Endometrial cancer: news from ASCO
Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients wit...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Petru, Edgar [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Magazine of European Medical Oncology - Wien : Springer, 2008, 15(2022), 4 vom: 24. Okt., Seite 275-277 |
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| Übergeordnetes Werk: |
volume:15 ; year:2022 ; number:4 ; day:24 ; month:10 ; pages:275-277 |
| Links: |
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| DOI / URN: |
10.1007/s12254-022-00844-3 |
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| Katalog-ID: |
SPR048810576 |
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| 520 | |a Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. | ||
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| 650 | 4 | |a Pembrolizumab |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dostarlimab |7 (dpeaa)DE-He213 | |
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10.1007/s12254-022-00844-3 doi (DE-627)SPR048810576 (SPR)s12254-022-00844-3-e DE-627 ger DE-627 rakwb eng Petru, Edgar verfasserin (orcid)0000-0001-8822-257X aut Endometrial cancer: news from ASCO 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. Endometrial cancer (dpeaa)DE-He213 Checkpoint inhibitors (dpeaa)DE-He213 Lenvatinib (dpeaa)DE-He213 Pembrolizumab (dpeaa)DE-He213 Dostarlimab (dpeaa)DE-He213 Enthalten in Magazine of European Medical Oncology Wien : Springer, 2008 15(2022), 4 vom: 24. Okt., Seite 275-277 (DE-627)568488733 (DE-600)2428960-7 1865-5076 nnns volume:15 year:2022 number:4 day:24 month:10 pages:275-277 https://dx.doi.org/10.1007/s12254-022-00844-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 24 10 275-277 |
| spelling |
10.1007/s12254-022-00844-3 doi (DE-627)SPR048810576 (SPR)s12254-022-00844-3-e DE-627 ger DE-627 rakwb eng Petru, Edgar verfasserin (orcid)0000-0001-8822-257X aut Endometrial cancer: news from ASCO 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. Endometrial cancer (dpeaa)DE-He213 Checkpoint inhibitors (dpeaa)DE-He213 Lenvatinib (dpeaa)DE-He213 Pembrolizumab (dpeaa)DE-He213 Dostarlimab (dpeaa)DE-He213 Enthalten in Magazine of European Medical Oncology Wien : Springer, 2008 15(2022), 4 vom: 24. Okt., Seite 275-277 (DE-627)568488733 (DE-600)2428960-7 1865-5076 nnns volume:15 year:2022 number:4 day:24 month:10 pages:275-277 https://dx.doi.org/10.1007/s12254-022-00844-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 24 10 275-277 |
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10.1007/s12254-022-00844-3 doi (DE-627)SPR048810576 (SPR)s12254-022-00844-3-e DE-627 ger DE-627 rakwb eng Petru, Edgar verfasserin (orcid)0000-0001-8822-257X aut Endometrial cancer: news from ASCO 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. Endometrial cancer (dpeaa)DE-He213 Checkpoint inhibitors (dpeaa)DE-He213 Lenvatinib (dpeaa)DE-He213 Pembrolizumab (dpeaa)DE-He213 Dostarlimab (dpeaa)DE-He213 Enthalten in Magazine of European Medical Oncology Wien : Springer, 2008 15(2022), 4 vom: 24. Okt., Seite 275-277 (DE-627)568488733 (DE-600)2428960-7 1865-5076 nnns volume:15 year:2022 number:4 day:24 month:10 pages:275-277 https://dx.doi.org/10.1007/s12254-022-00844-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 24 10 275-277 |
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10.1007/s12254-022-00844-3 doi (DE-627)SPR048810576 (SPR)s12254-022-00844-3-e DE-627 ger DE-627 rakwb eng Petru, Edgar verfasserin (orcid)0000-0001-8822-257X aut Endometrial cancer: news from ASCO 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. Endometrial cancer (dpeaa)DE-He213 Checkpoint inhibitors (dpeaa)DE-He213 Lenvatinib (dpeaa)DE-He213 Pembrolizumab (dpeaa)DE-He213 Dostarlimab (dpeaa)DE-He213 Enthalten in Magazine of European Medical Oncology Wien : Springer, 2008 15(2022), 4 vom: 24. Okt., Seite 275-277 (DE-627)568488733 (DE-600)2428960-7 1865-5076 nnns volume:15 year:2022 number:4 day:24 month:10 pages:275-277 https://dx.doi.org/10.1007/s12254-022-00844-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 24 10 275-277 |
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10.1007/s12254-022-00844-3 doi (DE-627)SPR048810576 (SPR)s12254-022-00844-3-e DE-627 ger DE-627 rakwb eng Petru, Edgar verfasserin (orcid)0000-0001-8822-257X aut Endometrial cancer: news from ASCO 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. Endometrial cancer (dpeaa)DE-He213 Checkpoint inhibitors (dpeaa)DE-He213 Lenvatinib (dpeaa)DE-He213 Pembrolizumab (dpeaa)DE-He213 Dostarlimab (dpeaa)DE-He213 Enthalten in Magazine of European Medical Oncology Wien : Springer, 2008 15(2022), 4 vom: 24. Okt., Seite 275-277 (DE-627)568488733 (DE-600)2428960-7 1865-5076 nnns volume:15 year:2022 number:4 day:24 month:10 pages:275-277 https://dx.doi.org/10.1007/s12254-022-00844-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 24 10 275-277 |
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Enthalten in Magazine of European Medical Oncology 15(2022), 4 vom: 24. Okt., Seite 275-277 volume:15 year:2022 number:4 day:24 month:10 pages:275-277 |
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The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. 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Endometrial cancer: news from ASCO |
| abstract |
Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. © The Author(s) 2022 |
| abstractGer |
Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. © The Author(s) 2022 |
| abstract_unstemmed |
Summary At ASCO 2022 important abstracts were presented. The programmed death1 (PD1) inhibitor dostarlimab was investigated in the phase III GARNET study in advanced or metastatic endometrial cancer after failure of previous platinum-based combination chemotherapy. In the first group of patients with tumors with dMMR (mismatch repair-deficiency) or MSI‑H (microsatellite-high; group A), the median progression-free survival (PFS) was significantly higher than in the group with pMMR (mismatch repair-proficiency) or those with MSS (microsatellite-stable) tumors (group B), i.e., 6.0 months in group A and 2.7 months in group B. Overall survival was > 50 months and 17 months, respectively. Immunotherapy-related adverse events were seen in 23% of patients, including grade 3 or 4 events in 8% of women. In all, 9% of patients discontinued treatment due to adverse events. Another important regimen is the combination of lenvatinib and pembrolizumab. In a randomized study of lenvatinib + pembrolizumab versus monotherapy with doxorubicin or paclitaxel in the second-line therapy of metastatic endometrial cancer, the chemotherapy-free regimen was superior. PFS2 was significantly higher in patients in the pMMR group and the all comer group if they received lenvatinib and pembrolizumab, compared to those receiving standard chemotherapy (p < 0.0001). In conclusion, checkpoint inhibitors ± lenvatinib are now established in the second-line treatment of advanced endometrial cancer. Overall, the inclusion of PD1 or PDL1 inhibitors in systemic treatment regimens offers a significant opportunity for patients whose treatment options in the past only included conventional chemotherapy, radiotherapy or hormonal therapy. © The Author(s) 2022 |
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Endometrial cancer: news from ASCO |
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https://dx.doi.org/10.1007/s12254-022-00844-3 |
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2024-07-03T21:37:15.138Z |
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| score |
7.4009523 |