited and relayed through a review of selected chart snippets and tests. The donor heart must work immediately unlike kidney transplantation where delayed function is common and not life-threatening. This review focuses on recent findings in the literature which are distilled for the transplant clinician to be eminently practical to advise teams as they consider which donor factors are important in individual situations. Recent Findings Left ventricular dysfunction has many causes and particularly in younger donors may resolve with time. Such donors can be utilized with excellent results. Donor age is still a critically important risk factor for outcome post-transplant though it is additive with other factors such as left ventricular hypertrophy and anticipated ischemic time. Donor size is another important factor and recent work suggests that calculation of predicted heart mass is superior to simple weight, height, and gender in reaching a decision about donor sizing. Recent work suggests that even donors with non-critical coronary lesions (50% or less) may be utilized with similar outcomes, including a similar incidence of progression of vasculopathy. Diabetes appears to be a manageable comorbidity particularly with careful screening. With the increase in drug-related deaths, a recent study looking at more than 23,000 accepted donors found no difference in long-term survival with multiple drugs in the toxicology screen of the donor which may allow increased use of such donors. Finally, we review the details of donation after circulatory determination of death (DCD). Currently, this is confined to certain specialized centers but this is anticipated to become more common worldwide and enhance the number of transplants over time. Summary Current evidence is reviewed and summarized to allow the busy transplant clinician to be up to date on the latest information regarding large and smaller important studies in this field. It is hoped that this review helps teams maximize their use of appropriate donors. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 |
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Heart Transplant Donor Selection: Recent Insights |
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Mohammed, Asim Macdonald, Peter Copeland, Hannah |
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Mohammed, Asim Macdonald, Peter Copeland, Hannah |
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10.1007/s40472-022-00355-4 |
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2024-07-03T22:34:38.245Z |
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| score |
7.4010277 |