Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats
Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus am...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bhatia, Nitish [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2021 |
|---|
| Schlagwörter: |
|---|
| Anmerkung: |
© Institute of Korean Medicine, Kyung Hee University 2021 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Oriental pharmacy and experimental medicine - Dordrecht : Springer, 2011, 22(2021), 2 vom: 21. Jan., Seite 305-314 |
|---|---|
| Übergeordnetes Werk: |
volume:22 ; year:2021 ; number:2 ; day:21 ; month:01 ; pages:305-314 |
| Links: |
|---|
| DOI / URN: |
10.1007/s13596-020-00545-4 |
|---|
| Katalog-ID: |
SPR047029579 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR047029579 | ||
| 003 | DE-627 | ||
| 005 | 20230519185102.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220518s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s13596-020-00545-4 |2 doi | |
| 035 | |a (DE-627)SPR047029579 | ||
| 035 | |a (SPR)s13596-020-00545-4-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bhatia, Nitish |e verfasserin |0 (orcid)0000-0001-9606-0419 |4 aut | |
| 245 | 1 | 0 | |a Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © Institute of Korean Medicine, Kyung Hee University 2021 | ||
| 520 | |a Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract | ||
| 650 | 4 | |a Chronic unpredictable stress |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Memory deficits |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antioxidants |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Stress |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kumar, Abhitinder |4 aut | |
| 700 | 1 | |a Kaur, Parminder |4 aut | |
| 700 | 1 | |a George, Benu |4 aut | |
| 700 | 1 | |a Kaur, Narinder |4 aut | |
| 700 | 1 | |a Khan, Masih Uzaaman |4 aut | |
| 700 | 1 | |a Dhawan, Ravi Kumar |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oriental pharmacy and experimental medicine |d Dordrecht : Springer, 2011 |g 22(2021), 2 vom: 21. Jan., Seite 305-314 |w (DE-627)689127340 |w (DE-600)2655275-9 |x 2211-1069 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2021 |g number:2 |g day:21 |g month:01 |g pages:305-314 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s13596-020-00545-4 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_120 | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2021 |e 2 |b 21 |c 01 |h 305-314 | ||
| author_variant |
n b nb a k ak p k pk b g bg n k nk m u k mu muk r k d rk rkd |
|---|---|
| matchkey_str |
article:22111069:2021----::rtciefetfrnsmgauntxrcocrncnrdcalsrscsnuemmrdfc |
| hierarchy_sort_str |
2021 |
| publishDate |
2021 |
| allfields |
10.1007/s13596-020-00545-4 doi (DE-627)SPR047029579 (SPR)s13596-020-00545-4-e DE-627 ger DE-627 rakwb eng Bhatia, Nitish verfasserin (orcid)0000-0001-9606-0419 aut Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Korean Medicine, Kyung Hee University 2021 Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract Chronic unpredictable stress (dpeaa)DE-He213 Memory deficits (dpeaa)DE-He213 Antioxidants (dpeaa)DE-He213 Stress (dpeaa)DE-He213 Kumar, Abhitinder aut Kaur, Parminder aut George, Benu aut Kaur, Narinder aut Khan, Masih Uzaaman aut Dhawan, Ravi Kumar aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 22(2021), 2 vom: 21. Jan., Seite 305-314 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:22 year:2021 number:2 day:21 month:01 pages:305-314 https://dx.doi.org/10.1007/s13596-020-00545-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 AR 22 2021 2 21 01 305-314 |
| spelling |
10.1007/s13596-020-00545-4 doi (DE-627)SPR047029579 (SPR)s13596-020-00545-4-e DE-627 ger DE-627 rakwb eng Bhatia, Nitish verfasserin (orcid)0000-0001-9606-0419 aut Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Korean Medicine, Kyung Hee University 2021 Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract Chronic unpredictable stress (dpeaa)DE-He213 Memory deficits (dpeaa)DE-He213 Antioxidants (dpeaa)DE-He213 Stress (dpeaa)DE-He213 Kumar, Abhitinder aut Kaur, Parminder aut George, Benu aut Kaur, Narinder aut Khan, Masih Uzaaman aut Dhawan, Ravi Kumar aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 22(2021), 2 vom: 21. Jan., Seite 305-314 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:22 year:2021 number:2 day:21 month:01 pages:305-314 https://dx.doi.org/10.1007/s13596-020-00545-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 AR 22 2021 2 21 01 305-314 |
| allfields_unstemmed |
10.1007/s13596-020-00545-4 doi (DE-627)SPR047029579 (SPR)s13596-020-00545-4-e DE-627 ger DE-627 rakwb eng Bhatia, Nitish verfasserin (orcid)0000-0001-9606-0419 aut Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Korean Medicine, Kyung Hee University 2021 Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract Chronic unpredictable stress (dpeaa)DE-He213 Memory deficits (dpeaa)DE-He213 Antioxidants (dpeaa)DE-He213 Stress (dpeaa)DE-He213 Kumar, Abhitinder aut Kaur, Parminder aut George, Benu aut Kaur, Narinder aut Khan, Masih Uzaaman aut Dhawan, Ravi Kumar aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 22(2021), 2 vom: 21. Jan., Seite 305-314 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:22 year:2021 number:2 day:21 month:01 pages:305-314 https://dx.doi.org/10.1007/s13596-020-00545-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 AR 22 2021 2 21 01 305-314 |
