Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential
Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p &l...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Misra, Ankita [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The National Academy of Sciences, India 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Proceedings of the National Academy of Sciences - New York, NY : Springer, 2012, 92(2022), 2 vom: 21. Apr., Seite 473-483 |
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| Übergeordnetes Werk: |
volume:92 ; year:2022 ; number:2 ; day:21 ; month:04 ; pages:473-483 |
| Links: |
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| DOI / URN: |
10.1007/s40011-022-01350-6 |
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| Katalog-ID: |
SPR047041587 |
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| 100 | 1 | |a Misra, Ankita |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential |
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| 520 | |a Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. | ||
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| 700 | 1 | |a Shukla, Pushpendra Kumar |4 aut | |
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| 700 | 1 | |a Rawat, Poonam |4 aut | |
| 700 | 1 | |a Srivastava, Sharad |0 (orcid)0000-0002-7508-235X |4 aut | |
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10.1007/s40011-022-01350-6 doi (DE-627)SPR047041587 (SPR)s40011-022-01350-6-e DE-627 ger DE-627 rakwb eng Misra, Ankita verfasserin aut Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The National Academy of Sciences, India 2022 Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. Gouty arthritis (dpeaa)DE-He213 Chemotaxonomy (dpeaa)DE-He213 Colchicine (dpeaa)DE-He213 Shukla, Pushpendra Kumar aut Kumar, Manish aut Rawat, Poonam aut Srivastava, Sharad (orcid)0000-0002-7508-235X aut Enthalten in Proceedings of the National Academy of Sciences New York, NY : Springer, 2012 92(2022), 2 vom: 21. Apr., Seite 473-483 (DE-627)73921361X (DE-600)2707745-7 2250-1746 nnns volume:92 year:2022 number:2 day:21 month:04 pages:473-483 https://dx.doi.org/10.1007/s40011-022-01350-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 92 2022 2 21 04 473-483 |
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10.1007/s40011-022-01350-6 doi (DE-627)SPR047041587 (SPR)s40011-022-01350-6-e DE-627 ger DE-627 rakwb eng Misra, Ankita verfasserin aut Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The National Academy of Sciences, India 2022 Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. Gouty arthritis (dpeaa)DE-He213 Chemotaxonomy (dpeaa)DE-He213 Colchicine (dpeaa)DE-He213 Shukla, Pushpendra Kumar aut Kumar, Manish aut Rawat, Poonam aut Srivastava, Sharad (orcid)0000-0002-7508-235X aut Enthalten in Proceedings of the National Academy of Sciences New York, NY : Springer, 2012 92(2022), 2 vom: 21. Apr., Seite 473-483 (DE-627)73921361X (DE-600)2707745-7 2250-1746 nnns volume:92 year:2022 number:2 day:21 month:04 pages:473-483 https://dx.doi.org/10.1007/s40011-022-01350-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 92 2022 2 21 04 473-483 |
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10.1007/s40011-022-01350-6 doi (DE-627)SPR047041587 (SPR)s40011-022-01350-6-e DE-627 ger DE-627 rakwb eng Misra, Ankita verfasserin aut Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The National Academy of Sciences, India 2022 Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. Gouty arthritis (dpeaa)DE-He213 Chemotaxonomy (dpeaa)DE-He213 Colchicine (dpeaa)DE-He213 Shukla, Pushpendra Kumar aut Kumar, Manish aut Rawat, Poonam aut Srivastava, Sharad (orcid)0000-0002-7508-235X aut Enthalten in Proceedings of the National Academy of Sciences New York, NY : Springer, 2012 92(2022), 2 vom: 21. Apr., Seite 473-483 (DE-627)73921361X (DE-600)2707745-7 2250-1746 nnns volume:92 year:2022 number:2 day:21 month:04 pages:473-483 https://dx.doi.org/10.1007/s40011-022-01350-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 92 2022 2 21 04 473-483 |
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10.1007/s40011-022-01350-6 doi (DE-627)SPR047041587 (SPR)s40011-022-01350-6-e DE-627 ger DE-627 rakwb eng Misra, Ankita verfasserin aut Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The National Academy of Sciences, India 2022 Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. Gouty arthritis (dpeaa)DE-He213 Chemotaxonomy (dpeaa)DE-He213 Colchicine (dpeaa)DE-He213 Shukla, Pushpendra Kumar aut Kumar, Manish aut Rawat, Poonam aut Srivastava, Sharad (orcid)0000-0002-7508-235X aut Enthalten in Proceedings of the National Academy of Sciences New York, NY : Springer, 2012 92(2022), 2 vom: 21. Apr., Seite 473-483 (DE-627)73921361X (DE-600)2707745-7 2250-1746 nnns volume:92 year:2022 number:2 day:21 month:04 pages:473-483 https://dx.doi.org/10.1007/s40011-022-01350-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 92 2022 2 21 04 473-483 |
