Nanotherapeutics in autophagy: a paradigm shift in cancer treatment
Autophagy is a catabolic process in which an organism responds to its nutrient or metabolic emergencies. It involves the degradation of cytoplasmic proteins and organelles by forming double-membrane vesicles called “autophagosomes.” They sequester cargoes, leading them to degradation in the lysosome...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Negi, Shloka [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© Controlled Release Society 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Drug Delivery and Translational Research - New York, NY [u.a.] : Springer, 2011, 12(2022), 11 vom: 11. Feb., Seite 2589-2612 |
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| Übergeordnetes Werk: |
volume:12 ; year:2022 ; number:11 ; day:11 ; month:02 ; pages:2589-2612 |
| Links: |
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| DOI / URN: |
10.1007/s13346-022-01125-6 |
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SPR04821423X |
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| 520 | |a Autophagy is a catabolic process in which an organism responds to its nutrient or metabolic emergencies. It involves the degradation of cytoplasmic proteins and organelles by forming double-membrane vesicles called “autophagosomes.” They sequester cargoes, leading them to degradation in the lysosomes. Although autophagy acts as a protective mechanism for maintaining homeostasis through cellular recycling, it is ostensibly a cause of certain cancers, but a cure for others. In other words, insufficient autophagy, due to genetic or cellular dysfunctions, can lead to tumorigenesis. However, many autophagy modulators are developed for cancer therapy. Diverse nanoparticles have been documented to induce autophagy. Also, the highly stable nanoparticles show blockage to autophagic flux. In this review, we revealed a general mechanism by which autophagy can be induced or blocked via nanoparticles as well as several studies recently performed to prove the stated fact. In addition, we have also elucidated the paradoxical roles of autophagy in cancer and how their differential role at different stages of various cancers can affect its treatment outcomes. And finally, we summarize the breakthroughs in cancer disease treatments by using metallic, polymeric, and liposomal nanoparticles as potent autophagy modulators. Graphical abstract | ||
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| 650 | 4 | |a Apoptosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chemotherapeutic agents |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nanoparticles |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Chaudhuri, Aiswarya |0 (orcid)0000-0002-6045-6590 |4 aut | |
| 700 | 1 | |a Kumar, Dulla Naveen |0 (orcid)0000-0003-2415-7806 |4 aut | |
| 700 | 1 | |a Dehari, Deepa |0 (orcid)0000-0002-2773-0850 |4 aut | |
| 700 | 1 | |a Singh, Sanjay |0 (orcid)0000-0002-6748-0585 |4 aut | |
| 700 | 1 | |a Agrawal, Ashish Kumar |0 (orcid)0000-0002-7302-3647 |4 aut | |
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10.1007/s13346-022-01125-6 doi (DE-627)SPR04821423X (SPR)s13346-022-01125-6-e DE-627 ger DE-627 rakwb eng Negi, Shloka verfasserin (orcid)0000-0002-9839-4030 aut Nanotherapeutics in autophagy: a paradigm shift in cancer treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Controlled Release Society 2022 Autophagy is a catabolic process in which an organism responds to its nutrient or metabolic emergencies. It involves the degradation of cytoplasmic proteins and organelles by forming double-membrane vesicles called “autophagosomes.” They sequester cargoes, leading them to degradation in the lysosomes. Although autophagy acts as a protective mechanism for maintaining homeostasis through cellular recycling, it is ostensibly a cause of certain cancers, but a cure for others. In other words, insufficient autophagy, due to genetic or cellular dysfunctions, can lead to tumorigenesis. However, many autophagy modulators are developed for cancer therapy. Diverse nanoparticles have been documented to induce autophagy. Also, the highly stable nanoparticles show blockage to autophagic flux. In this review, we revealed a general mechanism by which autophagy can be induced or blocked via nanoparticles as well as several studies recently performed to prove the stated fact. In addition, we have also elucidated the paradoxical roles of autophagy in cancer and how their differential role at different stages of various cancers can affect its treatment outcomes. And finally, we summarize the breakthroughs in cancer disease treatments by