| allfieldsGer |
10.1007/s13596-020-00545-4 doi (DE-627)SPR047029579 (SPR)s13596-020-00545-4-e DE-627 ger DE-627 rakwb eng Bhatia, Nitish verfasserin (orcid)0000-0001-9606-0419 aut Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Korean Medicine, Kyung Hee University 2021 Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract Chronic unpredictable stress (dpeaa)DE-He213 Memory deficits (dpeaa)DE-He213 Antioxidants (dpeaa)DE-He213 Stress (dpeaa)DE-He213 Kumar, Abhitinder aut Kaur, Parminder aut George, Benu aut Kaur, Narinder aut Khan, Masih Uzaaman aut Dhawan, Ravi Kumar aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 22(2021), 2 vom: 21. Jan., Seite 305-314 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:22 year:2021 number:2 day:21 month:01 pages:305-314 https://dx.doi.org/10.1007/s13596-020-00545-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 AR 22 2021 2 21 01 305-314 |
| allfieldsSound |
10.1007/s13596-020-00545-4 doi (DE-627)SPR047029579 (SPR)s13596-020-00545-4-e DE-627 ger DE-627 rakwb eng Bhatia, Nitish verfasserin (orcid)0000-0001-9606-0419 aut Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Institute of Korean Medicine, Kyung Hee University 2021 Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract Chronic unpredictable stress (dpeaa)DE-He213 Memory deficits (dpeaa)DE-He213 Antioxidants (dpeaa)DE-He213 Stress (dpeaa)DE-He213 Kumar, Abhitinder aut Kaur, Parminder aut George, Benu aut Kaur, Narinder aut Khan, Masih Uzaaman aut Dhawan, Ravi Kumar aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 22(2021), 2 vom: 21. Jan., Seite 305-314 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:22 year:2021 number:2 day:21 month:01 pages:305-314 https://dx.doi.org/10.1007/s13596-020-00545-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 AR 22 2021 2 21 01 305-314 |
| language |
English |
| source |
Enthalten in Oriental pharmacy and experimental medicine 22(2021), 2 vom: 21. Jan., Seite 305-314 volume:22 year:2021 number:2 day:21 month:01 pages:305-314 |
| sourceStr |
Enthalten in Oriental pharmacy and experimental medicine 22(2021), 2 vom: 21. Jan., Seite 305-314 volume:22 year:2021 number:2 day:21 month:01 pages:305-314 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Chronic unpredictable stress Memory deficits Antioxidants Stress |
| isfreeaccess_bool |
false |
| container_title |
Oriental pharmacy and experimental medicine |
| authorswithroles_txt_mv |
Bhatia, Nitish @@aut@@ Kumar, Abhitinder @@aut@@ Kaur, Parminder @@aut@@ George, Benu @@aut@@ Kaur, Narinder @@aut@@ Khan, Masih Uzaaman @@aut@@ Dhawan, Ravi Kumar @@aut@@ |
| publishDateDaySort_date |
2021-01-21T00:00:00Z |
| hierarchy_top_id |
689127340 |
| id |
SPR047029579 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR047029579</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519185102.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220518s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13596-020-00545-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR047029579</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13596-020-00545-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bhatia, Nitish</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-9606-0419</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Institute of Korean Medicine, Kyung Hee University 2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic unpredictable stress</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Memory deficits</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidants</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stress</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kumar, Abhitinder</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kaur, Parminder</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">George, Benu</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kaur, Narinder</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Khan, Masih Uzaaman</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dhawan, Ravi Kumar</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Oriental pharmacy and experimental medicine</subfield><subfield code="d">Dordrecht : Springer, 2011</subfield><subfield code="g">22(2021), 2 vom: 21. Jan., Seite 305-314</subfield><subfield code="w">(DE-627)689127340</subfield><subfield code="w">(DE-600)2655275-9</subfield><subfield code="x">2211-1069</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:22</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:2</subfield><subfield code="g">day:21</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:305-314</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13596-020-00545-4</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">22</subfield><subfield code="j">2021</subfield><subfield code="e">2</subfield><subfield code="b">21</subfield><subfield code="c">01</subfield><subfield code="h">305-314</subfield></datafield></record></collection>
|
| author |
Bhatia, Nitish |
| spellingShingle |
Bhatia, Nitish misc Chronic unpredictable stress misc Memory deficits misc Antioxidants misc Stress Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats |
| authorStr |
Bhatia, Nitish |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)689127340 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
2211-1069 |
