Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies

Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ea...
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Autor*in:	Horvath, Steve [verfasserIn] Haghani, Amin Zoller, Joseph A. Raj, Ken Sinha, Ishani Robeck, Todd R. Black, Pete Couzens, Aidan Lau, Clive Manoyan, Meghety Ruiz, Yadiamaris Aviles Talbott, Annais Belov, Katherine Hogg, Carolyn J. Sears, Karen E.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Opossum Aging Development Epigenetic clock DNA methylation

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Age - New York, NY : Springer Science+Business Media, 1978, 44(2022), 3 vom: 21. Apr., Seite 1825-1845
Übergeordnetes Werk:	volume:44 ; year:2022 ; number:3 ; day:21 ; month:04 ; pages:1825-1845

Links:	Volltext

DOI / URN:	10.1007/s11357-022-00569-5

Katalog-ID:	SPR047364459

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allfields	10.1007/s11357-022-00569-5 doi (DE-627)SPR047364459 (SPR)s11357-022-00569-5-e DE-627 ger DE-627 rakwb eng Horvath, Steve verfasserin (orcid)0000-0002-4110-3589 aut Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. Opossum (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Development (dpeaa)DE-He213 Epigenetic clock (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Haghani, Amin aut Zoller, Joseph A. aut Raj, Ken aut Sinha, Ishani aut Robeck, Todd R. aut Black, Pete aut Couzens, Aidan aut Lau, Clive aut Manoyan, Meghety aut Ruiz, Yadiamaris Aviles aut Talbott, Annais aut Belov, Katherine aut Hogg, Carolyn J. aut Sears, Karen E. aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 44(2022), 3 vom: 21. Apr., Seite 1825-1845 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:44 year:2022 number:3 day:21 month:04 pages:1825-1845 https://dx.doi.org/10.1007/s11357-022-00569-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 44 2022 3 21 04 1825-1845
spelling	10.1007/s11357-022-00569-5 doi (DE-627)SPR047364459 (SPR)s11357-022-00569-5-e DE-627 ger DE-627 rakwb eng Horvath, Steve verfasserin (orcid)0000-0002-4110-3589 aut Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. Opossum (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Development (dpeaa)DE-He213 Epigenetic clock (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Haghani, Amin aut Zoller, Joseph A. aut Raj, Ken aut Sinha, Ishani aut Robeck, Todd R. aut Black, Pete aut Couzens, Aidan aut Lau, Clive aut Manoyan, Meghety aut Ruiz, Yadiamaris Aviles aut Talbott, Annais aut Belov, Katherine aut Hogg, Carolyn J. aut Sears, Karen E. aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 44(2022), 3 vom: 21. Apr., Seite 1825-1845 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:44 year:2022 number:3 day:21 month:04 pages:1825-1845 https://dx.doi.org/10.1007/s11357-022-00569-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 44 2022 3 21 04 1825-1845
allfields_unstemmed	10.1007/s11357-022-00569-5 doi (DE-627)SPR047364459 (SPR)s11357-022-00569-5-e DE-627 ger DE-627 rakwb eng Horvath, Steve verfasserin (orcid)0000-0002-4110-3589 aut Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. Opossum (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Development (dpeaa)DE-He213 Epigenetic clock (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Haghani, Amin aut Zoller, Joseph A. aut Raj, Ken aut Sinha, Ishani aut Robeck, Todd R. aut Black, Pete aut Couzens, Aidan aut Lau, Clive aut Manoyan, Meghety aut Ruiz, Yadiamaris Aviles aut Talbott, Annais aut Belov, Katherine aut Hogg, Carolyn J. aut Sears, Karen E. aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 44(2022), 3 vom: 21. Apr., Seite 1825-1845 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:44 year:2022 number:3 day:21 month:04 pages:1825-1845 https://dx.doi.org/10.1007/s11357-022-00569-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 44 2022 3 21 04 1825-1845
allfieldsGer	10.1007/s11357-022-00569-5 doi (DE-627)SPR047364459 (SPR)s11357-022-00569-5-e DE-627 ger DE-627 rakwb eng Horvath, Steve verfasserin (orcid)0000-0002-4110-3589 aut Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. Opossum (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Development (dpeaa)DE-He213 Epigenetic clock (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Haghani, Amin aut Zoller, Joseph A. aut Raj, Ken aut Sinha, Ishani aut Robeck, Todd R. aut Black, Pete aut Couzens, Aidan aut Lau, Clive aut Manoyan, Meghety aut Ruiz, Yadiamaris Aviles aut Talbott, Annais aut Belov, Katherine aut Hogg, Carolyn J. aut Sears, Karen E. aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 44(2022), 3 vom: 21. Apr., Seite 1825-1845 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:44 year:2022 number:3 day:21 month:04 pages:1825-1845 https://dx.doi.org/10.1007/s11357-022-00569-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 44 2022 3 21 04 1825-1845
