Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediate...
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Autor*in:	Tan, Shiming [verfasserIn] Yang, Yiqing Yang, Wenjuan Han, Yaqian Huang, Lisheng Yang, Ruiqian Hu, Zifan Tao, Yi Liu, Lin Li, Yun Oyang, Linda Lin, Jinguan Peng, Qiu Jiang, Xianjie Xu, Xuemeng Xia, Longzheng Peng, Mingjing Wu, Nayiyuan Tang, Yanyan Cao, Deliang Liao, Qianjin Zhou, Yujuan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Exosomal cargo TME Metabolism CAFs Angiogenesis T lymphocytes TAMs Adipocytes Stellate cells ECM

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Journal of experimental & clinical cancer research - Berlin : Springer, 2008, 42(2023), 1 vom: 10. März
Übergeordnetes Werk:	volume:42 ; year:2023 ; number:1 ; day:10 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s13046-023-02634-z

Katalog-ID:	SPR049639455

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allfields	10.1186/s13046-023-02634-z doi (DE-627)SPR049639455 (SPR)s13046-023-02634-z-e DE-627 ger DE-627 rakwb eng Tan, Shiming verfasserin aut Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. Exosomal cargo (dpeaa)DE-He213 TME (dpeaa)DE-He213 Metabolism (dpeaa)DE-He213 CAFs (dpeaa)DE-He213 Angiogenesis (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 TAMs (dpeaa)DE-He213 Adipocytes (dpeaa)DE-He213 Stellate cells (dpeaa)DE-He213 ECM (dpeaa)DE-He213 Yang, Yiqing aut Yang, Wenjuan aut Han, Yaqian aut Huang, Lisheng aut Yang, Ruiqian aut Hu, Zifan aut Tao, Yi aut Liu, Lin aut Li, Yun aut Oyang, Linda aut Lin, Jinguan aut Peng, Qiu aut Jiang, Xianjie aut Xu, Xuemeng aut Xia, Longzheng aut Peng, Mingjing aut Wu, Nayiyuan aut Tang, Yanyan aut Cao, Deliang aut Liao, Qianjin (orcid)0000-0001-9320-3090 aut Zhou, Yujuan aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 42(2023), 1 vom: 10. März (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:42 year:2023 number:1 day:10 month:03 https://dx.doi.org/10.1186/s13046-023-02634-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2023 1 10 03
spelling	10.1186/s13046-023-02634-z doi (DE-627)SPR049639455 (SPR)s13046-023-02634-z-e DE-627 ger DE-627 rakwb eng Tan, Shiming verfasserin aut Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. Exosomal cargo (dpeaa)DE-He213 TME (dpeaa)DE-He213 Metabolism (dpeaa)DE-He213 CAFs (dpeaa)DE-He213 Angiogenesis (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 TAMs (dpeaa)DE-He213 Adipocytes (dpeaa)DE-He213 Stellate cells (dpeaa)DE-He213 ECM (dpeaa)DE-He213 Yang, Yiqing aut Yang, Wenjuan aut Han, Yaqian aut Huang, Lisheng aut Yang, Ruiqian aut Hu, Zifan aut Tao, Yi aut Liu, Lin aut Li, Yun aut Oyang, Linda aut Lin, Jinguan aut Peng, Qiu aut Jiang, Xianjie aut Xu, Xuemeng aut Xia, Longzheng aut Peng, Mingjing aut Wu, Nayiyuan aut Tang, Yanyan aut Cao, Deliang aut Liao, Qianjin (orcid)0000-0001-9320-3090 aut Zhou, Yujuan aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 42(2023), 1 vom: 10. März (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:42 year:2023 number:1 day:10 month:03 https://dx.doi.org/10.1186/s13046-023-02634-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2023 1 10 03
allfields_unstemmed	10.1186/s13046-023-02634-z doi (DE-627)SPR049639455 (SPR)s13046-023-02634-z-e DE-627 ger DE-627 rakwb eng Tan, Shiming verfasserin aut Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. Exosomal cargo (dpeaa)DE-He213 TME (dpeaa)DE-He213 Metabolism (dpeaa)DE-He213 CAFs (dpeaa)DE-He213 Angiogenesis (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 TAMs (dpeaa)DE-He213 Adipocytes (dpeaa)DE-He213 Stellate cells (dpeaa)DE-He213 ECM (dpeaa)DE-He213 Yang, Yiqing aut Yang, Wenjuan aut Han, Yaqian aut Huang, Lisheng aut Yang, Ruiqian aut Hu, Zifan aut Tao, Yi aut Liu, Lin aut Li, Yun aut Oyang, Linda aut Lin, Jinguan aut Peng, Qiu aut Jiang, Xianjie aut Xu, Xuemeng aut Xia, Longzheng aut Peng, Mingjing aut Wu, Nayiyuan aut Tang, Yanyan aut Cao, Deliang aut Liao, Qianjin (orcid)0000-0001-9320-3090 aut Zhou, Yujuan aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 42(2023), 1 vom: 10. März (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:42 year:2023 number:1 day:10 month:03 https://dx.doi.org/10.1186/s13046-023-02634-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2023 1 10 03
