Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial
Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residen...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bath, Philip M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2022 |
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| Übergeordnetes Werk: |
Enthalten in: European geriatric medicine - [Cham] : Springer International Publishing, 2010, 13(2022), 6 vom: 16. Nov., Seite 1343-1355 |
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| Übergeordnetes Werk: |
volume:13 ; year:2022 ; number:6 ; day:16 ; month:11 ; pages:1343-1355 |
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| DOI / URN: |
10.1007/s41999-022-00714-5 |
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| Katalog-ID: |
SPR048814423 |
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| 100 | 1 | |a Bath, Philip M. |e verfasserin |0 (orcid)0000-0003-2734-5132 |4 aut | |
| 245 | 1 | 0 | |a Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial |
| 264 | 1 | |c 2022 | |
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| 500 | |a © The Author(s) 2022 | ||
| 520 | |a Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. | ||
| 520 | |a Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. | ||
| 650 | 4 | |a Care home |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a COVID-19 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dietary supplementation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Infection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nitrate |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nitric oxide |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Skinner, Cameron J. C. |4 aut | |
| 700 | 1 | |a Bath, Charlotte S. |4 aut | |
| 700 | 1 | |a Woodhouse, Lisa J. |4 aut | |
| 700 | 1 | |a Korovesi, Anastasia Areti Kyriazopoulou |4 aut | |
| 700 | 1 | |a Long, Hongjiang |4 aut | |
| 700 | 1 | |a Havard, Diane |4 aut | |
| 700 | 1 | |a Coleman, Christopher M. |4 aut | |
| 700 | 1 | |a England, Timothy J. |4 aut | |
| 700 | 1 | |a Leyland, Valerie |4 aut | |
| 700 | 1 | |a Lim, Wei Shen |4 aut | |
| 700 | 1 | |a Montgomery, Alan A. |4 aut | |
| 700 | 1 | |a Royal, Simon |4 aut | |
| 700 | 1 | |a Avery, Amanda |4 aut | |
| 700 | 1 | |a Webb, Andrew J. |4 aut | |
| 700 | 1 | |a Gordon, Adam L. |4 aut | |
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10.1007/s41999-022-00714-5 doi (DE-627)SPR048814423 (SPR)s41999-022-00714-5-e DE-627 ger DE-627 rakwb eng Bath, Philip M. verfasserin (orcid)0000-0003-2734-5132 aut Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. Care home (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Dietary supplementation (dpeaa)DE-He213 Infection (dpeaa)DE-He213 Nitrate (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Skinner, Cameron J. C. aut Bath, Charlotte S. aut Woodhouse, Lisa J. aut Korovesi, Anastasia Areti Kyriazopoulou aut Long, Hongjiang aut Havard, Diane aut Coleman, Christopher M. aut England, Timothy J. aut Leyland, Valerie aut Lim, Wei Shen aut Montgomery, Alan A. aut Royal, Simon aut Avery, Amanda aut Webb, Andrew J. aut Gordon, Adam L. aut Enthalten in European geriatric medicine [Cham] : Springer International Publishing, 2010 13(2022), 6 vom: 16. Nov., Seite 1343-1355 (DE-627)627611737 (DE-600)2556794-9 1878-7657 nnns volume:13 year:2022 number:6 day:16 month:11 pages:1343-1355 https://dx.doi.org/10.1007/s41999-022-00714-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2022 6 16 11 1343-1355 |
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10.1007/s41999-022-00714-5 doi (DE-627)SPR048814423 (SPR)s41999-022-00714-5-e DE-627 ger DE-627 rakwb eng Bath, Philip M. verfasserin (orcid)0000-0003-2734-5132 aut Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. Care home (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Dietary supplementation (dpeaa)DE-He213 Infection (dpeaa)DE-He213 Nitrate (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Skinner, Cameron J. C. aut Bath, Charlotte S. aut Woodhouse, Lisa J. aut Korovesi, Anastasia Areti Kyriazopoulou aut Long, Hongjiang aut Havard, Diane aut Coleman, Christopher M. aut England, Timothy J. aut Leyland, Valerie aut Lim, Wei Shen aut Montgomery, Alan A. aut Royal, Simon aut Avery, Amanda aut Webb, Andrew J. aut Gordon, Adam L. aut Enthalten in European geriatric medicine [Cham] : Springer International Publishing, 2010 13(2022), 6 vom: 16. Nov., Seite 1343-1355 (DE-627)627611737 (DE-600)2556794-9 1878-7657 nnns volume:13 year:2022 number:6 day:16 month:11 pages:1343-1355 https://dx.doi.org/10.1007/s41999-022-00714-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2022 6 16 11 1343-1355 |
