Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers

Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiar...
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Autor*in:	Devaraja, K. [verfasserIn] Pujary, Kailesh Ramaswamy, Balakrishnan Nayak, Dipak Ranjan Shenoy, Kallya Rajgopal Rao, Prerit

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Hypopharyngeal cancer Total laryngopharyngectomy Gastric pull-up Gastric transposition Jejunal free flap Pharyngeal reconstruction

Anmerkung:	© Association of Otolaryngologists of India 2020

Übergeordnetes Werk:	Enthalten in: Indian journal of otolaryngology and head and neck surgery - New Delhi : Springer, 1950, 74(2020), 2 vom: 29. Jan., Seite 127-135
Übergeordnetes Werk:	volume:74 ; year:2020 ; number:2 ; day:29 ; month:01 ; pages:127-135

Links:	Volltext

DOI / URN:	10.1007/s12070-020-01806-z

Katalog-ID:	SPR047502916

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520			\|a Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative.
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allfields	10.1007/s12070-020-01806-z doi (DE-627)SPR047502916 (SPR)s12070-020-01806-z-e DE-627 ger DE-627 rakwb eng Devaraja, K. verfasserin aut Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association of Otolaryngologists of India 2020 Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. Hypopharyngeal cancer (dpeaa)DE-He213 Total laryngopharyngectomy (dpeaa)DE-He213 Gastric pull-up (dpeaa)DE-He213 Gastric transposition (dpeaa)DE-He213 Jejunal free flap (dpeaa)DE-He213 Pharyngeal reconstruction (dpeaa)DE-He213 Pujary, Kailesh (orcid)0000-0001-5200-6680 aut Ramaswamy, Balakrishnan aut Nayak, Dipak Ranjan aut Shenoy, Kallya Rajgopal aut Rao, Prerit aut Enthalten in Indian journal of otolaryngology and head and neck surgery New Delhi : Springer, 1950 74(2020), 2 vom: 29. Jan., Seite 127-135 (DE-627)482304308 (DE-600)2181728-5 0973-7707 nnns volume:74 year:2020 number:2 day:29 month:01 pages:127-135 https://dx.doi.org/10.1007/s12070-020-01806-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 74 2020 2 29 01 127-135
spelling	10.1007/s12070-020-01806-z doi (DE-627)SPR047502916 (SPR)s12070-020-01806-z-e DE-627 ger DE-627 rakwb eng Devaraja, K. verfasserin aut Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association of Otolaryngologists of India 2020 Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. Hypopharyngeal cancer (dpeaa)DE-He213 Total laryngopharyngectomy (dpeaa)DE-He213 Gastric pull-up (dpeaa)DE-He213 Gastric transposition (dpeaa)DE-He213 Jejunal free flap (dpeaa)DE-He213 Pharyngeal reconstruction (dpeaa)DE-He213 Pujary, Kailesh (orcid)0000-0001-5200-6680 aut Ramaswamy, Balakrishnan aut Nayak, Dipak Ranjan aut Shenoy, Kallya Rajgopal aut Rao, Prerit aut Enthalten in Indian journal of otolaryngology and head and neck surgery New Delhi : Springer, 1950 74(2020), 2 vom: 29. Jan., Seite 127-135 (DE-627)482304308 (DE-600)2181728-5 0973-7707 nnns volume:74 year:2020 number:2 day:29 month:01 pages:127-135 https://dx.doi.org/10.1007/s12070-020-01806-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 74 2020 2 29 01 127-135
allfields_unstemmed	10.1007/s12070-020-01806-z doi (DE-627)SPR047502916 (SPR)s12070-020-01806-z-e DE-627 ger DE-627 rakwb eng Devaraja, K. verfasserin aut Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association of Otolaryngologists of India 2020 Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. Hypopharyngeal cancer (dpeaa)DE-He213 Total laryngopharyngectomy (dpeaa)DE-He213 Gastric pull-up (dpeaa)DE-He213 Gastric transposition (dpeaa)DE-He213 Jejunal free flap (dpeaa)DE-He213 Pharyngeal reconstruction (dpeaa)DE-He213 Pujary, Kailesh (orcid)0000-0001-5200-6680 aut Ramaswamy, Balakrishnan aut Nayak, Dipak Ranjan aut Shenoy, Kallya Rajgopal aut Rao, Prerit aut Enthalten in Indian journal of otolaryngology and head and neck surgery New Delhi : Springer, 1950 74(2020), 2 vom: 29. Jan., Seite 127-135 (DE-627)482304308 (DE-600)2181728-5 0973-7707 nnns volume:74 year:2020 number:2 day:29 month:01 pages:127-135 https://dx.doi.org/10.1007/s12070-020-01806-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 74 2020 2 29 01 127-135
