A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway
Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application v...
Ausführliche Beschreibung
Autor*in: |
Yu, Kai [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Anmerkung: |
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
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Übergeordnetes Werk: |
Enthalten in: Molecular diversity - Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995, 26(2021), 2 vom: 09. Juni, Seite 1151-1159 |
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Übergeordnetes Werk: |
volume:26 ; year:2021 ; number:2 ; day:09 ; month:06 ; pages:1151-1159 |
Links: |
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DOI / URN: |
10.1007/s11030-021-10241-3 |
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Katalog-ID: |
SPR046897437 |
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245 | 1 | 2 | |a A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway |
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520 | |a Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract | ||
650 | 4 | |a Coordination polymer |7 (dpeaa)DE-He213 | |
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700 | 1 | |a Ma, Bingqin |4 aut | |
700 | 1 | |a Wang, Liangzhi |4 aut | |
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10.1007/s11030-021-10241-3 doi (DE-627)SPR046897437 (SPR)s11030-021-10241-3-e DE-627 ger DE-627 rakwb eng Yu, Kai verfasserin aut A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract Coordination polymer (dpeaa)DE-He213 Osteoporotic hip fractures (dpeaa)DE-He213 RT-PCR (dpeaa)DE-He213 Molecular docking (dpeaa)DE-He213 Yang, Jie aut Xie, Shangding aut Ma, Bingqin aut Wang, Liangzhi aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 26(2021), 2 vom: 09. Juni, Seite 1151-1159 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:26 year:2021 number:2 day:09 month:06 pages:1151-1159 https://dx.doi.org/10.1007/s11030-021-10241-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2021 2 09 06 1151-1159 |
spelling |
10.1007/s11030-021-10241-3 doi (DE-627)SPR046897437 (SPR)s11030-021-10241-3-e DE-627 ger DE-627 rakwb eng Yu, Kai verfasserin aut A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract Coordination polymer (dpeaa)DE-He213 Osteoporotic hip fractures (dpeaa)DE-He213 RT-PCR (dpeaa)DE-He213 Molecular docking (dpeaa)DE-He213 Yang, Jie aut Xie, Shangding aut Ma, Bingqin aut Wang, Liangzhi aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 26(2021), 2 vom: 09. Juni, Seite 1151-1159 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:26 year:2021 number:2 day:09 month:06 pages:1151-1159 https://dx.doi.org/10.1007/s11030-021-10241-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2021 2 09 06 1151-1159 |
allfields_unstemmed |
10.1007/s11030-021-10241-3 doi (DE-627)SPR046897437 (SPR)s11030-021-10241-3-e DE-627 ger DE-627 rakwb eng Yu, Kai verfasserin aut A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract Coordination polymer (dpeaa)DE-He213 Osteoporotic hip fractures (dpeaa)DE-He213 RT-PCR (dpeaa)DE-He213 Molecular docking (dpeaa)DE-He213 Yang, Jie aut Xie, Shangding aut Ma, Bingqin aut Wang, Liangzhi aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 26(2021), 2 vom: 09. Juni, Seite 1151-1159 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:26 year:2021 number:2 day:09 month:06 pages:1151-1159 https://dx.doi.org/10.1007/s11030-021-10241-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2021 2 09 06 1151-1159 |
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10.1007/s11030-021-10241-3 doi (DE-627)SPR046897437 (SPR)s11030-021-10241-3-e DE-627 ger DE-627 rakwb eng Yu, Kai verfasserin aut A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract Coordination polymer (dpeaa)DE-He213 Osteoporotic hip fractures (dpeaa)DE-He213 RT-PCR (dpeaa)DE-He213 Molecular docking (dpeaa)DE-He213 Yang, Jie aut Xie, Shangding aut Ma, Bingqin aut Wang, Liangzhi aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 26(2021), 2 vom: 09. Juni, Seite 1151-1159 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:26 year:2021 number:2 day:09 month:06 pages:1151-1159 https://dx.doi.org/10.1007/s11030-021-10241-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2021 2 09 06 1151-1159 |
allfieldsSound |
10.1007/s11030-021-10241-3 doi (DE-627)SPR046897437 (SPR)s11030-021-10241-3-e DE-627 ger DE-627 rakwb eng Yu, Kai verfasserin aut A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract Coordination polymer (dpeaa)DE-He213 Osteoporotic hip fractures (dpeaa)DE-He213 RT-PCR (dpeaa)DE-He213 Molecular docking (dpeaa)DE-He213 Yang, Jie aut Xie, Shangding aut Ma, Bingqin aut Wang, Liangzhi aut Enthalten in Molecular diversity Dordrecht [u.a.] : Springer Science + Business Media B.V., 1995 26(2021), 2 vom: 09. Juni, Seite 1151-1159 (DE-627)311010377 (DE-600)2003589-5 1573-501X nnns volume:26 year:2021 number:2 day:09 month:06 pages:1151-1159 https://dx.doi.org/10.1007/s11030-021-10241-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2021 2 09 06 1151-1159 |
