Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement

Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. Fro...
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Autor*in:	Stricagnoli, M. [verfasserIn] Sciaccaluga, C. Mandoli, G. E. Rizzo, L. Sisti, N. Aboumarie, H. S. Benfari, G. Maritan, L. Tsioulpas, C. Bernazzali, S. Maccherini, M. Natali, B. M. Focardi, M. D’Ascenzi, F. Lisi, M. Valente, S. Mondillo, S. Cameli, M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Right heart failure LVAD Predictors Echocardiography Strain

Anmerkung:	© The Author(s) 2021

Übergeordnetes Werk:	Enthalten in: The international journal of cardiovascular imaging - Dordrecht [u.a.] : Springer, 1985, 38(2021), 3 vom: 18. Okt., Seite 561-570
Übergeordnetes Werk:	volume:38 ; year:2021 ; number:3 ; day:18 ; month:10 ; pages:561-570

Links:	Volltext

DOI / URN:	10.1007/s10554-021-02433-7

Katalog-ID:	SPR04650074X

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100	1		\|a Stricagnoli, M. \|e verfasserin \|4 aut
245	1	0	\|a Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement
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520			\|a Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor.
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650		4	\|a Predictors \|7 (dpeaa)DE-He213
650		4	\|a Echocardiography \|7 (dpeaa)DE-He213
650		4	\|a Strain \|7 (dpeaa)DE-He213
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700	1		\|a Mandoli, G. E. \|4 aut
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700	1		\|a Sisti, N. \|4 aut
700	1		\|a Aboumarie, H. S. \|4 aut
700	1		\|a Benfari, G. \|4 aut
700	1		\|a Maritan, L. \|4 aut
700	1		\|a Tsioulpas, C. \|4 aut
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700	1		\|a Maccherini, M. \|4 aut
700	1		\|a Natali, B. M. \|4 aut
700	1		\|a Focardi, M. \|4 aut
700	1		\|a D’Ascenzi, F. \|4 aut
700	1		\|a Lisi, M. \|4 aut
700	1		\|a Valente, S. \|4 aut
700	1		\|a Mondillo, S. \|4 aut
700	1		\|a Cameli, M. \|4 aut
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allfields	10.1007/s10554-021-02433-7 doi (DE-627)SPR04650074X (SPR)s10554-021-02433-7-e DE-627 ger DE-627 rakwb eng Stricagnoli, M. verfasserin aut Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. Right heart failure (dpeaa)DE-He213 LVAD (dpeaa)DE-He213 Predictors (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Strain (dpeaa)DE-He213 Sciaccaluga, C. (orcid)0000-0002-1965-1773 aut Mandoli, G. E. aut Rizzo, L. aut Sisti, N. aut Aboumarie, H. S. aut Benfari, G. aut Maritan, L. aut Tsioulpas, C. aut Bernazzali, S. aut Maccherini, M. aut Natali, B. M. aut Focardi, M. aut D’Ascenzi, F. aut Lisi, M. aut Valente, S. aut Mondillo, S. aut Cameli, M. aut Enthalten in The international journal of cardiovascular imaging Dordrecht [u.a.] : Springer, 1985 38(2021), 3 vom: 18. Okt., Seite 561-570 (DE-627)320474321 (DE-600)2008950-8 1573-0743 nnns volume:38 year:2021 number:3 day:18 month:10 pages:561-570 https://dx.doi.org/10.1007/s10554-021-02433-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 3 18 10 561-570
spelling	10.1007/s10554-021-02433-7 doi (DE-627)SPR04650074X (SPR)s10554-021-02433-7-e DE-627 ger DE-627 rakwb eng Stricagnoli, M. verfasserin aut Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. Right heart failure (dpeaa)DE-He213 LVAD (dpeaa)DE-He213 Predictors (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Strain (dpeaa)DE-He213 Sciaccaluga, C. (orcid)0000-0002-1965-1773 aut Mandoli, G. E. aut Rizzo, L. aut Sisti, N. aut Aboumarie, H. S. aut Benfari, G. aut Maritan, L. aut Tsioulpas, C. aut Bernazzali, S. aut Maccherini, M. aut Natali, B. M. aut Focardi, M. aut D’Ascenzi, F. aut Lisi, M. aut Valente, S. aut Mondillo, S. aut Cameli, M. aut Enthalten in The international journal of cardiovascular imaging Dordrecht [u.a.] : Springer, 1985 38(2021), 3 vom: 18. Okt., Seite 561-570 (DE-627)320474321 (DE-600)2008950-8 1573-0743 nnns volume:38 year:2021 number:3 day:18 month:10 pages:561-570 https://dx.doi.org/10.1007/s10554-021-02433-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 3 18 10 561-570
