Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies

Objectives Perioperative chemo-(radio-) therapy is the accepted standard in European patients with locally advanced adenocarcinoma of the esophagogastric junction or stomach (AEG/AS). However, 30–85% of patients do not respond to this treatment. The aim of our study was the identification of predict...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Kleo, Karsten [verfasserIn]

Jovanovic, Vladimir M.

Arndold, Alexander

Lehmann, Annika

Lammert, Hedwig

Berg, Erika

Harloff, Hannah

Treese, Christoph

Hummel, Michael

Daum, Severin

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2022

Schlagwörter:

Gastric and esophagogastric adenocarcinoma

Perioperative chemotherapy

Histopathological response according to Becker score

Predictive biomarker in pre-therapeutic biopsies

Single nucleotide variants (SNV)

copy number variations (CNV)

gene expression

Anmerkung:

© The Author(s) 2022

Übergeordnetes Werk:

Enthalten in: Journal of cancer research and clinical oncology - Berlin : Springer, 1904, 149(2022), 3 vom: 05. März, Seite 1049-1061

Übergeordnetes Werk:

volume:149 ; year:2022 ; number:3 ; day:05 ; month:03 ; pages:1049-1061

Links:

Volltext

DOI / URN:

10.1007/s00432-022-03944-z

Katalog-ID:

SPR049534009

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