How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis

Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review...
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Autor*in:	Avila, Amanda [verfasserIn] Do, Michael T. Acuña, Alexander J. Samuel, Linsen T. Kamath, Atul F.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Total hip arthroplasty (THA) Periprosthetic joint infection (PJI) Intra-articular injections (IAIs) Systematic review Meta-analysis

Anmerkung:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022

Übergeordnetes Werk:	Enthalten in: Archives of orthopaedic and trauma surgery - Berlin : Springer, 1903, 143(2022), 3 vom: 12. Feb., Seite 1627-1635
Übergeordnetes Werk:	volume:143 ; year:2022 ; number:3 ; day:12 ; month:02 ; pages:1627-1635

Links:	Volltext

DOI / URN:	10.1007/s00402-022-04375-8

Katalog-ID:	SPR049469037

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520			\|a Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization.
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allfields	10.1007/s00402-022-04375-8 doi (DE-627)SPR049469037 (SPR)s00402-022-04375-8-e DE-627 ger DE-627 rakwb eng Avila, Amanda verfasserin aut How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. Total hip arthroplasty (THA) (dpeaa)DE-He213 Periprosthetic joint infection (PJI) (dpeaa)DE-He213 Intra-articular injections (IAIs) (dpeaa)DE-He213 Systematic review (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Do, Michael T. aut Acuña, Alexander J. aut Samuel, Linsen T. aut Kamath, Atul F. (orcid)0000-0002-9214-2756 aut Enthalten in Archives of orthopaedic and trauma surgery Berlin : Springer, 1903 143(2022), 3 vom: 12. Feb., Seite 1627-1635 (DE-627)253390087 (DE-600)1458452-9 1434-3916 nnns volume:143 year:2022 number:3 day:12 month:02 pages:1627-1635 https://dx.doi.org/10.1007/s00402-022-04375-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 143 2022 3 12 02 1627-1635
spelling	10.1007/s00402-022-04375-8 doi (DE-627)SPR049469037 (SPR)s00402-022-04375-8-e DE-627 ger DE-627 rakwb eng Avila, Amanda verfasserin aut How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. Total hip arthroplasty (THA) (dpeaa)DE-He213 Periprosthetic joint infection (PJI) (dpeaa)DE-He213 Intra-articular injections (IAIs) (dpeaa)DE-He213 Systematic review (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Do, Michael T. aut Acuña, Alexander J. aut Samuel, Linsen T. aut Kamath, Atul F. (orcid)0000-0002-9214-2756 aut Enthalten in Archives of orthopaedic and trauma surgery Berlin : Springer, 1903 143(2022), 3 vom: 12. Feb., Seite 1627-1635 (DE-627)253390087 (DE-600)1458452-9 1434-3916 nnns volume:143 year:2022 number:3 day:12 month:02 pages:1627-1635 https://dx.doi.org/10.1007/s00402-022-04375-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 143 2022 3 12 02 1627-1635
allfields_unstemmed	10.1007/s00402-022-04375-8 doi (DE-627)SPR049469037 (SPR)s00402-022-04375-8-e DE-627 ger DE-627 rakwb eng Avila, Amanda verfasserin aut How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. Total hip arthroplasty (THA) (dpeaa)DE-He213 Periprosthetic joint infection (PJI) (dpeaa)DE-He213 Intra-articular injections (IAIs) (dpeaa)DE-He213 Systematic review (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Do, Michael T. aut Acuña, Alexander J. aut Samuel, Linsen T. aut Kamath, Atul F. (orcid)0000-0002-9214-2756 aut Enthalten in Archives of orthopaedic and trauma surgery Berlin : Springer, 1903 143(2022), 3 vom: 12. Feb., Seite 1627-1635 (DE-627)253390087 (DE-600)1458452-9 1434-3916 nnns volume:143 year:2022 number:3 day:12 month:02 pages:1627-1635 https://dx.doi.org/10.1007/s00402-022-04375-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 143 2022 3 12 02 1627-1635
allfieldsGer	10.1007/s00402-022-04375-8 doi (DE-627)SPR049469037 (SPR)s00402-022-04375-8-e DE-627 ger DE-627 rakwb eng Avila, Amanda verfasserin aut How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. Total hip arthroplasty (THA) (dpeaa)DE-He213 Periprosthetic joint infection (PJI) (dpeaa)DE-He213 Intra-articular injections (IAIs) (dpeaa)DE-He213 Systematic review (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Do, Michael T. aut Acuña, Alexander J. aut Samuel, Linsen T. aut Kamath, Atul F. (orcid)0000-0002-9214-2756 aut Enthalten in Archives of orthopaedic and trauma surgery Berlin : Springer, 1903 143(2022), 3 vom: 12. Feb., Seite 1627-1635 (DE-627)253390087 (DE-600)1458452-9 1434-3916 nnns volume:143 year:2022 number:3 day:12 month:02 pages:1627-1635 https://dx.doi.org/10.1007/s00402-022-04375-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 143 2022 3 12 02 1627-1635
allfieldsSound	10.1007/s00402-022-04375-8 doi (DE-627)SPR049469037 (SPR)s00402-022-04375-8-e DE-627 ger DE-627 rakwb eng Avila, Amanda verfasserin aut How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. Total hip arthroplasty (THA) (dpeaa)DE-He213 Periprosthetic joint infection (PJI) (dpeaa)DE-He213 Intra-articular injections (IAIs) (dpeaa)DE-He213 Systematic review (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213 Do, Michael T. aut Acuña, Alexander J. aut Samuel, Linsen T. aut Kamath, Atul F. (orcid)0000-0002-9214-2756 aut Enthalten in Archives of orthopaedic and trauma surgery Berlin : Springer, 1903 143(2022), 3 vom: 12. Feb., Seite 1627-1635 (DE-627)253390087 (DE-600)1458452-9 1434-3916 nnns volume:143 year:2022 number:3 day:12 month:02 pages:1627-1635 https://dx.doi.org/10.1007/s00402-022-04375-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 143 2022 3 12 02 1627-1635
language	English
