Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers

Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disr...
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Autor*in:	Mukherjee Das, Ankan [verfasserIn] Gogia, Ajay Janardhanan, Rajiv Babu-Rajendran, Ramaswamy Das, Bhudev C.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Phthalates Endocrine-disrupting chemicals Everywhere chemicals Hormone-associated cancers Epidemiology Processed food Food packaging Public health India

Anmerkung:	© Indian Institute of Science 2022

Übergeordnetes Werk:	Enthalten in: Journal of the Indian Institute of Science - [New Delhi] : Springer India, 1914, 102(2022), 2 vom: Apr., Seite 731-742
Übergeordnetes Werk:	volume:102 ; year:2022 ; number:2 ; month:04 ; pages:731-742

Links:	Volltext

DOI / URN:	10.1007/s41745-022-00319-8

Katalog-ID:	SPR048251518

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520			\|a Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India.
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allfields	10.1007/s41745-022-00319-8 doi (DE-627)SPR048251518 (SPR)s41745-022-00319-8-e DE-627 ger DE-627 rakwb eng Mukherjee Das, Ankan verfasserin aut Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Institute of Science 2022 Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. Phthalates (dpeaa)DE-He213 Endocrine-disrupting chemicals (dpeaa)DE-He213 Everywhere chemicals (dpeaa)DE-He213 Hormone-associated cancers (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Processed food (dpeaa)DE-He213 Food packaging (dpeaa)DE-He213 Public health (dpeaa)DE-He213 India (dpeaa)DE-He213 Gogia, Ajay aut Janardhanan, Rajiv aut Babu-Rajendran, Ramaswamy aut Das, Bhudev C. (orcid)0000-0003-0692-3511 aut Enthalten in Journal of the Indian Institute of Science [New Delhi] : Springer India, 1914 102(2022), 2 vom: Apr., Seite 731-742 (DE-627)38292441X (DE-600)2139553-6 0019-4964 nnns volume:102 year:2022 number:2 month:04 pages:731-742 https://dx.doi.org/10.1007/s41745-022-00319-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 102 2022 2 04 731-742
spelling	10.1007/s41745-022-00319-8 doi (DE-627)SPR048251518 (SPR)s41745-022-00319-8-e DE-627 ger DE-627 rakwb eng Mukherjee Das, Ankan verfasserin aut Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Institute of Science 2022 Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. Phthalates (dpeaa)DE-He213 Endocrine-disrupting chemicals (dpeaa)DE-He213 Everywhere chemicals (dpeaa)DE-He213 Hormone-associated cancers (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Processed food (dpeaa)DE-He213 Food packaging (dpeaa)DE-He213 Public health (dpeaa)DE-He213 India (dpeaa)DE-He213 Gogia, Ajay aut Janardhanan, Rajiv aut Babu-Rajendran, Ramaswamy aut Das, Bhudev C. (orcid)0000-0003-0692-3511 aut Enthalten in Journal of the Indian Institute of Science [New Delhi] : Springer India, 1914 102(2022), 2 vom: Apr., Seite 731-742 (DE-627)38292441X (DE-600)2139553-6 0019-4964 nnns volume:102 year:2022 number:2 month:04 pages:731-742 https://dx.doi.org/10.1007/s41745-022-00319-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 102 2022 2 04 731-742
allfields_unstemmed	10.1007/s41745-022-00319-8 doi (DE-627)SPR048251518 (SPR)s41745-022-00319-8-e DE-627 ger DE-627 rakwb eng Mukherjee Das, Ankan verfasserin aut Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Institute of Science 2022 Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. Phthalates (dpeaa)DE-He213 Endocrine-disrupting chemicals (dpeaa)DE-He213 Everywhere chemicals (dpeaa)DE-He213 Hormone-associated cancers (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Processed food (dpeaa)DE-He213 Food packaging (dpeaa)DE-He213 Public health (dpeaa)DE-He213 India (dpeaa)DE-He213 Gogia, Ajay aut Janardhanan, Rajiv aut Babu-Rajendran, Ramaswamy aut Das, Bhudev C. (orcid)0000-0003-0692-3511 aut Enthalten in Journal of the Indian Institute of Science [New Delhi] : Springer India, 1914 102(2022), 2 vom: Apr., Seite 731-742 (DE-627)38292441X (DE-600)2139553-6 0019-4964 nnns volume:102 year:2022 number:2 month:04 pages:731-742 https://dx.doi.org/10.1007/s41745-022-00319-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 102 2022 2 04 731-742
allfieldsGer	10.1007/s41745-022-00319-8 doi (DE-627)SPR048251518 (SPR)s41745-022-00319-8-e DE-627 ger DE-627 rakwb eng Mukherjee Das, Ankan verfasserin aut Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Institute of Science 2022 Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. Phthalates (dpeaa)DE-He213 Endocrine-disrupting chemicals (dpeaa)DE-He213 Everywhere chemicals (dpeaa)DE-He213 Hormone-associated cancers (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Processed food (dpeaa)DE-He213 Food packaging (dpeaa)DE-He213 Public health (dpeaa)DE-He213 India (dpeaa)DE-He213 Gogia, Ajay aut Janardhanan, Rajiv aut Babu-Rajendran, Ramaswamy aut Das, Bhudev C. (orcid)0000-0003-0692-3511 aut Enthalten in Journal of the Indian Institute of Science [New Delhi] : Springer India, 1914 102(2022), 2 vom: Apr., Seite 731-742 (DE-627)38292441X (DE-600)2139553-6 0019-4964 nnns volume:102 year:2022 number:2 month:04 pages:731-742 https://dx.doi.org/10.1007/s41745-022-00319-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 102 2022 2 04 731-742
