Recommendation on an updated standardization of serum magnesium reference ranges

Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a mag...
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Autor*in:	Rosanoff, Andrea [verfasserIn] West, Christina Elin, Ronald J. Micke, Oliver Baniasadi, Shadi Barbagallo, Mario Campbell, Emily Cheng, Fu-Chou Costello, Rebecca B. Gamboa-Gomez, Claudia Guerrero-Romero, Fernando Gletsu-Miller, Nana von Ehrlich, Bodo Iotti, Stefano Kahe, Ka Kim, Dae Jung Kisters, Klaus Kolisek, Martin Kraus, Anton Maier, Jeanette A. Maj-Zurawska, Magdalena Merolle, Lucia Nechifor, Mihai Pourdowlat, Guitti Shechter, Michael Song, Yiqing Teoh, Yee Ping Touyz, Rhian M. Wallace, Taylor C. Yokota, Kuninobu Wolf, Federica

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Serum magnesium Serum magnesium reference range Chronic latent magnesium deficit CLMD Hypomagnesemia

Anmerkung:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022

Übergeordnetes Werk:	Enthalten in: Zeitschrift für Ernährungswissenschaft - Darmstadt : Steinkopff, 1960, 61(2022), 7 vom: 10. Juni, Seite 3697-3706
Übergeordnetes Werk:	volume:61 ; year:2022 ; number:7 ; day:10 ; month:06 ; pages:3697-3706

