Dark Mold Infections in Solid Organ Transplant Recipients
Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from ot...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Boyer, Johannes [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Current fungal infection reports - Philadelphia, Pa. : Current Medicine Group, 2007, 16(2022), 3 vom: 30. Juli, Seite 107-115 |
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| Übergeordnetes Werk: |
volume:16 ; year:2022 ; number:3 ; day:30 ; month:07 ; pages:107-115 |
| Links: |
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| DOI / URN: |
10.1007/s12281-022-00436-y |
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| Katalog-ID: |
SPR047938870 |
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| 520 | |a Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. | ||
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10.1007/s12281-022-00436-y doi (DE-627)SPR047938870 (SPR)s12281-022-00436-y-e DE-627 ger DE-627 rakwb eng Boyer, Johannes verfasserin (orcid)0000-0001-8783-1306 aut Dark Mold Infections in Solid Organ Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. Transplantation (dpeaa)DE-He213 Rare molds (dpeaa)DE-He213 Mucormycosis (dpeaa)DE-He213 Phaeohyphomycosis (dpeaa)DE-He213 Black molds (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Kriegl, Lisa aut Krause, Robert aut Hoenigl, Martin (orcid)0000-0002-1653-2824 aut Enthalten in Current fungal infection reports Philadelphia, Pa. : Current Medicine Group, 2007 16(2022), 3 vom: 30. Juli, Seite 107-115 (DE-627)563171448 (DE-600)2421752-9 1936-377X nnns volume:16 year:2022 number:3 day:30 month:07 pages:107-115 https://dx.doi.org/10.1007/s12281-022-00436-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2022 3 30 07 107-115 |
| spelling |
10.1007/s12281-022-00436-y doi (DE-627)SPR047938870 (SPR)s12281-022-00436-y-e DE-627 ger DE-627 rakwb eng Boyer, Johannes verfasserin (orcid)0000-0001-8783-1306 aut Dark Mold Infections in Solid Organ Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. Transplantation (dpeaa)DE-He213 Rare molds (dpeaa)DE-He213 Mucormycosis (dpeaa)DE-He213 Phaeohyphomycosis (dpeaa)DE-He213 Black molds (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Kriegl, Lisa aut Krause, Robert aut Hoenigl, Martin (orcid)0000-0002-1653-2824 aut Enthalten in Current fungal infection reports Philadelphia, Pa. : Current Medicine Group, 2007 16(2022), 3 vom: 30. Juli, Seite 107-115 (DE-627)563171448 (DE-600)2421752-9 1936-377X nnns volume:16 year:2022 number:3 day:30 month:07 pages:107-115 https://dx.doi.org/10.1007/s12281-022-00436-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2022 3 30 07 107-115 |
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10.1007/s12281-022-00436-y doi (DE-627)SPR047938870 (SPR)s12281-022-00436-y-e DE-627 ger DE-627 rakwb eng Boyer, Johannes verfasserin (orcid)0000-0001-8783-1306 aut Dark Mold Infections in Solid Organ Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. Transplantation (dpeaa)DE-He213 Rare molds (dpeaa)DE-He213 Mucormycosis (dpeaa)DE-He213 Phaeohyphomycosis (dpeaa)DE-He213 Black molds (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Kriegl, Lisa aut Krause, Robert aut Hoenigl, Martin (orcid)0000-0002-1653-2824 aut Enthalten in Current fungal infection reports Philadelphia, Pa. : Current Medicine Group, 2007 16(2022), 3 vom: 30. Juli, Seite 107-115 (DE-627)563171448 (DE-600)2421752-9 1936-377X nnns volume:16 year:2022 number:3 day:30 month:07 pages:107-115 https://dx.doi.org/10.1007/s12281-022-00436-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2022 3 30 07 107-115 |
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10.1007/s12281-022-00436-y doi (DE-627)SPR047938870 (SPR)s12281-022-00436-y-e DE-627 ger DE-627 rakwb eng Boyer, Johannes verfasserin (orcid)0000-0001-8783-1306 aut Dark Mold Infections in Solid Organ Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. Transplantation (dpeaa)DE-He213 Rare molds (dpeaa)DE-He213 Mucormycosis (dpeaa)DE-He213 Phaeohyphomycosis (dpeaa)DE-He213 Black molds (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Kriegl, Lisa aut Krause, Robert aut Hoenigl, Martin (orcid)0000-0002-1653-2824 aut Enthalten in Current fungal infection reports Philadelphia, Pa. : Current Medicine Group, 2007 16(2022), 3 vom: 30. Juli, Seite 107-115 (DE-627)563171448 (DE-600)2421752-9 1936-377X nnns volume:16 year:2022 number:3 day:30 month:07 pages:107-115 https://dx.doi.org/10.1007/s12281-022-00436-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2022 3 30 07 107-115 |
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10.1007/s12281-022-00436-y doi (DE-627)SPR047938870 (SPR)s12281-022-00436-y-e DE-627 ger DE-627 rakwb eng Boyer, Johannes verfasserin (orcid)0000-0001-8783-1306 aut Dark Mold Infections in Solid Organ Transplant Recipients 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. Transplantation (dpeaa)DE-He213 Rare molds (dpeaa)DE-He213 Mucormycosis (dpeaa)DE-He213 Phaeohyphomycosis (dpeaa)DE-He213 Black molds (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Kriegl, Lisa aut Krause, Robert aut Hoenigl, Martin (orcid)0000-0002-1653-2824 aut Enthalten in Current fungal infection reports Philadelphia, Pa. : Current Medicine Group, 2007 16(2022), 3 vom: 30. Juli, Seite 107-115 (DE-627)563171448 (DE-600)2421752-9 1936-377X nnns volume:16 year:2022 number:3 day:30 month:07 pages:107-115 https://dx.doi.org/10.1007/s12281-022-00436-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2022 3 30 07 107-115 |
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Boyer, Johannes |
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Dark Mold Infections in Solid Organ Transplant Recipients |
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dark mold infections in solid organ transplant recipients |
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Dark Mold Infections in Solid Organ Transplant Recipients |
| abstract |
Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Purpose of Review Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity and mortality are high, and the treatment may differ substantially from other more common invasive fungal infections. Recent Findings The incidence of black molds tends to be increasing. While the backbone of diagnosis remain traditional tools like histopathology and culture, the rapid evolution of non-culture-based methods for molecular detection promises improved identification of these rare fungi. While for many of those rare fungal infections liposomal amphotericin B remains the treatment of choice, mold active triazoles are the backbone for treatment of scedosporiosis and lomentosporiosis. New antifungal agents like ibrexafungerp, olorofim, and fosmanogepix may provide additional treatment options for the future. Summary In this paper, we review infections caused by black molds in SOT recipients. The focus lies on epidemiology, diagnostic work-up, and antifungal treatment. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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3 |
| title_short |
Dark Mold Infections in Solid Organ Transplant Recipients |
| url |
https://dx.doi.org/10.1007/s12281-022-00436-y |
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Kriegl, Lisa Krause, Robert Hoenigl, Martin |
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Kriegl, Lisa Krause, Robert Hoenigl, Martin |
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| doi_str |
10.1007/s12281-022-00436-y |
| up_date |
2024-07-03T15:59:36.591Z |
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1803574183554187264 |
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| score |
7.401865 |