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Enthalten in Molecular diversity 26(2021), 2 vom: 09. Juni, Seite 1151-1159 volume:26 year:2021 number:2 day:09 month:06 pages:1151-1159 |
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Yu, Kai @@aut@@ Yang, Jie @@aut@@ Xie, Shangding @@aut@@ Ma, Bingqin @@aut@@ Wang, Liangzhi @@aut@@ |
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The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. 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Yu, Kai |
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Yu, Kai misc Coordination polymer misc Osteoporotic hip fractures misc RT-PCR misc Molecular docking A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway |
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A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway Coordination polymer (dpeaa)DE-He213 Osteoporotic hip fractures (dpeaa)DE-He213 RT-PCR (dpeaa)DE-He213 Molecular docking (dpeaa)DE-He213 |
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new cu(ii)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway |
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A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway |
abstract |
Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
abstractGer |
Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
abstract_unstemmed |
Elderly osteoporosis hip fracture has drawn the attention of the researcher. The coordination polymer was now widely used in clinic because their multiple structures and biological activities. In this present research, the new coordination polymer was designed and synthesized and their application values on elderly osteoporosis hip were evaluated. The reaction between Cu(II) salt and 4,4'‐(1H‐1,2,4‐triazol‐1‐yl)methylene‐bis(benzoic acid) ($ H_{2} $tzmb), an aromatase inhibitor letrozole derivative with the aid of the organic linker 4,4-bipyridine (4,4′-bpy) affords a new coordination polymer based on Cu(II) ions as nodes of {[$ Cu_{2} $(tzmb)2(4,4′-bpy) (μ2-$ H_{2} $O)2(DMA) ($ H_{2} $O)2]·10DMA}n(1). The complex 1 gained is totally investigated with the powder X-ray diffraction study, thermogravimetric analyses, the diffraction of single-crystal X-ray, elemental analysis as well as the Fourier transform infrared spectrometer spectra. The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. Finally, it can be summed up that this compound has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. The results of the CCK-8 assay indicated that the compound has no cytotoxicity on the mesenchymal stem cell. The molecular docking simulation results have identified that only the carboxyl group on the Cu complex exhibits the activity for the hydrogen bond formation, however, the pyridine ring does not have such activity, instead, the pyridine ring only acts as the ligand that binds to the Cu ion. This Cu(II) coordination polymer has excellent application values on the elderly osteoporotic hip fractures treatment by increasing the activation of wnt signaling pathway in mesenchymal stem cell. Graphic abstract © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
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2 |
title_short |
A new Cu(II)-containing coordination polymer: protective effect and mechanism exploration on elderly osteoporotic hip fractures via regulating the wnt signaling pathway |
url |
https://dx.doi.org/10.1007/s11030-021-10241-3 |
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author2 |
Yang, Jie Xie, Shangding Ma, Bingqin Wang, Liangzhi |
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Yang, Jie Xie, Shangding Ma, Bingqin Wang, Liangzhi |
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doi_str |
10.1007/s11030-021-10241-3 |
up_date |
2024-07-04T00:55:53.573Z |
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The osteogenic differentiation of mesenchymal stem cell was measured with the western blotting assay through determining the Runx2 expression. The wnt signaling pathway relative expression in mesenchymal stem cell was detected through the determination of real-time RT-PCR. The cytotoxicity of the compound on the mesenchymal stem cell was determined with CCK-8 assay. The result of single-crystal X-ray diffraction reflects that the complex 1 has crystallized in space group R-3c of trigonal system and exhibits a three-dimensional skeleton architecture on the bases of the SBUs {Cu(tzmb)(μ2-$ H_{2} $O)}n. The western blotting assay results revealed that this compound could significantly promote the osteogenic differentiation of mesenchymal stem cell. Besides, the activation of wnt signaling pathway in mesenchymal stem cell was also increased by the compound exposure. 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score |
7.3999233 |