allfieldsGer	10.1186/s13046-023-02634-z doi (DE-627)SPR049639455 (SPR)s13046-023-02634-z-e DE-627 ger DE-627 rakwb eng Tan, Shiming verfasserin aut Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. Exosomal cargo (dpeaa)DE-He213 TME (dpeaa)DE-He213 Metabolism (dpeaa)DE-He213 CAFs (dpeaa)DE-He213 Angiogenesis (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 TAMs (dpeaa)DE-He213 Adipocytes (dpeaa)DE-He213 Stellate cells (dpeaa)DE-He213 ECM (dpeaa)DE-He213 Yang, Yiqing aut Yang, Wenjuan aut Han, Yaqian aut Huang, Lisheng aut Yang, Ruiqian aut Hu, Zifan aut Tao, Yi aut Liu, Lin aut Li, Yun aut Oyang, Linda aut Lin, Jinguan aut Peng, Qiu aut Jiang, Xianjie aut Xu, Xuemeng aut Xia, Longzheng aut Peng, Mingjing aut Wu, Nayiyuan aut Tang, Yanyan aut Cao, Deliang aut Liao, Qianjin (orcid)0000-0001-9320-3090 aut Zhou, Yujuan aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 42(2023), 1 vom: 10. März (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:42 year:2023 number:1 day:10 month:03 https://dx.doi.org/10.1186/s13046-023-02634-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2023 1 10 03
allfieldsSound	10.1186/s13046-023-02634-z doi (DE-627)SPR049639455 (SPR)s13046-023-02634-z-e DE-627 ger DE-627 rakwb eng Tan, Shiming verfasserin aut Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. Exosomal cargo (dpeaa)DE-He213 TME (dpeaa)DE-He213 Metabolism (dpeaa)DE-He213 CAFs (dpeaa)DE-He213 Angiogenesis (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 TAMs (dpeaa)DE-He213 Adipocytes (dpeaa)DE-He213 Stellate cells (dpeaa)DE-He213 ECM (dpeaa)DE-He213 Yang, Yiqing aut Yang, Wenjuan aut Han, Yaqian aut Huang, Lisheng aut Yang, Ruiqian aut Hu, Zifan aut Tao, Yi aut Liu, Lin aut Li, Yun aut Oyang, Linda aut Lin, Jinguan aut Peng, Qiu aut Jiang, Xianjie aut Xu, Xuemeng aut Xia, Longzheng aut Peng, Mingjing aut Wu, Nayiyuan aut Tang, Yanyan aut Cao, Deliang aut Liao, Qianjin (orcid)0000-0001-9320-3090 aut Zhou, Yujuan aut Enthalten in Journal of experimental & clinical cancer research Berlin : Springer, 2008 42(2023), 1 vom: 10. März (DE-627)568921380 (DE-600)2430698-8 1756-9966 nnns volume:42 year:2023 number:1 day:10 month:03 https://dx.doi.org/10.1186/s13046-023-02634-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2023 1 10 03
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authorswithroles_txt_mv	Tan, Shiming @@aut@@ Yang, Yiqing @@aut@@ Yang, Wenjuan @@aut@@ Han, Yaqian @@aut@@ Huang, Lisheng @@aut@@ Yang, Ruiqian @@aut@@ Hu, Zifan @@aut@@ Tao, Yi @@aut@@ Liu, Lin @@aut@@ Li, Yun @@aut@@ Oyang, Linda @@aut@@ Lin, Jinguan @@aut@@ Peng, Qiu @@aut@@ Jiang, Xianjie @@aut@@ Xu, Xuemeng @@aut@@ Xia, Longzheng @@aut@@ Peng, Mingjing @@aut@@ Wu, Nayiyuan @@aut@@ Tang, Yanyan @@aut@@ Cao, Deliang @@aut@@ Liao, Qianjin @@aut@@ Zhou, Yujuan @@aut@@
publishDateDaySort_date	2023-03-10T00:00:00Z
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author	Tan, Shiming
spellingShingle	Tan, Shiming misc Exosomal cargo misc TME misc Metabolism misc CAFs misc Angiogenesis misc T lymphocytes misc TAMs misc Adipocytes misc Stellate cells misc ECM Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
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topic_title	Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment Exosomal cargo (dpeaa)DE-He213 TME (dpeaa)DE-He213 Metabolism (dpeaa)DE-He213 CAFs (dpeaa)DE-He213 Angiogenesis (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 TAMs (dpeaa)DE-He213 Adipocytes (dpeaa)DE-He213 Stellate cells (dpeaa)DE-He213 ECM (dpeaa)DE-He213
topic	misc Exosomal cargo misc TME misc Metabolism misc CAFs misc Angiogenesis misc T lymphocytes misc TAMs misc Adipocytes misc Stellate cells misc ECM
topic_unstemmed	misc Exosomal cargo misc TME misc Metabolism misc CAFs misc Angiogenesis misc T lymphocytes misc TAMs misc Adipocytes misc Stellate cells misc ECM
topic_browse	misc Exosomal cargo misc TME misc Metabolism misc CAFs misc Angiogenesis misc T lymphocytes misc TAMs misc Adipocytes misc Stellate cells misc ECM
