Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry

Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15...
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Autor*in:	Dawoud, Bassant Mahmoud [verfasserIn] Darweesh, Abdelmonem Nooman Hefeda, Mohamed Mohamed Kamal, Rasha Mohamed Younis, Rasha Lotfy

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Asymmetry Breast cancer Contrast-enhanced mammography (CEM) Mammography

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: The Egyptian Journal of Radiology and Nuclear Medicine - Amsterdam [u.a.] : Elsevier, 2010, 53(2022), 1 vom: 16. Dez.
Übergeordnetes Werk:	volume:53 ; year:2022 ; number:1 ; day:16 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s43055-022-00943-5

Katalog-ID:	SPR048900354

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520			\|a Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US).
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allfields	10.1186/s43055-022-00943-5 doi (DE-627)SPR048900354 (SPR)s43055-022-00943-5-e DE-627 ger DE-627 rakwb eng Dawoud, Bassant Mahmoud verfasserin aut Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). Asymmetry (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Contrast-enhanced mammography (CEM) (dpeaa)DE-He213 Mammography (dpeaa)DE-He213 Darweesh, Abdelmonem Nooman aut Hefeda, Mohamed Mohamed aut Kamal, Rasha Mohamed aut Younis, Rasha Lotfy aut Enthalten in The Egyptian Journal of Radiology and Nuclear Medicine Amsterdam [u.a.] : Elsevier, 2010 53(2022), 1 vom: 16. Dez. (DE-627)641391862 (DE-600)2583928-7 2090-4762 nnns volume:53 year:2022 number:1 day:16 month:12 https://dx.doi.org/10.1186/s43055-022-00943-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2022 1 16 12
spelling	10.1186/s43055-022-00943-5 doi (DE-627)SPR048900354 (SPR)s43055-022-00943-5-e DE-627 ger DE-627 rakwb eng Dawoud, Bassant Mahmoud verfasserin aut Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). Asymmetry (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Contrast-enhanced mammography (CEM) (dpeaa)DE-He213 Mammography (dpeaa)DE-He213 Darweesh, Abdelmonem Nooman aut Hefeda, Mohamed Mohamed aut Kamal, Rasha Mohamed aut Younis, Rasha Lotfy aut Enthalten in The Egyptian Journal of Radiology and Nuclear Medicine Amsterdam [u.a.] : Elsevier, 2010 53(2022), 1 vom: 16. Dez. (DE-627)641391862 (DE-600)2583928-7 2090-4762 nnns volume:53 year:2022 number:1 day:16 month:12 https://dx.doi.org/10.1186/s43055-022-00943-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2022 1 16 12
allfields_unstemmed	10.1186/s43055-022-00943-5 doi (DE-627)SPR048900354 (SPR)s43055-022-00943-5-e DE-627 ger DE-627 rakwb eng Dawoud, Bassant Mahmoud verfasserin aut Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). Asymmetry (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Contrast-enhanced mammography (CEM) (dpeaa)DE-He213 Mammography (dpeaa)DE-He213 Darweesh, Abdelmonem Nooman aut Hefeda, Mohamed Mohamed aut Kamal, Rasha Mohamed aut Younis, Rasha Lotfy aut Enthalten in The Egyptian Journal of Radiology and Nuclear Medicine Amsterdam [u.a.] : Elsevier, 2010 53(2022), 1 vom: 16. Dez. (DE-627)641391862 (DE-600)2583928-7 2090-4762 nnns volume:53 year:2022 number:1 day:16 month:12 https://dx.doi.org/10.1186/s43055-022-00943-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2022 1 16 12
allfieldsGer	10.1186/s43055-022-00943-5 doi (DE-627)SPR048900354 (SPR)s43055-022-00943-5-e DE-627 ger DE-627 rakwb eng Dawoud, Bassant Mahmoud verfasserin aut Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). Asymmetry (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Contrast-enhanced mammography (CEM) (dpeaa)DE-He213 Mammography (dpeaa)DE-He213 Darweesh, Abdelmonem Nooman aut Hefeda, Mohamed Mohamed aut Kamal, Rasha Mohamed aut Younis, Rasha Lotfy aut Enthalten in The Egyptian Journal of Radiology and Nuclear Medicine Amsterdam [u.a.] : Elsevier, 2010 53(2022), 1 vom: 16. Dez. (DE-627)641391862 (DE-600)2583928-7 2090-4762 nnns volume:53 year:2022 number:1 day:16 month:12 https://dx.doi.org/10.1186/s43055-022-00943-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2022 1 16 12
allfieldsSound	10.1186/s43055-022-00943-5 doi (DE-627)SPR048900354 (SPR)s43055-022-00943-5-e DE-627 ger DE-627 rakwb eng Dawoud, Bassant Mahmoud verfasserin aut Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). Asymmetry (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Contrast-enhanced mammography (CEM) (dpeaa)DE-He213 Mammography (dpeaa)DE-He213 Darweesh, Abdelmonem Nooman aut Hefeda, Mohamed Mohamed aut Kamal, Rasha Mohamed aut Younis, Rasha Lotfy aut Enthalten in The Egyptian Journal of Radiology and Nuclear Medicine Amsterdam [u.a.] : Elsevier, 2010 53(2022), 1 vom: 16. Dez. (DE-627)641391862 (DE-600)2583928-7 2090-4762 nnns volume:53 year:2022 number:1 day:16 month:12 https://dx.doi.org/10.1186/s43055-022-00943-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 53 2022 1 16 12
language	English
source	Enthalten in The Egyptian Journal of Radiology and Nuclear Medicine 53(2022), 1 vom: 16. Dez. volume:53 year:2022 number:1 day:16 month:12
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format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Asymmetry Breast cancer Contrast-enhanced mammography (CEM) Mammography
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container_title	The Egyptian Journal of Radiology and Nuclear Medicine
authorswithroles_txt_mv	Dawoud, Bassant Mahmoud @@aut@@ Darweesh, Abdelmonem Nooman @@aut@@ Hefeda, Mohamed Mohamed @@aut@@ Kamal, Rasha Mohamed @@aut@@ Younis, Rasha Lotfy @@aut@@
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Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). 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author	Dawoud, Bassant Mahmoud
spellingShingle	Dawoud, Bassant Mahmoud misc Asymmetry misc Breast cancer misc Contrast-enhanced mammography (CEM) misc Mammography Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
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topic_title	Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry Asymmetry (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Contrast-enhanced mammography (CEM) (dpeaa)DE-He213 Mammography (dpeaa)DE-He213
topic	misc Asymmetry misc Breast cancer misc Contrast-enhanced mammography (CEM) misc Mammography
topic_unstemmed	misc Asymmetry misc Breast cancer misc Contrast-enhanced mammography (CEM) misc Mammography
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title	Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
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title_full	Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
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author_browse	Dawoud, Bassant Mahmoud Darweesh, Abdelmonem Nooman Hefeda, Mohamed Mohamed Kamal, Rasha Mohamed Younis, Rasha Lotfy
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title_sort	diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
title_auth	Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
abstract	Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). © The Author(s) 2022
abstractGer	Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). © The Author(s) 2022
abstract_unstemmed	Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). © The Author(s) 2022
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title_short	Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
url	https://dx.doi.org/10.1186/s43055-022-00943-5
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author2	Darweesh, Abdelmonem Nooman Hefeda, Mohamed Mohamed Kamal, Rasha Mohamed Younis, Rasha Lotfy
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Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry

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