Links:	Volltext

DOI / URN:	10.1007/s00394-022-02916-w

Katalog-ID:	SPR048064254

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520			\|a Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L).
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650		4	\|a Serum magnesium reference range \|7 (dpeaa)DE-He213
650		4	\|a Chronic latent magnesium deficit \|7 (dpeaa)DE-He213
650		4	\|a CLMD \|7 (dpeaa)DE-He213
650		4	\|a Hypomagnesemia \|7 (dpeaa)DE-He213
700	1		\|a West, Christina \|4 aut
700	1		\|a Elin, Ronald J. \|4 aut
700	1		\|a Micke, Oliver \|4 aut
700	1		\|a Baniasadi, Shadi \|4 aut
700	1		\|a Barbagallo, Mario \|4 aut
700	1		\|a Campbell, Emily \|4 aut
700	1		\|a Cheng, Fu-Chou \|4 aut
700	1		\|a Costello, Rebecca B. \|4 aut
700	1		\|a Gamboa-Gomez, Claudia \|4 aut
700	1		\|a Guerrero-Romero, Fernando \|4 aut
700	1		\|a Gletsu-Miller, Nana \|4 aut
700	1		\|a von Ehrlich, Bodo \|4 aut
700	1		\|a Iotti, Stefano \|4 aut
700	1		\|a Kahe, Ka \|4 aut
700	1		\|a Kim, Dae Jung \|4 aut
700	1		\|a Kisters, Klaus \|4 aut
700	1		\|a Kolisek, Martin \|4 aut
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700	1		\|a Shechter, Michael \|4 aut
700	1		\|a Song, Yiqing \|4 aut
700	1		\|a Teoh, Yee Ping \|4 aut
700	1		\|a Touyz, Rhian M. \|4 aut
700	1		\|a Wallace, Taylor C. \|4 aut
700	1		\|a Yokota, Kuninobu \|4 aut
700	1		\|a Wolf, Federica \|4 aut
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allfields	10.1007/s00394-022-02916-w doi (DE-627)SPR048064254 (SPR)s00394-022-02916-w-e DE-627 ger DE-627 rakwb eng Rosanoff, Andrea verfasserin (orcid)0000-0002-7811-9517 aut Recommendation on an updated standardization of serum magnesium reference ranges 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). Serum magnesium (dpeaa)DE-He213 Serum magnesium reference range (dpeaa)DE-He213 Chronic latent magnesium deficit (dpeaa)DE-He213 CLMD (dpeaa)DE-He213 Hypomagnesemia (dpeaa)DE-He213 West, Christina aut Elin, Ronald J. aut Micke, Oliver aut Baniasadi, Shadi aut Barbagallo, Mario aut Campbell, Emily aut Cheng, Fu-Chou aut Costello, Rebecca B. aut Gamboa-Gomez, Claudia aut Guerrero-Romero, Fernando aut Gletsu-Miller, Nana aut von Ehrlich, Bodo aut Iotti, Stefano aut Kahe, Ka aut Kim, Dae Jung aut Kisters, Klaus aut Kolisek, Martin aut Kraus, Anton aut Maier, Jeanette A. aut Maj-Zurawska, Magdalena aut Merolle, Lucia aut Nechifor, Mihai aut Pourdowlat, Guitti aut Shechter, Michael aut Song, Yiqing aut Teoh, Yee Ping aut Touyz, Rhian M. aut Wallace, Taylor C. aut Yokota, Kuninobu aut Wolf, Federica aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 61(2022), 7 vom: 10. Juni, Seite 3697-3706 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:61 year:2022 number:7 day:10 month:06 pages:3697-3706 https://dx.doi.org/10.1007/s00394-022-02916-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 AR 61 2022 7 10 06 3697-3706
spelling	10.1007/s00394-022-02916-w doi (DE-627)SPR048064254 (SPR)s00394-022-02916-w-e DE-627 ger DE-627 rakwb eng Rosanoff, Andrea verfasserin (orcid)0000-0002-7811-9517 aut Recommendation on an updated standardization of serum magnesium reference ranges 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). Serum magnesium (dpeaa)DE-He213 Serum magnesium reference range (dpeaa)DE-He213 Chronic latent magnesium deficit (dpeaa)DE-He213 CLMD (dpeaa)DE-He213 Hypomagnesemia (dpeaa)DE-He213 West, Christina aut Elin, Ronald J. aut Micke, Oliver aut Baniasadi, Shadi aut Barbagallo, Mario aut Campbell, Emily aut Cheng, Fu-Chou aut Costello, Rebecca B. aut Gamboa-Gomez, Claudia aut Guerrero-Romero, Fernando aut Gletsu-Miller, Nana aut von Ehrlich, Bodo aut Iotti, Stefano aut Kahe, Ka aut Kim, Dae Jung aut Kisters, Klaus aut Kolisek, Martin aut Kraus, Anton aut Maier, Jeanette A. aut Maj-Zurawska, Magdalena aut Merolle, Lucia aut Nechifor, Mihai aut Pourdowlat, Guitti aut Shechter, Michael aut Song, Yiqing aut Teoh, Yee Ping aut Touyz, Rhian M. aut Wallace, Taylor C. aut Yokota, Kuninobu aut Wolf, Federica aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 61(2022), 7 vom: 10. Juni, Seite 3697-3706 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:61 year:2022 number:7 day:10 month:06 pages:3697-3706 https://dx.doi.org/10.1007/s00394-022-02916-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 AR 61 2022 7 10 06 3697-3706