| topic_title |
Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats Chronic unpredictable stress (dpeaa)DE-He213 Memory deficits (dpeaa)DE-He213 Antioxidants (dpeaa)DE-He213 Stress (dpeaa)DE-He213 |
| topic |
misc Chronic unpredictable stress misc Memory deficits misc Antioxidants misc Stress |
| topic_unstemmed |
misc Chronic unpredictable stress misc Memory deficits misc Antioxidants misc Stress |
| topic_browse |
misc Chronic unpredictable stress misc Memory deficits misc Antioxidants misc Stress |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Oriental pharmacy and experimental medicine |
| hierarchy_parent_id |
689127340 |
| hierarchy_top_title |
Oriental pharmacy and experimental medicine |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)689127340 (DE-600)2655275-9 |
| title |
Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats |
| ctrlnum |
(DE-627)SPR047029579 (SPR)s13596-020-00545-4-e |
| title_full |
Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats |
| author_sort |
Bhatia, Nitish |
| journal |
Oriental pharmacy and experimental medicine |
| journalStr |
Oriental pharmacy and experimental medicine |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
2021 |
| contenttype_str_mv |
txt |
| container_start_page |
305 |
| author_browse |
Bhatia, Nitish Kumar, Abhitinder Kaur, Parminder George, Benu Kaur, Narinder Khan, Masih Uzaaman Dhawan, Ravi Kumar |
| container_volume |
22 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Bhatia, Nitish |
| doi_str_mv |
10.1007/s13596-020-00545-4 |
| normlink |
(ORCID)0000-0001-9606-0419 |
| normlink_prefix_str_mv |
(orcid)0000-0001-9606-0419 |
| title_sort |
protective effect of prunus amygdalus nut extract on chronic unpredictable stress (cus) induced memory deficits and biochemical alterations in rats |
| title_auth |
Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats |
| abstract |
Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract © Institute of Korean Medicine, Kyung Hee University 2021 |
| abstractGer |
Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract © Institute of Korean Medicine, Kyung Hee University 2021 |
| abstract_unstemmed |
Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract © Institute of Korean Medicine, Kyung Hee University 2021 |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 |
| container_issue |
2 |
| title_short |
Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats |
| url |
https://dx.doi.org/10.1007/s13596-020-00545-4 |
| remote_bool |
true |
| author2 |
Kumar, Abhitinder Kaur, Parminder George, Benu Kaur, Narinder Khan, Masih Uzaaman Dhawan, Ravi Kumar |
| author2Str |
Kumar, Abhitinder Kaur, Parminder George, Benu Kaur, Narinder Khan, Masih Uzaaman Dhawan, Ravi Kumar |
| ppnlink |
689127340 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s13596-020-00545-4 |
| up_date |
2024-07-04T01:32:44.724Z |
| _version_ |
1803610242134573056 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR047029579</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519185102.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220518s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13596-020-00545-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR047029579</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13596-020-00545-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bhatia, Nitish</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-9606-0419</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Protective effect of Prunus amygdalus nut extract on chronic unpredictable stress (CUS) induced memory deficits and biochemical alterations in rats</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Institute of Korean Medicine, Kyung Hee University 2021</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic unpredictable stress</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Memory deficits</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidants</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stress</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kumar, Abhitinder</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kaur, Parminder</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">George, Benu</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kaur, Narinder</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Khan, Masih Uzaaman</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dhawan, Ravi Kumar</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Oriental pharmacy and experimental medicine</subfield><subfield code="d">Dordrecht : Springer, 2011</subfield><subfield code="g">22(2021), 2 vom: 21. Jan., Seite 305-314</subfield><subfield code="w">(DE-627)689127340</subfield><subfield code="w">(DE-600)2655275-9</subfield><subfield code="x">2211-1069</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:22</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:2</subfield><subfield code="g">day:21</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:305-314</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13596-020-00545-4</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">22</subfield><subfield code="j">2021</subfield><subfield code="e">2</subfield><subfield code="b">21</subfield><subfield code="c">01</subfield><subfield code="h">305-314</subfield></datafield></record></collection>
|
| score |
7.3985224 |