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title	Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
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author_browse	Tan, Shiming Yang, Yiqing Yang, Wenjuan Han, Yaqian Huang, Lisheng Yang, Ruiqian Hu, Zifan Tao, Yi Liu, Lin Li, Yun Oyang, Linda Lin, Jinguan Peng, Qiu Jiang, Xianjie Xu, Xuemeng Xia, Longzheng Peng, Mingjing Wu, Nayiyuan Tang, Yanyan Cao, Deliang Liao, Qianjin Zhou, Yujuan
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title_sort	exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
title_auth	Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
abstract	Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. © The Author(s) 2023
abstractGer	Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. © The Author(s) 2023
abstract_unstemmed	Abstract Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. © The Author(s) 2023
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title_short	Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
url	https://dx.doi.org/10.1186/s13046-023-02634-z
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author2	Yang, Yiqing Yang, Wenjuan Han, Yaqian Huang, Lisheng Yang, Ruiqian Hu, Zifan Tao, Yi Liu, Lin Li, Yun Oyang, Linda Lin, Jinguan Peng, Qiu Jiang, Xianjie Xu, Xuemeng Xia, Longzheng Peng, Mingjing Wu, Nayiyuan Tang, Yanyan Cao, Deliang Liao, Qianjin Zhou, Yujuan
author2Str	Yang, Yiqing Yang, Wenjuan Han, Yaqian Huang, Lisheng Yang, Ruiqian Hu, Zifan Tao, Yi Liu, Lin Li, Yun Oyang, Linda Lin, Jinguan Peng, Qiu Jiang, Xianjie Xu, Xuemeng Xia, Longzheng Peng, Mingjing Wu, Nayiyuan Tang, Yanyan Cao, Deliang Liao, Qianjin Zhou, Yujuan
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up_date	2024-07-04T01:40:22.614Z
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As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Exosomal cargo</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">TME</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Metabolism</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CAFs</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Angiogenesis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">T lymphocytes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">TAMs</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Adipocytes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stellate cells</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ECM</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yang, Yiqing</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yang, Wenjuan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Yaqian</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Huang, Lisheng</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yang, Ruiqian</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hu, Zifan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tao, Yi</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liu, Lin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Yun</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oyang, Linda</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lin, Jinguan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Peng, Qiu</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jiang, Xianjie</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xu, Xuemeng</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xia, Longzheng</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Peng, Mingjing</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Nayiyuan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tang, Yanyan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cao, Deliang</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liao, Qianjin</subfield><subfield code="0">(orcid)0000-0001-9320-3090</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhou, Yujuan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of experimental & clinical cancer research</subfield><subfield code="d">Berlin : Springer, 2008</subfield><subfield code="g">42(2023), 1 vom: 10. 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Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

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