Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody
Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and st...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sato, Naofumi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1996 |
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| Schlagwörter: |
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| Anmerkung: |
© The Japan Society for Analytical Chemistry 1996 |
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| Übergeordnetes Werk: |
Enthalten in: Analytical sciences - [Cham] : Springer International Publishing, 1985, 12(1996), 6 vom: 01. Dez., Seite 853-858 |
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| Übergeordnetes Werk: |
volume:12 ; year:1996 ; number:6 ; day:01 ; month:12 ; pages:853-858 |
| Links: |
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| DOI / URN: |
10.2116/analsci.12.853 |
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| 520 | |a Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. | ||
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| 700 | 1 | |a Shirakawa, Kamon |4 aut | |
| 700 | 1 | |a Kakihara, Youko |4 aut | |
| 700 | 1 | |a Mochizuki, Hiroshi |4 aut | |
| 700 | 1 | |a Kanamori, Tosinori |4 aut | |
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10.2116/analsci.12.853 doi (DE-627)SPR048348627 (SPR)analsci.12.853-e DE-627 ger DE-627 rakwb eng Sato, Naofumi verfasserin aut Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japan Society for Analytical Chemistry 1996 Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. Acridinium ester (dpeaa)DE-He213 chemiluminescence immunoassay (dpeaa)DE-He213 human chorionic gonadotropin (hCG) (dpeaa)DE-He213 thyroid stimulating hormone (dpeaa)DE-He213 Shirakawa, Kamon aut Kakihara, Youko aut Mochizuki, Hiroshi aut Kanamori, Tosinori aut Enthalten in Analytical sciences [Cham] : Springer International Publishing, 1985 12(1996), 6 vom: 01. Dez., Seite 853-858 (DE-627)300895925 (DE-600)1483376-1 1348-2246 nnns volume:12 year:1996 number:6 day:01 month:12 pages:853-858 https://dx.doi.org/10.2116/analsci.12.853 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1996 6 01 12 853-858 |
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10.2116/analsci.12.853 doi (DE-627)SPR048348627 (SPR)analsci.12.853-e DE-627 ger DE-627 rakwb eng Sato, Naofumi verfasserin aut Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japan Society for Analytical Chemistry 1996 Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. Acridinium ester (dpeaa)DE-He213 chemiluminescence immunoassay (dpeaa)DE-He213 human chorionic gonadotropin (hCG) (dpeaa)DE-He213 thyroid stimulating hormone (dpeaa)DE-He213 Shirakawa, Kamon aut Kakihara, Youko aut Mochizuki, Hiroshi aut Kanamori, Tosinori aut Enthalten in Analytical sciences [Cham] : Springer International Publishing, 1985 12(1996), 6 vom: 01. Dez., Seite 853-858 (DE-627)300895925 (DE-600)1483376-1 1348-2246 nnns volume:12 year:1996 number:6 day:01 month:12 pages:853-858 https://dx.doi.org/10.2116/analsci.12.853 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1996 6 01 12 853-858 |
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10.2116/analsci.12.853 doi (DE-627)SPR048348627 (SPR)analsci.12.853-e DE-627 ger DE-627 rakwb eng Sato, Naofumi verfasserin aut Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japan Society for Analytical Chemistry 1996 Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. Acridinium ester (dpeaa)DE-He213 chemiluminescence immunoassay (dpeaa)DE-He213 human chorionic gonadotropin (hCG) (dpeaa)DE-He213 thyroid stimulating hormone (dpeaa)DE-He213 Shirakawa, Kamon aut Kakihara, Youko aut Mochizuki, Hiroshi aut Kanamori, Tosinori aut Enthalten in Analytical sciences [Cham] : Springer International Publishing, 1985 12(1996), 6 vom: 01. Dez., Seite 853-858 (DE-627)300895925 (DE-600)1483376-1 1348-2246 nnns volume:12 year:1996 number:6 day:01 month:12 pages:853-858 https://dx.doi.org/10.2116/analsci.12.853 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1996 6 01 12 853-858 |
