Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review

Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can caus...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Boer, Willem [verfasserIn] Verbrugghe, Walter Hoste, Eric Jacobs, Rita Jorens, Philippe G.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Citrate anticoagulation Calcium balance Hormones Phosphate Magnesium Review

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Annals of intensive care - Heidelberg : Springer, 2011, 13(2023), 1 vom: 11. März
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:1 ; day:11 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s13613-023-01113-0

Katalog-ID:	SPR049640194

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520			\|a Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account.
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allfields	10.1186/s13613-023-01113-0 doi (DE-627)SPR049640194 (SPR)s13613-023-01113-0-e DE-627 ger DE-627 rakwb eng Boer, Willem verfasserin (orcid)0000-0002-5010-4567 aut Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. Citrate anticoagulation (dpeaa)DE-He213 Calcium balance (dpeaa)DE-He213 Hormones (dpeaa)DE-He213 Phosphate (dpeaa)DE-He213 Magnesium (dpeaa)DE-He213 Review (dpeaa)DE-He213 Verbrugghe, Walter aut Hoste, Eric aut Jacobs, Rita aut Jorens, Philippe G. aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 13(2023), 1 vom: 11. März (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:13 year:2023 number:1 day:11 month:03 https://dx.doi.org/10.1186/s13613-023-01113-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 11 03
spelling	10.1186/s13613-023-01113-0 doi (DE-627)SPR049640194 (SPR)s13613-023-01113-0-e DE-627 ger DE-627 rakwb eng Boer, Willem verfasserin (orcid)0000-0002-5010-4567 aut Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. Citrate anticoagulation (dpeaa)DE-He213 Calcium balance (dpeaa)DE-He213 Hormones (dpeaa)DE-He213 Phosphate (dpeaa)DE-He213 Magnesium (dpeaa)DE-He213 Review (dpeaa)DE-He213 Verbrugghe, Walter aut Hoste, Eric aut Jacobs, Rita aut Jorens, Philippe G. aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 13(2023), 1 vom: 11. März (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:13 year:2023 number:1 day:11 month:03 https://dx.doi.org/10.1186/s13613-023-01113-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 11 03
allfields_unstemmed	10.1186/s13613-023-01113-0 doi (DE-627)SPR049640194 (SPR)s13613-023-01113-0-e DE-627 ger DE-627 rakwb eng Boer, Willem verfasserin (orcid)0000-0002-5010-4567 aut Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. Citrate anticoagulation (dpeaa)DE-He213 Calcium balance (dpeaa)DE-He213 Hormones (dpeaa)DE-He213 Phosphate (dpeaa)DE-He213 Magnesium (dpeaa)DE-He213 Review (dpeaa)DE-He213 Verbrugghe, Walter aut Hoste, Eric aut Jacobs, Rita aut Jorens, Philippe G. aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 13(2023), 1 vom: 11. März (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:13 year:2023 number:1 day:11 month:03 https://dx.doi.org/10.1186/s13613-023-01113-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 11 03
allfieldsGer	10.1186/s13613-023-01113-0 doi (DE-627)SPR049640194 (SPR)s13613-023-01113-0-e DE-627 ger DE-627 rakwb eng Boer, Willem verfasserin (orcid)0000-0002-5010-4567 aut Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. Citrate anticoagulation (dpeaa)DE-He213 Calcium balance (dpeaa)DE-He213 Hormones (dpeaa)DE-He213 Phosphate (dpeaa)DE-He213 Magnesium (dpeaa)DE-He213 Review (dpeaa)DE-He213 Verbrugghe, Walter aut Hoste, Eric aut Jacobs, Rita aut Jorens, Philippe G. aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 13(2023), 1 vom: 11. März (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:13 year:2023 number:1 day:11 month:03 https://dx.doi.org/10.1186/s13613-023-01113-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 11 03
allfieldsSound	10.1186/s13613-023-01113-0 doi (DE-627)SPR049640194 (SPR)s13613-023-01113-0-e DE-627 ger DE-627 rakwb eng Boer, Willem verfasserin (orcid)0000-0002-5010-4567 aut Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. Citrate anticoagulation (dpeaa)DE-He213 Calcium balance (dpeaa)DE-He213 Hormones (dpeaa)DE-He213 Phosphate (dpeaa)DE-He213 Magnesium (dpeaa)DE-He213 Review (dpeaa)DE-He213 Verbrugghe, Walter aut Hoste, Eric aut Jacobs, Rita aut Jorens, Philippe G. aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 13(2023), 1 vom: 11. März (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:13 year:2023 number:1 day:11 month:03 https://dx.doi.org/10.1186/s13613-023-01113-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 11 03
language	English
source	Enthalten in Annals of intensive care 13(2023), 1 vom: 11. März volume:13 year:2023 number:1 day:11 month:03
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format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Citrate anticoagulation Calcium balance Hormones Phosphate Magnesium Review
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container_title	Annals of intensive care
authorswithroles_txt_mv	Boer, Willem @@aut@@ Verbrugghe, Walter @@aut@@ Hoste, Eric @@aut@@ Jacobs, Rita @@aut@@ Jorens, Philippe G. @@aut@@
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author	Boer, Willem
spellingShingle	Boer, Willem misc Citrate anticoagulation misc Calcium balance misc Hormones misc Phosphate misc Magnesium misc Review Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review
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topic_title	Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review Citrate anticoagulation (dpeaa)DE-He213 Calcium balance (dpeaa)DE-He213 Hormones (dpeaa)DE-He213 Phosphate (dpeaa)DE-He213 Magnesium (dpeaa)DE-He213 Review (dpeaa)DE-He213
topic	misc Citrate anticoagulation misc Calcium balance misc Hormones misc Phosphate misc Magnesium misc Review
topic_unstemmed	misc Citrate anticoagulation misc Calcium balance misc Hormones misc Phosphate misc Magnesium misc Review
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title	Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review
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title_full	Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review
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title_sort	unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review
title_auth	Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review
abstract	Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. © The Author(s) 2023
abstractGer	Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. © The Author(s) 2023
abstract_unstemmed	Abstract The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid–base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant. We highlight the effects seen on the calcium balance and hormonal status, phosphate and magnesium balance, as well as oxidative stress resulting from these unapparent effects. As most of these data on these non-anticoagulation effects have been obtained in small observational studies, new and larger studies documenting both short- and long-term effects should be undertaken. Subsequent future guidelines for citrate-based continuous renal replacement therapy should take not only the metabolic but also these unapparent effects into account. © The Author(s) 2023
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title_short	Unapparent systemic effects of regional anticoagulation with citrate in continuous renal replacement therapy: a narrative review
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