Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device
Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nano...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mehrabi, Kamyar [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Analytical and bioanalytical chemistry - Berlin : Springer, 2002, 414(2022), 23 vom: 22. Juli, Seite 6743-6751 |
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| Übergeordnetes Werk: |
volume:414 ; year:2022 ; number:23 ; day:22 ; month:07 ; pages:6743-6751 |
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| DOI / URN: |
10.1007/s00216-022-04234-w |
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SPR047997265 |
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| 520 | |a Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract | ||
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| 700 | 1 | |a Dengler, Monika |4 aut | |
| 700 | 1 | |a Nilsson, Inga |4 aut | |
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| 700 | 1 | |a Mora, Carlos A. |4 aut | |
| 700 | 1 | |a Günther, Detlef |4 aut | |
| 700 | 1 | |a Gundlach-Graham, Alexander |4 aut | |
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10.1007/s00216-022-04234-w doi (DE-627)SPR047997265 (SPR)s00216-022-04234-w-e DE-627 ger DE-627 rakwb eng Mehrabi, Kamyar verfasserin aut Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2022 Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract Nanomaterial (dpeaa)DE-He213 Single-particle analysis (dpeaa)DE-He213 spICP-TOFMS (dpeaa)DE-He213 Medical device regulation (dpeaa)DE-He213 Aggregation (dpeaa)DE-He213 Dengler, Monika aut Nilsson, Inga aut Baumgartner, Manuel aut Mora, Carlos A. aut Günther, Detlef aut Gundlach-Graham, Alexander aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 414(2022), 23 vom: 22. Juli, Seite 6743-6751 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:414 year:2022 number:23 day:22 month:07 pages:6743-6751 https://dx.doi.org/10.1007/s00216-022-04234-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 414 2022 23 22 07 6743-6751 |
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10.1007/s00216-022-04234-w doi (DE-627)SPR047997265 (SPR)s00216-022-04234-w-e DE-627 ger DE-627 rakwb eng Mehrabi, Kamyar verfasserin aut Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2022 Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract Nanomaterial (dpeaa)DE-He213 Single-particle analysis (dpeaa)DE-He213 spICP-TOFMS (dpeaa)DE-He213 Medical device regulation (dpeaa)DE-He213 Aggregation (dpeaa)DE-He213 Dengler, Monika aut Nilsson, Inga aut Baumgartner, Manuel aut Mora, Carlos A. aut Günther, Detlef aut Gundlach-Graham, Alexander aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 414(2022), 23 vom: 22. Juli, Seite 6743-6751 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:414 year:2022 number:23 day:22 month:07 pages:6743-6751 https://dx.doi.org/10.1007/s00216-022-04234-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 414 2022 23 22 07 6743-6751 |
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10.1007/s00216-022-04234-w doi (DE-627)SPR047997265 (SPR)s00216-022-04234-w-e DE-627 ger DE-627 rakwb eng Mehrabi, Kamyar verfasserin aut Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2022 Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract Nanomaterial (dpeaa)DE-He213 Single-particle analysis (dpeaa)DE-He213 spICP-TOFMS (dpeaa)DE-He213 Medical device regulation (dpeaa)DE-He213 Aggregation (dpeaa)DE-He213 Dengler, Monika aut Nilsson, Inga aut Baumgartner, Manuel aut Mora, Carlos A. aut Günther, Detlef aut Gundlach-Graham, Alexander aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 414(2022), 23 vom: 22. Juli, Seite 6743-6751 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:414 year:2022 number:23 day:22 month:07 pages:6743-6751 https://dx.doi.org/10.1007/s00216-022-04234-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 414 2022 23 22 07 6743-6751 |
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10.1007/s00216-022-04234-w doi (DE-627)SPR047997265 (SPR)s00216-022-04234-w-e DE-627 ger DE-627 rakwb eng Mehrabi, Kamyar verfasserin aut Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2022 Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract Nanomaterial (dpeaa)DE-He213 Single-particle analysis (dpeaa)DE-He213 spICP-TOFMS (dpeaa)DE-He213 Medical device regulation (dpeaa)DE-He213 Aggregation (dpeaa)DE-He213 Dengler, Monika aut Nilsson, Inga aut Baumgartner, Manuel aut Mora, Carlos A. aut Günther, Detlef aut Gundlach-Graham, Alexander aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 414(2022), 23 vom: 22. Juli, Seite 6743-6751 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:414 year:2022 number:23 day:22 month:07 pages:6743-6751 https://dx.doi.org/10.1007/s00216-022-04234-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 414 2022 23 22 07 6743-6751 |
