Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke

Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on b...
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Autor*in:	Battaglini, Denise [verfasserIn] da Silva, Adriana Lopes Felix, Nathane Santanna Rodrigues, Gisele Antunes, Mariana Alves Rocha, Nazareth Novaes Capelozzi, Vera Luiza Morales, Marcelo Marcos Cruz, Fernanda Ferreira Robba, Chiara Silva, Pedro Leme Pelosi, Paolo Rocco, Patricia Rieken Macedo

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Neuroprotection Hypothermia Ischemic stroke Animal model Kidney

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Intensive Care Medicine Experimental - Berlin : SpringerOpen, 2013, 10(2022), 1 vom: 19. Dez.
Übergeordnetes Werk:	volume:10 ; year:2022 ; number:1 ; day:19 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s40635-022-00481-4

Katalog-ID:	SPR048904708

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245	1	0	\|a Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
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520			\|a Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage.
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700	1		\|a Pelosi, Paolo \|4 aut
700	1		\|a Rocco, Patricia Rieken Macedo \|0 (orcid)0000-0003-1412-7136 \|4 aut
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allfields	10.1186/s40635-022-00481-4 doi (DE-627)SPR048904708 (SPR)s40635-022-00481-4-e DE-627 ger DE-627 rakwb eng Battaglini, Denise verfasserin aut Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. Neuroprotection (dpeaa)DE-He213 Hypothermia (dpeaa)DE-He213 Ischemic stroke (dpeaa)DE-He213 Animal model (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 da Silva, Adriana Lopes aut Felix, Nathane Santanna aut Rodrigues, Gisele aut Antunes, Mariana Alves aut Rocha, Nazareth Novaes aut Capelozzi, Vera Luiza aut Morales, Marcelo Marcos aut Cruz, Fernanda Ferreira aut Robba, Chiara aut Silva, Pedro Leme aut Pelosi, Paolo aut Rocco, Patricia Rieken Macedo (orcid)0000-0003-1412-7136 aut Enthalten in Intensive Care Medicine Experimental Berlin : SpringerOpen, 2013 10(2022), 1 vom: 19. Dez. (DE-627)771394640 (DE-600)2740385-3 2197-425X nnns volume:10 year:2022 number:1 day:19 month:12 https://dx.doi.org/10.1186/s40635-022-00481-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 1 19 12
spelling	10.1186/s40635-022-00481-4 doi (DE-627)SPR048904708 (SPR)s40635-022-00481-4-e DE-627 ger DE-627 rakwb eng Battaglini, Denise verfasserin aut Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. Neuroprotection (dpeaa)DE-He213 Hypothermia (dpeaa)DE-He213 Ischemic stroke (dpeaa)DE-He213 Animal model (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 da Silva, Adriana Lopes aut Felix, Nathane Santanna aut Rodrigues, Gisele aut Antunes, Mariana Alves aut Rocha, Nazareth Novaes aut Capelozzi, Vera Luiza aut Morales, Marcelo Marcos aut Cruz, Fernanda Ferreira aut Robba, Chiara aut Silva, Pedro Leme aut Pelosi, Paolo aut Rocco, Patricia Rieken Macedo (orcid)0000-0003-1412-7136 aut Enthalten in Intensive Care Medicine Experimental Berlin : SpringerOpen, 2013 10(2022), 1 vom: 19. Dez. (DE-627)771394640 (DE-600)2740385-3 2197-425X nnns volume:10 year:2022 number:1 day:19 month:12 https://dx.doi.org/10.1186/s40635-022-00481-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 1 19 12