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10.1007/s41999-022-00714-5 doi (DE-627)SPR048814423 (SPR)s41999-022-00714-5-e DE-627 ger DE-627 rakwb eng Bath, Philip M. verfasserin (orcid)0000-0003-2734-5132 aut Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. Care home (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Dietary supplementation (dpeaa)DE-He213 Infection (dpeaa)DE-He213 Nitrate (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Skinner, Cameron J. C. aut Bath, Charlotte S. aut Woodhouse, Lisa J. aut Korovesi, Anastasia Areti Kyriazopoulou aut Long, Hongjiang aut Havard, Diane aut Coleman, Christopher M. aut England, Timothy J. aut Leyland, Valerie aut Lim, Wei Shen aut Montgomery, Alan A. aut Royal, Simon aut Avery, Amanda aut Webb, Andrew J. aut Gordon, Adam L. aut Enthalten in European geriatric medicine [Cham] : Springer International Publishing, 2010 13(2022), 6 vom: 16. Nov., Seite 1343-1355 (DE-627)627611737 (DE-600)2556794-9 1878-7657 nnns volume:13 year:2022 number:6 day:16 month:11 pages:1343-1355 https://dx.doi.org/10.1007/s41999-022-00714-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2022 6 16 11 1343-1355 |
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10.1007/s41999-022-00714-5 doi (DE-627)SPR048814423 (SPR)s41999-022-00714-5-e DE-627 ger DE-627 rakwb eng Bath, Philip M. verfasserin (orcid)0000-0003-2734-5132 aut Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. Care home (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Dietary supplementation (dpeaa)DE-He213 Infection (dpeaa)DE-He213 Nitrate (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Skinner, Cameron J. C. aut Bath, Charlotte S. aut Woodhouse, Lisa J. aut Korovesi, Anastasia Areti Kyriazopoulou aut Long, Hongjiang aut Havard, Diane aut Coleman, Christopher M. aut England, Timothy J. aut Leyland, Valerie aut Lim, Wei Shen aut Montgomery, Alan A. aut Royal, Simon aut Avery, Amanda aut Webb, Andrew J. aut Gordon, Adam L. aut Enthalten in European geriatric medicine [Cham] : Springer International Publishing, 2010 13(2022), 6 vom: 16. Nov., Seite 1343-1355 (DE-627)627611737 (DE-600)2556794-9 1878-7657 nnns volume:13 year:2022 number:6 day:16 month:11 pages:1343-1355 https://dx.doi.org/10.1007/s41999-022-00714-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2022 6 16 11 1343-1355 |
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10.1007/s41999-022-00714-5 doi (DE-627)SPR048814423 (SPR)s41999-022-00714-5-e DE-627 ger DE-627 rakwb eng Bath, Philip M. verfasserin (orcid)0000-0003-2734-5132 aut Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. Care home (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Dietary supplementation (dpeaa)DE-He213 Infection (dpeaa)DE-He213 Nitrate (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 Skinner, Cameron J. C. aut Bath, Charlotte S. aut Woodhouse, Lisa J. aut Korovesi, Anastasia Areti Kyriazopoulou aut Long, Hongjiang aut Havard, Diane aut Coleman, Christopher M. aut England, Timothy J. aut Leyland, Valerie aut Lim, Wei Shen aut Montgomery, Alan A. aut Royal, Simon aut Avery, Amanda aut Webb, Andrew J. aut Gordon, Adam L. aut Enthalten in European geriatric medicine [Cham] : Springer International Publishing, 2010 13(2022), 6 vom: 16. Nov., Seite 1343-1355 (DE-627)627611737 (DE-600)2556794-9 1878-7657 nnns volume:13 year:2022 number:6 day:16 month:11 pages:1343-1355 https://dx.doi.org/10.1007/s41999-022-00714-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 13 2022 6 16 11 1343-1355 |
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Enthalten in European geriatric medicine 13(2022), 6 vom: 16. Nov., Seite 1343-1355 volume:13 year:2022 number:6 day:16 month:11 pages:1343-1355 |
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Bath, Philip M. @@aut@@ Skinner, Cameron J. C. @@aut@@ Bath, Charlotte S. @@aut@@ Woodhouse, Lisa J. @@aut@@ Korovesi, Anastasia Areti Kyriazopoulou @@aut@@ Long, Hongjiang @@aut@@ Havard, Diane @@aut@@ Coleman, Christopher M. @@aut@@ England, Timothy J. @@aut@@ Leyland, Valerie @@aut@@ Lim, Wei Shen @@aut@@ Montgomery, Alan A. @@aut@@ Royal, Simon @@aut@@ Avery, Amanda @@aut@@ Webb, Andrew J. @@aut@@ Gordon, Adam L. @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR048814423</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519110853.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">221206s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s41999-022-00714-5</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR048814423</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s41999-022-00714-5-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bath, Philip M.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0003-2734-5132</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. 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| author |