allfieldsSound	10.1007/s41745-022-00319-8 doi (DE-627)SPR048251518 (SPR)s41745-022-00319-8-e DE-627 ger DE-627 rakwb eng Mukherjee Das, Ankan verfasserin aut Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Institute of Science 2022 Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. Phthalates (dpeaa)DE-He213 Endocrine-disrupting chemicals (dpeaa)DE-He213 Everywhere chemicals (dpeaa)DE-He213 Hormone-associated cancers (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Processed food (dpeaa)DE-He213 Food packaging (dpeaa)DE-He213 Public health (dpeaa)DE-He213 India (dpeaa)DE-He213 Gogia, Ajay aut Janardhanan, Rajiv aut Babu-Rajendran, Ramaswamy aut Das, Bhudev C. (orcid)0000-0003-0692-3511 aut Enthalten in Journal of the Indian Institute of Science [New Delhi] : Springer India, 1914 102(2022), 2 vom: Apr., Seite 731-742 (DE-627)38292441X (DE-600)2139553-6 0019-4964 nnns volume:102 year:2022 number:2 month:04 pages:731-742 https://dx.doi.org/10.1007/s41745-022-00319-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 102 2022 2 04 731-742
language	English
source	Enthalten in Journal of the Indian Institute of Science 102(2022), 2 vom: Apr., Seite 731-742 volume:102 year:2022 number:2 month:04 pages:731-742
sourceStr	Enthalten in Journal of the Indian Institute of Science 102(2022), 2 vom: Apr., Seite 731-742 volume:102 year:2022 number:2 month:04 pages:731-742
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Phthalates Endocrine-disrupting chemicals Everywhere chemicals Hormone-associated cancers Epidemiology Processed food Food packaging Public health India
isfreeaccess_bool	false
container_title	Journal of the Indian Institute of Science
authorswithroles_txt_mv	Mukherjee Das, Ankan @@aut@@ Gogia, Ajay @@aut@@ Janardhanan, Rajiv @@aut@@ Babu-Rajendran, Ramaswamy @@aut@@ Das, Bhudev C. @@aut@@
publishDateDaySort_date	2022-04-01T00:00:00Z
hierarchy_top_id	38292441X
id	SPR048251518
language_de	englisch
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author	Mukherjee Das, Ankan
spellingShingle	Mukherjee Das, Ankan misc Phthalates misc Endocrine-disrupting chemicals misc Everywhere chemicals misc Hormone-associated cancers misc Epidemiology misc Processed food misc Food packaging misc Public health misc India Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers
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topic_title	Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers Phthalates (dpeaa)DE-He213 Endocrine-disrupting chemicals (dpeaa)DE-He213 Everywhere chemicals (dpeaa)DE-He213 Hormone-associated cancers (dpeaa)DE-He213 Epidemiology (dpeaa)DE-He213 Processed food (dpeaa)DE-He213 Food packaging (dpeaa)DE-He213 Public health (dpeaa)DE-He213 India (dpeaa)DE-He213
topic	misc Phthalates misc Endocrine-disrupting chemicals misc Everywhere chemicals misc Hormone-associated cancers misc Epidemiology misc Processed food misc Food packaging misc Public health misc India
topic_unstemmed	misc Phthalates misc Endocrine-disrupting chemicals misc Everywhere chemicals misc Hormone-associated cancers misc Epidemiology misc Processed food misc Food packaging misc Public health misc India
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title	Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers
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title_full	Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers
author_sort	Mukherjee Das, Ankan
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author_browse	Mukherjee Das, Ankan Gogia, Ajay Janardhanan, Rajiv Babu-Rajendran, Ramaswamy Das, Bhudev C.
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author-letter	Mukherjee Das, Ankan
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title_sort	environmental contamination and chronic exposure to endocrine-disrupting phthalates: an overlooked and emerging determinant for hormone-sensitive cancers
title_auth	Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers
abstract	Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. © Indian Institute of Science 2022
abstractGer	Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. © Indian Institute of Science 2022
abstract_unstemmed	Abstract Despite several modifiable and non-modifiable risk factors of hormone-associated cancers have been established, less heed has been paid to chemicals, those having the potential to thwart the body’s normal detox system and affect the endocrine-hormonal pathways. Phthalates are endocrine-disrupting chemicals, most widely manufactured and used indiscriminately in several industries, including processed, ultra-processed and packaged food, single-use plastics, household and personal care/cosmetic products including diapers and electronics. The general population is regularly being exposed to phthalates on contact with these products, especially women and children are most vulnerable. It is therefore highly crucial to monitor and evaluate the biological burden of plasticizing phthalates in humans and understand the potential mechanisms of etiological link between pervasive exposure to phthalates and development of chronic diseases such as cancer through epigenetic and/or genetic alterations. It is also important to identify sustainable and scalable interventions for increasing public awareness, and restricting chronic phthalate exposure to individual and the population at large through relevant policy legislations, particularly in low-income and middle-income countries, such as India. © Indian Institute of Science 2022
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title_short	Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers
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Environmental Contamination and Chronic Exposure to Endocrine-Disrupting Phthalates: An Overlooked and Emerging Determinant for Hormone-Sensitive Cancers

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