allfields_unstemmed	10.1186/s40635-022-00481-4 doi (DE-627)SPR048904708 (SPR)s40635-022-00481-4-e DE-627 ger DE-627 rakwb eng Battaglini, Denise verfasserin aut Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. Neuroprotection (dpeaa)DE-He213 Hypothermia (dpeaa)DE-He213 Ischemic stroke (dpeaa)DE-He213 Animal model (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 da Silva, Adriana Lopes aut Felix, Nathane Santanna aut Rodrigues, Gisele aut Antunes, Mariana Alves aut Rocha, Nazareth Novaes aut Capelozzi, Vera Luiza aut Morales, Marcelo Marcos aut Cruz, Fernanda Ferreira aut Robba, Chiara aut Silva, Pedro Leme aut Pelosi, Paolo aut Rocco, Patricia Rieken Macedo (orcid)0000-0003-1412-7136 aut Enthalten in Intensive Care Medicine Experimental Berlin : SpringerOpen, 2013 10(2022), 1 vom: 19. Dez. (DE-627)771394640 (DE-600)2740385-3 2197-425X nnns volume:10 year:2022 number:1 day:19 month:12 https://dx.doi.org/10.1186/s40635-022-00481-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 1 19 12
allfieldsGer	10.1186/s40635-022-00481-4 doi (DE-627)SPR048904708 (SPR)s40635-022-00481-4-e DE-627 ger DE-627 rakwb eng Battaglini, Denise verfasserin aut Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. Neuroprotection (dpeaa)DE-He213 Hypothermia (dpeaa)DE-He213 Ischemic stroke (dpeaa)DE-He213 Animal model (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 da Silva, Adriana Lopes aut Felix, Nathane Santanna aut Rodrigues, Gisele aut Antunes, Mariana Alves aut Rocha, Nazareth Novaes aut Capelozzi, Vera Luiza aut Morales, Marcelo Marcos aut Cruz, Fernanda Ferreira aut Robba, Chiara aut Silva, Pedro Leme aut Pelosi, Paolo aut Rocco, Patricia Rieken Macedo (orcid)0000-0003-1412-7136 aut Enthalten in Intensive Care Medicine Experimental Berlin : SpringerOpen, 2013 10(2022), 1 vom: 19. Dez. (DE-627)771394640 (DE-600)2740385-3 2197-425X nnns volume:10 year:2022 number:1 day:19 month:12 https://dx.doi.org/10.1186/s40635-022-00481-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 1 19 12
allfieldsSound	10.1186/s40635-022-00481-4 doi (DE-627)SPR048904708 (SPR)s40635-022-00481-4-e DE-627 ger DE-627 rakwb eng Battaglini, Denise verfasserin aut Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. Neuroprotection (dpeaa)DE-He213 Hypothermia (dpeaa)DE-He213 Ischemic stroke (dpeaa)DE-He213 Animal model (dpeaa)DE-He213 Kidney (dpeaa)DE-He213 da Silva, Adriana Lopes aut Felix, Nathane Santanna aut Rodrigues, Gisele aut Antunes, Mariana Alves aut Rocha, Nazareth Novaes aut Capelozzi, Vera Luiza aut Morales, Marcelo Marcos aut Cruz, Fernanda Ferreira aut Robba, Chiara aut Silva, Pedro Leme aut Pelosi, Paolo aut Rocco, Patricia Rieken Macedo (orcid)0000-0003-1412-7136 aut Enthalten in Intensive Care Medicine Experimental Berlin : SpringerOpen, 2013 10(2022), 1 vom: 19. Dez. (DE-627)771394640 (DE-600)2740385-3 2197-425X nnns volume:10 year:2022 number:1 day:19 month:12 https://dx.doi.org/10.1186/s40635-022-00481-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2022 1 19 12
language	English
source	Enthalten in Intensive Care Medicine Experimental 10(2022), 1 vom: 19. Dez. volume:10 year:2022 number:1 day:19 month:12
sourceStr	Enthalten in Intensive Care Medicine Experimental 10(2022), 1 vom: 19. Dez. volume:10 year:2022 number:1 day:19 month:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neuroprotection Hypothermia Ischemic stroke Animal model Kidney
isfreeaccess_bool	true
container_title	Intensive Care Medicine Experimental
authorswithroles_txt_mv	Battaglini, Denise @@aut@@ da Silva, Adriana Lopes @@aut@@ Felix, Nathane Santanna @@aut@@ Rodrigues, Gisele @@aut@@ Antunes, Mariana Alves @@aut@@ Rocha, Nazareth Novaes @@aut@@ Capelozzi, Vera Luiza @@aut@@ Morales, Marcelo Marcos @@aut@@ Cruz, Fernanda Ferreira @@aut@@ Robba, Chiara @@aut@@ Silva, Pedro Leme @@aut@@ Pelosi, Paolo @@aut@@ Rocco, Patricia Rieken Macedo @@aut@@
publishDateDaySort_date	2022-12-19T00:00:00Z
hierarchy_top_id	771394640
id	SPR048904708
language_de	englisch
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However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. 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author	Battaglini, Denise
spellingShingle	Battaglini, Denise misc Neuroprotection misc Hypothermia misc Ischemic stroke misc Animal model misc Kidney Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