allfields_unstemmed	10.1007/s10554-021-02433-7 doi (DE-627)SPR04650074X (SPR)s10554-021-02433-7-e DE-627 ger DE-627 rakwb eng Stricagnoli, M. verfasserin aut Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. Right heart failure (dpeaa)DE-He213 LVAD (dpeaa)DE-He213 Predictors (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Strain (dpeaa)DE-He213 Sciaccaluga, C. (orcid)0000-0002-1965-1773 aut Mandoli, G. E. aut Rizzo, L. aut Sisti, N. aut Aboumarie, H. S. aut Benfari, G. aut Maritan, L. aut Tsioulpas, C. aut Bernazzali, S. aut Maccherini, M. aut Natali, B. M. aut Focardi, M. aut D’Ascenzi, F. aut Lisi, M. aut Valente, S. aut Mondillo, S. aut Cameli, M. aut Enthalten in The international journal of cardiovascular imaging Dordrecht [u.a.] : Springer, 1985 38(2021), 3 vom: 18. Okt., Seite 561-570 (DE-627)320474321 (DE-600)2008950-8 1573-0743 nnns volume:38 year:2021 number:3 day:18 month:10 pages:561-570 https://dx.doi.org/10.1007/s10554-021-02433-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 3 18 10 561-570
allfieldsGer	10.1007/s10554-021-02433-7 doi (DE-627)SPR04650074X (SPR)s10554-021-02433-7-e DE-627 ger DE-627 rakwb eng Stricagnoli, M. verfasserin aut Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. Right heart failure (dpeaa)DE-He213 LVAD (dpeaa)DE-He213 Predictors (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Strain (dpeaa)DE-He213 Sciaccaluga, C. (orcid)0000-0002-1965-1773 aut Mandoli, G. E. aut Rizzo, L. aut Sisti, N. aut Aboumarie, H. S. aut Benfari, G. aut Maritan, L. aut Tsioulpas, C. aut Bernazzali, S. aut Maccherini, M. aut Natali, B. M. aut Focardi, M. aut D’Ascenzi, F. aut Lisi, M. aut Valente, S. aut Mondillo, S. aut Cameli, M. aut Enthalten in The international journal of cardiovascular imaging Dordrecht [u.a.] : Springer, 1985 38(2021), 3 vom: 18. Okt., Seite 561-570 (DE-627)320474321 (DE-600)2008950-8 1573-0743 nnns volume:38 year:2021 number:3 day:18 month:10 pages:561-570 https://dx.doi.org/10.1007/s10554-021-02433-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 3 18 10 561-570
allfieldsSound	10.1007/s10554-021-02433-7 doi (DE-627)SPR04650074X (SPR)s10554-021-02433-7-e DE-627 ger DE-627 rakwb eng Stricagnoli, M. verfasserin aut Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. Right heart failure (dpeaa)DE-He213 LVAD (dpeaa)DE-He213 Predictors (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Strain (dpeaa)DE-He213 Sciaccaluga, C. (orcid)0000-0002-1965-1773 aut Mandoli, G. E. aut Rizzo, L. aut Sisti, N. aut Aboumarie, H. S. aut Benfari, G. aut Maritan, L. aut Tsioulpas, C. aut Bernazzali, S. aut Maccherini, M. aut Natali, B. M. aut Focardi, M. aut D’Ascenzi, F. aut Lisi, M. aut Valente, S. aut Mondillo, S. aut Cameli, M. aut Enthalten in The international journal of cardiovascular imaging Dordrecht [u.a.] : Springer, 1985 38(2021), 3 vom: 18. Okt., Seite 561-570 (DE-627)320474321 (DE-600)2008950-8 1573-0743 nnns volume:38 year:2021 number:3 day:18 month:10 pages:561-570 https://dx.doi.org/10.1007/s10554-021-02433-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 38 2021 3 18 10 561-570
language	English
source	Enthalten in The international journal of cardiovascular imaging 38(2021), 3 vom: 18. Okt., Seite 561-570 volume:38 year:2021 number:3 day:18 month:10 pages:561-570
sourceStr	Enthalten in The international journal of cardiovascular imaging 38(2021), 3 vom: 18. Okt., Seite 561-570 volume:38 year:2021 number:3 day:18 month:10 pages:561-570
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Right heart failure LVAD Predictors Echocardiography Strain
isfreeaccess_bool	true
container_title	The international journal of cardiovascular imaging
authorswithroles_txt_mv	Stricagnoli, M. @@aut@@ Sciaccaluga, C. @@aut@@ Mandoli, G. E. @@aut@@ Rizzo, L. @@aut@@ Sisti, N. @@aut@@ Aboumarie, H. S. @@aut@@ Benfari, G. @@aut@@ Maritan, L. @@aut@@ Tsioulpas, C. @@aut@@ Bernazzali, S. @@aut@@ Maccherini, M. @@aut@@ Natali, B. M. @@aut@@ Focardi, M. @@aut@@ D’Ascenzi, F. @@aut@@ Lisi, M. @@aut@@ Valente, S. @@aut@@ Mondillo, S. @@aut@@ Cameli, M. @@aut@@
publishDateDaySort_date	2021-10-18T00:00:00Z
hierarchy_top_id	320474321
