Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature

Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT...
Ausführliche Beschreibung

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Autor*in:	Xu, Kemin [verfasserIn] Ward, Nicholas

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	MALT lymphoma Multiple organ systems Clonal relationship

Anmerkung:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Journal of hematopathology - Berlin : Springer, 2008, 15(2022), 4 vom: 20. Sept., Seite 215-220
Übergeordnetes Werk:	volume:15 ; year:2022 ; number:4 ; day:20 ; month:09 ; pages:215-220

Links:	Volltext

DOI / URN:	10.1007/s12308-022-00516-5

Katalog-ID:	SPR048885851

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520			\|a Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease.
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allfields	10.1007/s12308-022-00516-5 doi (DE-627)SPR048885851 (SPR)s12308-022-00516-5-e DE-627 ger DE-627 rakwb eng Xu, Kemin verfasserin aut Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. MALT lymphoma (dpeaa)DE-He213 Multiple organ systems (dpeaa)DE-He213 Clonal relationship (dpeaa)DE-He213 Ward, Nicholas aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 15(2022), 4 vom: 20. Sept., Seite 215-220 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:15 year:2022 number:4 day:20 month:09 pages:215-220 https://dx.doi.org/10.1007/s12308-022-00516-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 20 09 215-220
spelling	10.1007/s12308-022-00516-5 doi (DE-627)SPR048885851 (SPR)s12308-022-00516-5-e DE-627 ger DE-627 rakwb eng Xu, Kemin verfasserin aut Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. MALT lymphoma (dpeaa)DE-He213 Multiple organ systems (dpeaa)DE-He213 Clonal relationship (dpeaa)DE-He213 Ward, Nicholas aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 15(2022), 4 vom: 20. Sept., Seite 215-220 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:15 year:2022 number:4 day:20 month:09 pages:215-220 https://dx.doi.org/10.1007/s12308-022-00516-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 20 09 215-220
allfields_unstemmed	10.1007/s12308-022-00516-5 doi (DE-627)SPR048885851 (SPR)s12308-022-00516-5-e DE-627 ger DE-627 rakwb eng Xu, Kemin verfasserin aut Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. MALT lymphoma (dpeaa)DE-He213 Multiple organ systems (dpeaa)DE-He213 Clonal relationship (dpeaa)DE-He213 Ward, Nicholas aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 15(2022), 4 vom: 20. Sept., Seite 215-220 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:15 year:2022 number:4 day:20 month:09 pages:215-220 https://dx.doi.org/10.1007/s12308-022-00516-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 20 09 215-220
allfieldsGer	10.1007/s12308-022-00516-5 doi (DE-627)SPR048885851 (SPR)s12308-022-00516-5-e DE-627 ger DE-627 rakwb eng Xu, Kemin verfasserin aut Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. MALT lymphoma (dpeaa)DE-He213 Multiple organ systems (dpeaa)DE-He213 Clonal relationship (dpeaa)DE-He213 Ward, Nicholas aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 15(2022), 4 vom: 20. Sept., Seite 215-220 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:15 year:2022 number:4 day:20 month:09 pages:215-220 https://dx.doi.org/10.1007/s12308-022-00516-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 20 09 215-220
allfieldsSound	10.1007/s12308-022-00516-5 doi (DE-627)SPR048885851 (SPR)s12308-022-00516-5-e DE-627 ger DE-627 rakwb eng Xu, Kemin verfasserin aut Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. MALT lymphoma (dpeaa)DE-He213 Multiple organ systems (dpeaa)DE-He213 Clonal relationship (dpeaa)DE-He213 Ward, Nicholas aut Enthalten in Journal of hematopathology Berlin : Springer, 2008 15(2022), 4 vom: 20. Sept., Seite 215-220 (DE-627)572421230 (DE-600)2438687-X 1865-5785 nnns volume:15 year:2022 number:4 day:20 month:09 pages:215-220 https://dx.doi.org/10.1007/s12308-022-00516-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2022 4 20 09 215-220
language	English
source	Enthalten in Journal of hematopathology 15(2022), 4 vom: 20. Sept., Seite 215-220 volume:15 year:2022 number:4 day:20 month:09 pages:215-220
sourceStr	Enthalten in Journal of hematopathology 15(2022), 4 vom: 20. Sept., Seite 215-220 volume:15 year:2022 number:4 day:20 month:09 pages:215-220
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topic_facet	MALT lymphoma Multiple organ systems Clonal relationship
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publishDateDaySort_date	2022-09-20T00:00:00Z
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author	Xu, Kemin
spellingShingle	Xu, Kemin misc MALT lymphoma misc Multiple organ systems misc Clonal relationship Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature
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topic_title	Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature MALT lymphoma (dpeaa)DE-He213 Multiple organ systems (dpeaa)DE-He213 Clonal relationship (dpeaa)DE-He213
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title_full	Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature
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title_sort	clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (malt lymphoma) involving multiple organ systems with review of the literature
title_auth	Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature
abstract	Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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container_issue	4
title_short	Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature
url	https://dx.doi.org/10.1007/s12308-022-00516-5
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author2	Ward, Nicholas
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doi_str	10.1007/s12308-022-00516-5
up_date	2024-07-03T22:04:49.454Z
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Clonal relationship of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ systems with review of the literature

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