The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis

Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chaulagain, Dipak [verfasserIn] Smolanka, Volodymyr Smolanka, Andriy Munakomi, Sunil Havryliv, Taras

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Extent of resection Low-grade astrocytoma Gross total resection

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Egyptian journal of neurosurgery - Berlin : Springer, 2014, 37(2022), 1 vom: 04. Juli
Übergeordnetes Werk:	volume:37 ; year:2022 ; number:1 ; day:04 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s41984-022-00161-1

Katalog-ID:	SPR047486228

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520			\|a Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection.
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allfields	10.1186/s41984-022-00161-1 doi (DE-627)SPR047486228 (SPR)s41984-022-00161-1-e DE-627 ger DE-627 rakwb eng Chaulagain, Dipak verfasserin (orcid)0000-0001-6428-8371 aut The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. Extent of resection (dpeaa)DE-He213 Low-grade astrocytoma (dpeaa)DE-He213 Gross total resection (dpeaa)DE-He213 Smolanka, Volodymyr (orcid)0000-0001-7296-8297 aut Smolanka, Andriy (orcid)0000-0002-6582-9472 aut Munakomi, Sunil (orcid)0000-0001-6079-3792 aut Havryliv, Taras (orcid)0000-0003-0271-8983 aut Enthalten in Egyptian journal of neurosurgery Berlin : Springer, 2014 37(2022), 1 vom: 04. Juli (DE-627)1024903680 (DE-600)2933751-3 2520-8225 nnns volume:37 year:2022 number:1 day:04 month:07 https://dx.doi.org/10.1186/s41984-022-00161-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2022 1 04 07
spelling	10.1186/s41984-022-00161-1 doi (DE-627)SPR047486228 (SPR)s41984-022-00161-1-e DE-627 ger DE-627 rakwb eng Chaulagain, Dipak verfasserin (orcid)0000-0001-6428-8371 aut The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. Extent of resection (dpeaa)DE-He213 Low-grade astrocytoma (dpeaa)DE-He213 Gross total resection (dpeaa)DE-He213 Smolanka, Volodymyr (orcid)0000-0001-7296-8297 aut Smolanka, Andriy (orcid)0000-0002-6582-9472 aut Munakomi, Sunil (orcid)0000-0001-6079-3792 aut Havryliv, Taras (orcid)0000-0003-0271-8983 aut Enthalten in Egyptian journal of neurosurgery Berlin : Springer, 2014 37(2022), 1 vom: 04. Juli (DE-627)1024903680 (DE-600)2933751-3 2520-8225 nnns volume:37 year:2022 number:1 day:04 month:07 https://dx.doi.org/10.1186/s41984-022-00161-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2022 1 04 07
allfields_unstemmed	10.1186/s41984-022-00161-1 doi (DE-627)SPR047486228 (SPR)s41984-022-00161-1-e DE-627 ger DE-627 rakwb eng Chaulagain, Dipak verfasserin (orcid)0000-0001-6428-8371 aut The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. Extent of resection (dpeaa)DE-He213 Low-grade astrocytoma (dpeaa)DE-He213 Gross total resection (dpeaa)DE-He213 Smolanka, Volodymyr (orcid)0000-0001-7296-8297 aut Smolanka, Andriy (orcid)0000-0002-6582-9472 aut Munakomi, Sunil (orcid)0000-0001-6079-3792 aut Havryliv, Taras (orcid)0000-0003-0271-8983 aut Enthalten in Egyptian journal of neurosurgery Berlin : Springer, 2014 37(2022), 1 vom: 04. Juli (DE-627)1024903680 (DE-600)2933751-3 2520-8225 nnns volume:37 year:2022 number:1 day:04 month:07 https://dx.doi.org/10.1186/s41984-022-00161-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2022 1 04 07
allfieldsGer	10.1186/s41984-022-00161-1 doi (DE-627)SPR047486228 (SPR)s41984-022-00161-1-e DE-627 ger DE-627 rakwb eng Chaulagain, Dipak verfasserin (orcid)0000-0001-6428-8371 aut The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. Extent of resection (dpeaa)DE-He213 Low-grade astrocytoma (dpeaa)DE-He213 Gross total resection (dpeaa)DE-He213 Smolanka, Volodymyr (orcid)0000-0001-7296-8297 aut Smolanka, Andriy (orcid)0000-0002-6582-9472 aut Munakomi, Sunil (orcid)0000-0001-6079-3792 aut Havryliv, Taras (orcid)0000-0003-0271-8983 aut Enthalten in Egyptian journal of neurosurgery Berlin : Springer, 2014 37(2022), 1 vom: 04. Juli (DE-627)1024903680 (DE-600)2933751-3 2520-8225 nnns volume:37 year:2022 number:1 day:04 month:07 https://dx.doi.org/10.1186/s41984-022-00161-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2022 1 04 07
