Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer

Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to co...
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Autor*in:	Lee, Esther [verfasserIn] Crowder, Hannah R. Gorelik, Daniel Badger, Christopher Schottler, Jennifer Li, Ning-Wei Siegel, Robert Sadeghi, Nader Thakkar, Punam G. Joshi, Arjun S. Goodman, Joseph F.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Oropharyngeal squamous cell carcinoma Neoadjuvant chemotherapy Transoral robotic surgery Swallowing Quality of life University of Washington Quality of Life (UW-QOL)

Anmerkung:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022

Übergeordnetes Werk:	Enthalten in: European archives of oto-rhino-laryngology and head & neck - Berlin : Springer, 1864, 279(2022), 9 vom: 23. Apr., Seite 4533-4540
Übergeordnetes Werk:	volume:279 ; year:2022 ; number:9 ; day:23 ; month:04 ; pages:4533-4540

Links:	Volltext

DOI / URN:	10.1007/s00405-022-07387-7

Katalog-ID:	SPR047803665

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520			\|a Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains.
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allfields	10.1007/s00405-022-07387-7 doi (DE-627)SPR047803665 (SPR)s00405-022-07387-7-e DE-627 ger DE-627 rakwb eng Lee, Esther verfasserin (orcid)0000-0002-5820-6111 aut Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. Oropharyngeal squamous cell carcinoma (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Transoral robotic surgery (dpeaa)DE-He213 Swallowing (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 University of Washington Quality of Life (UW-QOL) (dpeaa)DE-He213 Crowder, Hannah R. aut Gorelik, Daniel aut Badger, Christopher aut Schottler, Jennifer aut Li, Ning-Wei aut Siegel, Robert aut Sadeghi, Nader aut Thakkar, Punam G. aut Joshi, Arjun S. aut Goodman, Joseph F. aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 279(2022), 9 vom: 23. Apr., Seite 4533-4540 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:279 year:2022 number:9 day:23 month:04 pages:4533-4540 https://dx.doi.org/10.1007/s00405-022-07387-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 279 2022 9 23 04 4533-4540
spelling	10.1007/s00405-022-07387-7 doi (DE-627)SPR047803665 (SPR)s00405-022-07387-7-e DE-627 ger DE-627 rakwb eng Lee, Esther verfasserin (orcid)0000-0002-5820-6111 aut Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. Oropharyngeal squamous cell carcinoma (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Transoral robotic surgery (dpeaa)DE-He213 Swallowing (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 University of Washington Quality of Life (UW-QOL) (dpeaa)DE-He213 Crowder, Hannah R. aut Gorelik, Daniel aut Badger, Christopher aut Schottler, Jennifer aut Li, Ning-Wei aut Siegel, Robert aut Sadeghi, Nader aut Thakkar, Punam G. aut Joshi, Arjun S. aut Goodman, Joseph F. aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 279(2022), 9 vom: 23. Apr., Seite 4533-4540 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:279 year:2022 number:9 day:23 month:04 pages:4533-4540 https://dx.doi.org/10.1007/s00405-022-07387-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 279 2022 9 23 04 4533-4540
allfields_unstemmed	10.1007/s00405-022-07387-7 doi (DE-627)SPR047803665 (SPR)s00405-022-07387-7-e DE-627 ger DE-627 rakwb eng Lee, Esther verfasserin (orcid)0000-0002-5820-6111 aut Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. Oropharyngeal squamous cell carcinoma (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Transoral robotic surgery (dpeaa)DE-He213 Swallowing (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 University of Washington Quality of Life (UW-QOL) (dpeaa)DE-He213 Crowder, Hannah R. aut Gorelik, Daniel aut Badger, Christopher aut Schottler, Jennifer aut Li, Ning-Wei aut Siegel, Robert aut Sadeghi, Nader aut Thakkar, Punam G. aut Joshi, Arjun S. aut Goodman, Joseph F. aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 279(2022), 9 vom: 23. Apr., Seite 4533-4540 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:279 year:2022 number:9 day:23 month:04 pages:4533-4540 https://dx.doi.org/10.1007/s00405-022-07387-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 279 2022 9 23 04 4533-4540
allfieldsGer	10.1007/s00405-022-07387-7 doi (DE-627)SPR047803665 (SPR)s00405-022-07387-7-e DE-627 ger DE-627 rakwb eng Lee, Esther verfasserin (orcid)0000-0002-5820-6111 aut Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. Oropharyngeal squamous cell carcinoma (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Transoral robotic surgery (dpeaa)DE-He213 Swallowing (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 University of Washington Quality of Life (UW-QOL) (dpeaa)DE-He213 Crowder, Hannah R. aut Gorelik, Daniel aut Badger, Christopher aut Schottler, Jennifer aut Li, Ning-Wei aut Siegel, Robert aut Sadeghi, Nader aut Thakkar, Punam G. aut Joshi, Arjun S. aut Goodman, Joseph F. aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 279(2022), 9 vom: 23. Apr., Seite 4533-4540 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:279 year:2022 number:9 day:23 month:04 pages:4533-4540 https://dx.doi.org/10.1007/s00405-022-07387-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 279 2022 9 23 04 4533-4540