Bath, Philip M. |
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Bath, Philip M. misc Care home misc COVID-19 misc Dietary supplementation misc Infection misc Nitrate misc Nitric oxide Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial |
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Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial Care home (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Dietary supplementation (dpeaa)DE-He213 Infection (dpeaa)DE-He213 Nitrate (dpeaa)DE-He213 Nitric oxide (dpeaa)DE-He213 |
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misc Care home misc COVID-19 misc Dietary supplementation misc Infection misc Nitrate misc Nitric oxide |
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misc Care home misc COVID-19 misc Dietary supplementation misc Infection misc Nitrate misc Nitric oxide |
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misc Care home misc COVID-19 misc Dietary supplementation misc Infection misc Nitrate misc Nitric oxide |
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Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial |
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Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial |
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Bath, Philip M. Skinner, Cameron J. C. Bath, Charlotte S. Woodhouse, Lisa J. Korovesi, Anastasia Areti Kyriazopoulou Long, Hongjiang Havard, Diane Coleman, Christopher M. England, Timothy J. Leyland, Valerie Lim, Wei Shen Montgomery, Alan A. Royal, Simon Avery, Amanda Webb, Andrew J. Gordon, Adam L. |
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dietary nitrate supplementation for preventing and reducing the severity of winter infections, including covid-19, in care homes (beet-winter): a randomised placebo-controlled feasibility trial |
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Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter): a randomised placebo-controlled feasibility trial |
| abstract |
Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. © The Author(s) 2022 |
| abstractGer |
Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. © The Author(s) 2022 |
| abstract_unstemmed |
Aim To assess the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Findings Expressions of interest by care homes were not realised during the alpha COVID-19 wave of infections. Background dietary nitrate was < 30% of acceptable daily intake; most residents received a majority of their nitrate supplementation and supplementation increased urinary and salivary nitrate concentrations. Message Recruiting UK care homes during the COVID-19 pandemic was partially successful and supplemented dietary nitrate was tolerated and elevated urinary nitrate concentrations. Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in care home residents. Methods We performed a cluster-randomised placebo-controlled trial in UK residential and nursing care home residents and compared nitrate containing (400 mg) versus free (0 mg daily) beetroot juice given for 60 days. Outcomes comprised feasibility of recruitment, adherence, salivary and urinary nitrate, and ordinal infection/clinical events. Results Of 30 targeted care homes in late 2020, 16 expressed interest and only 6 participated. 49 residents were recruited (median 8 [interquartile range 7–12] per home), mean (standard deviation) age 82 (8) years, with proxy consent 41 (84%), advance directive for hospital non-admission 8 (16%) and ≥ 1 doses of COVID-19 vaccine 37 (82%). Background dietary nitrate was < 30% of acceptable daily intake. 34 (76%) residents received > 50% of juice. Residents randomised to nitrate vs placebo had higher urinary nitrate levels, median 50 [18–175] v 18 [10–50] mg/L, difference 25 [0–90]. Data paucity precluded clinical between-group comparisons; the outcome distribution was as follows: no infection 32 (67%), uncomplicated infection 0, infection requiring healthcare support 11 (23%), all-cause hospitalisation 5 (10%), all-cause mortality 0. Urinary tract infections were most common. Conclusions Recruiting UK care homes during the COVID-19 pandemic was partially successful. Supplemented dietary nitrate was tolerated and elevated urinary nitrate. Together, infections, hospitalisations and deaths occurred in 33% of residents over 60 days. A larger trial is now required. Trial Registration ISRCTN51124684. Application date 7/12/2020; assignment date 13/1/2021. © The Author(s) 2022 |
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| score |
7.3981237 |