using metallic, polymeric, and liposomal nanoparticles as potent autophagy modulators. Graphical abstract Autophagy (dpeaa)DE-He213 Autophagosomes (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Chemotherapeutic agents (dpeaa)DE-He213 Nanoparticles (dpeaa)DE-He213 Chaudhuri, Aiswarya (orcid)0000-0002-6045-6590 aut Kumar, Dulla Naveen (orcid)0000-0003-2415-7806 aut Dehari, Deepa (orcid)0000-0002-2773-0850 aut Singh, Sanjay (orcid)0000-0002-6748-0585 aut Agrawal, Ashish Kumar (orcid)0000-0002-7302-3647 aut Enthalten in Drug Delivery and Translational Research New York, NY [u.a.] : Springer, 2011 12(2022), 11 vom: 11. Feb., Seite 2589-2612 (DE-627)644739592 (DE-600)2590155-2 2190-3948 nnns volume:12 year:2022 number:11 day:11 month:02 pages:2589-2612 https://dx.doi.org/10.1007/s13346-022-01125-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2022 11 11 02 2589-2612 |
| spelling |
10.1007/s13346-022-01125-6 doi (DE-627)SPR04821423X (SPR)s13346-022-01125-6-e DE-627 ger DE-627 rakwb eng Negi, Shloka verfasserin (orcid)0000-0002-9839-4030 aut Nanotherapeutics in autophagy: a paradigm shift in cancer treatment 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Controlled Release Society 2022 Autophagy is a catabolic process in which an organism responds to its nutrient or metabolic emergencies. It involves the degradation of cytoplasmic proteins and organelles by forming double-membrane vesicles called “autophagosomes.” They sequester cargoes, leading them to degradation in the lysosomes. Although autophagy acts as a protective mechanism for maintaining homeostasis through cellular recycling, it is ostensibly a cause of certain cancers, but a cure for others. In other words, insufficient autophagy, due to genetic or cellular dysfunctions, can lead to tumorigenesis. However, many autophagy modulators are developed for cancer therapy. Diverse nanoparticles have been documented to induce autophagy. Also, the highly stable nanoparticles show blockage to autophagic flux. In this review, we revealed a general mechanism by which autophagy can be induced or blocked via nanoparticles as well as several studies recently performed to prove the stated fact. In addition, we have also elucidated the paradoxical roles of autophagy in cancer and how their differential role at different stages of various cancers can affect its treatment outcomes. And finally, we summarize the breakthroughs in cancer disease treatments by using metallic, polymeric, and liposomal nanoparticles as potent autophagy modulators. Graphical abstract Autophagy (dpeaa)DE-He213 Autophagosomes (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Chemotherapeutic agents (dpeaa)DE-He213 Nanoparticles (dpeaa)DE-He213 Chaudhuri, Aiswarya (orcid)0000-0002-6045-6590 aut Kumar, Dulla Naveen (orcid)0000-0003-2415-7806 aut Dehari, Deepa (orcid)0000-0002-2773-0850 aut Singh, Sanjay (orcid)0000-0002-6748-0585 aut Agrawal, Ashish Kumar (orcid)0000-0002-7302-3647 aut Enthalten in Drug Delivery and Translational Research New York, NY [u.a.] : Springer, 2011 12(2022), 11 vom: 11. Feb., Seite 2589-2612 (DE-627)644739592 (DE-600)2590155-2 2190-3948 nnns volume:12 year:2022 number:11 day:11 month:02 pages:2589-2612 https://dx.doi.org/10.1007/s13346-022-01125-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2022 11 11 02 2589-2612 |
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Enthalten in Drug Delivery and Translational Research 12(2022), 11 vom: 11. Feb., Seite 2589-2612 volume:12 year:2022 number:11 day:11 month:02 pages:2589-2612 |
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Enthalten in Drug Delivery and Translational Research 12(2022), 11 vom: 11. Feb., Seite 2589-2612 volume:12 year:2022 number:11 day:11 month:02 pages:2589-2612 |
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Autophagy Autophagosomes Apoptosis Cancer Chemotherapeutic agents Nanoparticles |
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Negi, Shloka @@aut@@ Chaudhuri, Aiswarya @@aut@@ Kumar, Dulla Naveen @@aut@@ Dehari, Deepa @@aut@@ Singh, Sanjay @@aut@@ Agrawal, Ashish Kumar @@aut@@ |
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Nanotherapeutics in autophagy: a paradigm shift in cancer treatment Autophagy (dpeaa)DE-He213 Autophagosomes (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Chemotherapeutic agents (dpeaa)DE-He213 Nanoparticles (dpeaa)DE-He213 |
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nanotherapeutics in autophagy: a paradigm shift in cancer treatment |
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Nanotherapeutics in autophagy: a paradigm shift in cancer treatment |
| abstract |