allfieldsGer	10.1007/s12070-020-01806-z doi (DE-627)SPR047502916 (SPR)s12070-020-01806-z-e DE-627 ger DE-627 rakwb eng Devaraja, K. verfasserin aut Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association of Otolaryngologists of India 2020 Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. Hypopharyngeal cancer (dpeaa)DE-He213 Total laryngopharyngectomy (dpeaa)DE-He213 Gastric pull-up (dpeaa)DE-He213 Gastric transposition (dpeaa)DE-He213 Jejunal free flap (dpeaa)DE-He213 Pharyngeal reconstruction (dpeaa)DE-He213 Pujary, Kailesh (orcid)0000-0001-5200-6680 aut Ramaswamy, Balakrishnan aut Nayak, Dipak Ranjan aut Shenoy, Kallya Rajgopal aut Rao, Prerit aut Enthalten in Indian journal of otolaryngology and head and neck surgery New Delhi : Springer, 1950 74(2020), 2 vom: 29. Jan., Seite 127-135 (DE-627)482304308 (DE-600)2181728-5 0973-7707 nnns volume:74 year:2020 number:2 day:29 month:01 pages:127-135 https://dx.doi.org/10.1007/s12070-020-01806-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 74 2020 2 29 01 127-135
allfieldsSound	10.1007/s12070-020-01806-z doi (DE-627)SPR047502916 (SPR)s12070-020-01806-z-e DE-627 ger DE-627 rakwb eng Devaraja, K. verfasserin aut Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association of Otolaryngologists of India 2020 Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. Hypopharyngeal cancer (dpeaa)DE-He213 Total laryngopharyngectomy (dpeaa)DE-He213 Gastric pull-up (dpeaa)DE-He213 Gastric transposition (dpeaa)DE-He213 Jejunal free flap (dpeaa)DE-He213 Pharyngeal reconstruction (dpeaa)DE-He213 Pujary, Kailesh (orcid)0000-0001-5200-6680 aut Ramaswamy, Balakrishnan aut Nayak, Dipak Ranjan aut Shenoy, Kallya Rajgopal aut Rao, Prerit aut Enthalten in Indian journal of otolaryngology and head and neck surgery New Delhi : Springer, 1950 74(2020), 2 vom: 29. Jan., Seite 127-135 (DE-627)482304308 (DE-600)2181728-5 0973-7707 nnns volume:74 year:2020 number:2 day:29 month:01 pages:127-135 https://dx.doi.org/10.1007/s12070-020-01806-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 74 2020 2 29 01 127-135
language	English
source	Enthalten in Indian journal of otolaryngology and head and neck surgery 74(2020), 2 vom: 29. Jan., Seite 127-135 volume:74 year:2020 number:2 day:29 month:01 pages:127-135
sourceStr	Enthalten in Indian journal of otolaryngology and head and neck surgery 74(2020), 2 vom: 29. Jan., Seite 127-135 volume:74 year:2020 number:2 day:29 month:01 pages:127-135
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Hypopharyngeal cancer Total laryngopharyngectomy Gastric pull-up Gastric transposition Jejunal free flap Pharyngeal reconstruction
isfreeaccess_bool	false
container_title	Indian journal of otolaryngology and head and neck surgery
authorswithroles_txt_mv	Devaraja, K. @@aut@@ Pujary, Kailesh @@aut@@ Ramaswamy, Balakrishnan @@aut@@ Nayak, Dipak Ranjan @@aut@@ Shenoy, Kallya Rajgopal @@aut@@ Rao, Prerit @@aut@@
publishDateDaySort_date	2020-01-29T00:00:00Z
hierarchy_top_id	482304308
id	SPR047502916
language_de	englisch
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author	Devaraja, K.
spellingShingle	Devaraja, K. misc Hypopharyngeal cancer misc Total laryngopharyngectomy misc Gastric pull-up misc Gastric transposition misc Jejunal free flap misc Pharyngeal reconstruction Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers
authorStr	Devaraja, K.
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topic_title	Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers Hypopharyngeal cancer (dpeaa)DE-He213 Total laryngopharyngectomy (dpeaa)DE-He213 Gastric pull-up (dpeaa)DE-He213 Gastric transposition (dpeaa)DE-He213 Jejunal free flap (dpeaa)DE-He213 Pharyngeal reconstruction (dpeaa)DE-He213