allfieldsSound	10.1186/s41984-022-00161-1 doi (DE-627)SPR047486228 (SPR)s41984-022-00161-1-e DE-627 ger DE-627 rakwb eng Chaulagain, Dipak verfasserin (orcid)0000-0001-6428-8371 aut The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. Extent of resection (dpeaa)DE-He213 Low-grade astrocytoma (dpeaa)DE-He213 Gross total resection (dpeaa)DE-He213 Smolanka, Volodymyr (orcid)0000-0001-7296-8297 aut Smolanka, Andriy (orcid)0000-0002-6582-9472 aut Munakomi, Sunil (orcid)0000-0001-6079-3792 aut Havryliv, Taras (orcid)0000-0003-0271-8983 aut Enthalten in Egyptian journal of neurosurgery Berlin : Springer, 2014 37(2022), 1 vom: 04. Juli (DE-627)1024903680 (DE-600)2933751-3 2520-8225 nnns volume:37 year:2022 number:1 day:04 month:07 https://dx.doi.org/10.1186/s41984-022-00161-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2022 1 04 07
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Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Extent of resection</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Low-grade astrocytoma</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gross total resection</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Smolanka, Volodymyr</subfield><subfield code="0">(orcid)0000-0001-7296-8297</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Smolanka, Andriy</subfield><subfield code="0">(orcid)0000-0002-6582-9472</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Munakomi, Sunil</subfield><subfield code="0">(orcid)0000-0001-6079-3792</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Havryliv, Taras</subfield><subfield code="0">(orcid)0000-0003-0271-8983</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Egyptian journal of neurosurgery</subfield><subfield code="d">Berlin : Springer, 2014</subfield><subfield code="g">37(2022), 1 vom: 04. 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author	Chaulagain, Dipak
spellingShingle	Chaulagain, Dipak misc Extent of resection misc Low-grade astrocytoma misc Gross total resection The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis
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topic_title	The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis Extent of resection (dpeaa)DE-He213 Low-grade astrocytoma (dpeaa)DE-He213 Gross total resection (dpeaa)DE-He213
topic	misc Extent of resection misc Low-grade astrocytoma misc Gross total resection
topic_unstemmed	misc Extent of resection misc Low-grade astrocytoma misc Gross total resection
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title	The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis
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title_full	The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis
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title_sort	role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis
title_auth	The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis
abstract	Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. © The Author(s) 2022
abstractGer	Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. © The Author(s) 2022
abstract_unstemmed	Purpose To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of low-grade astrocytoma. Materials and methods A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to November 14, 2021. All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the hazards ratio (HR) and corresponding 95% confidence interval. Result Five cohort studies were selected for meta-analysis. There was statistically significant effect of total resection on increase mortality after surgery in low-grade astrocytoma patients (HR = 0.70 [0.52, 0.94]; p = 0.02; I2 = Not applicable). On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. The gross total resection surgery should be preferred over subtotal resection since the incidence of malignant formation is low in gross total resection. © The Author(s) 2022
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title_short	The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis
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author2	Smolanka, Volodymyr Smolanka, Andriy Munakomi, Sunil Havryliv, Taras
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up_date	2024-07-04T03:17:08.937Z
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On the other hand, there was statistically nonsignificant effect of patient’s age (HR = 1.27 [0.95, 1.68]; p = 0.11; I2 = 83%), tumor size (HR = 1.13 [0.94, 1.35]; p = 0.19; I2 = 73%), and increasing KPS (HR = 0.59 [0.20, 1.77]; p = 0.35; I2 = 86%) on prognosis of low-grade astrocytoma after surgery. Conclusion The results of meta-analysis showed significant relationship of extent of resection and mortality, while factors such age, KPS score, and tumor size were nonsignificant to determine mortality in patient diagnosed with low-grade astrocytoma. 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The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis

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