allfieldsSound	10.1007/s11357-022-00569-5 doi (DE-627)SPR047364459 (SPR)s11357-022-00569-5-e DE-627 ger DE-627 rakwb eng Horvath, Steve verfasserin (orcid)0000-0002-4110-3589 aut Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. Opossum (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Development (dpeaa)DE-He213 Epigenetic clock (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Haghani, Amin aut Zoller, Joseph A. aut Raj, Ken aut Sinha, Ishani aut Robeck, Todd R. aut Black, Pete aut Couzens, Aidan aut Lau, Clive aut Manoyan, Meghety aut Ruiz, Yadiamaris Aviles aut Talbott, Annais aut Belov, Katherine aut Hogg, Carolyn J. aut Sears, Karen E. aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 44(2022), 3 vom: 21. Apr., Seite 1825-1845 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:44 year:2022 number:3 day:21 month:04 pages:1825-1845 https://dx.doi.org/10.1007/s11357-022-00569-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 44 2022 3 21 04 1825-1845
language	English
source	Enthalten in Age 44(2022), 3 vom: 21. Apr., Seite 1825-1845 volume:44 year:2022 number:3 day:21 month:04 pages:1825-1845
sourceStr	Enthalten in Age 44(2022), 3 vom: 21. Apr., Seite 1825-1845 volume:44 year:2022 number:3 day:21 month:04 pages:1825-1845
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Opossum Aging Development Epigenetic clock DNA methylation
isfreeaccess_bool	true
container_title	Age
authorswithroles_txt_mv	Horvath, Steve @@aut@@ Haghani, Amin @@aut@@ Zoller, Joseph A. @@aut@@ Raj, Ken @@aut@@ Sinha, Ishani @@aut@@ Robeck, Todd R. @@aut@@ Black, Pete @@aut@@ Couzens, Aidan @@aut@@ Lau, Clive @@aut@@ Manoyan, Meghety @@aut@@ Ruiz, Yadiamaris Aviles @@aut@@ Talbott, Annais @@aut@@ Belov, Katherine @@aut@@ Hogg, Carolyn J. @@aut@@ Sears, Karen E. @@aut@@
publishDateDaySort_date	2022-04-21T00:00:00Z
hierarchy_top_id	499546180
id	SPR047364459
language_de	englisch
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author	Horvath, Steve
spellingShingle	Horvath, Steve misc Opossum misc Aging misc Development misc Epigenetic clock misc DNA methylation Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies
authorStr	Horvath, Steve
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topic_title	Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies Opossum (dpeaa)DE-He213 Aging (dpeaa)DE-He213 Development (dpeaa)DE-He213 Epigenetic clock (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213
topic	misc Opossum misc Aging misc Development misc Epigenetic clock misc DNA methylation
topic_unstemmed	misc Opossum misc Aging misc Development misc Epigenetic clock misc DNA methylation
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title	Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies
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title_full	Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies
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author_browse	Horvath, Steve Haghani, Amin Zoller, Joseph A. Raj, Ken Sinha, Ishani Robeck, Todd R. Black, Pete Couzens, Aidan Lau, Clive Manoyan, Meghety Ruiz, Yadiamaris Aviles Talbott, Annais Belov, Katherine Hogg, Carolyn J. Sears, Karen E.
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title_sort	epigenetic clock and methylation studies in marsupials: opossums, tasmanian devils, kangaroos, and wallabies
title_auth	Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies
abstract	Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. © The Author(s) 2022
abstractGer	Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. © The Author(s) 2022
abstract_unstemmed	Abstract The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data from n = 100 opossum samples from the ear, liver, and tail. We contrasted postnatal development and later aging effects in the opossum methylome with those in mouse (Mus musculus, C57BL/6 J strain) and other marsupial species such as Tasmanian devil, kangaroos, and wallabies. While the opossum methylome is similar to that of mouse during postnatal development, it is distinct from that shared by other mammals when it comes to the age-related gain of methylation at target sites of polycomb repressive complex 2. Our immunohistochemical staining results provide additional support for the hypothesis that PRC2 activity increases with later aging in mouse tissues but remains constant in opossum tissues. We present several epigenetic clocks for opossums that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (opossum and human). Two dual-species human-opossum pan-tissue clocks accurately measure chronological age and relative age, respectively. The human-opossum epigenetic clocks are expected to provide a significant boost to the attractiveness of opossum as a biological model. Additional epigenetic clocks for Tasmanian devil, red kangaroos and other species of the genus Macropus may aid species conservation efforts. © The Author(s) 2022
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title_short	Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies
url	https://dx.doi.org/10.1007/s11357-022-00569-5
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Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies

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