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10.1007/s00216-022-04234-w doi (DE-627)SPR047997265 (SPR)s00216-022-04234-w-e DE-627 ger DE-627 rakwb eng Mehrabi, Kamyar verfasserin aut Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2022 Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract Nanomaterial (dpeaa)DE-He213 Single-particle analysis (dpeaa)DE-He213 spICP-TOFMS (dpeaa)DE-He213 Medical device regulation (dpeaa)DE-He213 Aggregation (dpeaa)DE-He213 Dengler, Monika aut Nilsson, Inga aut Baumgartner, Manuel aut Mora, Carlos A. aut Günther, Detlef aut Gundlach-Graham, Alexander aut Enthalten in Analytical and bioanalytical chemistry Berlin : Springer, 2002 414(2022), 23 vom: 22. Juli, Seite 6743-6751 (DE-627)25372337X (DE-600)1459122-4 1618-2650 nnns volume:414 year:2022 number:23 day:22 month:07 pages:6743-6751 https://dx.doi.org/10.1007/s00216-022-04234-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 414 2022 23 22 07 6743-6751 |
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Mehrabi, Kamyar @@aut@@ Dengler, Monika @@aut@@ Nilsson, Inga @@aut@@ Baumgartner, Manuel @@aut@@ Mora, Carlos A. @@aut@@ Günther, Detlef @@aut@@ Gundlach-Graham, Alexander @@aut@@ |
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Mehrabi, Kamyar |
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Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device Nanomaterial (dpeaa)DE-He213 Single-particle analysis (dpeaa)DE-He213 spICP-TOFMS (dpeaa)DE-He213 Medical device regulation (dpeaa)DE-He213 Aggregation (dpeaa)DE-He213 |
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Mehrabi, Kamyar Dengler, Monika Nilsson, Inga Baumgartner, Manuel Mora, Carlos A. Günther, Detlef Gundlach-Graham, Alexander |
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detection of magnetic iron nanoparticles by single-particle icp-tofms: case study for a magnetic filtration medical device |
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Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device |
| abstract |
Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract © Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
| abstractGer |
Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract © Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
| abstract_unstemmed |
Nanoparticles are increasingly used in medical products and devices. Their properties are critical for such applications, as particle characteristics determine their interaction with the biological system, and, therefore, the performance and safety of the final product. Among the most important nanoparticle characteristics and parameters are particle mass distribution, composition, total particle mass, and number concentration. In this study, we utilize single-particle inductively coupled plasma time-of-flight mass spectrometry (spICP-TOFMS) for the characterization of inorganic nanoparticles in complex biological fluids. We report online microdroplet calibration for reference-nanomaterial-free and matrix-matched calibration of carbon-coated iron carbide nanoparticles (C/$ Fe_{3} $C NPs). As a case study, we analyze C/$ Fe_{3} $C NPs designed for targeted blood purification. Through the analysis of NP mass distributions, we study the effect of the NP surface modification on aggregation of C/$ Fe_{3} $C NPs in whole blood. We also demonstrate the efficiency of removal of coated C/$ Fe_{3} $C NP from saline by magnetically enhanced filters. Magnetic filtering is shown to reduce the mass concentration of detectable C/$ Fe_{3} $C NPs by 99.99 ± 0.01% in water. Graphical abstract © Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
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Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device |
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https://dx.doi.org/10.1007/s00216-022-04234-w |
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Dengler, Monika Nilsson, Inga Baumgartner, Manuel Mora, Carlos A. Günther, Detlef Gundlach-Graham, Alexander |
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Dengler, Monika Nilsson, Inga Baumgartner, Manuel Mora, Carlos A. Günther, Detlef Gundlach-Graham, Alexander |
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|
| score |
7.40158 |