Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats
Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group):...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sadri, Salimeh [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 |
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| Übergeordnetes Werk: |
Enthalten in: Sport sciences for health - Milan : Springer Italia, 2004, 18(2021), 2 vom: 18. Sept., Seite 481-490 |
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| Übergeordnetes Werk: |
volume:18 ; year:2021 ; number:2 ; day:18 ; month:09 ; pages:481-490 |
| Links: |
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| DOI / URN: |
10.1007/s11332-021-00828-6 |
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| Katalog-ID: |
SPR047152346 |
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| 100 | 1 | |a Sadri, Salimeh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats |
| 264 | 1 | |c 2021 | |
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| 500 | |a © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 | ||
| 520 | |a Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. | ||
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10.1007/s11332-021-00828-6 doi (DE-627)SPR047152346 (SPR)s11332-021-00828-6-e DE-627 ger DE-627 rakwb eng Sadri, Salimeh verfasserin aut Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. Nano-BCAA (dpeaa)DE-He213 Concentric (dpeaa)DE-He213 Eccentric (dpeaa)DE-He213 Akt (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Sharifi, Gholamreza (orcid)0000-0002-5725-6723 aut Jalali Dehkordi, Khosro aut Enthalten in Sport sciences for health Milan : Springer Italia, 2004 18(2021), 2 vom: 18. Sept., Seite 481-490 (DE-627)482304715 (DE-600)2181783-2 1825-1234 nnns volume:18 year:2021 number:2 day:18 month:09 pages:481-490 https://dx.doi.org/10.1007/s11332-021-00828-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2021 2 18 09 481-490 |
| spelling |
10.1007/s11332-021-00828-6 doi (DE-627)SPR047152346 (SPR)s11332-021-00828-6-e DE-627 ger DE-627 rakwb eng Sadri, Salimeh verfasserin aut Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. Nano-BCAA (dpeaa)DE-He213 Concentric (dpeaa)DE-He213 Eccentric (dpeaa)DE-He213 Akt (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Sharifi, Gholamreza (orcid)0000-0002-5725-6723 aut Jalali Dehkordi, Khosro aut Enthalten in Sport sciences for health Milan : Springer Italia, 2004 18(2021), 2 vom: 18. Sept., Seite 481-490 (DE-627)482304715 (DE-600)2181783-2 1825-1234 nnns volume:18 year:2021 number:2 day:18 month:09 pages:481-490 https://dx.doi.org/10.1007/s11332-021-00828-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2021 2 18 09 481-490 |
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10.1007/s11332-021-00828-6 doi (DE-627)SPR047152346 (SPR)s11332-021-00828-6-e DE-627 ger DE-627 rakwb eng Sadri, Salimeh verfasserin aut Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. Nano-BCAA (dpeaa)DE-He213 Concentric (dpeaa)DE-He213 Eccentric (dpeaa)DE-He213 Akt (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Sharifi, Gholamreza (orcid)0000-0002-5725-6723 aut Jalali Dehkordi, Khosro aut Enthalten in Sport sciences for health Milan : Springer Italia, 2004 18(2021), 2 vom: 18. Sept., Seite 481-490 (DE-627)482304715 (DE-600)2181783-2 1825-1234 nnns volume:18 year:2021 number:2 day:18 month:09 pages:481-490 https://dx.doi.org/10.1007/s11332-021-00828-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2021 2 18 09 481-490 |
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10.1007/s11332-021-00828-6 doi (DE-627)SPR047152346 (SPR)s11332-021-00828-6-e DE-627 ger DE-627 rakwb eng Sadri, Salimeh verfasserin aut Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. Nano-BCAA (dpeaa)DE-He213 Concentric (dpeaa)DE-He213 Eccentric (dpeaa)DE-He213 Akt (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Sharifi, Gholamreza (orcid)0000-0002-5725-6723 aut Jalali Dehkordi, Khosro aut Enthalten in Sport sciences for health Milan : Springer Italia, 2004 18(2021), 2 vom: 18. Sept., Seite 481-490 (DE-627)482304715 (DE-600)2181783-2 1825-1234 nnns volume:18 year:2021 number:2 day:18 month:09 pages:481-490 https://dx.doi.org/10.1007/s11332-021-00828-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2021 2 18 09 481-490 |
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10.1007/s11332-021-00828-6 doi (DE-627)SPR047152346 (SPR)s11332-021-00828-6-e DE-627 ger DE-627 rakwb eng Sadri, Salimeh verfasserin aut Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. Nano-BCAA (dpeaa)DE-He213 Concentric (dpeaa)DE-He213 Eccentric (dpeaa)DE-He213 Akt (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Sharifi, Gholamreza (orcid)0000-0002-5725-6723 aut Jalali Dehkordi, Khosro aut Enthalten in Sport sciences for health Milan : Springer Italia, 2004 18(2021), 2 vom: 18. Sept., Seite 481-490 (DE-627)482304715 (DE-600)2181783-2 1825-1234 nnns volume:18 year:2021 number:2 day:18 month:09 pages:481-490 https://dx.doi.org/10.1007/s11332-021-00828-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 18 2021 2 18 09 481-490 |
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English |
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Enthalten in Sport sciences for health 18(2021), 2 vom: 18. Sept., Seite 481-490 volume:18 year:2021 number:2 day:18 month:09 pages:481-490 |
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Enthalten in Sport sciences for health 18(2021), 2 vom: 18. Sept., Seite 481-490 volume:18 year:2021 number:2 day:18 month:09 pages:481-490 |
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Nano-BCAA Concentric Eccentric Akt mTOR |
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Sadri, Salimeh @@aut@@ Sharifi, Gholamreza @@aut@@ Jalali Dehkordi, Khosro @@aut@@ |
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Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). 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Sadri, Salimeh |
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Sadri, Salimeh misc Nano-BCAA misc Concentric misc Eccentric misc Akt misc mTOR Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats |
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Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats Nano-BCAA (dpeaa)DE-He213 Concentric (dpeaa)DE-He213 Eccentric (dpeaa)DE-He213 Akt (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 |
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Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats |
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Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats |
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nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of akt and mtor on aged rats |
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Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats |
| abstract |
Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 |
| abstractGer |
Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 |
| abstract_unstemmed |
Aim This study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR. Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method. Results Administration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05). Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age. © The Author(s), under exclusive licence to Springer-Verlag Italia S.r.l., part of Springer Nature 2021 |
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Nano branched-chain amino acids enhance the effect of uphill (concentric) and downhill (eccentric) treadmill exercise on muscle gene expression of Akt and mTOR on aged rats |
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https://dx.doi.org/10.1007/s11332-021-00828-6 |
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Sharifi, Gholamreza Jalali Dehkordi, Khosro |
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10.1007/s11332-021-00828-6 |
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2024-07-04T02:05:09.113Z |
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| score |
7.4022093 |