OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis

Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chen, Xiuju [verfasserIn] Zhu, Wenyue Li, Xiaoxin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Biomarkers Fluorescein angiography Uveitis Optical coherence tomography Vascular leakage

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Ophthalmology and therapy - Berlin : SpringerOpen, 2012, 11(2022), 5 vom: 18. Aug., Seite 1913-1924
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:5 ; day:18 ; month:08 ; pages:1913-1924

Links:	Volltext

DOI / URN:	10.1007/s40123-022-00558-z

Katalog-ID:	SPR04800345X

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520			\|a Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis.
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allfields	10.1007/s40123-022-00558-z doi (DE-627)SPR04800345X (SPR)s40123-022-00558-z-e DE-627 ger DE-627 rakwb eng Chen, Xiuju verfasserin aut OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. Biomarkers (dpeaa)DE-He213 Fluorescein angiography (dpeaa)DE-He213 Uveitis (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Vascular leakage (dpeaa)DE-He213 Zhu, Wenyue aut Li, Xiaoxin aut Enthalten in Ophthalmology and therapy Berlin : SpringerOpen, 2012 11(2022), 5 vom: 18. Aug., Seite 1913-1924 (DE-627)726126225 (DE-600)2682230-1 2193-6528 nnns volume:11 year:2022 number:5 day:18 month:08 pages:1913-1924 https://dx.doi.org/10.1007/s40123-022-00558-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5 18 08 1913-1924
spelling	10.1007/s40123-022-00558-z doi (DE-627)SPR04800345X (SPR)s40123-022-00558-z-e DE-627 ger DE-627 rakwb eng Chen, Xiuju verfasserin aut OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. Biomarkers (dpeaa)DE-He213 Fluorescein angiography (dpeaa)DE-He213 Uveitis (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Vascular leakage (dpeaa)DE-He213 Zhu, Wenyue aut Li, Xiaoxin aut Enthalten in Ophthalmology and therapy Berlin : SpringerOpen, 2012 11(2022), 5 vom: 18. Aug., Seite 1913-1924 (DE-627)726126225 (DE-600)2682230-1 2193-6528 nnns volume:11 year:2022 number:5 day:18 month:08 pages:1913-1924 https://dx.doi.org/10.1007/s40123-022-00558-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5 18 08 1913-1924
allfields_unstemmed	10.1007/s40123-022-00558-z doi (DE-627)SPR04800345X (SPR)s40123-022-00558-z-e DE-627 ger DE-627 rakwb eng Chen, Xiuju verfasserin aut OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. Biomarkers (dpeaa)DE-He213 Fluorescein angiography (dpeaa)DE-He213 Uveitis (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Vascular leakage (dpeaa)DE-He213 Zhu, Wenyue aut Li, Xiaoxin aut Enthalten in Ophthalmology and therapy Berlin : SpringerOpen, 2012 11(2022), 5 vom: 18. Aug., Seite 1913-1924 (DE-627)726126225 (DE-600)2682230-1 2193-6528 nnns volume:11 year:2022 number:5 day:18 month:08 pages:1913-1924 https://dx.doi.org/10.1007/s40123-022-00558-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5 18 08 1913-1924
allfieldsGer	10.1007/s40123-022-00558-z doi (DE-627)SPR04800345X (SPR)s40123-022-00558-z-e DE-627 ger DE-627 rakwb eng Chen, Xiuju verfasserin aut OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. Biomarkers (dpeaa)DE-He213 Fluorescein angiography (dpeaa)DE-He213 Uveitis (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Vascular leakage (dpeaa)DE-He213 Zhu, Wenyue aut Li, Xiaoxin aut Enthalten in Ophthalmology and therapy Berlin : SpringerOpen, 2012 11(2022), 5 vom: 18. Aug., Seite 1913-1924 (DE-627)726126225 (DE-600)2682230-1 2193-6528 nnns volume:11 year:2022 number:5 day:18 month:08 pages:1913-1924 https://dx.doi.org/10.1007/s40123-022-00558-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5 18 08 1913-1924
allfieldsSound	10.1007/s40123-022-00558-z doi (DE-627)SPR04800345X (SPR)s40123-022-00558-z-e DE-627 ger DE-627 rakwb eng Chen, Xiuju verfasserin aut OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. Biomarkers (dpeaa)DE-He213 Fluorescein angiography (dpeaa)DE-He213 Uveitis (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Vascular leakage (dpeaa)DE-He213 Zhu, Wenyue aut Li, Xiaoxin aut Enthalten in Ophthalmology and therapy Berlin : SpringerOpen, 2012 11(2022), 5 vom: 18. Aug., Seite 1913-1924 (DE-627)726126225 (DE-600)2682230-1 2193-6528 nnns volume:11 year:2022 number:5 day:18 month:08 pages:1913-1924 https://dx.doi.org/10.1007/s40123-022-00558-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 5 18 08 1913-1924
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Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. 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author	Chen, Xiuju
spellingShingle	Chen, Xiuju misc Biomarkers misc Fluorescein angiography misc Uveitis misc Optical coherence tomography misc Vascular leakage OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis
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topic_title	OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis Biomarkers (dpeaa)DE-He213 Fluorescein angiography (dpeaa)DE-He213 Uveitis (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Vascular leakage (dpeaa)DE-He213
topic	misc Biomarkers misc Fluorescein angiography misc Uveitis misc Optical coherence tomography misc Vascular leakage
topic_unstemmed	misc Biomarkers misc Fluorescein angiography misc Uveitis misc Optical coherence tomography misc Vascular leakage
topic_browse	misc Biomarkers misc Fluorescein angiography misc Uveitis misc Optical coherence tomography misc Vascular leakage
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title	OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis
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title_full	OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis
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title_sort	oct macular volume as a predictor of vascular leakage in uveitis
title_auth	OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis
abstract	Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. © The Author(s) 2022
abstractGer	Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. © The Author(s) 2022
abstract_unstemmed	Introduction This study aimed to evaluate the optical coherence tomography (OCT) macular volume as a marker for active vascular leakage in patients with intermediate and pan uveitis. Methods In this single-center prospective longitudinal study, patients were included under three criteria: diagnosed with noninfectious intermediate or pan uveitis; presented vascular leakage at their initial visit; and were imaged with concurrent wide-field fluorescein angiography (FA) and OCT. A scoring system was employed to measure vascular leakage. OCT volume scans were performed on the patients to produce the corresponding thickness map. The central subfield thickness (CST) and macular volume (MV) were calculated. CST is defined as the average thickness within the 1-mm fovea circle, while MV includes the 3-mm and 6-mm circles on the thickness map. Mixed-effects models were applied to analyze the correlation between each patient’s OCT and FA imaging results. Results A total of 72 patients (115 eyes) were included. The median follow-up time was 11 months (interquartile range 1.8–16.1 months). A total of 679 observations across all time points were analyzed. Both CST and MV were found to be positively associated with the leakage scores (p < 0.001). In the mixed-effects models, MV in the 6-mm circle presented the strongest correlation with leakage scores, which explained 57% of the variation in leakage (p < 0.001). MV in the 3-mm circle and CST explained 45.8% and 39.5%, respectively. Conclusion CST and MV in both the 6-mm and the 3-mm circles demonstrated significant correlations with angiographic inflammatory activity. Among those imaging parameters, MV in the 6-mm circle has the highest correlation. The study results suggest that this parameter can be considered a quantitative and non-invasive alternative to FA for monitoring vasculitic inflammation in uveitis. © The Author(s) 2022
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title_short	OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis
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OCT Macular Volume as a Predictor of Vascular Leakage in Uveitis

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