Functional individual variability development of the neonatal brain

Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significa...
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Autor*in:	Gao, Wenjian [verfasserIn] Huang, Ziyi Ou, Wenfei Tang, Xiaoqian Lv, Wanying Nie, Jingxin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Individual variability Neonate fMRI Neuro development

Anmerkung:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022

Übergeordnetes Werk:	Enthalten in: Anatomy and embryology - Berlin : Springer, 1891, 227(2022), 6 vom: 06. Juni, Seite 2181-2190
Übergeordnetes Werk:	volume:227 ; year:2022 ; number:6 ; day:06 ; month:06 ; pages:2181-2190

Links:	Volltext

DOI / URN:	10.1007/s00429-022-02516-8

Katalog-ID:	SPR047397837

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allfields	10.1007/s00429-022-02516-8 doi (DE-627)SPR047397837 (SPR)s00429-022-02516-8-e DE-627 ger DE-627 rakwb eng Gao, Wenjian verfasserin aut Functional individual variability development of the neonatal brain 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. Individual variability (dpeaa)DE-He213 Neonate (dpeaa)DE-He213 fMRI (dpeaa)DE-He213 Neuro development (dpeaa)DE-He213 Huang, Ziyi aut Ou, Wenfei aut Tang, Xiaoqian aut Lv, Wanying aut Nie, Jingxin (orcid)0000-0002-0237-2559 aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 227(2022), 6 vom: 06. Juni, Seite 2181-2190 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:227 year:2022 number:6 day:06 month:06 pages:2181-2190 https://dx.doi.org/10.1007/s00429-022-02516-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 AR 227 2022 6 06 06 2181-2190
spelling	10.1007/s00429-022-02516-8 doi (DE-627)SPR047397837 (SPR)s00429-022-02516-8-e DE-627 ger DE-627 rakwb eng Gao, Wenjian verfasserin aut Functional individual variability development of the neonatal brain 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. Individual variability (dpeaa)DE-He213 Neonate (dpeaa)DE-He213 fMRI (dpeaa)DE-He213 Neuro development (dpeaa)DE-He213 Huang, Ziyi aut Ou, Wenfei aut Tang, Xiaoqian aut Lv, Wanying aut Nie, Jingxin (orcid)0000-0002-0237-2559 aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 227(2022), 6 vom: 06. Juni, Seite 2181-2190 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:227 year:2022 number:6 day:06 month:06 pages:2181-2190 https://dx.doi.org/10.1007/s00429-022-02516-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 AR 227 2022 6 06 06 2181-2190
allfields_unstemmed	10.1007/s00429-022-02516-8 doi (DE-627)SPR047397837 (SPR)s00429-022-02516-8-e DE-627 ger DE-627 rakwb eng Gao, Wenjian verfasserin aut Functional individual variability development of the neonatal brain 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. Individual variability (dpeaa)DE-He213 Neonate (dpeaa)DE-He213 fMRI (dpeaa)DE-He213 Neuro development (dpeaa)DE-He213 Huang, Ziyi aut Ou, Wenfei aut Tang, Xiaoqian aut Lv, Wanying aut Nie, Jingxin (orcid)0000-0002-0237-2559 aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 227(2022), 6 vom: 06. Juni, Seite 2181-2190 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:227 year:2022 number:6 day:06 month:06 pages:2181-2190 https://dx.doi.org/10.1007/s00429-022-02516-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 AR 227 2022 6 06 06 2181-2190
allfieldsGer	10.1007/s00429-022-02516-8 doi (DE-627)SPR047397837 (SPR)s00429-022-02516-8-e DE-627 ger DE-627 rakwb eng Gao, Wenjian verfasserin aut Functional individual variability development of the neonatal brain 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. Individual variability (dpeaa)DE-He213 Neonate (dpeaa)DE-He213 fMRI (dpeaa)DE-He213 Neuro development (dpeaa)DE-He213 Huang, Ziyi aut Ou, Wenfei aut Tang, Xiaoqian aut Lv, Wanying aut Nie, Jingxin (orcid)0000-0002-0237-2559 aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 227(2022), 6 vom: 06. Juni, Seite 2181-2190 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:227 year:2022 number:6 day:06 month:06 pages:2181-2190 https://dx.doi.org/10.1007/s00429-022-02516-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 AR 227 2022 6 06 06 2181-2190
allfieldsSound	10.1007/s00429-022-02516-8 doi (DE-627)SPR047397837 (SPR)s00429-022-02516-8-e DE-627 ger DE-627 rakwb eng Gao, Wenjian verfasserin aut Functional individual variability development of the neonatal brain 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. Individual variability (dpeaa)DE-He213 Neonate (dpeaa)DE-He213 fMRI (dpeaa)DE-He213 Neuro development (dpeaa)DE-He213 Huang, Ziyi aut Ou, Wenfei aut Tang, Xiaoqian aut Lv, Wanying aut Nie, Jingxin (orcid)0000-0002-0237-2559 aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 227(2022), 6 vom: 06. Juni, Seite 2181-2190 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:227 year:2022 number:6 day:06 month:06 pages:2181-2190 https://dx.doi.org/10.1007/s00429-022-02516-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 AR 227 2022 6 06 06 2181-2190
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source	Enthalten in Anatomy and embryology 227(2022), 6 vom: 06. Juni, Seite 2181-2190 volume:227 year:2022 number:6 day:06 month:06 pages:2181-2190
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author	Gao, Wenjian
spellingShingle	Gao, Wenjian misc Individual variability misc Neonate misc fMRI misc Neuro development Functional individual variability development of the neonatal brain
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topic_title	Functional individual variability development of the neonatal brain Individual variability (dpeaa)DE-He213 Neonate (dpeaa)DE-He213 fMRI (dpeaa)DE-He213 Neuro development (dpeaa)DE-He213
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title	Functional individual variability development of the neonatal brain
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title_full	Functional individual variability development of the neonatal brain
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author_browse	Gao, Wenjian Huang, Ziyi Ou, Wenfei Tang, Xiaoqian Lv, Wanying Nie, Jingxin
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title_sort	functional individual variability development of the neonatal brain
title_auth	Functional individual variability development of the neonatal brain
abstract	Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
abstractGer	Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
abstract_unstemmed	Abstract Individual variability in cognition and behavior results from the differences in brain structure and function that have already emerged before birth. However, little is known about individual variability in brain functional architecture at local level in neonates which is of great significance to explore owing to largely undeveloped long-range functional connectivity and segregated functions in early brain development. To address this, resting-state fMRI data of 163 neonates ranged from 32 to 45 postconceptional weeks (PCW) were used in this study, and various functional features including functional parcellation similarity, local brain activity and local functional connectivity were used to characterize individual functional variability. We observed significantly higher local functional individual variability in superior parietal, sensorimotor, and visual cortex, and lower variability in the frontal, insula and cingulate cortex relative to other regions within each hemisphere. The mean local functional individual variability significantly increased with age, and the age effect was found larger in brain regions such as the occipital, temporal, prefrontal and parietal cortex. Our findings promote the understanding of brain plasticity and regional differential maturation in the early stage. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
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title_short	Functional individual variability development of the neonatal brain
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