allfields_unstemmed	10.1007/s00394-022-02916-w doi (DE-627)SPR048064254 (SPR)s00394-022-02916-w-e DE-627 ger DE-627 rakwb eng Rosanoff, Andrea verfasserin (orcid)0000-0002-7811-9517 aut Recommendation on an updated standardization of serum magnesium reference ranges 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). Serum magnesium (dpeaa)DE-He213 Serum magnesium reference range (dpeaa)DE-He213 Chronic latent magnesium deficit (dpeaa)DE-He213 CLMD (dpeaa)DE-He213 Hypomagnesemia (dpeaa)DE-He213 West, Christina aut Elin, Ronald J. aut Micke, Oliver aut Baniasadi, Shadi aut Barbagallo, Mario aut Campbell, Emily aut Cheng, Fu-Chou aut Costello, Rebecca B. aut Gamboa-Gomez, Claudia aut Guerrero-Romero, Fernando aut Gletsu-Miller, Nana aut von Ehrlich, Bodo aut Iotti, Stefano aut Kahe, Ka aut Kim, Dae Jung aut Kisters, Klaus aut Kolisek, Martin aut Kraus, Anton aut Maier, Jeanette A. aut Maj-Zurawska, Magdalena aut Merolle, Lucia aut Nechifor, Mihai aut Pourdowlat, Guitti aut Shechter, Michael aut Song, Yiqing aut Teoh, Yee Ping aut Touyz, Rhian M. aut Wallace, Taylor C. aut Yokota, Kuninobu aut Wolf, Federica aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 61(2022), 7 vom: 10. Juni, Seite 3697-3706 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:61 year:2022 number:7 day:10 month:06 pages:3697-3706 https://dx.doi.org/10.1007/s00394-022-02916-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 AR 61 2022 7 10 06 3697-3706
allfieldsGer	10.1007/s00394-022-02916-w doi (DE-627)SPR048064254 (SPR)s00394-022-02916-w-e DE-627 ger DE-627 rakwb eng Rosanoff, Andrea verfasserin (orcid)0000-0002-7811-9517 aut Recommendation on an updated standardization of serum magnesium reference ranges 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). Serum magnesium (dpeaa)DE-He213 Serum magnesium reference range (dpeaa)DE-He213 Chronic latent magnesium deficit (dpeaa)DE-He213 CLMD (dpeaa)DE-He213 Hypomagnesemia (dpeaa)DE-He213 West, Christina aut Elin, Ronald J. aut Micke, Oliver aut Baniasadi, Shadi aut Barbagallo, Mario aut Campbell, Emily aut Cheng, Fu-Chou aut Costello, Rebecca B. aut Gamboa-Gomez, Claudia aut Guerrero-Romero, Fernando aut Gletsu-Miller, Nana aut von Ehrlich, Bodo aut Iotti, Stefano aut Kahe, Ka aut Kim, Dae Jung aut Kisters, Klaus aut Kolisek, Martin aut Kraus, Anton aut Maier, Jeanette A. aut Maj-Zurawska, Magdalena aut Merolle, Lucia aut Nechifor, Mihai aut Pourdowlat, Guitti aut Shechter, Michael aut Song, Yiqing aut Teoh, Yee Ping aut Touyz, Rhian M. aut Wallace, Taylor C. aut Yokota, Kuninobu aut Wolf, Federica aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 61(2022), 7 vom: 10. Juni, Seite 3697-3706 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:61 year:2022 number:7 day:10 month:06 pages:3697-3706 https://dx.doi.org/10.1007/s00394-022-02916-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 AR 61 2022 7 10 06 3697-3706
allfieldsSound	10.1007/s00394-022-02916-w doi (DE-627)SPR048064254 (SPR)s00394-022-02916-w-e DE-627 ger DE-627 rakwb eng Rosanoff, Andrea verfasserin (orcid)0000-0002-7811-9517 aut Recommendation on an updated standardization of serum magnesium reference ranges 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). Serum magnesium (dpeaa)DE-He213 Serum magnesium reference range (dpeaa)DE-He213 Chronic latent magnesium deficit (dpeaa)DE-He213 CLMD (dpeaa)DE-He213 Hypomagnesemia (dpeaa)DE-He213 West, Christina aut Elin, Ronald J. aut Micke, Oliver aut Baniasadi, Shadi aut Barbagallo, Mario aut Campbell, Emily aut Cheng, Fu-Chou aut Costello, Rebecca B. aut Gamboa-Gomez, Claudia aut Guerrero-Romero, Fernando aut Gletsu-Miller, Nana aut von Ehrlich, Bodo aut Iotti, Stefano aut Kahe, Ka aut Kim, Dae Jung aut Kisters, Klaus aut Kolisek, Martin aut Kraus, Anton aut Maier, Jeanette A. aut Maj-Zurawska, Magdalena aut Merolle, Lucia aut Nechifor, Mihai aut Pourdowlat, Guitti aut Shechter, Michael aut Song, Yiqing aut Teoh, Yee Ping aut Touyz, Rhian M. aut Wallace, Taylor C. aut Yokota, Kuninobu aut Wolf, Federica aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 61(2022), 7 vom: 10. Juni, Seite 3697-3706 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:61 year:2022 number:7 day:10 month:06 pages:3697-3706 https://dx.doi.org/10.1007/s00394-022-02916-w lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 AR 61 2022 7 10 06 3697-3706
language	English
source	Enthalten in Zeitschrift für Ernährungswissenschaft 61(2022), 7 vom: 10. Juni, Seite 3697-3706 volume:61 year:2022 number:7 day:10 month:06 pages:3697-3706
sourceStr	Enthalten in Zeitschrift für Ernährungswissenschaft 61(2022), 7 vom: 10. Juni, Seite 3697-3706 volume:61 year:2022 number:7 day:10 month:06 pages:3697-3706