id	SPR04650074X
language_de	englisch
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author	Stricagnoli, M.
spellingShingle	Stricagnoli, M. misc Right heart failure misc LVAD misc Predictors misc Echocardiography misc Strain Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement
authorStr	Stricagnoli, M.
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topic_title	Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement Right heart failure (dpeaa)DE-He213 LVAD (dpeaa)DE-He213 Predictors (dpeaa)DE-He213 Echocardiography (dpeaa)DE-He213 Strain (dpeaa)DE-He213
topic	misc Right heart failure misc LVAD misc Predictors misc Echocardiography misc Strain
topic_unstemmed	misc Right heart failure misc LVAD misc Predictors misc Echocardiography misc Strain
topic_browse	misc Right heart failure misc LVAD misc Predictors misc Echocardiography misc Strain
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title	Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement
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title_full	Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement
author_sort	Stricagnoli, M.
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author_browse	Stricagnoli, M. Sciaccaluga, C. Mandoli, G. E. Rizzo, L. Sisti, N. Aboumarie, H. S. Benfari, G. Maritan, L. Tsioulpas, C. Bernazzali, S. Maccherini, M. Natali, B. M. Focardi, M. D’Ascenzi, F. Lisi, M. Valente, S. Mondillo, S. Cameli, M.
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author-letter	Stricagnoli, M.
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title_sort	clinical, echocardiographic and hemodynamic predictors of right heart failure after lvad placement
title_auth	Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement
abstract	Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. © The Author(s) 2021
abstractGer	Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. © The Author(s) 2021
abstract_unstemmed	Abstract Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled. Preoperative clinical, laboratory, echocardiographic and haemodynamic parameters were reported. Overall, eight patients (21%) developed RVF over time, which revealed to be strongly related to overall mortality. Pulmonary artery pulsatility index (PAPi) resulted to be the most significant right heart catheterization index in discriminating RVF vs no RVF patients [(1.32 ± 0.26 vs. 3.95 ± 3.39 respectively) p = 0.0036]. Regarding transthoracic echocardiography, RVF was associated with reduced free wall right ventricular longitudinal strain (fw-RVLS) (− 7.9 ± 1.29 vs. − 16.14 ± 5.83) (p < 0.009), which was superior to other echocardiographic determinants of RVF. Among laboratory values, N-terminal pro-brain natriuretic peptide (NT-proBNP) was strongly increased in RVF patients [(10,496.13 pg/ml ± 5272.96 pg/ml vs. 2865, 5 pg/ml ± 2595.61 pg/ml) p = 0.006]. PAPi, NT-proBNP and fwRVLS were the best pre-operative predictors of RVF, a post-LVAD implant complication which was confirmed to have a great impact on survival. In particular, fwRVLS has been proven to be the strongest independent predictor. © The Author(s) 2021
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title_short	Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement
url	https://dx.doi.org/10.1007/s10554-021-02433-7
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author2	Sciaccaluga, C. Mandoli, G. E. Rizzo, L. Sisti, N. Aboumarie, H. S. Benfari, G. Maritan, L. Tsioulpas, C. Bernazzali, S. Maccherini, M. Natali, B. M. Focardi, M. D’Ascenzi, F. Lisi, M. Valente, S. Mondillo, S. Cameli, M.
author2Str	Sciaccaluga, C. Mandoli, G. E. Rizzo, L. Sisti, N. Aboumarie, H. S. Benfari, G. Maritan, L. Tsioulpas, C. Bernazzali, S. Maccherini, M. Natali, B. M. Focardi, M. D’Ascenzi, F. Lisi, M. Valente, S. Mondillo, S. Cameli, M.
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doi_str	10.1007/s10554-021-02433-7
up_date	2024-07-03T22:55:11.655Z
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Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement

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