Targeting purinergic receptors to attenuate inflammation of dry eye

Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulati...
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Autor*in:	Wang, Jia-Ning [verfasserIn] Fan, Hua Song, Jian-Tao

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Dry eye disease Purines Purinergic receptors Inflammation

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Purinergic signalling - Dordrecht : Springer Science + Business Media B.V., 2004, 19(2022), 1 vom: 26. Feb., Seite 199-206
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:1 ; day:26 ; month:02 ; pages:199-206

Links:	Volltext

DOI / URN:	10.1007/s11302-022-09851-9

Katalog-ID:	SPR049538748

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520			\|a Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future.
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author_variant	j n w jnw h f hf j t s jts
matchkey_str	article:15739546:2022----::agtnprnrircposoteutif
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publishDate	2022
allfields	10.1007/s11302-022-09851-9 doi (DE-627)SPR049538748 (SPR)s11302-022-09851-9-e DE-627 ger DE-627 rakwb eng Wang, Jia-Ning verfasserin aut Targeting purinergic receptors to attenuate inflammation of dry eye 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. Dry eye disease (dpeaa)DE-He213 Purines (dpeaa)DE-He213 Purinergic receptors (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Fan, Hua aut Song, Jian-Tao aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 19(2022), 1 vom: 26. Feb., Seite 199-206 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:19 year:2022 number:1 day:26 month:02 pages:199-206 https://dx.doi.org/10.1007/s11302-022-09851-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2022 1 26 02 199-206
spelling	10.1007/s11302-022-09851-9 doi (DE-627)SPR049538748 (SPR)s11302-022-09851-9-e DE-627 ger DE-627 rakwb eng Wang, Jia-Ning verfasserin aut Targeting purinergic receptors to attenuate inflammation of dry eye 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. Dry eye disease (dpeaa)DE-He213 Purines (dpeaa)DE-He213 Purinergic receptors (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Fan, Hua aut Song, Jian-Tao aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 19(2022), 1 vom: 26. Feb., Seite 199-206 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:19 year:2022 number:1 day:26 month:02 pages:199-206 https://dx.doi.org/10.1007/s11302-022-09851-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2022 1 26 02 199-206
allfields_unstemmed	10.1007/s11302-022-09851-9 doi (DE-627)SPR049538748 (SPR)s11302-022-09851-9-e DE-627 ger DE-627 rakwb eng Wang, Jia-Ning verfasserin aut Targeting purinergic receptors to attenuate inflammation of dry eye 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. Dry eye disease (dpeaa)DE-He213 Purines (dpeaa)DE-He213 Purinergic receptors (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Fan, Hua aut Song, Jian-Tao aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 19(2022), 1 vom: 26. Feb., Seite 199-206 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:19 year:2022 number:1 day:26 month:02 pages:199-206 https://dx.doi.org/10.1007/s11302-022-09851-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2022 1 26 02 199-206
allfieldsGer	10.1007/s11302-022-09851-9 doi (DE-627)SPR049538748 (SPR)s11302-022-09851-9-e DE-627 ger DE-627 rakwb eng Wang, Jia-Ning verfasserin aut Targeting purinergic receptors to attenuate inflammation of dry eye 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. Dry eye disease (dpeaa)DE-He213 Purines (dpeaa)DE-He213 Purinergic receptors (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Fan, Hua aut Song, Jian-Tao aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 19(2022), 1 vom: 26. Feb., Seite 199-206 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:19 year:2022 number:1 day:26 month:02 pages:199-206 https://dx.doi.org/10.1007/s11302-022-09851-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2022 1 26 02 199-206
allfieldsSound	10.1007/s11302-022-09851-9 doi (DE-627)SPR049538748 (SPR)s11302-022-09851-9-e DE-627 ger DE-627 rakwb eng Wang, Jia-Ning verfasserin aut Targeting purinergic receptors to attenuate inflammation of dry eye 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. Dry eye disease (dpeaa)DE-He213 Purines (dpeaa)DE-He213 Purinergic receptors (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Fan, Hua aut Song, Jian-Tao aut Enthalten in Purinergic signalling Dordrecht : Springer Science + Business Media B.V., 2004 19(2022), 1 vom: 26. Feb., Seite 199-206 (DE-627)476536294 (DE-600)2172143-9 1573-9546 nnns volume:19 year:2022 number:1 day:26 month:02 pages:199-206 https://dx.doi.org/10.1007/s11302-022-09851-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2022 1 26 02 199-206
language	English
source	Enthalten in Purinergic signalling 19(2022), 1 vom: 26. Feb., Seite 199-206 volume:19 year:2022 number:1 day:26 month:02 pages:199-206
sourceStr	Enthalten in Purinergic signalling 19(2022), 1 vom: 26. Feb., Seite 199-206 volume:19 year:2022 number:1 day:26 month:02 pages:199-206
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Dry eye disease Purines Purinergic receptors Inflammation
isfreeaccess_bool	true
container_title	Purinergic signalling
authorswithroles_txt_mv	Wang, Jia-Ning @@aut@@ Fan, Hua @@aut@@ Song, Jian-Tao @@aut@@
publishDateDaySort_date	2022-02-26T00:00:00Z
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id	SPR049538748
language_de	englisch
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author	Wang, Jia-Ning
spellingShingle	Wang, Jia-Ning misc Dry eye disease misc Purines misc Purinergic receptors misc Inflammation Targeting purinergic receptors to attenuate inflammation of dry eye
authorStr	Wang, Jia-Ning
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topic_title	Targeting purinergic receptors to attenuate inflammation of dry eye Dry eye disease (dpeaa)DE-He213 Purines (dpeaa)DE-He213 Purinergic receptors (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213
topic	misc Dry eye disease misc Purines misc Purinergic receptors misc Inflammation
topic_unstemmed	misc Dry eye disease misc Purines misc Purinergic receptors misc Inflammation
topic_browse	misc Dry eye disease misc Purines misc Purinergic receptors misc Inflammation
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title	Targeting purinergic receptors to attenuate inflammation of dry eye
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title_full	Targeting purinergic receptors to attenuate inflammation of dry eye
author_sort	Wang, Jia-Ning
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author_browse	Wang, Jia-Ning Fan, Hua Song, Jian-Tao
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author-letter	Wang, Jia-Ning
doi_str_mv	10.1007/s11302-022-09851-9
title_sort	targeting purinergic receptors to attenuate inflammation of dry eye
title_auth	Targeting purinergic receptors to attenuate inflammation of dry eye
abstract	Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. © The Author(s) 2022
abstractGer	Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. © The Author(s) 2022
abstract_unstemmed	Abstract Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic $ A_{1} $, $ A_{2A} $, $ A_{3} $, P2X4, P2X7, $ P2Y_{1} $, $ P2Y_{2} $, and $ P2Y_{4} $ receptors play an important role in the regulation of inflammation in DED: $ A_{1} $ adenosine receptor ($ A_{1R} $) is a systemic pro-inflammatory factor; $ A_{2AR} $ is involved in the activation of the MAPK/NF-kB pathway; $ A_{3R} $ combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/$ Ca^{2+} $ signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future. © The Author(s) 2022
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container_issue	1
title_short	Targeting purinergic receptors to attenuate inflammation of dry eye
url	https://dx.doi.org/10.1007/s11302-022-09851-9
remote_bool	true
author2	Fan, Hua Song, Jian-Tao
author2Str	Fan, Hua Song, Jian-Tao
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doi_str	10.1007/s11302-022-09851-9
up_date	2024-07-04T01:14:05.815Z
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Targeting purinergic receptors to attenuate inflammation of dry eye

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