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Serum magnesium Serum magnesium reference range Chronic latent magnesium deficit CLMD Hypomagnesemia
isfreeaccess_bool	false
container_title	Zeitschrift für Ernährungswissenschaft
authorswithroles_txt_mv	Rosanoff, Andrea @@aut@@ West, Christina @@aut@@ Elin, Ronald J. @@aut@@ Micke, Oliver @@aut@@ Baniasadi, Shadi @@aut@@ Barbagallo, Mario @@aut@@ Campbell, Emily @@aut@@ Cheng, Fu-Chou @@aut@@ Costello, Rebecca B. @@aut@@ Gamboa-Gomez, Claudia @@aut@@ Guerrero-Romero, Fernando @@aut@@ Gletsu-Miller, Nana @@aut@@ von Ehrlich, Bodo @@aut@@ Iotti, Stefano @@aut@@ Kahe, Ka @@aut@@ Kim, Dae Jung @@aut@@ Kisters, Klaus @@aut@@ Kolisek, Martin @@aut@@ Kraus, Anton @@aut@@ Maier, Jeanette A. @@aut@@ Maj-Zurawska, Magdalena @@aut@@ Merolle, Lucia @@aut@@ Nechifor, Mihai @@aut@@ Pourdowlat, Guitti @@aut@@ Shechter, Michael @@aut@@ Song, Yiqing @@aut@@ Teoh, Yee Ping @@aut@@ Touyz, Rhian M. @@aut@@ Wallace, Taylor C. @@aut@@ Yokota, Kuninobu @@aut@@ Wolf, Federica @@aut@@
publishDateDaySort_date	2022-06-10T00:00:00Z
hierarchy_top_id	461907356
id	SPR048064254
language_de	englisch
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Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. 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author	Rosanoff, Andrea
spellingShingle	Rosanoff, Andrea misc Serum magnesium misc Serum magnesium reference range misc Chronic latent magnesium deficit misc CLMD misc Hypomagnesemia Recommendation on an updated standardization of serum magnesium reference ranges
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topic_title	Recommendation on an updated standardization of serum magnesium reference ranges Serum magnesium (dpeaa)DE-He213 Serum magnesium reference range (dpeaa)DE-He213 Chronic latent magnesium deficit (dpeaa)DE-He213 CLMD (dpeaa)DE-He213 Hypomagnesemia (dpeaa)DE-He213
topic	misc Serum magnesium misc Serum magnesium reference range misc Chronic latent magnesium deficit misc CLMD misc Hypomagnesemia
topic_unstemmed	misc Serum magnesium misc Serum magnesium reference range misc Chronic latent magnesium deficit misc CLMD misc Hypomagnesemia
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title	Recommendation on an updated standardization of serum magnesium reference ranges
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title_full	Recommendation on an updated standardization of serum magnesium reference ranges
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author_browse	Rosanoff, Andrea West, Christina Elin, Ronald J. Micke, Oliver Baniasadi, Shadi Barbagallo, Mario Campbell, Emily Cheng, Fu-Chou Costello, Rebecca B. Gamboa-Gomez, Claudia Guerrero-Romero, Fernando Gletsu-Miller, Nana von Ehrlich, Bodo Iotti, Stefano Kahe, Ka Kim, Dae Jung Kisters, Klaus Kolisek, Martin Kraus, Anton Maier, Jeanette A. Maj-Zurawska, Magdalena Merolle, Lucia Nechifor, Mihai Pourdowlat, Guitti Shechter, Michael Song, Yiqing Teoh, Yee Ping Touyz, Rhian M. Wallace, Taylor C. Yokota, Kuninobu Wolf, Federica
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title_sort	recommendation on an updated standardization of serum magnesium reference ranges
title_auth	Recommendation on an updated standardization of serum magnesium reference ranges
abstract	Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022
abstractGer	Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022
abstract_unstemmed	Purpose Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L). © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022
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title_short	Recommendation on an updated standardization of serum magnesium reference ranges
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author2	West, Christina Elin, Ronald J. Micke, Oliver Baniasadi, Shadi Barbagallo, Mario Campbell, Emily Cheng, Fu-Chou Costello, Rebecca B. Gamboa-Gomez, Claudia Guerrero-Romero, Fernando Gletsu-Miller, Nana von Ehrlich, Bodo Iotti, Stefano Kahe, Ka Kim, Dae Jung Kisters, Klaus Kolisek, Martin Kraus, Anton Maier, Jeanette A. Maj-Zurawska, Magdalena Merolle, Lucia Nechifor, Mihai Pourdowlat, Guitti Shechter, Michael Song, Yiqing Teoh, Yee Ping Touyz, Rhian M. Wallace, Taylor C. Yokota, Kuninobu Wolf, Federica
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Recommendation on an updated standardization of serum magnesium reference ranges

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