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topic_title	Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke Neuroprotection (dpeaa)DE-He213 Hypothermia (dpeaa)DE-He213 Ischemic stroke (dpeaa)DE-He213 Animal model (dpeaa)DE-He213 Kidney (dpeaa)DE-He213
topic	misc Neuroprotection misc Hypothermia misc Ischemic stroke misc Animal model misc Kidney
topic_unstemmed	misc Neuroprotection misc Hypothermia misc Ischemic stroke misc Animal model misc Kidney
topic_browse	misc Neuroprotection misc Hypothermia misc Ischemic stroke misc Animal model misc Kidney
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title	Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
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title_full	Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
author_sort	Battaglini, Denise
journal	Intensive Care Medicine Experimental
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author_browse	Battaglini, Denise da Silva, Adriana Lopes Felix, Nathane Santanna Rodrigues, Gisele Antunes, Mariana Alves Rocha, Nazareth Novaes Capelozzi, Vera Luiza Morales, Marcelo Marcos Cruz, Fernanda Ferreira Robba, Chiara Silva, Pedro Leme Pelosi, Paolo Rocco, Patricia Rieken Macedo
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author-letter	Battaglini, Denise
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title_sort	mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
title_auth	Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
abstract	Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. © The Author(s) 2022
abstractGer	Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. © The Author(s) 2022
abstract_unstemmed	Background Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combination of mild hypothermia or normothermia with propofol or dexmedetomidine on brain, lung, and kidney in experimental AIS. AIS-induced Wistar rats (n = 30) were randomly assigned, after 24 h, to normothermia or mild hypothermia (32–35 °C) with propofol or dexmedetomidine. Histologic injury score and molecular biomarkers were evaluated not only in brain, but also in lung and kidney. Hemodynamics, ventilatory parameters, and carotid Doppler ultrasonography were analyzed for 60 min. Results In brain: (1) hypothermia compared to normothermia, regardless of sedative, decreased tumor necrosis factor (TNF)-α expression and histologic injury score; (2) normothermia + dexmedetomidine reduced TNF-α and histologic injury score compared to normothermia + propofol; (3) hypothermia + dexmedetomidine increased zonula occludens-1 expression compared to normothermia + dexmedetomidine. In lungs: (1) hypothermia + propofol compared to normothermia + propofol reduced TNF-α and histologic injury score; (2) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine reduced histologic injury score. In kidneys: (1) hypothermia + dexmedetomidine compared to normothermia + dexmedetomidine decreased syndecan expression and histologic injury score; (2) hypothermia + dexmedetomidine compared to hypothermia + propofol decreased histologic injury score. Conclusions In experimental AIS, the combination of mild hypothermia with dexmedetomidine reduced brain, lung, and kidney damage. © The Author(s) 2022
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title_short	Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
url	https://dx.doi.org/10.1186/s40635-022-00481-4
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author2	da Silva, Adriana Lopes Felix, Nathane Santanna Rodrigues, Gisele Antunes, Mariana Alves Rocha, Nazareth Novaes Capelozzi, Vera Luiza Morales, Marcelo Marcos Cruz, Fernanda Ferreira Robba, Chiara Silva, Pedro Leme Pelosi, Paolo Rocco, Patricia Rieken Macedo
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