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10.2116/analsci.12.853 doi (DE-627)SPR048348627 (SPR)analsci.12.853-e DE-627 ger DE-627 rakwb eng Sato, Naofumi verfasserin aut Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japan Society for Analytical Chemistry 1996 Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. Acridinium ester (dpeaa)DE-He213 chemiluminescence immunoassay (dpeaa)DE-He213 human chorionic gonadotropin (hCG) (dpeaa)DE-He213 thyroid stimulating hormone (dpeaa)DE-He213 Shirakawa, Kamon aut Kakihara, Youko aut Mochizuki, Hiroshi aut Kanamori, Tosinori aut Enthalten in Analytical sciences [Cham] : Springer International Publishing, 1985 12(1996), 6 vom: 01. Dez., Seite 853-858 (DE-627)300895925 (DE-600)1483376-1 1348-2246 nnns volume:12 year:1996 number:6 day:01 month:12 pages:853-858 https://dx.doi.org/10.2116/analsci.12.853 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1996 6 01 12 853-858 |
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10.2116/analsci.12.853 doi (DE-627)SPR048348627 (SPR)analsci.12.853-e DE-627 ger DE-627 rakwb eng Sato, Naofumi verfasserin aut Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody 1996 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Japan Society for Analytical Chemistry 1996 Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. Acridinium ester (dpeaa)DE-He213 chemiluminescence immunoassay (dpeaa)DE-He213 human chorionic gonadotropin (hCG) (dpeaa)DE-He213 thyroid stimulating hormone (dpeaa)DE-He213 Shirakawa, Kamon aut Kakihara, Youko aut Mochizuki, Hiroshi aut Kanamori, Tosinori aut Enthalten in Analytical sciences [Cham] : Springer International Publishing, 1985 12(1996), 6 vom: 01. Dez., Seite 853-858 (DE-627)300895925 (DE-600)1483376-1 1348-2246 nnns volume:12 year:1996 number:6 day:01 month:12 pages:853-858 https://dx.doi.org/10.2116/analsci.12.853 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 1996 6 01 12 853-858 |
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Enthalten in Analytical sciences 12(1996), 6 vom: 01. Dez., Seite 853-858 volume:12 year:1996 number:6 day:01 month:12 pages:853-858 |
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Sato, Naofumi @@aut@@ Shirakawa, Kamon @@aut@@ Kakihara, Youko @@aut@@ Mochizuki, Hiroshi @@aut@@ Kanamori, Tosinori @@aut@@ |
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Sato, Naofumi |
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Sato, Naofumi misc Acridinium ester misc chemiluminescence immunoassay misc human chorionic gonadotropin (hCG) misc thyroid stimulating hormone Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody |
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preliminary studies on chemiluminescence immunoassay for human chorionic gonadotropin and thyrotropin using acridinium ester-labeled antibody |
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Preliminary Studies on Chemiluminescence Immunoassay for Human Chorionic Gonadotropin and Thyrotropin Using Acridinium Ester-Labeled Antibody |
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Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. © The Japan Society for Analytical Chemistry 1996 |
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Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. © The Japan Society for Analytical Chemistry 1996 |
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Abstract A highly sensitive chemiluminescence assay system for human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH) was developed using a newly synthesized acridinium ester (AE) with a binding substitutional group at the N-10 position and having excellent chemiluminescence and stability. AE-labeled antibodies with an excellent chemiluminescence intensity were prepared after studying the labeling of anti-hCG antibodies with AE under different conditions. By studying the purification conditions for AE-labeled antibodies we produced AE-labeled antibodies having a low background value when assayed. When the detection limit is defined as the signal value+3SD at a concentration of zero for each substance measured, the detection limit for hCG is 0.01 IU/l and that for TSH is 0.001 μIU/ ml, demonstrating extremely high sensitivity. The labeled antibody’s stability is also excellent. © The Japan Society for Analytical Chemistry 1996 |
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