allfieldsSound	10.1007/s00405-022-07387-7 doi (DE-627)SPR047803665 (SPR)s00405-022-07387-7-e DE-627 ger DE-627 rakwb eng Lee, Esther verfasserin (orcid)0000-0002-5820-6111 aut Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. Oropharyngeal squamous cell carcinoma (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Transoral robotic surgery (dpeaa)DE-He213 Swallowing (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 University of Washington Quality of Life (UW-QOL) (dpeaa)DE-He213 Crowder, Hannah R. aut Gorelik, Daniel aut Badger, Christopher aut Schottler, Jennifer aut Li, Ning-Wei aut Siegel, Robert aut Sadeghi, Nader aut Thakkar, Punam G. aut Joshi, Arjun S. aut Goodman, Joseph F. aut Enthalten in European archives of oto-rhino-laryngology and head & neck Berlin : Springer, 1864 279(2022), 9 vom: 23. Apr., Seite 4533-4540 (DE-627)253722667 (DE-600)1459042-6 1434-4726 nnns volume:279 year:2022 number:9 day:23 month:04 pages:4533-4540 https://dx.doi.org/10.1007/s00405-022-07387-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 279 2022 9 23 04 4533-4540
language	English
source	Enthalten in European archives of oto-rhino-laryngology and head & neck 279(2022), 9 vom: 23. Apr., Seite 4533-4540 volume:279 year:2022 number:9 day:23 month:04 pages:4533-4540
sourceStr	Enthalten in European archives of oto-rhino-laryngology and head & neck 279(2022), 9 vom: 23. Apr., Seite 4533-4540 volume:279 year:2022 number:9 day:23 month:04 pages:4533-4540
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Oropharyngeal squamous cell carcinoma Neoadjuvant chemotherapy Transoral robotic surgery Swallowing Quality of life University of Washington Quality of Life (UW-QOL)
isfreeaccess_bool	false
container_title	European archives of oto-rhino-laryngology and head & neck
authorswithroles_txt_mv	Lee, Esther @@aut@@ Crowder, Hannah R. @@aut@@ Gorelik, Daniel @@aut@@ Badger, Christopher @@aut@@ Schottler, Jennifer @@aut@@ Li, Ning-Wei @@aut@@ Siegel, Robert @@aut@@ Sadeghi, Nader @@aut@@ Thakkar, Punam G. @@aut@@ Joshi, Arjun S. @@aut@@ Goodman, Joseph F. @@aut@@
publishDateDaySort_date	2022-04-23T00:00:00Z
hierarchy_top_id	253722667
id	SPR047803665
language_de	englisch
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author	Lee, Esther
spellingShingle	Lee, Esther misc Oropharyngeal squamous cell carcinoma misc Neoadjuvant chemotherapy misc Transoral robotic surgery misc Swallowing misc Quality of life misc University of Washington Quality of Life (UW-QOL) Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer
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topic_title	Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer Oropharyngeal squamous cell carcinoma (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Transoral robotic surgery (dpeaa)DE-He213 Swallowing (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 University of Washington Quality of Life (UW-QOL) (dpeaa)DE-He213
topic	misc Oropharyngeal squamous cell carcinoma misc Neoadjuvant chemotherapy misc Transoral robotic surgery misc Swallowing misc Quality of life misc University of Washington Quality of Life (UW-QOL)
topic_unstemmed	misc Oropharyngeal squamous cell carcinoma misc Neoadjuvant chemotherapy misc Transoral robotic surgery misc Swallowing misc Quality of life misc University of Washington Quality of Life (UW-QOL)
topic_browse	misc Oropharyngeal squamous cell carcinoma misc Neoadjuvant chemotherapy misc Transoral robotic surgery misc Swallowing misc Quality of life misc University of Washington Quality of Life (UW-QOL)
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title	Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer
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title_full	Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer
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author_browse	Lee, Esther Crowder, Hannah R. Gorelik, Daniel Badger, Christopher Schottler, Jennifer Li, Ning-Wei Siegel, Robert Sadeghi, Nader Thakkar, Punam G. Joshi, Arjun S. Goodman, Joseph F.
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title_sort	comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer
title_auth	Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer
abstract	Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
abstractGer	Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
abstract_unstemmed	Background Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). Conclusion NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
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title_short	Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer
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author2	Crowder, Hannah R. Gorelik, Daniel Badger, Christopher Schottler, Jennifer Li, Ning-Wei Siegel, Robert Sadeghi, Nader Thakkar, Punam G. Joshi, Arjun S. Goodman, Joseph F.
author2Str	Crowder, Hannah R. Gorelik, Daniel Badger, Christopher Schottler, Jennifer Li, Ning-Wei Siegel, Robert Sadeghi, Nader Thakkar, Punam G. Joshi, Arjun S. Goodman, Joseph F.
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doi_str	10.1007/s00405-022-07387-7
up_date	2024-07-03T15:04:56.743Z
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Methods All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. Results The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0–7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). 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Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer

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