Autophagy is a catabolic process in which an organism responds to its nutrient or metabolic emergencies. It involves the degradation of cytoplasmic proteins and organelles by forming double-membrane vesicles called “autophagosomes.” They sequester cargoes, leading them to degradation in the lysosomes. Although autophagy acts as a protective mechanism for maintaining homeostasis through cellular recycling, it is ostensibly a cause of certain cancers, but a cure for others. In other words, insufficient autophagy, due to genetic or cellular dysfunctions, can lead to tumorigenesis. However, many autophagy modulators are developed for cancer therapy. Diverse nanoparticles have been documented to induce autophagy. Also, the highly stable nanoparticles show blockage to autophagic flux. In this review, we revealed a general mechanism by which autophagy can be induced or blocked via nanoparticles as well as several studies recently performed to prove the stated fact. In addition, we have also elucidated the paradoxical roles of autophagy in cancer and how their differential role at different stages of various cancers can affect its treatment outcomes. And finally, we summarize the breakthroughs in cancer disease treatments by using metallic, polymeric, and liposomal nanoparticles as potent autophagy modulators. Graphical abstract © Controlled Release Society 2022 |
| abstractGer |
Autophagy is a catabolic process in which an organism responds to its nutrient or metabolic emergencies. It involves the degradation of cytoplasmic proteins and organelles by forming double-membrane vesicles called “autophagosomes.” They sequester cargoes, leading them to degradation in the lysosomes. Although autophagy acts as a protective mechanism for maintaining homeostasis through cellular recycling, it is ostensibly a cause of certain cancers, but a cure for others. In other words, insufficient autophagy, due to genetic or cellular dysfunctions, can lead to tumorigenesis. However, many autophagy modulators are developed for cancer therapy. Diverse nanoparticles have been documented to induce autophagy. Also, the highly stable nanoparticles show blockage to autophagic flux. In this review, we revealed a general mechanism by which autophagy can be induced or blocked via nanoparticles as well as several studies recently performed to prove the stated fact. In addition, we have also elucidated the paradoxical roles of autophagy in cancer and how their differential role at different stages of various cancers can affect its treatment outcomes. And finally, we summarize the breakthroughs in cancer disease treatments by using metallic, polymeric, and liposomal nanoparticles as potent autophagy modulators. Graphical abstract © Controlled Release Society 2022 |
| abstract_unstemmed |
Autophagy is a catabolic process in which an organism responds to its nutrient or metabolic emergencies. It involves the degradation of cytoplasmic proteins and organelles by forming double-membrane vesicles called “autophagosomes.” They sequester cargoes, leading them to degradation in the lysosomes. Although autophagy acts as a protective mechanism for maintaining homeostasis through cellular recycling, it is ostensibly a cause of certain cancers, but a cure for others. In other words, insufficient autophagy, due to genetic or cellular dysfunctions, can lead to tumorigenesis. However, many autophagy modulators are developed for cancer therapy. Diverse nanoparticles have been documented to induce autophagy. Also, the highly stable nanoparticles show blockage to autophagic flux. In this review, we revealed a general mechanism by which autophagy can be induced or blocked via nanoparticles as well as several studies recently performed to prove the stated fact. In addition, we have also elucidated the paradoxical roles of autophagy in cancer and how their differential role at different stages of various cancers can affect its treatment outcomes. And finally, we summarize the breakthroughs in cancer disease treatments by using metallic, polymeric, and liposomal nanoparticles as potent autophagy modulators. Graphical abstract © Controlled Release Society 2022 |
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Nanotherapeutics in autophagy: a paradigm shift in cancer treatment |
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Chaudhuri, Aiswarya Kumar, Dulla Naveen Dehari, Deepa Singh, Sanjay Agrawal, Ashish Kumar |
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10.1007/s13346-022-01125-6 |
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2024-07-03T17:45:35.332Z |
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| score |
7.4004126 |