source	Enthalten in Archives of orthopaedic and trauma surgery 143(2022), 3 vom: 12. Feb., Seite 1627-1635 volume:143 year:2022 number:3 day:12 month:02 pages:1627-1635
sourceStr	Enthalten in Archives of orthopaedic and trauma surgery 143(2022), 3 vom: 12. Feb., Seite 1627-1635 volume:143 year:2022 number:3 day:12 month:02 pages:1627-1635
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Total hip arthroplasty (THA) Periprosthetic joint infection (PJI) Intra-articular injections (IAIs) Systematic review Meta-analysis
isfreeaccess_bool	false
container_title	Archives of orthopaedic and trauma surgery
authorswithroles_txt_mv	Avila, Amanda @@aut@@ Do, Michael T. @@aut@@ Acuña, Alexander J. @@aut@@ Samuel, Linsen T. @@aut@@ Kamath, Atul F. @@aut@@
publishDateDaySort_date	2022-02-12T00:00:00Z
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language_de	englisch
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author	Avila, Amanda
spellingShingle	Avila, Amanda misc Total hip arthroplasty (THA) misc Periprosthetic joint infection (PJI) misc Intra-articular injections (IAIs) misc Systematic review misc Meta-analysis How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis
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topic_title	How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis Total hip arthroplasty (THA) (dpeaa)DE-He213 Periprosthetic joint infection (PJI) (dpeaa)DE-He213 Intra-articular injections (IAIs) (dpeaa)DE-He213 Systematic review (dpeaa)DE-He213 Meta-analysis (dpeaa)DE-He213
topic	misc Total hip arthroplasty (THA) misc Periprosthetic joint infection (PJI) misc Intra-articular injections (IAIs) misc Systematic review misc Meta-analysis
topic_unstemmed	misc Total hip arthroplasty (THA) misc Periprosthetic joint infection (PJI) misc Intra-articular injections (IAIs) misc Systematic review misc Meta-analysis
topic_browse	misc Total hip arthroplasty (THA) misc Periprosthetic joint infection (PJI) misc Intra-articular injections (IAIs) misc Systematic review misc Meta-analysis
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title	How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis
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title_full	How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis
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author_browse	Avila, Amanda Do, Michael T. Acuña, Alexander J. Samuel, Linsen T. Kamath, Atul F.
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title_sort	how do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? a systematic review and meta-analysis
title_auth	How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis
abstract	Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
abstractGer	Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
abstract_unstemmed	Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. IAI receipt within 3-months of THA was associated with significantly higher PJI rates (OR: 1.68, 95% CI 1.48–1.90; p < 0.001). However, no significant difference was demonstrated in the > 3–6 month (OR: 1.19, 95% CI 0.94–1.52; p = 0.16) and > 6 + month sub-analyses (OR: 1.20, 95% CI 0.96–1.50; p = 0.11). The results of all sub-analyses remained were robust. Discussion Our findings suggest that patients requiring THA should wait at least 3-months following IAI to reduce post-operative infection risk. This information can help inform patients considering OA management options, as well as adult reconstruction surgeons during preoperative optimization. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
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title_short	How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis
url	https://dx.doi.org/10.1007/s00402-022-04375-8
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author2	Do, Michael T. Acuña, Alexander J. Samuel, Linsen T. Kamath, Atul F.
author2Str	Do, Michael T. Acuña, Alexander J. Samuel, Linsen T. Kamath, Atul F.
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doi_str	10.1007/s00402-022-04375-8
up_date	2024-07-04T00:56:12.913Z
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A systematic review and meta-analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction Although intra-articular injections (IAIs) serve as the first-line non-surgical management for severe osteoarthritis (OA), recent analyses have suggested they are associated with an increased infection risk following primary total hip arthroplasty (THA). Therefore, our systematic review and meta-analysis explored the relationship between IAIs and periprosthetic joint infection (PJI) following THA reported in the current literature. Methods Five online databases were queried for analyses published from January 1st, 2000–May 1st, 2021 reporting on PJI rates between patients undergoing primary THA who did and did not preoperatively receive an IAI. The overall pooled effect of injection status on PJI incidence was determined using Mantel–Haenszel (M-H) models. This was similarly conducted for segregated preoperative intervals: 0–3 months, > 3–6 months, > 6 + months. Results A total of 11 articles were included in our analysis reporting on 278,782 THAs (IAI: n = 41,138; no IAI: n = 237,644). Patients receiving pre-operative injections had a significantly higher risk of PJI (OR: 1.31, 95% CI 1.07–1.62; p = 0.009). However, this finding was not robust. 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How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis

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