topic	misc Hypopharyngeal cancer misc Total laryngopharyngectomy misc Gastric pull-up misc Gastric transposition misc Jejunal free flap misc Pharyngeal reconstruction
topic_unstemmed	misc Hypopharyngeal cancer misc Total laryngopharyngectomy misc Gastric pull-up misc Gastric transposition misc Jejunal free flap misc Pharyngeal reconstruction
topic_browse	misc Hypopharyngeal cancer misc Total laryngopharyngectomy misc Gastric pull-up misc Gastric transposition misc Jejunal free flap misc Pharyngeal reconstruction
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title	Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers
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title_full	Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers
author_sort	Devaraja, K.
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author_browse	Devaraja, K. Pujary, Kailesh Ramaswamy, Balakrishnan Nayak, Dipak Ranjan Shenoy, Kallya Rajgopal Rao, Prerit
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title_sort	role of total laryngopharyngoesophagectomy with gastric pull up in the management of locally advanced hypopharyngeal cancers
title_auth	Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers
abstract	Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. © Association of Otolaryngologists of India 2020
abstractGer	Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. © Association of Otolaryngologists of India 2020
abstract_unstemmed	Abstract The current consensus in the management of hypopharyngeal cancers favors the non-surgical management. However, many studies have reported relatively better oncological and functional outcomes with the surgical approach in locally advanced hypopharyngeal cancers. In here, we report a tertiary care center’s experience with total laryngopharyngoesophagectomy with gastric pull-up done for such cases. We also describe a slight modification of the procedure that has been followed at our institute, and discuss its advantages. It is a retrospective study of patients who have undergone the surgical procedure between the September 2016 and the March 2019. The primary objective was to analyze the surgical complications and the benefits in terms of disease clearance, survival duration, and functional outcomes. Study consisted of 15 patients, mostly men, with mean age of 56 years. 12/15 had stage IV disease and 7/15 were failed chemoradiotherapy. Most common complication of surgery was anastomotic failure (33%). Perioperative mortality rate was 13.3%. Higher complications could probably be attributed to poor nutrition and tension over the anastomosis. Mean survival duration and disease free interval were 12.1 and 11 months, respectively. Oral feeds was restored in 77%, and the average time to restore oral feeds was 17 days. Most of our results were comparable with the literature, which supports the surgical excision of larynx–pharynx–esophagus and reconstruction by pull-up, in all those medically fit cases of radio-recurrent/residual tumors, and also in primary cases of locally advanced hypopharyngeal cancers with non-functional larynx. In these scenarios, the radical surgical treatment would atleast serve as palliative if not curative. © Association of Otolaryngologists of India 2020
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title_short	Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers
url	https://dx.doi.org/10.1007/s12070-020-01806-z
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author2	Pujary, Kailesh Ramaswamy, Balakrishnan Nayak, Dipak Ranjan Shenoy, Kallya Rajgopal Rao, Prerit
author2Str	Pujary, Kailesh Ramaswamy, Balakrishnan Nayak, Dipak Ranjan Shenoy, Kallya Rajgopal Rao, Prerit
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doi_str	10.1007/s12070-020-01806-z
up_date	2024-07-04T03:20:30.378Z
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