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10.1007/s40011-022-01350-6 doi (DE-627)SPR047041587 (SPR)s40011-022-01350-6-e DE-627 ger DE-627 rakwb eng Misra, Ankita verfasserin aut Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The National Academy of Sciences, India 2022 Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. Gouty arthritis (dpeaa)DE-He213 Chemotaxonomy (dpeaa)DE-He213 Colchicine (dpeaa)DE-He213 Shukla, Pushpendra Kumar aut Kumar, Manish aut Rawat, Poonam aut Srivastava, Sharad (orcid)0000-0002-7508-235X aut Enthalten in Proceedings of the National Academy of Sciences New York, NY : Springer, 2012 92(2022), 2 vom: 21. Apr., Seite 473-483 (DE-627)73921361X (DE-600)2707745-7 2250-1746 nnns volume:92 year:2022 number:2 day:21 month:04 pages:473-483 https://dx.doi.org/10.1007/s40011-022-01350-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 92 2022 2 21 04 473-483 |
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Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The National Academy of Sciences, India 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. 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Misra, Ankita |
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Misra, Ankita misc Gouty arthritis misc Chemotaxonomy misc Colchicine Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential |
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Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential Gouty arthritis (dpeaa)DE-He213 Chemotaxonomy (dpeaa)DE-He213 Colchicine (dpeaa)DE-He213 |
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intraspecific variation in gloriosa superba (l.) population from western himalayas (india) and evaluation of in vitro antigout potential |
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Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential |
| abstract |
Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. © The National Academy of Sciences, India 2022 |
| abstractGer |
Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. © The National Academy of Sciences, India 2022 |
| abstract_unstemmed |
Abstract The natural population(s) of Gloriosa superba L. was mapped from 19 different locations of Western Himalayas, up to altitude of 1800 m and no significant morphotypic variation was observed. The major metabolite colchicine was quantified through HPTLC (validated) method and significant (p < 0.05) intraspecific variation was recorded. The colchicine content ranges from 0.023 to 0.256% and maximum was in NBG-03 from Jyolikot, Nainital (Uttarakhand, India). Total polyphenolics content was also significant among the collected samples. Cluster analysis based on colchicine and total polyphenolic content of the population’s results in identification of five elite chemotypes viz. NBG-03, NBG-54, NBG-57, NBG-65 and NBG-80. The in vitro antigout activity of elite germplasms reveals that NBG-57 was the most promising, although its colchicine content was in moderation. Therefore, it is suggested that the whole extract may exert more promising antigout potential due to the synergistic action of various phytomolecules. Hence, the study will promote the conservation and cultivation of targeted species in Western Himalayas for the availability of good quality raw material for industry. It will also aid in commercial cultivation of elite germplasm(s) which can be used in herbal product development as well as in the economic upliftment of local inhabitants. © The National Academy of Sciences, India 2022 |
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Intraspecific Variation in Gloriosa Superba (L.) Population from Western Himalayas (India) and Evaluation of in vitro Antigout Potential |
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https://dx.doi.org/10.1007/s40011-022-01350-6 |
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Shukla, Pushpendra Kumar Kumar, Manish Rawat, Poonam Srivastava, Sharad |
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Shukla, Pushpendra Kumar Kumar, Manish Rawat, Poonam Srivastava, Sharad |
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| doi_str |
10.1007/s40011-022-01350-6 |
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2024-07-04T01:36:07.950Z |
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|
| score |
7.400485 |