Research Progress of Biomarkers of Sepsis-Associated Encephalopathy

Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation o...
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Autor*in:	Tang, ChengXin [verfasserIn] Zhou, WuShuang Chen, XiaoYing Wang, FengLin Men, WenXian Liu, JingLun Zhang, Dan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Sepsis-associated encephalopathy Biomarkers Diagnosis and evaluation

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Intensive Care Research - Springer Netherlands, 2022, 3(2023), 1 vom: 11. Jan., Seite 69-76
Übergeordnetes Werk:	volume:3 ; year:2023 ; number:1 ; day:11 ; month:01 ; pages:69-76

Links:	Volltext

DOI / URN:	10.1007/s44231-022-00023-2

Katalog-ID:	SPR04964808X

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allfields	10.1007/s44231-022-00023-2 doi (DE-627)SPR04964808X (SPR)s44231-022-00023-2-e DE-627 ger DE-627 rakwb eng Tang, ChengXin verfasserin aut Research Progress of Biomarkers of Sepsis-Associated Encephalopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. Sepsis-associated encephalopathy (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Diagnosis and evaluation (dpeaa)DE-He213 Zhou, WuShuang aut Chen, XiaoYing aut Wang, FengLin aut Men, WenXian aut Liu, JingLun aut Zhang, Dan aut Enthalten in Intensive Care Research Springer Netherlands, 2022 3(2023), 1 vom: 11. Jan., Seite 69-76 (DE-627)1807087301 2666-9862 nnns volume:3 year:2023 number:1 day:11 month:01 pages:69-76 https://dx.doi.org/10.1007/s44231-022-00023-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 1 11 01 69-76
spelling	10.1007/s44231-022-00023-2 doi (DE-627)SPR04964808X (SPR)s44231-022-00023-2-e DE-627 ger DE-627 rakwb eng Tang, ChengXin verfasserin aut Research Progress of Biomarkers of Sepsis-Associated Encephalopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. Sepsis-associated encephalopathy (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Diagnosis and evaluation (dpeaa)DE-He213 Zhou, WuShuang aut Chen, XiaoYing aut Wang, FengLin aut Men, WenXian aut Liu, JingLun aut Zhang, Dan aut Enthalten in Intensive Care Research Springer Netherlands, 2022 3(2023), 1 vom: 11. Jan., Seite 69-76 (DE-627)1807087301 2666-9862 nnns volume:3 year:2023 number:1 day:11 month:01 pages:69-76 https://dx.doi.org/10.1007/s44231-022-00023-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 1 11 01 69-76
allfields_unstemmed	10.1007/s44231-022-00023-2 doi (DE-627)SPR04964808X (SPR)s44231-022-00023-2-e DE-627 ger DE-627 rakwb eng Tang, ChengXin verfasserin aut Research Progress of Biomarkers of Sepsis-Associated Encephalopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. Sepsis-associated encephalopathy (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Diagnosis and evaluation (dpeaa)DE-He213 Zhou, WuShuang aut Chen, XiaoYing aut Wang, FengLin aut Men, WenXian aut Liu, JingLun aut Zhang, Dan aut Enthalten in Intensive Care Research Springer Netherlands, 2022 3(2023), 1 vom: 11. Jan., Seite 69-76 (DE-627)1807087301 2666-9862 nnns volume:3 year:2023 number:1 day:11 month:01 pages:69-76 https://dx.doi.org/10.1007/s44231-022-00023-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 1 11 01 69-76
allfieldsGer	10.1007/s44231-022-00023-2 doi (DE-627)SPR04964808X (SPR)s44231-022-00023-2-e DE-627 ger DE-627 rakwb eng Tang, ChengXin verfasserin aut Research Progress of Biomarkers of Sepsis-Associated Encephalopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. Sepsis-associated encephalopathy (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Diagnosis and evaluation (dpeaa)DE-He213 Zhou, WuShuang aut Chen, XiaoYing aut Wang, FengLin aut Men, WenXian aut Liu, JingLun aut Zhang, Dan aut Enthalten in Intensive Care Research Springer Netherlands, 2022 3(2023), 1 vom: 11. Jan., Seite 69-76 (DE-627)1807087301 2666-9862 nnns volume:3 year:2023 number:1 day:11 month:01 pages:69-76 https://dx.doi.org/10.1007/s44231-022-00023-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 1 11 01 69-76
allfieldsSound	10.1007/s44231-022-00023-2 doi (DE-627)SPR04964808X (SPR)s44231-022-00023-2-e DE-627 ger DE-627 rakwb eng Tang, ChengXin verfasserin aut Research Progress of Biomarkers of Sepsis-Associated Encephalopathy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. Sepsis-associated encephalopathy (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Diagnosis and evaluation (dpeaa)DE-He213 Zhou, WuShuang aut Chen, XiaoYing aut Wang, FengLin aut Men, WenXian aut Liu, JingLun aut Zhang, Dan aut Enthalten in Intensive Care Research Springer Netherlands, 2022 3(2023), 1 vom: 11. Jan., Seite 69-76 (DE-627)1807087301 2666-9862 nnns volume:3 year:2023 number:1 day:11 month:01 pages:69-76 https://dx.doi.org/10.1007/s44231-022-00023-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2023 1 11 01 69-76
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source	Enthalten in Intensive Care Research 3(2023), 1 vom: 11. Jan., Seite 69-76 volume:3 year:2023 number:1 day:11 month:01 pages:69-76
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author	Tang, ChengXin
spellingShingle	Tang, ChengXin misc Sepsis-associated encephalopathy misc Biomarkers misc Diagnosis and evaluation Research Progress of Biomarkers of Sepsis-Associated Encephalopathy
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topic_title	Research Progress of Biomarkers of Sepsis-Associated Encephalopathy Sepsis-associated encephalopathy (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Diagnosis and evaluation (dpeaa)DE-He213
topic	misc Sepsis-associated encephalopathy misc Biomarkers misc Diagnosis and evaluation
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title	Research Progress of Biomarkers of Sepsis-Associated Encephalopathy
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title_full	Research Progress of Biomarkers of Sepsis-Associated Encephalopathy
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title_sort	research progress of biomarkers of sepsis-associated encephalopathy
title_auth	Research Progress of Biomarkers of Sepsis-Associated Encephalopathy
abstract	Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. © The Author(s) 2023
abstractGer	Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. © The Author(s) 2023
abstract_unstemmed	Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence of up to 71%. Pathological neuroinflammation after sepsis leads to acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, the evaluation of SAE severity and prognosis mainly depends on clinical manifestations and imaging features, but lack of effectiveness and timeliness. Biomarkers of nerve injuries nowadays, have shown good application value and perspectives in the diagnosis and evaluation of SAE. This article will review the current biomarkers for accurate diagnosis and evaluation, basing on the possible pathophysiological mechanism of different stages of SAE. © The Author(s) 2023
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title_short	Research Progress of Biomarkers of Sepsis-Associated Encephalopathy
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